BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
238270	FC(F)c1nn(C2CCCCC2)cc1-n1cc(-c2cnn3ccc(N4C[C@H]5C[C@@H]4CO5)nc23)nn1	InChI=1S/C23H25F2N9O/c24-22(25)21-19(12-33(29-21)14-4-2-1-3-5-14)34-11-18(28-30-34)17-9-26-32-7-6-20(27-23(17)32)31-10-16-8-15(31)13-35-16/h6-7,9,11-12,14-16,22H,1-5,8,10,13H2	FCRLAPAWFHUVSK-UHFFFAOYSA-N	540199	(1R,4R)-5-(3-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)-2-oxa-5-azabicyclo[2.2.1]heptane::US20260028337, Compound 1A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540199&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446944	464925185							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238271	N#Cc1cnc2c(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)cnn2c1	InChI=1S/C19H17F2N9/c20-18(21)17-16(11-28(26-17)13-4-2-1-3-5-13)29-10-15(25-27-29)14-8-24-30-9-12(6-22)7-23-19(14)30/h7-11,13,18H,1-5H2	GUXRHDDLFCAPQE-UHFFFAOYSA-N	540200	3-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl) pyrazolo[1,5-a]pyrimidine-6-carbonitrile::US20260028337, Compound 3A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540200&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446945	464925186							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238272	FC(F)c1nn(C2CCCCC2)cc1-n1cc(-c2cnn3ccc(N4CCOCC4)nc23)nn1	InChI=1S/C22H25F2N9O/c23-21(24)20-18(14-32(28-20)15-4-2-1-3-5-15)33-13-17(27-29-33)16-12-25-31-7-6-19(26-22(16)31)30-8-10-34-11-9-30/h6-7,12-15,21H,1-5,8-11H2	VYFPYUTVHVPVRB-UHFFFAOYSA-N	540201	4-(3-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl) pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 4A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540201&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447384	464925187							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238273	N#Cc1cnc2c(ccn2-c2cn(-c3cn(C4CCCCC4)nc3C(F)F)nn2)c1	InChI=1S/C20H18F2N8/c21-19(22)18-16(11-29(26-18)15-4-2-1-3-5-15)30-12-17(25-27-30)28-7-6-14-8-13(9-23)10-24-20(14)28/h6-8,10-12,15,19H,1-5H2	CSBFLINRYDJUCC-UHFFFAOYSA-N	540202	1-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile::US20260028337, Compound 43A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540202&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446946	464925188							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238274	FC(F)c1nn(C2CCCCC2)cc1-n1cc(-n2ccc3ccc(N4CCOCC4)nc32)nn1	InChI=1S/C23H26F2N8O/c24-22(25)21-18(14-32(28-21)17-4-2-1-3-5-17)33-15-20(27-29-33)31-9-8-16-6-7-19(26-23(16)31)30-10-12-34-13-11-30/h6-9,14-15,17,22H,1-5,10-13H2	XKMQFJOOXXWSML-UHFFFAOYSA-N	540203	4-(1-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)morpholine::US20260028337, Compound 45A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540203&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447025	464925189							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238275	Cn1cc(-n2cc(-c3cnn4ccc(N5C[C@H]6C[C@@H]5CO6)nc34)nn2)c(C(F)F)n1	InChI=1S/C18H17F2N9O/c1-26-8-14(16(24-26)17(19)20)29-7-13(23-25-29)12-5-21-28-3-2-15(22-18(12)28)27-6-11-4-10(27)9-30-11/h2-3,5,7-8,10-11,17H,4,6,9H2,1H3	SHCRAWMVPUISCF-UHFFFAOYSA-N	540204	(1R,4R)-5-(3-(1-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-2-oxa-5-azabicyclo[2.2.1]heptane::US20260028337, Compound 46A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540204&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447261	464925190							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238276	FC(F)c1nn(C2CCCCC2)cc1-n1cc(-c2cnn3cccnc23)nn1	InChI=1S/C18H18F2N8/c19-17(20)16-15(11-27(24-16)12-5-2-1-3-6-12)28-10-14(23-25-28)13-9-22-26-8-4-7-21-18(13)26/h4,7-12,17H,1-3,5-6H2	COJGVNCXVAJQBK-UHFFFAOYSA-N	540205	3-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidine::US20260028337, Compound 56A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540205&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447008	464925191							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238277	NC(=O)c1cnn2c(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)ccc2c1	InChI=1S/C20H20F2N8O/c21-19(22)18-17(11-28(26-18)13-4-2-1-3-5-13)29-10-15(25-27-29)16-7-6-14-8-12(20(23)31)9-24-30(14)16/h6-11,13,19H,1-5H2,(H2,23,31)	SNQWCOBSAWJVHX-UHFFFAOYSA-N	540206	7-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrrolo[1,2-b]pyridazine-3-formamide::US20260028337, Compound 60A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540206&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447385	464925192							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238278	O=C(O)c1cnn2c(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)ccc2c1	InChI=1S/C20H19F2N7O2/c21-19(22)18-17(11-27(25-18)13-4-2-1-3-5-13)28-10-15(24-26-28)16-7-6-14-8-12(20(30)31)9-23-29(14)16/h6-11,13,19H,1-5H2,(H,30,31)	JAMRWBTZUDYIRB-UHFFFAOYSA-N	540207	7-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]pyrrolo[1, 2-b]pyridazine-3-carboxylic acid::US20260028337, Compound 61A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540207&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447219	464925193							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238279	O=C(c1cnn2c(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)ccc2c1)N1CCNCC1	InChI=1S/C24H27F2N9O/c25-23(26)22-21(15-33(30-22)17-4-2-1-3-5-17)34-14-19(29-31-34)20-7-6-18-12-16(13-28-35(18)20)24(36)32-10-8-27-9-11-32/h6-7,12-15,17,23,27H,1-5,8-11H2	PBFGZCSYEIKZPO-UHFFFAOYSA-N	540208	(7-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrrolo[1,2-b]pyridazin-3-yl)(piperazin-1-yl)methanone::US20260028337, Compound 64A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540208&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447395	464925194							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238280	NC(=O)c1cnc2c(ccn2-c2cn(-c3cn(C4CCCCC4)nc3C(F)F)nn2)c1	InChI=1S/C20H20F2N8O/c21-18(22)17-15(10-29(26-17)14-4-2-1-3-5-14)30-11-16(25-27-30)28-7-6-12-8-13(19(23)31)9-24-20(12)28/h6-11,14,18H,1-5H2,(H2,23,31)	BSKVCFQZHLOIHK-UHFFFAOYSA-N	540209	1-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-formamide::US20260028337, Compound 65A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540209&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447010	464925195							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238281	O=C(O)c1cnc2c(ccn2-c2cn(-c3cn(C4CCCCC4)nc3C(F)F)nn2)c1	InChI=1S/C20H19F2N7O2/c21-18(22)17-15(10-28(25-17)14-4-2-1-3-5-14)29-11-16(24-26-29)27-7-6-12-8-13(20(30)31)9-23-19(12)27/h6-11,14,18H,1-5H2,(H,30,31)	RETQTXGRKNEDML-UHFFFAOYSA-N	540210	1-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid::US20260028337, Compound 66A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540210&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447145	464925196							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238282	O=C(NC1CCNC1)c1cnn2c(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)ccc2c1	InChI=1S/C24H27F2N9O/c25-23(26)22-21(14-33(31-22)17-4-2-1-3-5-17)34-13-19(30-32-34)20-7-6-18-10-15(11-28-35(18)20)24(36)29-16-8-9-27-12-16/h6-7,10-11,13-14,16-17,23,27H,1-5,8-9,12H2,(H,29,36)	FQOYQYNBKOTNHV-UHFFFAOYSA-N	540211	7-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]-N-(pyrrolidin-3-yl)pyrrolo[1,2-b]pyridazine-3-formamide::US20260028337, Compound 67A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		>5000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540211&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446948	464925197							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238283	O=C(NC1CNCC1(F)F)c1cnn2c(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)ccc2c1	InChI=1S/C24H25F4N9O/c25-22(26)21-19(12-35(33-21)15-4-2-1-3-5-15)36-11-17(32-34-36)18-7-6-16-8-14(9-30-37(16)18)23(38)31-20-10-29-13-24(20,27)28/h6-9,11-12,15,20,22,29H,1-5,10,13H2,(H,31,38)	BKFMVDZDXHBXHD-UHFFFAOYSA-N	540212	7-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]-N-(4,4-difluoropyrrolidin-3-yl)pyrrolo[1, 2-b]pyridazine-3-formamide::US20260028337, Compound 68A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 3000							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540212&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447210	464925198							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238284	FC(F)c1nn(C2CCNCC2)cc1-n1cc(-c2cnn3ccc(N4CCOCC4)nc23)nn1	InChI=1S/C21H24F2N10O/c22-20(23)19-17(13-32(28-19)14-1-4-24-5-2-14)33-12-16(27-29-33)15-11-25-31-6-3-18(26-21(15)31)30-7-9-34-10-8-30/h3,6,11-14,20,24H,1-2,4-5,7-10H2	YESZNXWFZUDRQS-UHFFFAOYSA-N	540213	4-(3-(1-(3-(difluoromethyl)-1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 69A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540213&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447027	464925199							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238285	C[C@@H]1C[C@H](n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C22H26F2N10O/c1-14-10-15(2-4-25-14)33-13-18(20(29-33)21(23)24)34-12-17(28-30-34)16-11-26-32-5-3-19(27-22(16)32)31-6-8-35-9-7-31/h3,5,11-15,21,25H,2,4,6-10H2,1H3	AEHGDODTGCNUOJ-UHFFFAOYSA-N	540214	4-(3-(1-(3-(difluoromethyl)-1-((2R,4R)-2-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 72A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540214&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447211	464925200							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238286	C[C@@H]1C[C@@H](n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C22H26F2N10O/c1-14-10-15(2-4-25-14)33-13-18(20(29-33)21(23)24)34-12-17(28-30-34)16-11-26-32-5-3-19(27-22(16)32)31-6-8-35-9-7-31/h3,5,11-15,21,25H,2,4,6-10H2,1H3	AEHGDODTGCNUOJ-UHFFFAOYSA-N	540215	4-(3-(1-(3-(difluoromethyl)-1-((2R,4S)-2-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 73A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540215&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446949	464925201							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238287	C[C@H]1CC(n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C22H26F2N10O/c1-14-10-15(2-4-25-14)33-13-18(20(29-33)21(23)24)34-12-17(28-30-34)16-11-26-32-5-3-19(27-22(16)32)31-6-8-35-9-7-31/h3,5,11-15,21,25H,2,4,6-10H2,1H3	AEHGDODTGCNUOJ-UHFFFAOYSA-N	540216	4-(3-(1-(3-(difluoromethyl)-1-((2S)-2-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 79A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540216&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447026	464925202							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238288	C[C@@H]1CC(n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C22H26F2N10O/c1-14-10-15(2-4-25-14)33-13-18(20(29-33)21(23)24)34-12-17(28-30-34)16-11-26-32-5-3-19(27-22(16)32)31-6-8-35-9-7-31/h3,5,11-15,21,25H,2,4,6-10H2,1H3	AEHGDODTGCNUOJ-UHFFFAOYSA-N	540217	4-(3-(1-(3-(difluoromethyl)-1-((2R)-2-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 80A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540217&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447017	464925203							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238289	C[C@H]1COCCN1c1ccn2ncc(-c3cn(-c4cn(C5CCCCC5)nc4C(F)F)nn3)c2n1	InChI=1S/C23H27F2N9O/c1-15-14-35-10-9-31(15)20-7-8-32-23(27-20)17(11-26-32)18-12-34(30-28-18)19-13-33(29-21(19)22(24)25)16-5-3-2-4-6-16/h7-8,11-13,15-16,22H,2-6,9-10,14H2,1H3	VCVJYLJGHNANCW-UHFFFAOYSA-N	540218	(S)-4-(3-(1-(1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-3-methylmorpholine::US20260028337, Compound 82A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540218&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447216	464925204							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238290	C[C@H]1CN(c2ccn3ncc(-c4cn(-c5cn(C6CCCCC6)nc5C(F)F)nn4)c3n2)CCO1	InChI=1S/C23H27F2N9O/c1-15-12-31(9-10-35-15)20-7-8-32-23(27-20)17(11-26-32)18-13-34(30-28-18)19-14-33(29-21(19)22(24)25)16-5-3-2-4-6-16/h7-8,11,13-16,22H,2-6,9-10,12H2,1H3	INBAQAMLGYONBY-UHFFFAOYSA-N	540219	(2S)-4-(3-{1-[1-cyclohexyl-3-(difluoromethyl)-1H-pyrazol-4-yl]-1H-1,2,3-triazol-4-yl}pyrazolo[1,5-a]pyrimidin-5-yl)-2-methylmorpholine::US20260028337, Compound 83A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540219&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446950	464925205							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238291	NC(=O)c1cnn2c(-c3cn(-c4cn(C5CCNCC5)nc4C(F)F)nn3)ccc2c1	InChI=1S/C19H19F2N9O/c20-18(21)17-16(10-28(26-17)12-3-5-23-6-4-12)29-9-14(25-27-29)15-2-1-13-7-11(19(22)31)8-24-30(13)15/h1-2,7-10,12,18,23H,3-6H2,(H2,22,31)	MJNVBAHRRHQZBG-UHFFFAOYSA-N	540220	7-(1-(3-(difluoromethyl)-1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrrolo[1,2-b]pyridazine-3-formamide::US20260028337, Compound 84A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540220&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446951	464925206							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238292	CC1(C)CC(n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C23H28F2N10O/c1-23(2)11-15(3-5-26-23)34-14-18(20(30-34)21(24)25)35-13-17(29-31-35)16-12-27-33-6-4-19(28-22(16)33)32-7-9-36-10-8-32/h4,6,12-15,21,26H,3,5,7-11H2,1-2H3	OSNNSJUZOGNTCX-UHFFFAOYSA-N	540221	4-(3-(1-(3-(difluoromethyl)-1-(2,2-dimethylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 85A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540221&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446953	464925207							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238293	CC1(C)C[C@H](n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C23H28F2N10O/c1-23(2)11-15(3-5-26-23)34-14-18(20(30-34)21(24)25)35-13-17(29-31-35)16-12-27-33-6-4-19(28-22(16)33)32-7-9-36-10-8-32/h4,6,12-15,21,26H,3,5,7-11H2,1-2H3	OSNNSJUZOGNTCX-UHFFFAOYSA-N	540222	(R)-4-(3-(1-(3-(difluoromethyl)-1-(2,2-dimethylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 86A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540222&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447399	464925208							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238294	CC1(C)C[C@H](n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CCN1	InChI=1S/C23H28F2N10O/c1-23(2)11-15(3-5-26-23)34-14-18(20(30-34)21(24)25)35-13-17(29-31-35)16-12-27-33-6-4-19(28-22(16)33)32-7-9-36-10-8-32/h4,6,12-15,21,26H,3,5,7-11H2,1-2H3	OSNNSJUZOGNTCX-UHFFFAOYSA-N	540223	(R)-4-(3-(1-(3-(difluoromethyl)-1-(2,2-dimethylpiperidin-4-yl)-1H-pyrazol-4-yl)-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)morpholine::US20260028337, Compound 87A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540223&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447214	464925209							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238295	CC1(C)COCCN1c1ccn2ncc(-c3cn(-c4cn(C5CCC(CO)CC5)nc4C(F)F)nn3)c2n1	InChI=1S/C25H31F2N9O2/c1-25(2)15-38-10-9-33(25)21-7-8-34-24(29-21)18(11-28-34)19-12-36(32-30-19)20-13-35(31-22(20)23(26)27)17-5-3-16(14-37)4-6-17/h7-8,11-13,16-17,23,37H,3-6,9-10,14-15H2,1-2H3	GWUYWOXASHSDLD-UHFFFAOYSA-N	540224	(4-(3-(difluoromethyl)-4-(4-(5-(3,3-dimethylmorpholinyl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 88A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540224&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447029	464925210							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238296	CC1(C)CN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)CCO1	InChI=1S/C25H31F2N9O2/c1-25(2)15-33(9-10-38-25)21-7-8-34-24(29-21)18(11-28-34)19-12-36(32-30-19)20-13-35(31-22(20)23(26)27)17-5-3-16(14-37)4-6-17/h7-8,11-13,16-17,23,37H,3-6,9-10,14-15H2,1-2H3	QNDOBFJYSFIWEX-UHFFFAOYSA-N	540225	(4-(3-(difluoromethyl)-4-(4-(5-(2,2-dimethylmorpholinyl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 89A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540225&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446952	464925211							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238297	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CC7(COC7)C6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C24H27F2N9O2/c25-22(26)21-19(9-34(30-21)16-3-1-15(10-36)2-4-16)35-8-18(29-31-35)17-7-27-33-6-5-20(28-23(17)33)32-11-24(12-32)13-37-14-24/h5-9,15-16,22,36H,1-4,10-14H2	QXVIUTPZBDZFOW-UHFFFAOYSA-N	540226	(4-(4-(4-(5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 90A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540226&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447405	464925212							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238298	O=S1(=O)CCN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)CC1	InChI=1S/C23H27F2N9O3S/c24-22(25)21-19(13-33(29-21)16-3-1-15(14-35)2-4-16)34-12-18(28-30-34)17-11-26-32-6-5-20(27-23(17)32)31-7-9-38(36,37)10-8-31/h5-6,11-13,15-16,22,35H,1-4,7-10,14H2	DCJAEKIDPCINLH-UHFFFAOYSA-N	540227	4-(3-(1-(3-(difluoromethyl)-1-(4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)thiomorpholine 1,1-dioxide::US20260028337, Compound 91A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540227&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447411	464925213							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238299	CC(C)(O)CCNc1ccn2ncc(-c3cn(-c4cn(C5CCC(CO)CC5)nc4C(F)F)nn3)c2n1	InChI=1S/C24H31F2N9O2/c1-24(2,37)8-9-27-20-7-10-33-23(29-20)17(11-28-33)18-12-35(32-30-18)19-13-34(31-21(19)22(25)26)16-5-3-15(14-36)4-6-16/h7,10-13,15-16,22,36-37H,3-6,8-9,14H2,1-2H3,(H,27,29)	SFQBBGURNXRECS-UHFFFAOYSA-N	540228	4-((3-(1-(3-(difluoromethyl)-1-(4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-2-methylbutan-2-ol::US20260028337, Compound 92A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540228&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447419	464925214							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238300	CC1(O)CCN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)CC1	InChI=1S/C25H31F2N9O2/c1-25(38)7-10-33(11-8-25)21-6-9-34-24(29-21)18(12-28-34)19-13-36(32-30-19)20-14-35(31-22(20)23(26)27)17-4-2-16(15-37)3-5-17/h6,9,12-14,16-17,23,37-38H,2-5,7-8,10-11,15H2,1H3	FFGPMUHKDUFQDU-UHFFFAOYSA-N	540229	1-(3-(1-(3-(difluoromethyl)-1-(4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-methylpiperidin-4-ol::US20260028337, Compound 93A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540229&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447149	464925215							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238301	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(NCC6CC6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C23H27F2N9O/c24-22(25)21-19(12-33(30-21)16-5-3-15(13-35)4-6-16)34-11-18(29-31-34)17-10-27-32-8-7-20(28-23(17)32)26-9-14-1-2-14/h7-8,10-12,14-16,22,35H,1-6,9,13H2,(H,26,28)	WSPKESKDLYDKEW-UHFFFAOYSA-N	540230	(4-(4-(4-(5-((cyclopropylmethyl)amino)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 94A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540230&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447153	464925216							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238302	CN1CCN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)CC1	InChI=1S/C24H30F2N10O/c1-32-8-10-33(11-9-32)21-6-7-34-24(28-21)18(12-27-34)19-13-36(31-29-19)20-14-35(30-22(20)23(25)26)17-4-2-16(15-37)3-5-17/h6-7,12-14,16-17,23,37H,2-5,8-11,15H2,1H3	RUXKADRNQJDXEK-UHFFFAOYSA-N	540231	4-(3-(difluoromethyl)-4-(4-(5-(4-methylpiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)cyclohexylmethanol::US20260028337, Compound 95A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540231&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446954	464925217							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238303	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CC(O)C6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C22H25F2N9O2/c23-21(24)20-18(11-32(28-20)14-3-1-13(12-34)2-4-14)33-10-17(27-29-33)16-7-25-31-6-5-19(26-22(16)31)30-8-15(35)9-30/h5-7,10-11,13-15,21,34-35H,1-4,8-9,12H2	FZFXPVSFRUVRFM-UHFFFAOYSA-N	540232	1-(3-(1-(3-(difluoromethyl)-1-(-4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)azetidin-3-ol::US20260028337, Compound 96A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540232&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446956	464925218							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238304	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CCC(O)CC6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C24H29F2N9O2/c25-23(26)22-20(13-34(30-22)16-3-1-15(14-36)2-4-16)35-12-19(29-31-35)18-11-27-33-10-7-21(28-24(18)33)32-8-5-17(37)6-9-32/h7,10-13,15-17,23,36-37H,1-6,8-9,14H2	WYSAVBRQOUZHMX-UHFFFAOYSA-N	540233	1-(3-(1-(3-(difluoromethyl)-1-(-4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-4-ol::US20260028337, Compound 97A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540233&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447284	464925219							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238305	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(C6CCOC6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C23H26F2N8O2/c24-22(25)21-20(11-32(29-21)16-3-1-14(12-34)2-4-16)33-10-19(28-30-33)17-9-26-31-7-5-18(27-23(17)31)15-6-8-35-13-15/h5,7,9-11,14-16,22,34H,1-4,6,8,12-13H2	BPNQSMWWYOLSOK-UHFFFAOYSA-N	540234	(4-(4-(4-(5-(1-oxacyclopent-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 98A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540234&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447154	464925220							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238306	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CC7CCC(C6)O7)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C25H29F2N9O2/c26-24(27)23-21(13-35(31-23)16-3-1-15(14-37)2-4-16)36-12-20(30-32-36)19-9-28-34-8-7-22(29-25(19)34)33-10-17-5-6-18(11-33)38-17/h7-9,12-13,15-18,24,37H,1-6,10-11,14H2	DZWJFFYLIMFLEK-UHFFFAOYSA-N	540235	(4-(4-(4-(5-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 99A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540235&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447033	464925221							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238307	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CCCC(O)C6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C24H29F2N9O2/c25-23(26)22-20(13-34(30-22)16-5-3-15(14-36)4-6-16)35-12-19(29-31-35)18-10-27-33-9-7-21(28-24(18)33)32-8-1-2-17(37)11-32/h7,9-10,12-13,15-17,23,36-37H,1-6,8,11,14H2	HXDTYASGYWXCDB-UHFFFAOYSA-N	540236	1-(3-(1-(3-(difluoromethyl)-1-(-4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-ol::US20260028337, Compound 100A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540236&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447160	464925222							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238308	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CCC(O)C6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C23H27F2N9O2/c24-22(25)21-19(12-33(29-21)15-3-1-14(13-35)2-4-15)34-11-18(28-30-34)17-9-26-32-8-6-20(27-23(17)32)31-7-5-16(36)10-31/h6,8-9,11-12,14-16,22,35-36H,1-5,7,10,13H2	YZLKNDNZXFUQMS-UHFFFAOYSA-N	540237	1-(3-(1-(3-(difluoromethyl)-1-(-4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)pyrrolidin-3-ol::US20260028337, Compound 101A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540237&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447415	464925223							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238309	CN(C)C1CCN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)CC1	InChI=1S/C26H34F2N10O/c1-34(2)18-7-10-35(11-8-18)23-9-12-36-26(30-23)20(13-29-36)21-14-38(33-31-21)22-15-37(32-24(22)25(27)28)19-5-3-17(16-39)4-6-19/h9,12-15,17-19,25,39H,3-8,10-11,16H2,1-2H3	YRPAABHQRWDWNC-UHFFFAOYSA-N	540238	(4-(3-(difluoromethyl)-4-(4-(5-(4-(dimethylamino)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 102A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540238&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121446955	464925224							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238310	N[C@H]1CCCN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)C1	InChI=1S/C24H30F2N10O/c25-23(26)22-20(13-35(31-22)17-5-3-15(14-37)4-6-17)36-12-19(30-32-36)18-10-28-34-9-7-21(29-24(18)34)33-8-1-2-16(27)11-33/h7,9-10,12-13,15-17,23,37H,1-6,8,11,14,27H2	GWUGWFJRPBAKNZ-UHFFFAOYSA-N	540239	(4-(4-(4-(5-((S)-3-aminopiperidin-1-yl) pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 103A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540239&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			132201438	464925225							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238311	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CCOCC6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C23H27F2N9O2/c24-22(25)21-19(13-33(29-21)16-3-1-15(14-35)2-4-16)34-12-18(28-30-34)17-11-26-32-6-5-20(27-23(17)32)31-7-9-36-10-8-31/h5-6,11-13,15-16,22,35H,1-4,7-10,14H2	DVYMTVVOOJDMLF-UHFFFAOYSA-N	540240	(4-(3-(difluoromethyl)-4-(4-(5-morpholinyl-pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]cyclohexyl)methanol::US20260028337, Compound 104A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540240&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447036	464925226							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238312	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6C[C@H]7C[C@@H]6CO7)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C24H27F2N9O2/c25-23(26)22-20(11-34(30-22)15-3-1-14(12-36)2-4-15)35-10-19(29-31-35)18-8-27-33-6-5-21(28-24(18)33)32-9-17-7-16(32)13-37-17/h5-6,8,10-11,14-17,23,36H,1-4,7,9,12-13H2	PYDANJYOPPBNGX-UHFFFAOYSA-N	540241	(4-(4-(4-(5-((1R,4r)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 105A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		 550							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540241&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447038	464925227							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238313	N[C@@H]1CCCN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)C1	InChI=1S/C24H30F2N10O/c25-23(26)22-20(13-35(31-22)17-5-3-15(14-37)4-6-17)36-12-19(30-32-36)18-10-28-34-9-7-21(29-24(18)34)33-8-1-2-16(27)11-33/h7,9-10,12-13,15-17,23,37H,1-6,8,11,14,27H2	GWUGWFJRPBAKNZ-UHFFFAOYSA-N	540242	(4-(4-(4-(5-((R)-3-aminopiperidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 106A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540242&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447162	464925228							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238314	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N[C@H]6CCCC[C@H]6O)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C25H31F2N9O2/c26-24(27)23-20(13-35(32-23)16-7-5-15(14-37)6-8-16)36-12-19(31-33-36)17-11-28-34-10-9-22(30-25(17)34)29-18-3-1-2-4-21(18)38/h9-13,15-16,18,21,24,37-38H,1-8,14H2,(H,29,30)	HNVODEXQTBBMDU-UHFFFAOYSA-N	540243	(1R,2S)-2-((3-(1-(3-(difluoromethyl)-1-(4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)amino)cyclohexan-1-ol::US20260028337, Compound 107A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540243&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447249	464925229							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238315	NC1CN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)CC(F)(F)C1	InChI=1S/C24H28F4N10O/c25-22(26)21-19(11-37(33-21)16-3-1-14(12-39)2-4-16)38-10-18(32-34-38)17-8-30-36-6-5-20(31-23(17)36)35-9-15(29)7-24(27,28)13-35/h5-6,8,10-11,14-16,22,39H,1-4,7,9,12-13,29H2	BZILJGMVBPRYHH-UHFFFAOYSA-N	540244	(4-(4-(4-(5-(5-amino-3,3-difluoropiperidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-3-(difluoromethyl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 108A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540244&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447043	464925230							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238316	C[C@H]1CN(c2ccn3ncc(-c4cn(-c5cn(C6CCC(CO)CC6)nc5C(F)F)nn4)c3n2)C[C@H](C)O1	InChI=1S/C25H31F2N9O2/c1-15-10-33(11-16(2)38-15)22-7-8-34-25(29-22)19(9-28-34)20-12-36(32-30-20)21-13-35(31-23(21)24(26)27)18-5-3-17(14-37)4-6-18/h7-9,12-13,15-18,24,37H,3-6,10-11,14H2,1-2H3	ROLWVZXFVWDMTL-UHFFFAOYSA-N	540245	(4-(3-(difluoromethyl)-4-(4-(5-((2S,6S)-2,6-dimethylmorpholinyl)pyrazolo[1,5-a]pyrimidin-3-yl)-1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)cyclohexyl)methanol::US20260028337, Compound 109A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540245&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447179	464925231							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238317	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(NC6CCCCC6O)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C25H31F2N9O2/c26-24(27)23-20(13-35(32-23)16-7-5-15(14-37)6-8-16)36-12-19(31-33-36)17-11-28-34-10-9-22(30-25(17)34)29-18-3-1-2-4-21(18)38/h9-13,15-16,18,21,24,37-38H,1-8,14H2,(H,29,30)	HNVODEXQTBBMDU-UHFFFAOYSA-N	540246	2-((3-(1-(3-(difluoromethyl)-1-(4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl]pyrazolo[1,5-a]pyrimidin-5-yl)amino)cyclohexan-1-ol::US20260028337, Compound 111A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540246&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447181	464925232							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238318	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CCC[C@H](O)C6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C24H29F2N9O2/c25-23(26)22-20(13-34(30-22)16-5-3-15(14-36)4-6-16)35-12-19(29-31-35)18-10-27-33-9-7-21(28-24(18)33)32-8-1-2-17(37)11-32/h7,9-10,12-13,15-17,23,36-37H,1-6,8,11,14H2	HXDTYASGYWXCDB-UHFFFAOYSA-N	540247	(S)-1-(3-(1-(3-(difluoromethyl)-1-(-4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-ol::US20260028337, Compound 112A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540247&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447418	464925233							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
238319	OCC1CCC(n2cc(-n3cc(-c4cnn5ccc(N6CCC[C@@H](O)C6)nc45)nn3)c(C(F)F)n2)CC1	InChI=1S/C24H29F2N9O2/c25-23(26)22-20(13-34(30-22)16-5-3-15(14-36)4-6-16)35-12-19(29-31-35)18-10-27-33-9-7-21(28-24(18)33)32-8-1-2-17(37)11-32/h7,9-10,12-13,15-17,23,36-37H,1-6,8,11,14H2	HXDTYASGYWXCDB-UHFFFAOYSA-N	540248	(R)-1-(3-(1-(3-(difluoromethyl)-1-(-4-(methylol)cyclohexyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-3-ol::US20260028337, Compound 113A	Interleukin-1 receptor-associated kinase 4	Homo sapiens		<100							US Patent		10.7270/Q2Z60TWZ		aid1800122	US20260028337	DU, X; XU, H; DU, L; CHEN, Z; LI, Y; MI, Y; QU, M; JIA, J; MA, J; ZOU, J; ZOU, R; WEN, X; WANG, S; CHEN, B; ZHANG, P	1/29/2026	6/10/2026	Shenzhen Zhongge Biological Technology	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5405&target=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540248&enzyme=Interleukin-1+receptor-associated+kinase+4&column=ki&startPg=0&Increment=50&submit=Search			121447051	464925234							1	MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS	8DKS,8UCC,8UCB,8TX0,8TVN,8TVM,6EGA,6EG9,4RMZ,2NRY,2NRU,9R9K,9R9J,9R9G,7QG5,7QG3,7QG2,6TIA,6TI8,6THZ,6THX,6THW,8W3X,8W3W,7QG1,6RFJ,6RFI,6F3I,5UIU,5UIT,5UIS,5UIR,5UIQ,9PSU,9PST,9PSS,9NA6,9NA5,9NA4,9NA3,9NA2,6O8U,6MOM,5T1T,5T1S,5KX8,5KX7,5K7I,5K7G,5K76,5K75,5K72,4ZTN,4ZTM,4ZTL,4YP8,4YO6,4XS2,2OID,2OIC,2OIB,4Y73,6UYA,6O9D,6O95,6O94,7C2V,8BR5,2O8Y,6N8G,7C2W,6F3G,6F3E,6F3D,3MOP	Interleukin-1 receptor-associated kinase 4	IRAK4_HUMAN	Q9NWZ3	Q69FE1 Q8TDF7 Q9Y589