BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
370054	N=S(=O)(CCc1ccc(Cl)cc1)CC[C@H](N)C(=O)O	InChI=1S/C12H17ClN2O3S/c13-10-3-1-9(2-4-10)5-7-19(15,18)8-6-11(14)12(16)17/h1-4,11,15H,5-8,14H2,(H,16,17)	JYSKCWQOTLTEKK-UHFFFAOYSA-N	610972	US20260034094, Compound 1	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802305	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=610972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=610972&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			135341213	483621137							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
370055	N=S(=O)(CCc1ccccc1)CC[C@H](N)C(=O)O	InChI=1S/C12H18N2O3S/c13-11(12(15)16)7-9-18(14,17)8-6-10-4-2-1-3-5-10/h1-5,11,14H,6-9,13H2,(H,15,16)	RFTQKSWXFGAXHZ-UHFFFAOYSA-N	612704	US20260034094, Compound 2	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802305	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=612704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=612704&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			137443244	483622833							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
370056	N=[S@SP2](=O)(CCc1cccc(C(F)(F)F)c1)CCC(N)C(=O)O	InChI=1S/C13H17F3N2O3S/c14-13(15,16)10-3-1-2-9(8-10)4-6-22(18,21)7-5-11(17)12(19)20/h1-3,8,11,18H,4-7,17H2,(H,19,20)	COYMTXGCABNCDT-UHFFFAOYSA-N	612730	US20260034094, Compound 3	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802305	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=612730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=612730&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			137443244	483622858							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
370057	N=S(=O)(CCc1cccc(OC(F)(F)F)c1)CC[C@H](N)C(=O)O	InChI=1S/C13H17F3N2O4S/c14-13(15,16)22-10-3-1-2-9(8-10)4-6-23(18,21)7-5-11(17)12(19)20/h1-3,8,11,18H,4-7,17H2,(H,19,20)	FWLRSFLIRNKQAS-UHFFFAOYSA-N	719090	US20260034094, Compound 4	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802305	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=719090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=719090&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			167511183	513839142							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
370058	N=S(=O)(CCc1ccc(F)c(F)c1)CC[C@H](N)C(=O)O	InChI=1S/C12H16F2N2O3S/c13-9-2-1-8(7-10(9)14)3-5-20(16,19)6-4-11(15)12(17)18/h1-2,7,11,16H,3-6,15H2,(H,17,18)	KXEDENFCTPSSJE-UHFFFAOYSA-N	764605	US20260034094, Compound 5	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802305	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764605&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			155770395	520666060							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378089	N=S(=O)(CCc1ccncc1)CC[C@H](N)C(=O)O	InChI=1S/C11H17N3O3S/c12-10(11(15)16)4-8-18(13,17)7-3-9-1-5-14-6-2-9/h1-2,5-6,10,13H,3-4,7-8,12H2,(H,15,16)	FPNOHDWPVLLPTL-UHFFFAOYSA-N	764662	US20260034094, Compound 6	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 2270000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764662&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			155770430	520666117							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378090	N=S(=O)(CC[C@H](N)C(=O)O)CCn1ccnc1	InChI=1S/C9H16N4O3S/c10-8(9(14)15)1-5-17(11,16)6-4-13-3-2-12-7-13/h2-3,7-8,11H,1,4-6,10H2,(H,14,15)	FXDZJCCUAHAMIB-UHFFFAOYSA-N	764663	US20260034094, Compound 7	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=764663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=764663&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			155770389	520666118							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378091	N=S(=O)(CCc1cn[nH]c1)CC[C@H](N)C(=O)O	InChI=1S/C9H16N4O3S/c10-8(9(14)15)2-4-17(11,16)3-1-7-5-12-13-6-7/h5-6,8,11H,1-4,10H2,(H,12,13)(H,14,15)	UESUNJWHJWRROY-UHFFFAOYSA-N	790311	US20260034094, Compound 8	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790311&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770442	528498098							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378092	N=S(=O)(CCc1cnoc1)CC[C@H](N)C(=O)O	InChI=1S/C9H15N3O4S/c10-8(9(13)14)2-4-17(11,15)3-1-7-5-12-16-6-7/h5-6,8,11H,1-4,10H2,(H,13,14)	JJXWXTXBYDASBJ-UHFFFAOYSA-N	790324	US20260034094, Compound 9	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790324&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378093	N=S(=O)(CCc1nccs1)CC[C@H](N)C(=O)O	InChI=1S/C9H15N3O3S2/c10-7(9(13)14)1-5-17(11,15)6-2-8-12-3-4-16-8/h3-4,7,11H,1-2,5-6,10H2,(H,13,14)	UBUBJBHCUMJSLY-UHFFFAOYSA-N	790325	US20260034094, Compound 10	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790325&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378094	Cc1ccc(CCS(=N)(=O)CC[C@H](N)C(=O)O)cc1	InChI=1S/C13H20N2O3S/c1-10-2-4-11(5-3-10)6-8-19(15,18)9-7-12(14)13(16)17/h2-5,12,15H,6-9,14H2,1H3,(H,16,17)	KUXUUZNJBVWITA-UHFFFAOYSA-N	790360	US20260034094, Compound 11	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790360&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378095	COc1ccc(CCS(=N)(=O)CC[C@H](N)C(=O)O)cc1	InChI=1S/C13H20N2O4S/c1-19-11-4-2-10(3-5-11)6-8-20(15,18)9-7-12(14)13(16)17/h2-5,12,15H,6-9,14H2,1H3,(H,16,17)	MJZXHWLEUKNSNT-UHFFFAOYSA-N	790361	US20260034094, Compound 12	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790361&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378096	N=S(=O)(CCc1ccc(Cl)c(Cl)c1)CC[C@H](N)C(=O)O	InChI=1S/C12H16Cl2N2O3S/c13-9-2-1-8(7-10(9)14)3-5-20(16,19)6-4-11(15)12(17)18/h1-2,7,11,16H,3-6,15H2,(H,17,18)	UBOMTQYHCSGPOR-UHFFFAOYSA-N	790362	US20260034094, Compound 13	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790362&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378097	Cc1ccccc1OCCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C13H20N2O4S/c1-10-4-2-3-5-12(10)19-7-9-20(15,18)8-6-11(14)13(16)17/h2-5,11,15H,6-9,14H2,1H3,(H,16,17)	LBYLMLHCRJZWSC-UHFFFAOYSA-N	790363	US20260034094, Compound 14	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790363&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378098	N=S(=O)(CCc1ccccc1C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C13H17F3N2O3S/c14-13(15,16)10-4-2-1-3-9(10)5-7-22(18,21)8-6-11(17)12(19)20/h1-4,11,18H,5-8,17H2,(H,19,20)	MIHSQPQDLDPQNY-UHFFFAOYSA-N	790364	US20260034094, Compound 15	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790364&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378099	N=S(=O)(CCc1cccc(F)c1F)CC[C@H](N)C(=O)O	InChI=1S/C12H16F2N2O3S/c13-9-3-1-2-8(11(9)14)4-6-20(16,19)7-5-10(15)12(17)18/h1-3,10,16H,4-7,15H2,(H,17,18)	AISHPTGBGLXMEN-UHFFFAOYSA-N	790365	US20260034094, Compound 16	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790365&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378100	N=S(=O)(CCc1nc(-c2ccccc2)cs1)CC[C@H](N)C(=O)O	InChI=1S/C15H19N3O3S2/c16-12(15(19)20)6-8-23(17,21)9-7-14-18-13(10-22-14)11-4-2-1-3-5-11/h1-5,10,12,17H,6-9,16H2,(H,19,20)	YJVDFKPBKQEYPF-UHFFFAOYSA-N	790366	US20260034094, Compound 17	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790366&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378101	N=S(=O)(CCc1cccc2c1OC(F)(F)O2)CC[C@H](N)C(=O)O	InChI=1S/C13H16F2N2O5S/c14-13(15)21-10-3-1-2-8(11(10)22-13)4-6-23(17,20)7-5-9(16)12(18)19/h1-3,9,17H,4-7,16H2,(H,18,19)	RWUGSUAMBYUKHV-UHFFFAOYSA-N	790367	US20260034094, Compound 18	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790367&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378102	N=S(=O)(CCc1ccccc1Cl)CC[C@H](N)C(=O)O	InChI=1S/C12H17ClN2O3S/c13-10-4-2-1-3-9(10)5-7-19(15,18)8-6-11(14)12(16)17/h1-4,11,15H,5-8,14H2,(H,16,17)	CUEICTSRIRNPJA-UHFFFAOYSA-N	790368	US20260034094, Compound 19	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790368&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378103	COc1ccccc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C13H20N2O4S/c1-19-12-5-3-2-4-10(12)6-8-20(15,18)9-7-11(14)13(16)17/h2-5,11,15H,6-9,14H2,1H3,(H,16,17)	JRVKUXFKQRHHES-UHFFFAOYSA-N	790369	US20260034094, Compound 20	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790369&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378104	N=S(=O)(CCc1ccccc1O)CC[C@H](N)C(=O)O	InChI=1S/C12H18N2O4S/c13-10(12(16)17)6-8-19(14,18)7-5-9-3-1-2-4-11(9)15/h1-4,10,14-15H,5-8,13H2,(H,16,17)	POAAFIDGVUEHIU-UHFFFAOYSA-N	790370	US20260034094, Compound 21	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790370&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378105	N=S(=O)(CCc1ccccc1C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C13H17F3N2O3S/c14-13(15,16)10-4-2-1-3-9(10)5-7-22(18,21)8-6-11(17)12(19)20/h1-4,11,18H,5-8,17H2,(H,19,20)	MIHSQPQDLDPQNY-UHFFFAOYSA-N	790371	US20260034094, Compound 22	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790371&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378106	N=S(=O)(CCc1ccccc1F)CC[C@H](N)C(=O)O	InChI=1S/C12H17FN2O3S/c13-10-4-2-1-3-9(10)5-7-19(15,18)8-6-11(14)12(16)17/h1-4,11,15H,5-8,14H2,(H,16,17)	QDYRBVRSQBTDLG-UHFFFAOYSA-N	790372	US20260034094, Compound 23	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790372&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378107	N=S(=O)(CCc1cccc(F)c1)CC[C@H](N)C(=O)O	InChI=1S/C12H17FN2O3S/c13-10-3-1-2-9(8-10)4-6-19(15,18)7-5-11(14)12(16)17/h1-3,8,11,15H,4-7,14H2,(H,16,17)	SPCJWPISZGKIQX-UHFFFAOYSA-N	790373	US20260034094, Compound 24	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790373&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378108	N=S(=O)(CCc1cccc(Cl)c1Cl)CC[C@H](N)C(=O)O	InChI=1S/C12H16Cl2N2O3S/c13-9-3-1-2-8(11(9)14)4-6-20(16,19)7-5-10(15)12(17)18/h1-3,10,16H,4-7,15H2,(H,17,18)	BCTWZVAIUUYERV-UHFFFAOYSA-N	790374	US20260034094, Compound 25	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790374&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378109	Cc1c(F)cccc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C13H19FN2O3S/c1-9-10(3-2-4-11(9)14)5-7-20(16,19)8-6-12(15)13(17)18/h2-4,12,16H,5-8,15H2,1H3,(H,17,18)	SQKITTVNBGBVBZ-UHFFFAOYSA-N	790375	US20260034094, Compound 26	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790375&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378110	Cc1cccc(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1C	InChI=1S/C14H22N2O3S/c1-10-4-3-5-12(11(10)2)6-8-20(16,19)9-7-13(15)14(17)18/h3-5,13,16H,6-9,15H2,1-2H3,(H,17,18)	UVRNXRCBEKDDCN-UHFFFAOYSA-N	790376	US20260034094, Compound 27	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790376&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378111	N=S(=O)(CCc1cccc(Cl)c1F)CC[C@H](N)C(=O)O	InChI=1S/C12H16ClFN2O3S/c13-9-3-1-2-8(11(9)14)4-6-20(16,19)7-5-10(15)12(17)18/h1-3,10,16H,4-7,15H2,(H,17,18)	ZSDDSVNIVFJCNZ-UHFFFAOYSA-N	790377	US20260034094, Compound 28	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790377&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378112	Cc1c(F)cccc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C13H19FN2O3S/c1-9-10(3-2-4-11(9)14)5-7-20(16,19)8-6-12(15)13(17)18/h2-4,12,16H,5-8,15H2,1H3,(H,17,18)	SQKITTVNBGBVBZ-UHFFFAOYSA-N	790378	US20260034094, Compound 29	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790378&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378113	N#Cc1ccccc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C13H17N3O3S/c14-9-11-4-2-1-3-10(11)5-7-20(16,19)8-6-12(15)13(17)18/h1-4,12,16H,5-8,15H2,(H,17,18)	USYROSJEKDNCMT-UHFFFAOYSA-N	790379	US20260034094, Compound 30	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790379&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378114	N=S(=O)(CCc1cccc2ccccc12)CC[C@H](N)C(=O)O	InChI=1S/C16H20N2O3S/c17-15(16(19)20)9-11-22(18,21)10-8-13-6-3-5-12-4-1-2-7-14(12)13/h1-7,15,18H,8-11,17H2,(H,19,20)	JZJDNIMKWNCNQT-UHFFFAOYSA-N	790380	US20260034094, Compound 31	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790380&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378115	Cc1cccc(C)c1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C14H22N2O3S/c1-10-4-3-5-11(2)12(10)6-8-20(16,19)9-7-13(15)14(17)18/h3-5,13,16H,6-9,15H2,1-2H3,(H,17,18)	BIUJEELRJMBLQF-UHFFFAOYSA-N	790381	US20260034094, Compound 32	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790381&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378116	CCc1ccccc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C14H22N2O3S/c1-2-11-5-3-4-6-12(11)7-9-20(16,19)10-8-13(15)14(17)18/h3-6,13,16H,2,7-10,15H2,1H3,(H,17,18)	WFVHOLMKCXDXQA-UHFFFAOYSA-N	790382	US20260034094, Compound 33	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790382&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378117	N=S(=O)(CCc1ccccc1C1CC1)CC[C@H](N)C(=O)O	InChI=1S/C15H22N2O3S/c16-14(15(18)19)8-10-21(17,20)9-7-11-3-1-2-4-13(11)12-5-6-12/h1-4,12,14,17H,5-10,16H2,(H,18,19)	FAPOAUFOUYJOKX-UHFFFAOYSA-N	790383	US20260034094, Compound 34	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790383&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378118	Cc1noc(C)c1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C11H19N3O4S/c1-7-9(8(2)18-14-7)3-5-19(13,17)6-4-10(12)11(15)16/h10,13H,3-6,12H2,1-2H3,(H,15,16)	IPEYQMIGVFVVCR-UHFFFAOYSA-N	790384	US20260034094, Compound 35	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790384&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378119	N=[S@SP2](=O)(CCc1ccc(C(F)(F)F)cc1C(F)(F)F)CCC(N)C(=O)O	InChI=1S/C14H16F6N2O3S/c15-13(16,17)9-2-1-8(10(7-9)14(18,19)20)3-5-26(22,25)6-4-11(21)12(23)24/h1-2,7,11,22H,3-6,21H2,(H,23,24)	CIFMQESFUZYRFT-UHFFFAOYSA-N	790385	US20260034094, Compound 36	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790385&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378120	Cc1ccc(CCS(=N)(=O)CC[C@H](N)C(=O)O)c(F)c1	InChI=1S/C13H19FN2O3S/c1-9-2-3-10(11(14)8-9)4-6-20(16,19)7-5-12(15)13(17)18/h2-3,8,12,16H,4-7,15H2,1H3,(H,17,18)	WRELQUHZCQEQGM-UHFFFAOYSA-N	790386	US20260034094, Compound 37	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790386&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378121	CC(CS(=N)(=O)CC[C@H](N)C(=O)O)c1ccccc1Cl	InChI=1S/C13H19ClN2O3S/c1-9(10-4-2-3-5-11(10)14)8-20(16,19)7-6-12(15)13(17)18/h2-5,9,12,16H,6-8,15H2,1H3,(H,17,18)	SZAJKDZTNDAZQL-UHFFFAOYSA-N	790387	US20260034094, Compound 38	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790387&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378122	Cc1ccc(Cl)c(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1	InChI=1S/C13H19ClN2O3S/c1-9-2-3-11(14)10(8-9)4-6-20(16,19)7-5-12(15)13(17)18/h2-3,8,12,16H,4-7,15H2,1H3,(H,17,18)	CQCMJKSAAAEPEQ-UHFFFAOYSA-N	790388	US20260034094, Compound 39	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790388&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378123	CCOC(=O)c1ccc(C)c(CCS(=N)(=O)CC[C@H](N)C(=O)OC)c1	InChI=1S/C17H26N2O5S/c1-4-24-16(20)14-6-5-12(2)13(11-14)7-9-25(19,22)10-8-15(18)17(21)23-3/h5-6,11,15,19H,4,7-10,18H2,1-3H3	IRROBTNYRNYKSV-UHFFFAOYSA-N	790389	US20260034094, Compound 40	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790389&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378124	Cc1ccc(C(=O)O)cc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C14H20N2O5S/c1-9-2-3-11(13(17)18)8-10(9)4-6-22(16,21)7-5-12(15)14(19)20/h2-3,8,12,16H,4-7,15H2,1H3,(H,17,18)(H,19,20)	XOGXJXAQWBQEIY-UHFFFAOYSA-N	790390	US20260034094, Compound 41	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790390&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378125	Cc1cccc(Cl)c1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C13H19ClN2O3S/c1-9-3-2-4-11(14)10(9)5-7-20(16,19)8-6-12(15)13(17)18/h2-4,12,16H,5-8,15H2,1H3,(H,17,18)	LVNVGDQYVSAMOA-UHFFFAOYSA-N	790391	US20260034094, Compound 42	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790391&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378126	Cc1ccc(CCS(=N)(=O)CC[C@H](N)C(=O)O)c(Cl)c1	InChI=1S/C13H19ClN2O3S/c1-9-2-3-10(11(14)8-9)4-6-20(16,19)7-5-12(15)13(17)18/h2-3,8,12,16H,4-7,15H2,1H3,(H,17,18)	QXBNZODCCCZZJC-UHFFFAOYSA-N	790392	US20260034094, Compound 43	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790392&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378127	Cc1ccc(C(F)(F)F)c(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1	InChI=1S/C14H19F3N2O3S/c1-9-2-3-11(14(15,16)17)10(8-9)4-6-23(19,22)7-5-12(18)13(20)21/h2-3,8,12,19H,4-7,18H2,1H3,(H,20,21)	WFEHGTQIOJZOQN-UHFFFAOYSA-N	790395	US20260034094, Compound 44	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790395&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378128	Cc1ccc(-c2nn[nH]n2)cc1CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C14H20N6O3S/c1-9-2-3-11(13-17-19-20-18-13)8-10(9)4-6-24(16,23)7-5-12(15)14(21)22/h2-3,8,12,16H,4-7,15H2,1H3,(H,21,22)(H,17,18,19,20)	KZJKQDJDLNERIA-UHFFFAOYSA-N	790396	US20260034094, Compound 45	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790396&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170769768	528498183							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378129	N=S(=O)(CC[C@H](N)C(=O)O)C[C@H](O)c1ccccc1	InChI=1S/C12H18N2O4S/c13-10(12(16)17)6-7-19(14,18)8-11(15)9-4-2-1-3-5-9/h1-5,10-11,14-15H,6-8,13H2,(H,16,17)	ROJVTXQTGKUQID-UHFFFAOYSA-N	790397	US20260034094, Compound 46	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790397&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378130	CCC(CS(=N)(=O)CC[C@H](N)C(=O)O)c1ccccc1C(F)(F)F	InChI=1S/C15H21F3N2O3S/c1-2-10(9-24(20,23)8-7-13(19)14(21)22)11-5-3-4-6-12(11)15(16,17)18/h3-6,10,13,20H,2,7-9,19H2,1H3,(H,21,22)	QZSQQYCFMFQAFZ-UHFFFAOYSA-N	790398	US20260034094, Compound 47	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790398&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378131	N=S(=O)(CCc1cccs1)CC[C@H](N)C(=O)O	InChI=1S/C10H16N2O3S2/c11-9(10(13)14)4-7-17(12,15)6-3-8-2-1-5-16-8/h1-2,5,9,12H,3-4,6-7,11H2,(H,13,14)	IKLBOXCCFHFOFE-UHFFFAOYSA-N	790399	US20260034094, Compound 48	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790399&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378132	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ccccc1	InChI=1S/C15H24N2O3S/c1-15(2,12-6-4-3-5-7-12)9-11-21(17,20)10-8-13(16)14(18)19/h3-7,13,17H,8-11,16H2,1-2H3,(H,18,19)	RMQVMRMSZKLKSF-UHFFFAOYSA-N	790400	US20260034094, Compound 49	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790400&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378133	N=S(=O)(CCCc1cn[nH]c1)CC[C@H](N)C(=O)O	InChI=1S/C10H18N4O3S/c11-9(10(15)16)3-5-18(12,17)4-1-2-8-6-13-14-7-8/h6-7,9,12H,1-5,11H2,(H,13,14)(H,15,16)	HWPSPOOENWWDTB-UHFFFAOYSA-N	790401	US20260034094, Compound 50	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790401&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770533	528498188							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378134	N=S(=O)(CCCc1ccccc1)CC[C@H](N)C(=O)O	InChI=1S/C13H20N2O3S/c14-12(13(16)17)8-10-19(15,18)9-4-7-11-5-2-1-3-6-11/h1-3,5-6,12,15H,4,7-10,14H2,(H,16,17)	XSWYSDXFVBLXHG-UHFFFAOYSA-N	790402	US20260034094, Compound 51	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790402&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378135	N=S(=O)(CCCCc1ccccc1)CC[C@H](N)C(=O)O	InChI=1S/C14H22N2O3S/c15-13(14(17)18)9-11-20(16,19)10-5-4-8-12-6-2-1-3-7-12/h1-3,6-7,13,16H,4-5,8-11,15H2,(H,17,18)	JRHNSHULJVBEHY-UHFFFAOYSA-N	790403	US20260034094, Compound 52	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790403&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378136	N=S(=O)(CCC(c1ccccc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H19F3N2O3S/c15-14(16,17)11(10-4-2-1-3-5-10)6-8-23(19,22)9-7-12(18)13(20)21/h1-5,11-12,19H,6-9,18H2,(H,20,21)	YZYZRUSQTZPNIU-UHFFFAOYSA-N	790404	US20260034094, Compound 53	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790404&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378137	N=S(=O)(CC[C@H](N)C(=O)O)CC[C@H](O)c1ccccc1	InChI=1S/C13H20N2O4S/c14-11(13(17)18)6-8-20(15,19)9-7-12(16)10-4-2-1-3-5-10/h1-5,11-12,15-16H,6-9,14H2,(H,17,18)	MIBBYGZTOSXHDU-UHFFFAOYSA-N	790405	US20260034094, Compound 54	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790405&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378138	N=S(=O)(CCC(c1ccccc1)c1ccccc1)CC[C@H](N)C(=O)O	InChI=1S/C19H24N2O3S/c20-18(19(22)23)12-14-25(21,24)13-11-17(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-18,21H,11-14,20H2,(H,22,23)	RKBOCSQQNLGOFS-UHFFFAOYSA-N	790406	US20260034094, Compound 55	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790406&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378139	Cc1ccc(C(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O)cc1	InChI=1S/C16H26N2O3S/c1-12-4-6-13(7-5-12)16(2,3)9-11-22(18,21)10-8-14(17)15(19)20/h4-7,14,18H,8-11,17H2,1-3H3,(H,19,20)	DEQFDIRKEMQGEZ-UHFFFAOYSA-N	790407	US20260034094, Compound 56	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790407&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378140	Cc1cccc(C(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O)c1	InChI=1S/C16H26N2O3S/c1-12-5-4-6-13(11-12)16(2,3)8-10-22(18,21)9-7-14(17)15(19)20/h4-6,11,14,18H,7-10,17H2,1-3H3,(H,19,20)	RZSNMROVDSYILF-UHFFFAOYSA-N	790408	US20260034094, Compound 57	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790408&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378141	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ccc(F)cc1	InChI=1S/C15H23FN2O3S/c1-15(2,11-3-5-12(16)6-4-11)8-10-22(18,21)9-7-13(17)14(19)20/h3-6,13,18H,7-10,17H2,1-2H3,(H,19,20)	ZTJHLVDNYSCIER-UHFFFAOYSA-N	790409	US20260034094, Compound 58	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790409&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378142	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ccccc1F	InChI=1S/C15H23FN2O3S/c1-15(2,11-5-3-4-6-12(11)16)8-10-22(18,21)9-7-13(17)14(19)20/h3-6,13,18H,7-10,17H2,1-2H3,(H,19,20)	VGHTVPRWQORTOI-UHFFFAOYSA-N	790410	US20260034094, Compound 59	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790410&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378143	N=[S@](=O)(CC[C@H](c1ccccc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H19F3N2O3S/c15-14(16,17)11(10-4-2-1-3-5-10)6-8-23(19,22)9-7-12(18)13(20)21/h1-5,11-12,19H,6-9,18H2,(H,20,21)	YZYZRUSQTZPNIU-UHFFFAOYSA-N	790411	US20260034094, Compound 60	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790411&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378144	N=[S@@](=O)(CC[C@H](N)C(=O)O)CC[C@@H](c1ccccc1)C(F)(F)F	InChI=1S/C14H19F3N2O3S/c15-14(16,17)11(10-4-2-1-3-5-10)6-8-23(19,22)9-7-12(18)13(20)21/h1-5,11-12,19H,6-9,18H2,(H,20,21)	YZYZRUSQTZPNIU-UHFFFAOYSA-N	790412	US20260034094, Compound 61	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790412&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378145	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccccc2)CCC1	InChI=1S/C16H24N2O3S/c17-14(15(19)20)7-11-22(18,21)12-10-16(8-4-9-16)13-5-2-1-3-6-13/h1-3,5-6,14,18H,4,7-12,17H2,(H,19,20)	VNXVGGGLUGGXMB-UHFFFAOYSA-N	790413	US20260034094, Compound 62	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790413&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378146	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1cnoc1	InChI=1S/C12H21N3O4S/c1-12(2,9-7-15-19-8-9)4-6-20(14,18)5-3-10(13)11(16)17/h7-8,10,14H,3-6,13H2,1-2H3,(H,16,17)	KIKQTRIBBDISEH-UHFFFAOYSA-N	790414	US20260034094, Compound 63	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790414&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378147	N=S(=O)(CCC(c1c[nH]c2ccccc12)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C16H20F3N3O3S/c17-16(18,19)12(11-9-22-14-4-2-1-3-10(11)14)5-7-26(21,25)8-6-13(20)15(23)24/h1-4,9,12-13,21-22H,5-8,20H2,(H,23,24)	CPFVNVUUZMYLJV-UHFFFAOYSA-N	790415	US20260034094, Compound 64	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790415&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174245955	528498202							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378148	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)Cc1ccccc1	InChI=1S/C16H26N2O3S/c1-16(2,12-13-6-4-3-5-7-13)9-11-22(18,21)10-8-14(17)15(19)20/h3-7,14,18H,8-12,17H2,1-2H3,(H,19,20)	OHUQUZFAKZWCAE-UHFFFAOYSA-N	790416	US20260034094, Compound 65	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790416&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378149	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ccccc1Cl	InChI=1S/C15H23ClN2O3S/c1-15(2,11-5-3-4-6-12(11)16)8-10-22(18,21)9-7-13(17)14(19)20/h3-6,13,18H,7-10,17H2,1-2H3,(H,19,20)	GDSJGFGEPJWAJB-UHFFFAOYSA-N	790417	US20260034094, Compound 66	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790417&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378150	COC(=O)[C@@H](N)CCS(=N)(=O)CCc1cnccn1	InChI=1S/C11H18N4O3S/c1-18-11(16)10(12)3-7-19(13,17)6-2-9-8-14-4-5-15-9/h4-5,8,10,13H,2-3,6-7,12H2,1H3	QYOSREDTQQWPJI-UHFFFAOYSA-N	790418	US20260034094, Compound 67	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790418&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378151	COC(=O)[C@@H](N)CCS(=N)(=O)CCc1ccccc1	InChI=1S/C13H20N2O3S/c1-18-13(16)12(14)8-10-19(15,17)9-7-11-5-3-2-4-6-11/h2-6,12,15H,7-10,14H2,1H3	XDRHUHBYNXSDLG-UHFFFAOYSA-N	790419	US20260034094, Compound 68	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790419&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378152	COC(=O)[C@@H](N)CCS(=N)(=O)CCc1nnn[nH]1	InChI=1S/C8H16N6O3S/c1-17-8(15)6(9)2-4-18(10,16)5-3-7-11-13-14-12-7/h6,10H,2-5,9H2,1H3,(H,11,12,13,14)	HRUWBNDNWLUJNV-UHFFFAOYSA-N	790420	US20260034094, Compound 69	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790420&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770667	528498207							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378153	COC(=O)[C@@H](N)CCS(=N)(=O)CCCc1ccccc1	InChI=1S/C14H22N2O3S/c1-19-14(17)13(15)9-11-20(16,18)10-5-8-12-6-3-2-4-7-12/h2-4,6-7,13,16H,5,8-11,15H2,1H3	BPMLDRUTVYBTNJ-UHFFFAOYSA-N	790421	US20260034094, Compound 70	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790421&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378154	COC(=O)[C@@H](N)CCS(=N)(=O)CCCC1CC1	InChI=1S/C11H22N2O3S/c1-16-11(14)10(12)6-8-17(13,15)7-2-3-9-4-5-9/h9-10,13H,2-8,12H2,1H3	AGHWDFABMIELDA-UHFFFAOYSA-N	790422	US20260034094, Compound 71	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790422&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378155	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)C	InChI=1S/C14H30N2O3S/c1-5-6-9-19-13(17)12(15)7-10-20(16,18)11-8-14(2,3)4/h12,16H,5-11,15H2,1-4H3	RZGOJOSIJCQRNH-UHFFFAOYSA-N	790423	US20260034094, Compound 72	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790423&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378156	CCCCS(=N)(=O)CC[C@H](N)C(=O)OCc1oc(=O)oc1C	InChI=1S/C13H22N2O6S/c1-3-4-6-22(15,18)7-5-10(14)12(16)19-8-11-9(2)20-13(17)21-11/h10,15H,3-8,14H2,1-2H3	FCKKAUQSGLXLJR-UHFFFAOYSA-N	790424	US20260034094, Compound 73	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 77400							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790424&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378157	COC(=O)[C@@H](N)CCS(=N)(=O)CCC1CCCC1	InChI=1S/C12H24N2O3S/c1-17-12(15)11(13)7-9-18(14,16)8-6-10-4-2-3-5-10/h10-11,14H,2-9,13H2,1H3	AMPRZZGSUGIQDZ-UHFFFAOYSA-N	790425	US20260034094, Compound 74	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790425&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378158	COCCCS(=N)(=O)CC[C@H](N)C(=O)OC	InChI=1S/C9H20N2O4S/c1-14-5-3-6-16(11,13)7-4-8(10)9(12)15-2/h8,11H,3-7,10H2,1-2H3	IDBCEELXOZTEOD-UHFFFAOYSA-N	790426	US20260034094, Compound 75	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 594000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790426&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378159	COCCCCS(=N)(=O)CC[C@H](N)C(=O)OC	InChI=1S/C10H22N2O4S/c1-15-6-3-4-7-17(12,14)8-5-9(11)10(13)16-2/h9,12H,3-8,11H2,1-2H3	RUUKPMPAMYQCOF-UHFFFAOYSA-N	790427	US20260034094, Compound 76	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790427&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378160	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCC1CCCC1	InChI=1S/C15H30N2O3S/c1-2-3-10-20-15(18)14(16)9-12-21(17,19)11-8-13-6-4-5-7-13/h13-14,17H,2-12,16H2,1H3	AKQHJXNOFKYPQW-UHFFFAOYSA-N	790428	US20260034094, Compound 77	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790428&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378161	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCC1CCCCC1	InChI=1S/C16H32N2O3S/c1-2-3-11-21-16(19)15(17)10-13-22(18,20)12-9-14-7-5-4-6-8-14/h14-15,18H,2-13,17H2,1H3	ABULBEXGKKGPEK-UHFFFAOYSA-N	790430	US20260034094, Compound 78	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790430&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378162	CCCCOC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C12H23F3N2O3S/c1-2-3-7-20-11(18)10(16)5-9-21(17,19)8-4-6-12(13,14)15/h10,17H,2-9,16H2,1H3	LTBDHQNAOJMVAJ-UHFFFAOYSA-N	790431	US20260034094, Compound 79	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790431&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378163	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)OC1CCCCC1	InChI=1S/C14H25F3N2O3S/c15-14(16,17)8-4-9-23(19,21)10-7-12(18)13(20)22-11-5-2-1-3-6-11/h11-12,19H,1-10,18H2	DZZQEATWENPGIU-UHFFFAOYSA-N	790432	US20260034094, Compound 80	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790432&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378164	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)OCC1CCCCC1	InChI=1S/C15H27F3N2O3S/c16-15(17,18)8-4-9-24(20,22)10-7-13(19)14(21)23-11-12-5-2-1-3-6-12/h12-13,20H,1-11,19H2	PZCGSWUCFZQMOV-UHFFFAOYSA-N	790433	US20260034094, Compound 81	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790433&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378165	CCCC(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C13H25F3N2O3S/c1-3-5-10(2)21-12(19)11(17)6-9-22(18,20)8-4-7-13(14,15)16/h10-11,18H,3-9,17H2,1-2H3	YWPDKBARFNINPH-UHFFFAOYSA-N	790435	US20260034094, Compound 82	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790435&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378166	COCCOC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C11H21F3N2O4S/c1-19-5-6-20-10(17)9(15)3-8-21(16,18)7-2-4-11(12,13)14/h9,16H,2-8,15H2,1H3	XTNPZWVKCMXDSL-UHFFFAOYSA-N	790436	US20260034094, Compound 83	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790436&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378167	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)OC1CCOCC1	InChI=1S/C13H23F3N2O4S/c14-13(15,16)5-1-8-23(18,20)9-4-11(17)12(19)22-10-2-6-21-7-3-10/h10-11,18H,1-9,17H2	KUDVJOISBFDIGQ-UHFFFAOYSA-N	790437	US20260034094, Compound 84	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790437&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378168	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)OCc1ccccc1	InChI=1S/C15H21F3N2O3S/c16-15(17,18)8-4-9-24(20,22)10-7-13(19)14(21)23-11-12-5-2-1-3-6-12/h1-3,5-6,13,20H,4,7-11,19H2	QNLLGMWAHCNRPS-UHFFFAOYSA-N	790438	US20260034094, Compound 85	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790438&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378169	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)OCc1ccccc1	InChI=1S/C15H21F3N2O3S/c16-15(17,18)8-4-9-24(20,22)10-7-13(19)14(21)23-11-12-5-2-1-3-6-12/h1-3,5-6,13,20H,4,7-11,19H2	QNLLGMWAHCNRPS-UHFFFAOYSA-N	790439	US20260034094, Compound 86	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790439&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378170	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)c1ccccc1	InChI=1S/C19H32N2O3S/c1-4-5-13-24-18(22)17(20)11-14-25(21,23)15-12-19(2,3)16-9-7-6-8-10-16/h6-10,17,21H,4-5,11-15,20H2,1-3H3	ZSUGJYPMAXXIPZ-UHFFFAOYSA-N	790440	US20260034094, Compound 87	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790440&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378171	CC(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C11H21F3N2O3S/c1-8(2)19-10(17)9(15)4-7-20(16,18)6-3-5-11(12,13)14/h8-9,16H,3-7,15H2,1-2H3	JHSDRQYOLWJMHE-UHFFFAOYSA-N	790442	US20260034094, Compound 88	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790442&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378172	CCCC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C14H27F3N2O3S/c1-4-7-13(2,3)22-12(20)11(18)6-10-23(19,21)9-5-8-14(15,16)17/h11,19H,4-10,18H2,1-3H3	WTKSPLKWBVYDQB-UHFFFAOYSA-N	790443	US20260034094, Compound 89	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790443&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378173	CCCCOC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C12H23F3N2O3S/c1-2-3-7-20-11(18)10(16)5-9-21(17,19)8-4-6-12(13,14)15/h10,17H,2-9,16H2,1H3	LTBDHQNAOJMVAJ-UHFFFAOYSA-N	790444	US20260034094, Compound 90	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790444&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378174	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCc1ccccc1Cl	InChI=1S/C16H25ClN2O3S/c1-2-3-10-22-16(20)15(18)9-12-23(19,21)11-8-13-6-4-5-7-14(13)17/h4-7,15,19H,2-3,8-12,18H2,1H3	VMAFMVIZRQMIHH-UHFFFAOYSA-N	790445	US20260034094, Compound 91	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790445&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378175	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCc1cccc(F)c1C(F)(F)F	InChI=1S/C17H24F4N2O3S/c1-2-3-9-26-16(24)14(22)8-11-27(23,25)10-7-12-5-4-6-13(18)15(12)17(19,20)21/h4-6,14,23H,2-3,7-11,22H2,1H3	SVCYKKHYGUJKDE-UHFFFAOYSA-N	790446	US20260034094, Compound 92	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790446&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378176	CC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C12H23F3N2O3S/c1-11(2,3)20-10(18)9(16)5-8-21(17,19)7-4-6-12(13,14)15/h9,17H,4-8,16H2,1-3H3	LGNZGSLSFRQZLE-UHFFFAOYSA-N	790447	US20260034094, Compound 93	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790447&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378177	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCc1ccccc1C(F)(F)F	InChI=1S/C17H25F3N2O3S/c1-2-3-10-25-16(23)15(21)9-12-26(22,24)11-8-13-6-4-5-7-14(13)17(18,19)20/h4-7,15,22H,2-3,8-12,21H2,1H3	VXYRHUXNUHOXII-UHFFFAOYSA-N	790448	US20260034094, Compound 94	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790448&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378178	CCCCOC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)C	InChI=1S/C13H28N2O3S/c1-4-5-8-18-13(16)12(14)7-10-19(15,17)9-6-11(2)3/h11-12,15H,4-10,14H2,1-3H3	QGWROXCKCGMHGE-UHFFFAOYSA-N	790449	US20260034094, Compound 95	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790449&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378179	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)OC(C)(C)C	InChI=1S/C14H30N2O3S/c1-13(2,3)8-10-20(16,18)9-7-11(15)12(17)19-14(4,5)6/h11,16H,7-10,15H2,1-6H3	YFGKNBDORNNKDS-UHFFFAOYSA-N	790450	US20260034094, Compound 96	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790450&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378180	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)OC1CCCCC1	InChI=1S/C16H32N2O3S/c1-16(2,3)10-12-22(18,20)11-9-14(17)15(19)21-13-7-5-4-6-8-13/h13-14,18H,4-12,17H2,1-3H3	ILBINUJMBZYSKK-UHFFFAOYSA-N	790451	US20260034094, Compound 97	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790451&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378181	CC(COC(=O)c1ccccc1)OC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)C	InChI=1S/C20H32N2O5S/c1-15(14-26-18(23)16-8-6-5-7-9-16)27-19(24)17(21)10-12-28(22,25)13-11-20(2,3)4/h5-9,15,17,22H,10-14,21H2,1-4H3	IRFDJSHWMFTKRO-UHFFFAOYSA-N	790452	US20260034094, Compound 98	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790452&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378182	CCCC(C)(C)OC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)C	InChI=1S/C16H34N2O3S/c1-7-9-16(5,6)21-14(19)13(17)8-11-22(18,20)12-10-15(2,3)4/h13,18H,7-12,17H2,1-6H3	VYQOFVZAPKNHFV-UHFFFAOYSA-N	790453	US20260034094, Compound 99	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790453&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378183	CCCCNC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)C	InChI=1S/C14H31N3O2S/c1-5-6-9-17-13(18)12(15)7-10-20(16,19)11-8-14(2,3)4/h12,16H,5-11,15H2,1-4H3,(H,17,18)	RNFJCNCYVJTDEK-UHFFFAOYSA-N	790454	US20260034094, Compound 100	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790454&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378184	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)Nc1cccnc1	InChI=1S/C15H26N4O2S/c1-15(2,3)7-10-22(17,21)9-6-13(16)14(20)19-12-5-4-8-18-11-12/h4-5,8,11,13,17H,6-7,9-10,16H2,1-3H3,(H,19,20)	YRIROHMSJYMVMJ-UHFFFAOYSA-N	790455	US20260034094, Compound 101	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790455&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378185	CC(C)(C)CC[S@@](=N)(=O)CC[C@H](N)C(=O)Nc1cccnc1	InChI=1S/C15H26N4O2S/c1-15(2,3)7-10-22(17,21)9-6-13(16)14(20)19-12-5-4-8-18-11-12/h4-5,8,11,13,17H,6-7,9-10,16H2,1-3H3,(H,19,20)	YRIROHMSJYMVMJ-UHFFFAOYSA-N	790456	US20260034094, Compound 102	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790456&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378186	CC(C)(C)CC[S@](=N)(=O)CC[C@H](N)C(=O)Nc1cccnc1	InChI=1S/C15H26N4O2S/c1-15(2,3)7-10-22(17,21)9-6-13(16)14(20)19-12-5-4-8-18-11-12/h4-5,8,11,13,17H,6-7,9-10,16H2,1-3H3,(H,19,20)	YRIROHMSJYMVMJ-UHFFFAOYSA-N	790457	US20260034094, Compound 103	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790457&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378187	CCCCS(=N)(=O)CC[C@H](N)C(=O)NS(C)(=O)=O	InChI=1S/C9H21N3O4S2/c1-3-4-6-18(11,16)7-5-8(10)9(13)12-17(2,14)15/h8,11H,3-7,10H2,1-2H3,(H,12,13)	YKUNIKONJJSNPA-UHFFFAOYSA-N	790458	US20260034094, Compound 104	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790458&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378188	CCCCS(=N)(=O)CC[C@H](N)C(N)=O	InChI=1S/C8H19N3O2S/c1-2-3-5-14(11,13)6-4-7(9)8(10)12/h7,11H,2-6,9H2,1H3,(H2,10,12)	CQTJLRSHNXFECL-UHFFFAOYSA-N	790460	US20260034094, Compound 105	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790460&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378189	CCCCS(=N)(=O)CC[C@H](N)C(=O)NCC#N	InChI=1S/C10H20N4O2S/c1-2-3-7-17(13,16)8-4-9(12)10(15)14-6-5-11/h9,13H,2-4,6-8,12H2,1H3,(H,14,15)	JPVHSENGCNHJIS-UHFFFAOYSA-N	790461	US20260034094, Compound 106	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790461&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378190	CCCCS(=N)(=O)CC[C@H](N)C(=O)NC	InChI=1S/C9H21N3O2S/c1-3-4-6-15(11,14)7-5-8(10)9(13)12-2/h8,11H,3-7,10H2,1-2H3,(H,12,13)	ZWRIGAQOAATILT-UHFFFAOYSA-N	790462	US20260034094, Compound 107	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1960000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790462&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378191	CCCCS(=N)(=O)CC[C@H](N)C(=O)NS(=O)(=O)C(F)(F)F	InChI=1S/C9H18F3N3O4S2/c1-2-3-5-20(14,17)6-4-7(13)8(16)15-21(18,19)9(10,11)12/h7,14H,2-6,13H2,1H3,(H,15,16)	QJQNTWJKOYOQHA-UHFFFAOYSA-N	790463	US20260034094, Compound 108	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790463&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378192	CCCCS(=N)(=O)CC[C@H](N)C(=O)NS(=O)(=O)C1CC1	InChI=1S/C11H23N3O4S2/c1-2-3-7-19(13,16)8-6-10(12)11(15)14-20(17,18)9-4-5-9/h9-10,13H,2-8,12H2,1H3,(H,14,15)	IPPQUQPKZCKKJE-UHFFFAOYSA-N	790464	US20260034094, Compound 109	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790464&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378193	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H22N2O3S/c1-10(2,3)5-7-16(12,15)6-4-8(11)9(13)14/h8,12H,4-7,11H2,1-3H3,(H,13,14)	GEVDRXXDCGARMO-UHFFFAOYSA-N	790465	US20260034094, Compound 110	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790465&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378194	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NS(C)(=O)=O	InChI=1S/C11H25N3O4S2/c1-11(2,3)6-8-20(13,18)7-5-9(12)10(15)14-19(4,16)17/h9,13H,5-8,12H2,1-4H3,(H,14,15)	UBTRLIQOIGHYJR-UHFFFAOYSA-N	790466	US20260034094, Compound 111	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790466&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378195	CCCCS(=N)(=O)CC[C@H](N)C(=O)NCC(N)=O	InChI=1S/C10H22N4O3S/c1-2-3-5-18(13,17)6-4-8(11)10(16)14-7-9(12)15/h8,13H,2-7,11H2,1H3,(H2,12,15)(H,14,16)	FHYQHTDBHIBTKR-UHFFFAOYSA-N	790467	US20260034094, Compound 112	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790467&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378196	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NC1CC1	InChI=1S/C13H27N3O2S/c1-13(2,3)7-9-19(15,18)8-6-11(14)12(17)16-10-4-5-10/h10-11,15H,4-9,14H2,1-3H3,(H,16,17)	COYOBYXVZXUQRS-UHFFFAOYSA-N	790468	US20260034094, Compound 113	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790468&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378197	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NCC(F)(F)F	InChI=1S/C12H24F3N3O2S/c1-11(2,3)5-7-21(17,20)6-4-9(16)10(19)18-8-12(13,14)15/h9,17H,4-8,16H2,1-3H3,(H,18,19)	PMLXCRARKAJAJR-UHFFFAOYSA-N	790469	US20260034094, Compound 114	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790469&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378198	CN(C)C(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)C	InChI=1S/C12H27N3O2S/c1-12(2,3)7-9-18(14,17)8-6-10(13)11(16)15(4)5/h10,14H,6-9,13H2,1-5H3	VMYFNGZWQZFEJH-UHFFFAOYSA-N	790470	US20260034094, Compound 115	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790470&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378199	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)N1CCCC1	InChI=1S/C14H29N3O2S/c1-14(2,3)7-11-20(16,19)10-6-12(15)13(18)17-8-4-5-9-17/h12,16H,4-11,15H2,1-3H3	ZHIUYSPXBZEHMN-UHFFFAOYSA-N	790471	US20260034094, Compound 116	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790471&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378200	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NC(C)(C)C	InChI=1S/C14H31N3O2S/c1-13(2,3)8-10-20(16,19)9-7-11(15)12(18)17-14(4,5)6/h11,16H,7-10,15H2,1-6H3,(H,17,18)	NKMQVDCWODEXBB-UHFFFAOYSA-N	790473	US20260034094, Compound 117	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790473&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378201	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)Nc1ccccc1	InChI=1S/C16H27N3O2S/c1-16(2,3)10-12-22(18,21)11-9-14(17)15(20)19-13-7-5-4-6-8-13/h4-8,14,18H,9-12,17H2,1-3H3,(H,19,20)	XRQXEBFEFYJQOE-UHFFFAOYSA-N	790474	US20260034094, Compound 118	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790474&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378202	CC(C)CCOC(=O)[C@@H](N)CCS(=N)(=O)CCC(C)(C)C	InChI=1S/C15H32N2O3S/c1-12(2)6-9-20-14(18)13(16)7-10-21(17,19)11-8-15(3,4)5/h12-13,17H,6-11,16H2,1-5H3	CRPWGFKICLPWON-UHFFFAOYSA-N	790475	US20260034094, Compound 119	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790475&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378203	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NC1CCOCC1	InChI=1S/C15H31N3O3S/c1-15(2,3)7-11-22(17,20)10-6-13(16)14(19)18-12-4-8-21-9-5-12/h12-13,17H,4-11,16H2,1-3H3,(H,18,19)	USLKMDWLDVFYPM-UHFFFAOYSA-N	790476	US20260034094, Compound 120	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790476&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378204	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)Nc1nccs1	InChI=1S/C13H24N4O2S2/c1-13(2,3)5-9-21(15,19)8-4-10(14)11(18)17-12-16-6-7-20-12/h6-7,10,15H,4-5,8-9,14H2,1-3H3,(H,16,17,18)	DUVIPYFDHSAGMZ-UHFFFAOYSA-N	790477	US20260034094, Compound 121	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790477&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378205	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NCc1ccccc1	InChI=1S/C17H29N3O2S/c1-17(2,3)10-12-23(19,22)11-9-15(18)16(21)20-13-14-7-5-4-6-8-14/h4-8,15,19H,9-13,18H2,1-3H3,(H,20,21)	FIBHBIJVZBHERR-UHFFFAOYSA-N	790478	US20260034094, Compound 122	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790478&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378206	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)Nc1cc[nH]n1	InChI=1S/C13H25N5O2S/c1-13(2,3)6-9-21(15,20)8-5-10(14)12(19)17-11-4-7-16-18-11/h4,7,10,15H,5-6,8-9,14H2,1-3H3,(H2,16,17,18,19)	ABWXHRZJTQKBJG-UHFFFAOYSA-N	790479	US20260034094, Compound 123	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1160000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790479&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770260	528498266							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378207	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NCc1cncs1	InChI=1S/C14H26N4O2S2/c1-14(2,3)5-7-22(16,20)6-4-12(15)13(19)18-9-11-8-17-10-21-11/h8,10,12,16H,4-7,9,15H2,1-3H3,(H,18,19)	QONVCSXGLUJXHR-UHFFFAOYSA-N	790480	US20260034094, Compound 124	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790480&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378208	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NCCC(C)(C)O	InChI=1S/C15H33N3O3S/c1-14(2,3)8-11-22(17,21)10-6-12(16)13(19)18-9-7-15(4,5)20/h12,17,20H,6-11,16H2,1-5H3,(H,18,19)	OFWQVVJSWSFZFE-UHFFFAOYSA-N	790481	US20260034094, Compound 125	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790481&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378209	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NC(CO)CO	InChI=1S/C13H29N3O4S/c1-13(2,3)5-7-21(15,20)6-4-11(14)12(19)16-10(8-17)9-18/h10-11,15,17-18H,4-9,14H2,1-3H3,(H,16,19)	YZNXWYDGSBYCAA-UHFFFAOYSA-N	790482	US20260034094, Compound 126	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790482&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378210	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)Nc1ccncc1	InChI=1S/C15H26N4O2S/c1-15(2,3)7-11-22(17,21)10-6-13(16)14(20)19-12-4-8-18-9-5-12/h4-5,8-9,13,17H,6-7,10-11,16H2,1-3H3,(H,18,19,20)	JSMZWKYFMVHLSJ-UHFFFAOYSA-N	790483	US20260034094, Compound 127	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790483&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378211	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)Nc1ccccn1	InChI=1S/C15H26N4O2S/c1-15(2,3)8-11-22(17,21)10-7-12(16)14(20)19-13-6-4-5-9-18-13/h4-6,9,12,17H,7-8,10-11,16H2,1-3H3,(H,18,19,20)	LKQRTWZEZQMYGK-UHFFFAOYSA-N	790484	US20260034094, Compound 128	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790484&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378212	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NC1COC1	InChI=1S/C13H27N3O3S/c1-13(2,3)5-7-20(15,18)6-4-11(14)12(17)16-10-8-19-9-10/h10-11,15H,4-9,14H2,1-3H3,(H,16,17)	IMMAMCLZDCHYHQ-UHFFFAOYSA-N	790485	US20260034094, Compound 129	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790485&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378213	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)NC1CC1	InChI=1S/C11H20F3N3O2S/c12-11(13,14)5-1-6-20(16,19)7-4-9(15)10(18)17-8-2-3-8/h8-9,16H,1-7,15H2,(H,17,18)	FUZAEUCMGYAKLY-UHFFFAOYSA-N	790486	US20260034094, Compound 130	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1730000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790486&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378214	CCCCNC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C12H24F3N3O2S/c1-2-3-7-18-11(19)10(16)5-9-21(17,20)8-4-6-12(13,14)15/h10,17H,2-9,16H2,1H3,(H,18,19)	ULJPJOHOTAZDPO-UHFFFAOYSA-N	790487	US20260034094, Compound 131	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790487&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378215	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)Nc1ccccc1	InChI=1S/C14H20F3N3O2S/c15-14(16,17)8-4-9-23(19,22)10-7-12(18)13(21)20-11-5-2-1-3-6-11/h1-3,5-6,12,19H,4,7-10,18H2,(H,20,21)	DHJNULKACYOEMC-UHFFFAOYSA-N	790488	US20260034094, Compound 132	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790488&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378216	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)NS(N)(=O)=O	InChI=1S/C10H24N4O4S2/c1-10(2,3)5-7-19(12,16)6-4-8(11)9(15)14-20(13,17)18/h8,12H,4-7,11H2,1-3H3,(H,14,15)(H2,13,17,18)	BRALROMVLFXECK-UHFFFAOYSA-N	790489	US20260034094, Compound 133	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790489&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378217	N=S(=O)(CCCC1CC1)CC[C@H](N)C(=O)O	InChI=1S/C10H20N2O3S/c11-9(10(13)14)5-7-16(12,15)6-1-2-8-3-4-8/h8-9,12H,1-7,11H2,(H,13,14)	XDOLGGCUDZLYPP-UHFFFAOYSA-N	790490	US20260034094, Compound 134	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790490&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378218	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(O)CC1	InChI=1S/C9H18N2O4S/c10-7(8(12)13)1-5-16(11,15)6-4-9(14)2-3-9/h7,11,14H,1-6,10H2,(H,12,13)	UCQPJDCDHASSPP-UHFFFAOYSA-N	790491	US20260034094, Compound 135	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790491&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378219	N=S(=O)(CC[C@H](N)C(=O)O)CC(=O)C1CCCC1	InChI=1S/C11H20N2O4S/c12-9(11(15)16)5-6-18(13,17)7-10(14)8-3-1-2-4-8/h8-9,13H,1-7,12H2,(H,15,16)	MYQKMQCSIHKNGX-UHFFFAOYSA-N	790492	US20260034094, Compound 136	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790492&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378220	N=S(=O)(CC[C@H](N)C(=O)O)CC(O)C1CCCC1	InChI=1S/C11H22N2O4S/c12-9(11(15)16)5-6-18(13,17)7-10(14)8-3-1-2-4-8/h8-10,13-14H,1-7,12H2,(H,15,16)	UAVHWZKZMRPPTB-UHFFFAOYSA-N	790493	US20260034094, Compound 137	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790493&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378221	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)O	InChI=1S/C8H15F3N2O3S/c9-8(10,11)3-1-4-17(13,16)5-2-6(12)7(14)15/h6,13H,1-5,12H2,(H,14,15)	JTYPKXBZXTWMDG-UHFFFAOYSA-N	790494	US20260034094, Compound 139	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790494&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378222	N=S(=O)(CC[C@H](N)C(=O)O)Cc1ccccc1	InChI=1S/C11H16N2O3S/c12-10(11(14)15)6-7-17(13,16)8-9-4-2-1-3-5-9/h1-5,10,13H,6-8,12H2,(H,14,15)	PQCLYYXFFGPYCT-UHFFFAOYSA-N	790495	US20260034094, Compound 140	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790495&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378223	N=S(=O)(CCC1CCCC1)CC[C@H](N)C(=O)O	InChI=1S/C11H22N2O3S/c12-10(11(14)15)6-8-17(13,16)7-5-9-3-1-2-4-9/h9-10,13H,1-8,12H2,(H,14,15)	MZPFFDUCRODFAC-UHFFFAOYSA-N	790498	US20260034094, Compound 141	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790498&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378224	N=S(=O)(CCC1CCCCC1)CC[C@H](N)C(=O)O	InChI=1S/C12H24N2O3S/c13-11(12(15)16)7-9-18(14,17)8-6-10-4-2-1-3-5-10/h10-11,14H,1-9,13H2,(H,15,16)	ASFDIBWIUROEID-UHFFFAOYSA-N	790499	US20260034094, Compound 142	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790499&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378225	N=S(=O)(CCC1C2CC3CC(C2)CC1C3)CC[C@H](N)C(=O)O	InChI=1S/C16H28N2O3S/c17-15(16(19)20)2-4-22(18,21)3-1-14-12-6-10-5-11(8-12)9-13(14)7-10/h10-15,18H,1-9,17H2,(H,19,20)	HAHRXLQIFFEFFG-UHFFFAOYSA-N	790501	US20260034094, Compound 143	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790501&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378226	CC#CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C8H14N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,4-6,9H2,1H3,(H,11,12)	CTJLEPGYTIOYET-UHFFFAOYSA-N	790502	US20260034094, Compound 144	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790502&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378227	N=S(=O)(CC[C@H](N)C(=O)O)CCN1CCCC1=O	InChI=1S/C10H19N3O4S/c11-8(10(15)16)3-6-18(12,17)7-5-13-4-1-2-9(13)14/h8,12H,1-7,11H2,(H,15,16)	XFVUWHOAHGCTOY-UHFFFAOYSA-N	790503	US20260034094, Compound 145	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790503&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378228	CC#CCCCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H18N2O3S/c1-2-3-4-5-7-16(12,15)8-6-9(11)10(13)14/h9,12H,4-8,11H2,1H3,(H,13,14)	QDKZNHJHWVMUMG-UHFFFAOYSA-N	790504	US20260034094, Compound 146	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790504&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378229	CC(C)(C)[C@@H](N)CS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H23N3O3S/c1-10(2,3)8(12)6-17(13,16)5-4-7(11)9(14)15/h7-8,13H,4-6,11-12H2,1-3H3,(H,14,15)	RYBFLEBEKUWYFJ-UHFFFAOYSA-N	790510	US20260034094, Compound 147	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790510&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378230	CC(C)(C)[C@H](N)CS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H23N3O3S/c1-10(2,3)8(12)6-17(13,16)5-4-7(11)9(14)15/h7-8,13H,4-6,11-12H2,1-3H3,(H,14,15)	RYBFLEBEKUWYFJ-UHFFFAOYSA-N	790511	US20260034094, Compound 148	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790511&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378231	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H22N2O3S/c1-10(2,3)5-7-16(12,15)6-4-8(11)9(13)14/h8,12H,4-7,11H2,1-3H3,(H,13,14)	GEVDRXXDCGARMO-UHFFFAOYSA-N	790512	US20260034094, Compound 149	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790512&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378232	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)C(=O)O	InChI=1S/C8H15F3N2O3S/c9-8(10,11)3-1-4-17(13,16)5-2-6(12)7(14)15/h6,13H,1-5,12H2,(H,14,15)	JTYPKXBZXTWMDG-UHFFFAOYSA-N	790514	US20260034094, Compound 150	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790514&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378233	[C-]#[N+]C1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CC1	InChI=1S/C10H17N3O3S/c1-13-10(3-4-10)5-7-17(12,16)6-2-8(11)9(14)15/h8,12H,2-7,11H2,(H,14,15)	VNBSCHIVFFWDIR-UHFFFAOYSA-N	790515	US20260034094, Compound 151	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790515&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378234	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F	InChI=1S/C10H19F3N2O3S/c1-9(2,10(11,12)13)4-6-19(15,18)5-3-7(14)8(16)17/h7,15H,3-6,14H2,1-2H3,(H,16,17)	VXSWPECAPLXKQP-UHFFFAOYSA-N	790516	US20260034094, Compound 152	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790516&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378235	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(O)CCC1	InChI=1S/C10H20N2O4S/c11-8(9(13)14)2-6-17(12,16)7-5-10(15)3-1-4-10/h8,12,15H,1-7,11H2,(H,13,14)	PMJQBMRHCQXKRD-UHFFFAOYSA-N	790517	US20260034094, Compound 153	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790517&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378236	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)C(F)(F)F	InChI=1S/C8H15F3N2O4S/c9-8(10,11)6(14)2-4-18(13,17)3-1-5(12)7(15)16/h5-6,13-14H,1-4,12H2,(H,15,16)	DKJFFPCIWXTSGY-UHFFFAOYSA-N	790518	US20260034094, Compound 154	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790518&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378237	COC(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-18-7(9(10,11)12)3-5-19(14,17)4-2-6(13)8(15)16/h6-7,14H,2-5,13H2,1H3,(H,15,16)	WSDNZEKYUUHNAZ-UHFFFAOYSA-N	790519	US20260034094, Compound 155	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790519&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378238	N=S(=O)(/C=C/c1ccccc1)CC[C@H](N)C(=O)O	InChI=1S/C12H16N2O3S/c13-11(12(15)16)7-9-18(14,17)8-6-10-4-2-1-3-5-10/h1-6,8,11,14H,7,9,13H2,(H,15,16)	UWHCALOVHDZBCA-UHFFFAOYSA-N	790520	US20260034094, Compound 156	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790520&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378239	N=S(=O)(CCC1CCOCC1)CC[C@H](N)C(=O)O	InChI=1S/C11H22N2O4S/c12-10(11(14)15)4-8-18(13,16)7-3-9-1-5-17-6-2-9/h9-10,13H,1-8,12H2,(H,14,15)	FLIHDBPHVZXAQZ-UHFFFAOYSA-N	790521	US20260034094, Compound 157	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790521&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378240	COC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H22N2O4S/c1-10(2,16-3)5-7-17(12,15)6-4-8(11)9(13)14/h8,12H,4-7,11H2,1-3H3,(H,13,14)	WOPZYPNDHBYZGK-UHFFFAOYSA-N	790522	US20260034094, Compound 158	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790522&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378241	CCCCS(=N)(=O)CC[C@H](NC)C(=O)O	InChI=1S/C9H20N2O3S/c1-3-4-6-15(10,14)7-5-8(11-2)9(12)13/h8,10-11H,3-7H2,1-2H3,(H,12,13)	AAZDXLABZKMXBN-UHFFFAOYSA-N	790523	US20260034094, Compound 159	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790523&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378242	N=S(=O)(CCCF)CC[C@H](N)C(=O)O	InChI=1S/C7H15FN2O3S/c8-3-1-4-14(10,13)5-2-6(9)7(11)12/h6,10H,1-5,9H2,(H,11,12)	KXNHLZOITWGZAY-UHFFFAOYSA-N	790524	US20260034094, Compound 160	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790524&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378243	N=S(=O)(CCC1CC(F)(F)C1)CC[C@H](N)C(=O)O	InChI=1S/C10H18F2N2O3S/c11-10(12)5-7(6-10)1-3-18(14,17)4-2-8(13)9(15)16/h7-8,14H,1-6,13H2,(H,15,16)	GHUYJSFQJARPFJ-UHFFFAOYSA-N	790525	US20260034094, Compound 161	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790525&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378244	CC(C)OCCCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H22N2O4S/c1-8(2)16-5-3-6-17(12,15)7-4-9(11)10(13)14/h8-9,12H,3-7,11H2,1-2H3,(H,13,14)	LSYOSBGXUVLBCR-UHFFFAOYSA-N	790526	US20260034094, Compound 162	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790526&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378245	CC(C)(F)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C9H19FN2O3S/c1-9(2,10)4-6-16(12,15)5-3-7(11)8(13)14/h7,12H,3-6,11H2,1-2H3,(H,13,14)	HTULYHYQEQPRDR-UHFFFAOYSA-N	790527	US20260034094, Compound 163	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790527&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378246	COCCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C7H16N2O4S/c1-13-3-5-14(9,12)4-2-6(8)7(10)11/h6,9H,2-5,8H2,1H3,(H,10,11)	PSNOTBZZTXCGFJ-UHFFFAOYSA-N	790528	US20260034094, Compound 164	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790528&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378247	N=S(=O)(CCC1CCC1)CC[C@H](N)C(=O)O	InChI=1S/C10H20N2O3S/c11-9(10(13)14)5-7-16(12,15)6-4-8-2-1-3-8/h8-9,12H,1-7,11H2,(H,13,14)	QHEQUKQENFLABI-UHFFFAOYSA-N	790529	US20260034094, Compound 165	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790529&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378248	CC(C)OCCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C9H20N2O4S/c1-7(2)15-4-6-16(11,14)5-3-8(10)9(12)13/h7-8,11H,3-6,10H2,1-2H3,(H,12,13)	LZYMKXQQIBRTEM-UHFFFAOYSA-N	790530	US20260034094, Compound 166	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790530&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378249	COC(=O)C(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C11H22N2O5S/c1-11(2,10(16)18-3)5-7-19(13,17)6-4-8(12)9(14)15/h8,13H,4-7,12H2,1-3H3,(H,14,15)	FBDGZJHXOHEHNT-UHFFFAOYSA-N	790531	US20260034094, Compound 167	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790531&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378250	N=S(=O)(CC[C@H](N)C(=O)O)Cc1ccccc1C(=O)O	InChI=1S/C12H16N2O5S/c13-10(12(17)18)5-6-20(14,19)7-8-3-1-2-4-9(8)11(15)16/h1-4,10,14H,5-7,13H2,(H,15,16)(H,17,18)	OHYGRSMXRMEXIK-UHFFFAOYSA-N	790532	US20260034094, Compound 168	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790532&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378251	N=S(=O)(CCCC(F)F)CC[C@H](N)C(=O)O	InChI=1S/C8H16F2N2O3S/c9-7(10)2-1-4-16(12,15)5-3-6(11)8(13)14/h6-7,12H,1-5,11H2,(H,13,14)	MSROYZMAJQIMEE-UHFFFAOYSA-N	790533	US20260034094, Compound 169	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 10200							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790533&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378252	N=S(=O)(CCOC(F)F)CC[C@H](N)C(=O)O	InChI=1S/C7H14F2N2O4S/c8-7(9)15-2-4-16(11,14)3-1-5(10)6(12)13/h5,7,11H,1-4,10H2,(H,12,13)	GKWUXVUDUTZZNS-UHFFFAOYSA-N	790534	US20260034094, Compound 170	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790534&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378253	[C-]#[N+]C(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H19N3O3S/c1-10(2,13-3)5-7-17(12,16)6-4-8(11)9(14)15/h8,12H,4-7,11H2,1-2H3,(H,14,15)	BXVOLMGMNZDXBE-UHFFFAOYSA-N	790535	US20260034094, Compound 171	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790535&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378254	CCC(CC(F)(F)F)C[S@SP3](=N)(=O)CCC(N)C(=O)O	InChI=1S/C10H19F3N2O3S/c1-2-7(5-10(11,12)13)6-19(15,18)4-3-8(14)9(16)17/h7-8,15H,2-6,14H2,1H3,(H,16,17)	QQHLTYYNTIERJO-UHFFFAOYSA-N	790536	US20260034094, Compound 172	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790536&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378255	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(F)CCC1	InChI=1S/C10H19FN2O3S/c11-10(3-1-4-10)5-7-17(13,16)6-2-8(12)9(14)15/h8,13H,1-7,12H2,(H,14,15)	BWVCBMWDMCAPDP-UHFFFAOYSA-N	790537	US20260034094, Compound 173	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790537&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378256	CC(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-8(17,9(10,11)12)3-5-19(14,18)4-2-6(13)7(15)16/h6,14,17H,2-5,13H2,1H3,(H,15,16)	SQLALGOQTMEDGJ-UHFFFAOYSA-N	790538	US20260034094, Compound 174	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790538&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378257	N=[S@SP2](=O)(CCOCC(F)(F)F)CCC(N)C(=O)O	InChI=1S/C8H15F3N2O4S/c9-8(10,11)5-17-2-4-18(13,16)3-1-6(12)7(14)15/h6,13H,1-5,12H2,(H,14,15)	FBJIRVYBVPINOP-UHFFFAOYSA-N	790539	US20260034094, Compound 175	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790539&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378258	COC(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-18-7(9(10,11)12)3-5-19(14,17)4-2-6(13)8(15)16/h6-7,14H,2-5,13H2,1H3,(H,15,16)	WSDNZEKYUUHNAZ-UHFFFAOYSA-N	790540	US20260034094, Compound 176	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790540&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378259	COC(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-18-7(9(10,11)12)3-5-19(14,17)4-2-6(13)8(15)16/h6-7,14H,2-5,13H2,1H3,(H,15,16)	WSDNZEKYUUHNAZ-UHFFFAOYSA-N	790541	US20260034094, Compound 177	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790541&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378260	COC(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-18-7(9(10,11)12)3-5-19(14,17)4-2-6(13)8(15)16/h6-7,14H,2-5,13H2,1H3,(H,15,16)	WSDNZEKYUUHNAZ-UHFFFAOYSA-N	790542	US20260034094, Compound 178	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790542&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378261	COC(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-18-7(9(10,11)12)3-5-19(14,17)4-2-6(13)8(15)16/h6-7,14H,2-5,13H2,1H3,(H,15,16)	WSDNZEKYUUHNAZ-UHFFFAOYSA-N	790543	US20260034094, Compound 179	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790543&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378262	N=S(=O)(CCC1CCCC1(F)F)CC[C@H](N)C(=O)O	InChI=1S/C11H20F2N2O3S/c12-11(13)5-1-2-8(11)3-6-19(15,18)7-4-9(14)10(16)17/h8-9,15H,1-7,14H2,(H,16,17)	SGULECXYLZYFJN-UHFFFAOYSA-N	790544	US20260034094, Compound 180	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790544&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378263	N=S(=O)(CCC1COC1)CC[C@H](N)C(=O)O	InChI=1S/C9H18N2O4S/c10-8(9(12)13)2-4-16(11,14)3-1-7-5-15-6-7/h7-8,11H,1-6,10H2,(H,12,13)	HOLJHWGYVWSGIM-UHFFFAOYSA-N	790545	US20260034094, Compound 181	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790545&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378264	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(CO)CCC1	InChI=1S/C11H22N2O4S/c12-9(10(15)16)2-6-18(13,17)7-5-11(8-14)3-1-4-11/h9,13-14H,1-8,12H2,(H,15,16)	MWUUBTCNCBRGRN-UHFFFAOYSA-N	790546	US20260034094, Compound 182	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790546&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378265	CC(C)(N)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C9H21N3O3S/c1-9(2,11)4-6-16(12,15)5-3-7(10)8(13)14/h7,12H,3-6,10-11H2,1-2H3,(H,13,14)	QOWJUDABLLBPBW-UHFFFAOYSA-N	790547	US20260034094, Compound 183	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790547&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378266	CC(C)(CO)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H22N2O4S/c1-10(2,7-13)4-6-17(12,16)5-3-8(11)9(14)15/h8,12-13H,3-7,11H2,1-2H3,(H,14,15)	QVSOYRPTLOBLFS-UHFFFAOYSA-N	790548	US20260034094, Compound 184	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790548&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378267	CC1(CCS(=N)(=O)CC[C@H](N)C(=O)O)COC1	InChI=1S/C10H20N2O4S/c1-10(6-16-7-10)3-5-17(12,15)4-2-8(11)9(13)14/h8,12H,2-7,11H2,1H3,(H,13,14)	KLFBIVCQAGFAJJ-UHFFFAOYSA-N	790549	US20260034094, Compound 185	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790549&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378268	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(C(F)(F)F)C(F)(F)F	InChI=1S/C9H14F6N2O3S/c10-8(11,12)6(9(13,14)15)2-4-21(17,20)3-1-5(16)7(18)19/h5-6,17H,1-4,16H2,(H,18,19)	ZMHAMWJXSXQJOU-UHFFFAOYSA-N	790550	US20260034094, Compound 186	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 22000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790550&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378269	CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C10H22N2O3S/c1-10(2,3)5-7-16(12,15)6-4-8(11)9(13)14/h8,12H,4-7,11H2,1-3H3,(H,13,14)	GEVDRXXDCGARMO-UHFFFAOYSA-N	790551	US20260034094, Compound 187	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790551&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378270	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(C(N)=O)CCC1	InChI=1S/C11H21N3O4S/c12-8(9(15)16)2-6-19(14,18)7-5-11(10(13)17)3-1-4-11/h8,14H,1-7,12H2,(H2,13,17)(H,15,16)	JOTPFWHKUBVKQX-UHFFFAOYSA-N	790552	US20260034094, Compound 188	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790552&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378271	CCOC(=O)C1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC1	InChI=1S/C13H24N2O5S/c1-2-20-12(18)13(5-3-6-13)7-9-21(15,19)8-4-10(14)11(16)17/h10,15H,2-9,14H2,1H3,(H,16,17)	VTOIYCLCEQWGED-UHFFFAOYSA-N	790553	US20260034094, Compound 189	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790553&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378272	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(N)=O	InChI=1S/C10H21N3O4S/c1-10(2,9(12)16)4-6-18(13,17)5-3-7(11)8(14)15/h7,13H,3-6,11H2,1-2H3,(H2,12,16)(H,14,15)	XCDIRAGJIFJCSQ-UHFFFAOYSA-N	790554	US20260034094, Compound 190	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790554&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378273	CCOC(=O)C1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC1	InChI=1S/C13H24N2O5S/c1-2-20-12(18)13(5-3-6-13)7-9-21(15,19)8-4-10(14)11(16)17/h10,15H,2-9,14H2,1H3,(H,16,17)	VTOIYCLCEQWGED-UHFFFAOYSA-N	790555	US20260034094, Compound 191	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790555&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378274	CCOC(=O)C1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC1	InChI=1S/C13H24N2O5S/c1-2-20-12(18)13(5-3-6-13)7-9-21(15,19)8-4-10(14)11(16)17/h10,15H,2-9,14H2,1H3,(H,16,17)	VTOIYCLCEQWGED-UHFFFAOYSA-N	790555	US20260034094, Compound 191	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790555&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378275	CNC(=O)C1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC1	InChI=1S/C12H23N3O4S/c1-15-11(18)12(4-2-5-12)6-8-20(14,19)7-3-9(13)10(16)17/h9,14H,2-8,13H2,1H3,(H,15,18)(H,16,17)	LKWRMPXYGLWQRX-UHFFFAOYSA-N	790556	US20260034094, Compound 192	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790556&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378276	CN(C)C(=O)C1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC1	InChI=1S/C13H25N3O4S/c1-16(2)12(19)13(5-3-6-13)7-9-21(15,20)8-4-10(14)11(17)18/h10,15H,3-9,14H2,1-2H3,(H,17,18)	NLPDWMPSBPEWEG-UHFFFAOYSA-N	790557	US20260034094, Compound 193	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790557&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378277	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(C(=O)N2CCCC2)CCC1	InChI=1S/C15H27N3O4S/c16-12(13(19)20)4-10-23(17,22)11-7-15(5-3-6-15)14(21)18-8-1-2-9-18/h12,17H,1-11,16H2,(H,19,20)	UIKYJHCFOZQAOK-UHFFFAOYSA-N	790558	US20260034094, Compound 194	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790558&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378278	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(C(=O)Nc2ccccc2)CCC1	InChI=1S/C17H25N3O4S/c18-14(15(21)22)7-11-25(19,24)12-10-17(8-4-9-17)16(23)20-13-5-2-1-3-6-13/h1-3,5-6,14,19H,4,7-12,18H2,(H,20,23)(H,21,22)	ULMGDJOCGLTIBB-UHFFFAOYSA-N	790559	US20260034094, Compound 195	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790559&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378279	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(C(=O)N2CCC2)CCC1	InChI=1S/C14H25N3O4S/c15-11(12(18)19)3-9-22(16,21)10-6-14(4-1-5-14)13(20)17-7-2-8-17/h11,16H,1-10,15H2,(H,18,19)	PBJZZAIBAVRIAB-UHFFFAOYSA-N	790560	US20260034094, Compound 196	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790560&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378280	CCCCS(=O)(CC[C@H](N)C(=O)OC)=NC(C)=O	InChI=1S/C11H22N2O4S/c1-4-5-7-18(16,13-9(2)14)8-6-10(12)11(15)17-3/h10H,4-8,12H2,1-3H3	RBKFRGBARKSKGZ-UHFFFAOYSA-N	790561	US20260034094, Compound 197	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790561&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378281	CCCCS(=N)(=O)CC[C@H](NC(=O)OC)C(=O)OC	InChI=1S/C11H22N2O5S/c1-4-5-7-19(12,16)8-6-9(10(14)17-2)13-11(15)18-3/h9,12H,4-8H2,1-3H3,(H,13,15)	JMAOXJPQFMQSAY-UHFFFAOYSA-N	790562	US20260034094, Compound 198	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790562&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378282	CCCCS(=N)(=O)CC[C@H](N)C#N	InChI=1S/C8H17N3OS/c1-2-3-5-13(11,12)6-4-8(10)7-9/h8,11H,2-6,10H2,1H3	UTBIBDDXBJTSNH-UHFFFAOYSA-N	790563	US20260034094, Compound 199	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790563&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378283	CCCCS(=N)(=O)CC[C@H](N)c1nnn[nH]1	InChI=1S/C8H18N6OS/c1-2-3-5-16(10,15)6-4-7(9)8-11-13-14-12-8/h7,10H,2-6,9H2,1H3,(H,11,12,13,14)	VCKIZOSAPHECRJ-UHFFFAOYSA-N	790564	US20260034094, Compound 200	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790564&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174246182	528498351							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378284	CC(C)(C)CCS1(=O)=NC(=O)[C@@H](N)CC1	InChI=1S/C10H20N2O2S/c1-10(2,3)5-7-15(14)6-4-8(11)9(13)12-15/h8H,4-7,11H2,1-3H3	CBFKICSXEPHPLO-UHFFFAOYSA-N	790565	US20260034094, Compound 201	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790565&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378285	NC1CC[S@TB5](=O)(CCCC(F)(F)F)=NC1=O	InChI=1S/C8H13F3N2O2S/c9-8(10,11)3-1-4-16(15)5-2-6(12)7(14)13-16/h6H,1-5,12H2	OLHZJXPOWWOOBR-UHFFFAOYSA-N	790566	US20260034094, Compound 202	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790566&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378286	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)c1ncon1	InChI=1S/C9H15F3N4O2S/c10-9(11,12)3-1-4-19(14,17)5-2-7(13)8-15-6-18-16-8/h6-7,14H,1-5,13H2	XZLNBDVJRHNLCH-UHFFFAOYSA-N	790567	US20260034094, Compound 203	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790567&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378287	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)c1ncno1	InChI=1S/C9H15F3N4O2S/c10-9(11,12)3-1-4-19(14,17)5-2-7(13)8-15-6-16-18-8/h6-7,14H,1-5,13H2	FMEPMNZMJMGKBO-UHFFFAOYSA-N	790568	US20260034094, Compound 204	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790568&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378288	N=[S@SP2](=O)(CCCC(F)(F)F)CCC(N)c1ncn[nH]1	InChI=1S/C9H16F3N5OS/c10-9(11,12)3-1-4-19(14,18)5-2-7(13)8-15-6-16-17-8/h6-7,14H,1-5,13H2,(H,15,16,17)	GSLFJMYJTODCGD-UHFFFAOYSA-N	790569	US20260034094, Compound 205	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 19000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790569&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174246184	528498356							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378289	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(NC(N)=O)CCC1	InChI=1S/C11H22N4O4S/c12-8(9(16)17)2-6-20(14,19)7-5-11(3-1-4-11)15-10(13)18/h8,14H,1-7,12H2,(H,16,17)(H3,13,15,18)	MEGDPTAIPOVJPJ-UHFFFAOYSA-N	790570	US20260034094, Compound 206	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790570&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378290	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)n1cc(-c2ccccc2)nn1	InChI=1S/C17H25N5O3S/c1-17(2,9-11-26(19,25)10-8-14(18)16(23)24)22-12-15(20-21-22)13-6-4-3-5-7-13/h3-7,12,14,19H,8-11,18H2,1-2H3,(H,23,24)	RJTRFNXCGRGABP-UHFFFAOYSA-N	790571	US20260034094, Compound 207	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790571&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378291	CC(C)(CCS(=N)(=O)CC[C@H](N)C(=O)O)n1ncc(-c2ccccc2)n1	InChI=1S/C17H25N5O3S/c1-17(2,9-11-26(19,25)10-8-14(18)16(23)24)22-20-12-15(21-22)13-6-4-3-5-7-13/h3-7,12,14,19H,8-11,18H2,1-2H3,(H,23,24)	FQSSAICCMKYSDK-UHFFFAOYSA-N	790572	US20260034094, Compound 208	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 20400							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790572&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378292	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccccc1Cl)C(F)(F)F	InChI=1S/C14H18ClF3N2O4S/c15-10-4-2-1-3-9(10)13(23,14(16,17)18)6-8-25(20,24)7-5-11(19)12(21)22/h1-4,11,20,23H,5-8,19H2,(H,21,22)	UYRORESJHMGIHD-UHFFFAOYSA-N	790573	US20260034094, Compound 209	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790573&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378293	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(N)C(F)(F)F	InChI=1S/C8H16F3N3O3S/c9-8(10,11)6(13)2-4-18(14,17)3-1-5(12)7(15)16/h5-6,14H,1-4,12-13H2,(H,15,16)	SZFDICICHZLSOM-UHFFFAOYSA-N	790574	US20260034094, Compound 210	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790574&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378294	N=S(=O)(CCC(c1ccc(-c2ccccc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H23F3N2O3S/c21-20(22,23)17(10-12-29(25,28)13-11-18(24)19(26)27)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17-18,25H,10-13,24H2,(H,26,27)	ZIRVAGAHSTZCGM-UHFFFAOYSA-N	790575	US20260034094, Compound 211	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790575&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378295	N=S(=O)(CCC(c1ccc(-c2ccccc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-17-4-2-1-3-15(17)13-5-7-14(8-6-13)16(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,16,18,26H,9-12,25H2,(H,27,28)	SDXFOIIWHCBKAQ-UHFFFAOYSA-N	790576	US20260034094, Compound 212	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790576&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378296	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(c1ccc(CCC(F)(F)F)cc1)C(F)(F)F	InChI=1S/C17H22F6N2O3S/c18-16(19,20)8-5-11-1-3-12(4-2-11)13(17(21,22)23)6-9-29(25,28)10-7-14(24)15(26)27/h1-4,13-14,25H,5-10,24H2,(H,26,27)	POCBLNZSULOXMU-UHFFFAOYSA-N	790577	US20260034094, Compound 213	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790577&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378297	[C-]#[N+]C1CC=C(c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)CC1	InChI=1S/C21H26F3N3O3S/c1-27-17-8-6-15(7-9-17)14-2-4-16(5-3-14)18(21(22,23)24)10-12-31(26,30)13-11-19(25)20(28)29/h2-6,17-19,26H,7-13,25H2,(H,28,29)	XMOQOKYROIVILO-UHFFFAOYSA-N	790578	US20260034094, Compound 214	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790578&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378298	N=S(=O)(CCC(c1ccc(C#Cc2ccccc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C22H23F3N2O3S/c23-22(24,25)19(12-14-31(27,30)15-13-20(26)21(28)29)18-10-8-17(9-11-18)7-6-16-4-2-1-3-5-16/h1-5,8-11,19-20,27H,12-15,26H2,(H,28,29)	ABXZXJMJPRRCIK-UHFFFAOYSA-N	790579	US20260034094, Compound 215	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790579&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378299	N=S(=O)(CCC(c1ccc(S(=O)(=O)c2ccccc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H23F3N2O5S2/c21-20(22,23)17(10-12-31(25,28)13-11-18(24)19(26)27)14-6-8-16(9-7-14)32(29,30)15-4-2-1-3-5-15/h1-9,17-18,25H,10-13,24H2,(H,26,27)	JSNCZLMSHIJJJL-UHFFFAOYSA-N	790580	US20260034094, Compound 216	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790580&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378300	N=S(=O)(CCC(c1ccc(-c2ccccc2F)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22F4N2O3S/c21-17-4-2-1-3-15(17)13-5-7-14(8-6-13)16(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,16,18,26H,9-12,25H2,(H,27,28)	NZUANAWPHNAHKY-UHFFFAOYSA-N	790581	US20260034094, Compound 217	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790581&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378301	N=S(=O)(CCC(c1ccc(-c2ccccc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-17-4-2-1-3-15(17)13-5-7-14(8-6-13)16(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,16,18,26H,9-12,25H2,(H,27,28)	SDXFOIIWHCBKAQ-UHFFFAOYSA-N	790582	US20260034094, Compound 218	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790582&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378302	N=S(=O)(CCC(c1ccc(-c2ccccc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-17-4-2-1-3-15(17)13-5-7-14(8-6-13)16(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,16,18,26H,9-12,25H2,(H,27,28)	SDXFOIIWHCBKAQ-UHFFFAOYSA-N	790583	US20260034094, Compound 219	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790583&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378303	N=S(=O)(CCC(c1ccc(-c2ccccc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-17-4-2-1-3-15(17)13-5-7-14(8-6-13)16(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,16,18,26H,9-12,25H2,(H,27,28)	SDXFOIIWHCBKAQ-UHFFFAOYSA-N	790584	US20260034094, Compound 220	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790584&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378304	N=S(=O)(CCC(c1ccc(-c2ccccc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-17-4-2-1-3-15(17)13-5-7-14(8-6-13)16(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,16,18,26H,9-12,25H2,(H,27,28)	SDXFOIIWHCBKAQ-UHFFFAOYSA-N	790585	US20260034094, Compound 221	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790585&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378305	N=S(=O)(CCC(c1ccc(-c2cc(F)cc(F)c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21F5N2O3S/c21-15-9-14(10-16(22)11-15)12-1-3-13(4-2-12)17(20(23,24)25)5-7-31(27,30)8-6-18(26)19(28)29/h1-4,9-11,17-18,27H,5-8,26H2,(H,28,29)	NFNBBKKDWJBFEQ-UHFFFAOYSA-N	790586	US20260034094, Compound 222	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790586&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378306	CCCc1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C17H25F3N2O3S/c1-2-3-12-4-6-13(7-5-12)14(17(18,19)20)8-10-26(22,25)11-9-15(21)16(23)24/h4-7,14-15,22H,2-3,8-11,21H2,1H3,(H,23,24)	NMRNVIIRFCGQRW-UHFFFAOYSA-N	790587	US20260034094, Compound 223	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790587&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378307	CCCCc1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C18H27F3N2O3S/c1-2-3-4-13-5-7-14(8-6-13)15(18(19,20)21)9-11-27(23,26)12-10-16(22)17(24)25/h5-8,15-16,23H,2-4,9-12,22H2,1H3,(H,24,25)	NRBNFOYKAAENCC-UHFFFAOYSA-N	790588	US20260034094, Compound 224	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790588&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378308	N=S(=O)(CCC(c1ccc(C2CC2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C17H23F3N2O3S/c18-17(19,20)14(13-5-3-12(4-6-13)11-1-2-11)7-9-26(22,25)10-8-15(21)16(23)24/h3-6,11,14-15,22H,1-2,7-10,21H2,(H,23,24)	HQMOBWPIZWPKDX-UHFFFAOYSA-N	790589	US20260034094, Compound 225	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790589&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378309	N=S(=O)(CCC(c1ccc(-c2ccc(Br)cc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22BrF3N2O3S/c21-16-7-5-14(6-8-16)13-1-3-15(4-2-13)17(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,17-18,26H,9-12,25H2,(H,27,28)	CQGMHLRKQQADLC-UHFFFAOYSA-N	790590	US20260034094, Compound 226	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790590&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378310	N=S(=O)(CCC(c1ccc(-c2cn[nH]c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C17H21F3N4O3S/c18-17(19,20)14(5-7-28(22,27)8-6-15(21)16(25)26)12-3-1-11(2-4-12)13-9-23-24-10-13/h1-4,9-10,14-15,22H,5-8,21H2,(H,23,24)(H,25,26)	YRSUMYGRRQBREP-UHFFFAOYSA-N	790591	US20260034094, Compound 227	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790591&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170769920	528498378							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378311	N=S(=O)(CCC(c1ccc(-c2cc[nH]n2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C17H21F3N4O3S/c18-17(19,20)13(6-9-28(22,27)10-7-14(21)16(25)26)11-1-3-12(4-2-11)15-5-8-23-24-15/h1-5,8,13-14,22H,6-7,9-10,21H2,(H,23,24)(H,25,26)	QUBMGWCBSMAMIJ-UHFFFAOYSA-N	790592	US20260034094, Compound 228	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790592&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174246969	528498379							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378312	N=S(=O)(CCC(c1ccc(-c2cccc(C(N)=O)c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H24F3N3O4S/c22-21(23,24)17(8-10-32(27,31)11-9-18(25)20(29)30)14-6-4-13(5-7-14)15-2-1-3-16(12-15)19(26)28/h1-7,12,17-18,27H,8-11,25H2,(H2,26,28)(H,29,30)	NWDWCYKBGVBZJW-UHFFFAOYSA-N	790593	US20260034094, Compound 229	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790593&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378313	CNC(=O)c1cccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c1	InChI=1S/C22H26F3N3O4S/c1-28-20(29)17-4-2-3-16(13-17)14-5-7-15(8-6-14)18(22(23,24)25)9-11-33(27,32)12-10-19(26)21(30)31/h2-8,13,18-19,27H,9-12,26H2,1H3,(H,28,29)(H,30,31)	YKJOZIMPANHDQH-UHFFFAOYSA-N	790594	US20260034094, Compound 230	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790594&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378314	N=S(=O)(CCC(c1ccc(-c2ccc(C(F)F)cc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H23F5N2O3S/c22-19(23)16-7-3-14(4-8-16)13-1-5-15(6-2-13)17(21(24,25)26)9-11-32(28,31)12-10-18(27)20(29)30/h1-8,17-19,28H,9-12,27H2,(H,29,30)	XHLRCLKSZJGYRX-UHFFFAOYSA-N	790595	US20260034094, Compound 231	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790595&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378315	N=S(=O)(CCC(c1ccc(-c2cc(F)ccc2O)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22F4N2O4S/c21-14-5-6-18(27)15(11-14)12-1-3-13(4-2-12)16(20(22,23)24)7-9-31(26,30)10-8-17(25)19(28)29/h1-6,11,16-17,26-27H,7-10,25H2,(H,28,29)	VXIZIAOKVFEUOA-UHFFFAOYSA-N	790596	US20260034094, Compound 232	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790596&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378316	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)C(F)(F)F	InChI=1S/C21H22F6N2O4S/c22-20(23,24)17(9-11-34(29,32)12-10-18(28)19(30)31)15-3-1-13(2-4-15)14-5-7-16(8-6-14)33-21(25,26)27/h1-8,17-18,29H,9-12,28H2,(H,30,31)	VPUWYAAQRDMMCA-UHFFFAOYSA-N	790597	US20260034094, Compound 233	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790597&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378317	N=S(=O)(CCC(c1ccc(-c2cc(Cl)cc(Cl)c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21Cl2F3N2O3S/c21-15-9-14(10-16(22)11-15)12-1-3-13(4-2-12)17(20(23,24)25)5-7-31(27,30)8-6-18(26)19(28)29/h1-4,9-11,17-18,27H,5-8,26H2,(H,28,29)	VPJAFNLIFNXLBJ-UHFFFAOYSA-N	790598	US20260034094, Compound 234	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790598&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378318	N=S(=O)(CCC(c1ccc(-c2ccccc2O)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H23F3N2O4S/c21-20(22,23)16(9-11-30(25,29)12-10-17(24)19(27)28)14-7-5-13(6-8-14)15-3-1-2-4-18(15)26/h1-8,16-17,25-26H,9-12,24H2,(H,27,28)	VWXNBISDNXJNLN-UHFFFAOYSA-N	790599	US20260034094, Compound 235	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790599&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378319	COc1ccc(Cl)cc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H24ClF3N2O4S/c1-31-19-7-6-15(22)12-16(19)13-2-4-14(5-3-13)17(21(23,24)25)8-10-32(27,30)11-9-18(26)20(28)29/h2-7,12,17-18,27H,8-11,26H2,1H3,(H,28,29)	GIMZMQNZCFAIBL-UHFFFAOYSA-N	790600	US20260034094, Compound 236	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790600&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378320	N=S(=O)(CCC(c1ccc(-c2ccc(Cl)c(C(F)(F)F)c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H21ClF6N2O3S/c22-17-6-5-14(11-16(17)21(26,27)28)12-1-3-13(4-2-12)15(20(23,24)25)7-9-34(30,33)10-8-18(29)19(31)32/h1-6,11,15,18,30H,7-10,29H2,(H,31,32)	NQVIKIFQDLRYGQ-UHFFFAOYSA-N	790601	US20260034094, Compound 237	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790601&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378321	N=S(=O)(CCC(c1ccc(-c2cc(F)ccc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21ClF4N2O3S/c21-17-6-5-14(22)11-15(17)12-1-3-13(4-2-12)16(20(23,24)25)7-9-31(27,30)10-8-18(26)19(28)29/h1-6,11,16,18,27H,7-10,26H2,(H,28,29)	HEGAUARTODOAFT-UHFFFAOYSA-N	790602	US20260034094, Compound 238	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790602&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378322	N=S(=O)(CCC(c1ccc(-c2cccc(N)c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H24F3N3O3S/c21-20(22,23)17(8-10-30(26,29)11-9-18(25)19(27)28)14-6-4-13(5-7-14)15-2-1-3-16(24)12-15/h1-7,12,17-18,26H,8-11,24-25H2,(H,27,28)	HGWJRUJKRCCXME-UHFFFAOYSA-N	790603	US20260034094, Compound 239	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790603&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378323	N#Cc1cccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c1F	InChI=1S/C21H21F4N3O3S/c22-19-15(12-26)2-1-3-16(19)13-4-6-14(7-5-13)17(21(23,24)25)8-10-32(28,31)11-9-18(27)20(29)30/h1-7,17-18,28H,8-11,27H2,(H,29,30)	MWTSVWNIZOLEJZ-UHFFFAOYSA-N	790604	US20260034094, Compound 240	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790604&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378324	CC(C)(O)c1cccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c1	InChI=1S/C23H29F3N2O4S/c1-22(2,31)18-5-3-4-17(14-18)15-6-8-16(9-7-15)19(23(24,25)26)10-12-33(28,32)13-11-20(27)21(29)30/h3-9,14,19-20,28,31H,10-13,27H2,1-2H3,(H,29,30)	LSDGONCVIVUGHO-UHFFFAOYSA-N	790605	US20260034094, Compound 241	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790605&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378325	COc1cncc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c1	InChI=1S/C20H24F3N3O4S/c1-30-16-10-15(11-26-12-16)13-2-4-14(5-3-13)17(20(21,22)23)6-8-31(25,29)9-7-18(24)19(27)28/h2-5,10-12,17-18,25H,6-9,24H2,1H3,(H,27,28)	GYMVABAXFBQBNH-UHFFFAOYSA-N	790606	US20260034094, Compound 242	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790606&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378326	N=S(=O)(CCC(c1ccc(-c2cccnc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C19H22F3N3O3S/c20-19(21,22)16(7-10-29(24,28)11-8-17(23)18(26)27)14-5-3-13(4-6-14)15-2-1-9-25-12-15/h1-6,9,12,16-17,24H,7-8,10-11,23H2,(H,26,27)	BPVAVOZZTWKFOK-UHFFFAOYSA-N	790607	US20260034094, Compound 243	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790607&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378327	[C-]#[N+]c1ccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)cn1	InChI=1S/C20H21F3N4O3S/c1-26-18-7-6-15(12-27-18)13-2-4-14(5-3-13)16(20(21,22)23)8-10-31(25,30)11-9-17(24)19(28)29/h2-7,12,16-17,25H,8-11,24H2,(H,28,29)	TVPDVRDYMUOGQJ-UHFFFAOYSA-N	790608	US20260034094, Compound 244	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790608&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
378328	N=S(=O)(CCC(c1ccc(-c2ccc(C(N)=O)nc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H23F3N4O4S/c21-20(22,23)15(7-9-32(26,31)10-8-16(24)19(29)30)13-3-1-12(2-4-13)14-5-6-17(18(25)28)27-11-14/h1-6,11,15-16,26H,7-10,24H2,(H2,25,28)(H,29,30)	ONROFOIFCOHZAQ-UHFFFAOYSA-N	790609	US20260034094, Compound 245	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802462	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790609&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379045	Cc1ccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)cn1	InChI=1S/C20H24F3N3O3S/c1-13-2-3-16(12-26-13)14-4-6-15(7-5-14)17(20(21,22)23)8-10-30(25,29)11-9-18(24)19(27)28/h2-7,12,17-18,25H,8-11,24H2,1H3,(H,27,28)	GOXIVFVACJTNBB-UHFFFAOYSA-N	790610	US20260034094, Compound 246	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790610&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379046	N=S(=O)(CCC(c1ccc(-c2cncc(F)c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C19H21F4N3O3S/c20-15-9-14(10-26-11-15)12-1-3-13(4-2-12)16(19(21,22)23)5-7-30(25,29)8-6-17(24)18(27)28/h1-4,9-11,16-17,25H,5-8,24H2,(H,27,28)	JZPGNNXPKZVRTP-UHFFFAOYSA-N	790611	US20260034094, Compound 247	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790611&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379047	Cc1nc(Cl)ccc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C20H23ClF3N3O3S/c1-12-15(6-7-18(21)27-12)13-2-4-14(5-3-13)16(20(22,23)24)8-10-31(26,30)11-9-17(25)19(28)29/h2-7,16-17,26H,8-11,25H2,1H3,(H,28,29)	MBNRAUUUAYHKSE-UHFFFAOYSA-N	790612	US20260034094, Compound 248	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790612&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379048	CN1CCN(c2ccc(-c3ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc3)cn2)CC1	InChI=1S/C24H32F3N5O3S/c1-31-10-12-32(13-11-31)22-7-6-19(16-30-22)17-2-4-18(5-3-17)20(24(25,26)27)8-14-36(29,35)15-9-21(28)23(33)34/h2-7,16,20-21,29H,8-15,28H2,1H3,(H,33,34)	GOAUXPQDKVCPFY-UHFFFAOYSA-N	790613	US20260034094, Compound 249	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790613&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379049	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(c1ccc(-c2cncc(C(F)(F)F)c2)cc1)C(F)(F)F	InChI=1S/C20H21F6N3O3S/c21-19(22,23)15-9-14(10-29-11-15)12-1-3-13(4-2-12)16(20(24,25)26)5-7-33(28,32)8-6-17(27)18(30)31/h1-4,9-11,16-17,28H,5-8,27H2,(H,30,31)	NRVHTEVJQJOCMJ-UHFFFAOYSA-N	790614	US20260034094, Compound 250	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790614&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379050	N=S(=O)(CCC(c1ccc(-c2cnc(N)nc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H22F3N5O3S/c19-18(20,21)14(5-7-30(24,29)8-6-15(22)16(27)28)12-3-1-11(2-4-12)13-9-25-17(23)26-10-13/h1-4,9-10,14-15,24H,5-8,22H2,(H,27,28)(H2,23,25,26)	FJKLPGPIVKNJNG-UHFFFAOYSA-N	790615	US20260034094, Compound 251	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790615&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379051	N=S(=O)(CCC(c1ccc(-c2cnc(C3CC3)nc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H25F3N4O3S/c22-21(23,24)17(7-9-32(26,31)10-8-18(25)20(29)30)14-3-1-13(2-4-14)16-11-27-19(28-12-16)15-5-6-15/h1-4,11-12,15,17-18,26H,5-10,25H2,(H,29,30)	QEFBZKSGXLZIQP-UHFFFAOYSA-N	790616	US20260034094, Compound 252	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790616&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379052	N=S(=O)(CCC(c1ccc(-c2cnc3[nH]ccc3c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H23F3N4O3S/c22-21(23,24)17(6-9-32(26,31)10-7-18(25)20(29)30)14-3-1-13(2-4-14)16-11-15-5-8-27-19(15)28-12-16/h1-5,8,11-12,17-18,26H,6-7,9-10,25H2,(H,27,28)(H,29,30)	OPSQQKIWYQRSIF-UHFFFAOYSA-N	790617	US20260034094, Compound 253	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790617&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770433	528498404							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379053	N=S(=O)(CCC(c1ccc(-c2cnc3[nH]ncc3c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22F3N5O3S/c21-20(22,23)16(5-7-32(25,31)8-6-17(24)19(29)30)13-3-1-12(2-4-13)14-9-15-11-27-28-18(15)26-10-14/h1-4,9-11,16-17,25H,5-8,24H2,(H,29,30)(H,26,27,28)	BEUKYNVRXGSHQH-UHFFFAOYSA-N	790618	US20260034094, Compound 254	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790618&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174247065	528498405							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379054	N=S(=O)(CCC(c1ccc(-c2ccc3cn[nH]c3c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H23F3N4O3S/c22-21(23,24)17(7-9-32(26,31)10-8-18(25)20(29)30)14-3-1-13(2-4-14)15-5-6-16-12-27-28-19(16)11-15/h1-6,11-12,17-18,26H,7-10,25H2,(H,27,28)(H,29,30)	LYIXMXPKXCFJMR-UHFFFAOYSA-N	790619	US20260034094, Compound 255	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790619&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174247066	528498406							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379055	N=S(=O)(CCC(c1ccc(-c2ccc(Cl)s2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H20ClF3N2O3S2/c19-16-6-5-15(28-16)12-3-1-11(2-4-12)13(18(20,21)22)7-9-29(24,27)10-8-14(23)17(25)26/h1-6,13-14,24H,7-10,23H2,(H,25,26)	SMFNWJSLDVKWRQ-UHFFFAOYSA-N	790620	US20260034094, Compound 256	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790620&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379056	N=S(=O)(CCC(c1ccc(-c2ccsc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H21F3N2O3S2/c19-18(20,21)15(6-9-28(23,26)10-7-16(22)17(24)25)13-3-1-12(2-4-13)14-5-8-27-11-14/h1-5,8,11,15-16,23H,6-7,9-10,22H2,(H,24,25)	WANIJNDLUOIBSV-UHFFFAOYSA-N	790621	US20260034094, Compound 257	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790621&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379057	N=S(=O)(CCC(c1ccc(-c2ccoc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H21F3N2O4S/c19-18(20,21)15(6-9-28(23,26)10-7-16(22)17(24)25)13-3-1-12(2-4-13)14-5-8-27-11-14/h1-5,8,11,15-16,23H,6-7,9-10,22H2,(H,24,25)	FDESQHCVXIOKMZ-UHFFFAOYSA-N	790622	US20260034094, Compound 258	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790622&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379058	N=S(=O)(CCC(c1ccc(C2=CCNCC2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C19H26F3N3O3S/c20-19(21,22)16(7-11-29(24,28)12-8-17(23)18(26)27)15-3-1-13(2-4-15)14-5-9-25-10-6-14/h1-5,16-17,24-25H,6-12,23H2,(H,26,27)	GXJIRSOWHUFQHF-UHFFFAOYSA-N	790623	US20260034094, Compound 259	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790623&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379059	C=C(c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1)C(F)(F)F	InChI=1S/C17H20F6N2O3S/c1-10(16(18,19)20)11-2-4-12(5-3-11)13(17(21,22)23)6-8-29(25,28)9-7-14(24)15(26)27/h2-5,13-14,25H,1,6-9,24H2,(H,26,27)	PDJOFELJNOVCLH-UHFFFAOYSA-N	790624	US20260034094, Compound 260	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790624&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379060	C=Cc1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C16H21F3N2O3S/c1-2-11-3-5-12(6-4-11)13(16(17,18)19)7-9-25(21,24)10-8-14(20)15(22)23/h2-6,13-14,21H,1,7-10,20H2,(H,22,23)	WLRAWGPEIZGNEH-UHFFFAOYSA-N	790625	US20260034094, Compound 261	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790625&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
379061	C=C(C)c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C17H23F3N2O3S/c1-11(2)12-3-5-13(6-4-12)14(17(18,19)20)7-9-26(22,25)10-8-15(21)16(23)24/h3-6,14-15,22H,1,7-10,21H2,2H3,(H,23,24)	OXPQZXHWYVEIRT-UHFFFAOYSA-N	790626	US20260034094, Compound 262	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802466	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790626&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396090	CC(C)(O)c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C17H25F3N2O4S/c1-16(2,25)12-5-3-11(4-6-12)13(17(18,19)20)7-9-27(22,26)10-8-14(21)15(23)24/h3-6,13-14,22,25H,7-10,21H2,1-2H3,(H,23,24)	XCJVWPFYCLCBIN-UHFFFAOYSA-N	790627	US20260034094, Compound 263	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790627&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396091	COc1ccccc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H25F3N2O4S/c1-30-19-5-3-2-4-16(19)14-6-8-15(9-7-14)17(21(22,23)24)10-12-31(26,29)13-11-18(25)20(27)28/h2-9,17-18,26H,10-13,25H2,1H3,(H,27,28)	JPNICFDQIRICCC-UHFFFAOYSA-N	790628	US20260034094, Compound 264	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790628&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396092	Cc1ccccc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H25F3N2O3S/c1-14-4-2-3-5-17(14)15-6-8-16(9-7-15)18(21(22,23)24)10-12-30(26,29)13-11-19(25)20(27)28/h2-9,18-19,26H,10-13,25H2,1H3,(H,27,28)	LFWXUYNOTYNTTP-UHFFFAOYSA-N	790629	US20260034094, Compound 265	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790629&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396093	CC(C)c1ccccc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C23H29F3N2O3S/c1-15(2)18-5-3-4-6-19(18)16-7-9-17(10-8-16)20(23(24,25)26)11-13-32(28,31)14-12-21(27)22(29)30/h3-10,15,20-21,28H,11-14,27H2,1-2H3,(H,29,30)	AIIVOTLNZDSQEG-UHFFFAOYSA-N	790630	US20260034094, Compound 266	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790630&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396094	N=S(=O)(CCC(c1ccc(-c2ccccc2C(F)(F)F)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H22F6N2O3S/c22-20(23,24)16(9-11-33(29,32)12-10-18(28)19(30)31)14-7-5-13(6-8-14)15-3-1-2-4-17(15)21(25,26)27/h1-8,16,18,29H,9-12,28H2,(H,30,31)	DSZBLRNWLNGRES-UHFFFAOYSA-N	790631	US20260034094, Compound 267	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790631&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396095	COc1ccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(Cl)c1	InChI=1S/C21H24ClF3N2O4S/c1-31-15-6-7-16(18(22)12-15)13-2-4-14(5-3-13)17(21(23,24)25)8-10-32(27,30)11-9-19(26)20(28)29/h2-7,12,17,19,27H,8-11,26H2,1H3,(H,28,29)	IKRUKHJZJROEJD-UHFFFAOYSA-N	790632	US20260034094, Compound 268	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790632&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396096	N=S(=O)(CCC(c1ccc(-c2ccc(Cl)cc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21Cl2F3N2O3S/c21-14-5-6-15(17(22)11-14)12-1-3-13(4-2-12)16(20(23,24)25)7-9-31(27,30)10-8-18(26)19(28)29/h1-6,11,16,18,27H,7-10,26H2,(H,28,29)	NRYZDEPJYJKFHG-UHFFFAOYSA-N	790633	US20260034094, Compound 269	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790633&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396097	N=S(=O)(CCC(c1ccc(-c2ccc(O)cc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O4S/c21-17-11-14(27)5-6-15(17)12-1-3-13(4-2-12)16(20(22,23)24)7-9-31(26,30)10-8-18(25)19(28)29/h1-6,11,16,18,26-27H,7-10,25H2,(H,28,29)	PDZAIKMSSXCXDP-UHFFFAOYSA-N	790634	US20260034094, Compound 270	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790634&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396098	N=S(=O)(CCC(c1ccc(-c2ccc(F)cc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21ClF4N2O3S/c21-17-11-14(22)5-6-15(17)12-1-3-13(4-2-12)16(20(23,24)25)7-9-31(27,30)10-8-18(26)19(28)29/h1-6,11,16,18,27H,7-10,26H2,(H,28,29)	OZLZHICJWCYMHJ-UHFFFAOYSA-N	790635	US20260034094, Compound 271	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790635&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396099	C#Cc1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C16H19F3N2O3S/c1-2-11-3-5-12(6-4-11)13(16(17,18)19)7-9-25(21,24)10-8-14(20)15(22)23/h1,3-6,13-14,21H,7-10,20H2,(H,22,23)	FRFCZSSHKRRXJZ-UHFFFAOYSA-N	790636	US20260034094, Compound 272	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790636&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396100	N=S(=O)(CCC(c1cccc(C#Cc2ccccc2)c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C22H23F3N2O3S/c23-22(24,25)19(11-13-31(27,30)14-12-20(26)21(28)29)18-8-4-7-17(15-18)10-9-16-5-2-1-3-6-16/h1-8,15,19-20,27H,11-14,26H2,(H,28,29)	CDIWOPJENOIXLK-UHFFFAOYSA-N	790637	US20260034094, Compound 273	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790637&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396101	N=S(=O)(CCC(c1ccc(-c2ccc3ccc(=O)[nH]c3c2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C23H24F3N3O4S/c24-23(25,26)18(9-11-34(28,33)12-10-19(27)22(31)32)15-3-1-14(2-4-15)17-6-5-16-7-8-21(30)29-20(16)13-17/h1-8,13,18-19,28H,9-12,27H2,(H,29,30)(H,31,32)	VBXRILHTRAZDLJ-UHFFFAOYSA-N	790638	US20260034094, Compound 274	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790638&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			178348142	528498425							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396102	Cc1cc(Cl)ccc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H24ClF3N2O3S/c1-13-12-16(22)6-7-17(13)14-2-4-15(5-3-14)18(21(23,24)25)8-10-31(27,30)11-9-19(26)20(28)29/h2-7,12,18-19,27H,8-11,26H2,1H3,(H,28,29)	FTVUNNHSZXNANK-UHFFFAOYSA-N	790639	US20260034094, Compound 275	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790639&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396103	Cc1ccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(Cl)c1	InChI=1S/C21H24ClF3N2O3S/c1-13-2-7-16(18(22)12-13)14-3-5-15(6-4-14)17(21(23,24)25)8-10-31(27,30)11-9-19(26)20(28)29/h2-7,12,17,19,27H,8-11,26H2,1H3,(H,28,29)	AARRJUUCYSEALG-UHFFFAOYSA-N	790640	US20260034094, Compound 276	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790640&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396104	N=S(=O)(CCC(c1ccc(-c2ccc(Cl)cc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-16-7-5-14(6-8-16)13-1-3-15(4-2-13)17(20(22,23)24)9-11-30(26,29)12-10-18(25)19(27)28/h1-8,17-18,26H,9-12,25H2,(H,27,28)	UTJVXYIVLYXLEN-UHFFFAOYSA-N	790641	US20260034094, Compound 277	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790641&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396105	Cc1cc(F)ccc1-c1ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H24F4N2O3S/c1-13-12-16(22)6-7-17(13)14-2-4-15(5-3-14)18(21(23,24)25)8-10-31(27,30)11-9-19(26)20(28)29/h2-7,12,18-19,27H,8-11,26H2,1H3,(H,28,29)	RDUPJEMFYPTNQK-UHFFFAOYSA-N	790642	US20260034094, Compound 278	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790642&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396106	Cc1ccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(Cl)c1	InChI=1S/C21H24ClF3N2O3S/c1-13-2-7-16(18(22)12-13)14-3-5-15(6-4-14)17(21(23,24)25)8-10-31(27,30)11-9-19(26)20(28)29/h2-7,12,17,19,27H,8-11,26H2,1H3,(H,28,29)	AARRJUUCYSEALG-UHFFFAOYSA-N	790643	US20260034094, Compound 279	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790643&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396107	Cc1ccc(-c2ccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(C)c1	InChI=1S/C22H27F3N2O3S/c1-14-3-8-18(15(2)13-14)16-4-6-17(7-5-16)19(22(23,24)25)9-11-31(27,30)12-10-20(26)21(28)29/h3-8,13,19-20,27H,9-12,26H2,1-2H3,(H,28,29)	NEHJAQMCGOJFKZ-UHFFFAOYSA-N	790644	US20260034094, Compound 280	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790644&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396108	N=S(=O)(CCC(c1ccc(-c2ccc(F)cc2O)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22F4N2O4S/c21-14-5-6-15(18(27)11-14)12-1-3-13(4-2-12)16(20(22,23)24)7-9-31(26,30)10-8-17(25)19(28)29/h1-6,11,16-17,26-27H,7-10,25H2,(H,28,29)	JFYXFDFRFMOBNG-UHFFFAOYSA-N	790645	US20260034094, Compound 281	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790645&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396109	N=S(=O)(CCC(c1ccc(-c2ccc(Cl)cc2O)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O4S/c21-14-5-6-15(18(27)11-14)12-1-3-13(4-2-12)16(20(22,23)24)7-9-31(26,30)10-8-17(25)19(28)29/h1-6,11,16-17,26-27H,7-10,25H2,(H,28,29)	NLJNEIVEQRWYCX-UHFFFAOYSA-N	790646	US20260034094, Compound 282	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790646&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396110	Cc1cc(Cl)ccc1-c1cccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)c1	InChI=1S/C21H24ClF3N2O3S/c1-13-11-16(22)5-6-17(13)14-3-2-4-15(12-14)18(21(23,24)25)7-9-31(27,30)10-8-19(26)20(28)29/h2-6,11-12,18-19,27H,7-10,26H2,1H3,(H,28,29)	NPYUXFVBVBSURG-UHFFFAOYSA-N	790647	US20260034094, Compound 283	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790647&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396111	Cc1ccc(-c2cccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)c2)c(F)c1	InChI=1S/C21H24F4N2O3S/c1-13-5-6-16(18(22)11-13)14-3-2-4-15(12-14)17(21(23,24)25)7-9-31(27,30)10-8-19(26)20(28)29/h2-6,11-12,17,19,27H,7-10,26H2,1H3,(H,28,29)	IYBRZGRGMUGNNT-UHFFFAOYSA-N	790648	US20260034094, Compound 284	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790648&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396112	Cc1ccc(-c2cccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)c2)cc1	InChI=1S/C21H25F3N2O3S/c1-14-5-7-15(8-6-14)16-3-2-4-17(13-16)18(21(22,23)24)9-11-30(26,29)12-10-19(25)20(27)28/h2-8,13,18-19,26H,9-12,25H2,1H3,(H,27,28)	VSMBXKJLHUXKBS-UHFFFAOYSA-N	790649	US20260034094, Compound 285	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790649&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396113	Cc1cccc(-c2cccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)c2)c1	InChI=1S/C21H25F3N2O3S/c1-14-4-2-5-15(12-14)16-6-3-7-17(13-16)18(21(22,23)24)8-10-30(26,29)11-9-19(25)20(27)28/h2-7,12-13,18-19,26H,8-11,25H2,1H3,(H,27,28)	JHEXHWCYZFIBAN-UHFFFAOYSA-N	790650	US20260034094, Compound 286	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790650&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396114	N=S(=O)(CCC(c1cccc(-c2cccc(F)c2)c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22F4N2O3S/c21-16-6-2-4-14(12-16)13-3-1-5-15(11-13)17(20(22,23)24)7-9-30(26,29)10-8-18(25)19(27)28/h1-6,11-12,17-18,26H,7-10,25H2,(H,27,28)	IXMKIOBYFRHSCP-UHFFFAOYSA-N	790651	US20260034094, Compound 287	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790651&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396115	N=S(=O)(CCC(c1cccc(-c2ccc(Cl)cc2Cl)c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21Cl2F3N2O3S/c21-14-4-5-15(17(22)11-14)12-2-1-3-13(10-12)16(20(23,24)25)6-8-31(27,30)9-7-18(26)19(28)29/h1-5,10-11,16,18,27H,6-9,26H2,(H,28,29)	YPGAXIWHAACNDK-UHFFFAOYSA-N	790652	US20260034094, Compound 288	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790652&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396116	Cc1cc(F)ccc1-c1cccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)OC(C)(C)C)C(F)(F)F)c1	InChI=1S/C25H32F4N2O3S/c1-16-14-19(26)8-9-20(16)17-6-5-7-18(15-17)21(25(27,28)29)10-12-35(31,33)13-11-22(30)23(32)34-24(2,3)4/h5-9,14-15,21-22,31H,10-13,30H2,1-4H3	SNQAOOBUWMRGHB-UHFFFAOYSA-N	790653	US20260034094, Compound 289	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790653&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396117	Cc1ccc(-c2cccc(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)c2)cc1F	InChI=1S/C21H24F4N2O3S/c1-13-5-6-15(12-18(13)22)14-3-2-4-16(11-14)17(21(23,24)25)7-9-31(27,30)10-8-19(26)20(28)29/h2-6,11-12,17,19,27H,7-10,26H2,1H3,(H,28,29)	CKJRTSWBLUWEDZ-UHFFFAOYSA-N	790654	US20260034094, Compound 290	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790654&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396118	N=S(=O)(CCC(c1ccc(S(=O)(=O)Cc2ccccc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C21H25F3N2O5S2/c22-21(23,24)18(10-12-32(26,29)13-11-19(25)20(27)28)16-6-8-17(9-7-16)33(30,31)14-15-4-2-1-3-5-15/h1-9,18-19,26H,10-14,25H2,(H,27,28)	YXKUJXIIPOCGJO-UHFFFAOYSA-N	790655	US20260034094, Compound 291	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790655&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396119	N=S(=O)(CCC(Cc1ccccc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C15H21F3N2O3S/c16-15(17,18)12(10-11-4-2-1-3-5-11)6-8-24(20,23)9-7-13(19)14(21)22/h1-5,12-13,20H,6-10,19H2,(H,21,22)	ODNXGMYPFFIODS-UHFFFAOYSA-N	790656	US20260034094, Compound 292	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790656&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396120	CC(CCS(=N)(=O)CC[C@H](N)C(=O)O)(c1ccccc1)C(F)(F)F	InChI=1S/C15H21F3N2O3S/c1-14(15(16,17)18,11-5-3-2-4-6-11)8-10-24(20,23)9-7-12(19)13(21)22/h2-6,12,20H,7-10,19H2,1H3,(H,21,22)	DNYLYXILIPEXAP-UHFFFAOYSA-N	790657	US20260034094, Compound 293	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790657&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396121	N=S(=O)(CC[C@H](N)C(=O)O)CCC12CC(C1)C2	InChI=1S/C11H20N2O3S/c12-9(10(14)15)1-3-17(13,16)4-2-11-5-8(6-11)7-11/h8-9,13H,1-7,12H2,(H,14,15)	FXUIYSBZTDPLGW-UHFFFAOYSA-N	790658	US20260034094, Compound 294	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790658&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396122	COC(C)(C)CCCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C11H24N2O4S/c1-11(2,17-3)6-4-7-18(13,16)8-5-9(12)10(14)15/h9,13H,4-8,12H2,1-3H3,(H,14,15)	WMCAOGGOBVYVLU-UHFFFAOYSA-N	790659	US20260034094, Compound 295	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790659&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396123	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(C(F)(F)F)CCC1	InChI=1S/C11H19F3N2O3S/c12-11(13,14)10(3-1-4-10)5-7-20(16,19)6-2-8(15)9(17)18/h8,16H,1-7,15H2,(H,17,18)	GRVSTOHZJJMKTC-UHFFFAOYSA-N	790660	US20260034094, Compound 296	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790660&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396124	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(O)CCCCC1	InChI=1S/C12H24N2O4S/c13-10(11(15)16)4-8-19(14,18)9-7-12(17)5-2-1-3-6-12/h10,14,17H,1-9,13H2,(H,15,16)	KWSOKMYBAQEJLA-UHFFFAOYSA-N	790661	US20260034094, Compound 297	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790661&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396125	CC1(C)CC(CCS(=N)(=O)CC[C@H](N)C(=O)O)C1	InChI=1S/C12H24N2O3S/c1-12(2)7-9(8-12)3-5-18(14,17)6-4-10(13)11(15)16/h9-10,14H,3-8,13H2,1-2H3,(H,15,16)	LWMSTUMIYUKUMA-UHFFFAOYSA-N	790662	US20260034094, Compound 298	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790662&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396126	C#CC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C11H20N2O3S/c1-4-11(2,3)6-8-17(13,16)7-5-9(12)10(14)15/h1,9,13H,5-8,12H2,2-3H3,(H,14,15)	HPVBMPPRZKOXAQ-UHFFFAOYSA-N	790663	US20260034094, Compound 299	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790663&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396127	CC1(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCCCC1	InChI=1S/C13H26N2O3S/c1-13(6-3-2-4-7-13)8-10-19(15,18)9-5-11(14)12(16)17/h11,15H,2-10,14H2,1H3,(H,16,17)	DDXXYBTVTZYTLA-UHFFFAOYSA-N	790664	US20260034094, Compound 300	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790664&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396128	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(C(F)(F)F)C(F)(F)F	InChI=1S/C9H14F6N2O4S/c10-8(11,12)7(20,9(13,14)15)2-4-22(17,21)3-1-5(16)6(18)19/h5,17,20H,1-4,16H2,(H,18,19)	IUUBSWIIHDXMTF-UHFFFAOYSA-N	790665	US20260034094, Compound 301	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790665&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396129	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(O)[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2	InChI=1S/C16H28N2O4S/c17-14(15(19)20)1-3-23(18,22)4-2-16(21)12-6-10-5-11(8-12)9-13(16)7-10/h10-14,18,21H,1-9,17H2,(H,19,20)	ZQGGWRMGYMFVQI-UHFFFAOYSA-N	790666	US20260034094, Compound 302	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790666&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396130	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(O)CC(F)(F)C1	InChI=1S/C10H18F2N2O4S/c11-10(12)5-9(17,6-10)2-4-19(14,18)3-1-7(13)8(15)16/h7,14,17H,1-6,13H2,(H,15,16)	OETFORKXKPWXNS-UHFFFAOYSA-N	790667	US20260034094, Compound 303	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790667&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396131	N=S(=O)(CCC1CCO1)CC[C@H](N)C(=O)O	InChI=1S/C9H18N2O4S/c10-8(9(12)13)3-6-16(11,14)5-2-7-1-4-15-7/h7-8,11H,1-6,10H2,(H,12,13)	NLFTVLHRCRBTNH-UHFFFAOYSA-N	790668	US20260034094, Compound 304	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790668&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396132	COC(=O)C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F	InChI=1S/C10H17F3N2O5S/c1-20-9(18)6(10(11,12)13)2-4-21(15,19)5-3-7(14)8(16)17/h6-7,15H,2-5,14H2,1H3,(H,16,17)	KFOKCCCMXCVCTG-UHFFFAOYSA-N	790669	US20260034094, Compound 305	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790669&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396133	N=S(=O)(CCC(C(=O)O)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C9H15F3N2O5S/c10-9(11,12)5(7(15)16)1-3-20(14,19)4-2-6(13)8(17)18/h5-6,14H,1-4,13H2,(H,15,16)(H,17,18)	FFOYMYBNKAVERC-UHFFFAOYSA-N	790670	US20260034094, Compound 306	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790670&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396134	CNC(=O)C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F	InChI=1S/C10H18F3N3O4S/c1-16-8(17)6(10(11,12)13)2-4-21(15,20)5-3-7(14)9(18)19/h6-7,15H,2-5,14H2,1H3,(H,16,17)(H,18,19)	GRVCMIKAIABLAL-UHFFFAOYSA-N	790671	US20260034094, Compound 307	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790671&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396135	N=S(=O)(CCC(C(N)=O)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C9H16F3N3O4S/c10-9(11,12)5(7(14)16)1-3-20(15,19)4-2-6(13)8(17)18/h5-6,15H,1-4,13H2,(H2,14,16)(H,17,18)	SPULDLVOHMRUBK-UHFFFAOYSA-N	790672	US20260034094, Compound 308	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790672&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396136	N=S(=O)(CCC(c1ccccc1Cl)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H18ClF3N2O3S/c15-11-4-2-1-3-9(11)10(14(16,17)18)5-7-24(20,23)8-6-12(19)13(21)22/h1-4,10,12,20H,5-8,19H2,(H,21,22)	GFFGOIHWAAEARK-UHFFFAOYSA-N	790673	US20260034094, Compound 309	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790673&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396137	N=S(=O)(CCC(c1ccc2ccccc2c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H21F3N2O3S/c19-18(20,21)15(7-9-27(23,26)10-8-16(22)17(24)25)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11,15-16,23H,7-10,22H2,(H,24,25)	WYQIJKHUDPKYMV-UHFFFAOYSA-N	790674	US20260034094, Compound 310	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790674&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396138	N=S(=O)(CCC(c1cccc2ccccc12)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H21F3N2O3S/c19-18(20,21)15(8-10-27(23,26)11-9-16(22)17(24)25)14-7-3-5-12-4-1-2-6-13(12)14/h1-7,15-16,23H,8-11,22H2,(H,24,25)	LFPSZJYYVXIIME-UHFFFAOYSA-N	790675	US20260034094, Compound 311	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790675&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396139	CC1(CCCS(=N)(=O)CC[C@H](N)C(=O)O)COC1	InChI=1S/C11H22N2O4S/c1-11(7-17-8-11)4-2-5-18(13,16)6-3-9(12)10(14)15/h9,13H,2-8,12H2,1H3,(H,14,15)	IVVJUHNYZYXESZ-UHFFFAOYSA-N	790676	US20260034094, Compound 312	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790676&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396140	N=S(=O)(CCC(c1ccccn1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C13H18F3N3O3S/c14-13(15,16)9(11-3-1-2-6-19-11)4-7-23(18,22)8-5-10(17)12(20)21/h1-3,6,9-10,18H,4-5,7-8,17H2,(H,20,21)	DGWOMBOZDFJZBR-UHFFFAOYSA-N	790677	US20260034094, Compound 313	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790677&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396141	CC(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ncc(-c2ccccc2)[nH]1	InChI=1S/C17H24N4O3S/c1-12(7-9-25(19,24)10-8-14(18)17(22)23)16-20-11-15(21-16)13-5-3-2-4-6-13/h2-6,11-12,14,19H,7-10,18H2,1H3,(H,20,21)(H,22,23)	ICMARDOWJLKODI-UHFFFAOYSA-N	790678	US20260034094, Compound 314	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790678&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			178348147	528498465							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396142	N=S(=O)(CCC(c1ccc(-c2ccccc2)cc1Cl)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H22ClF3N2O3S/c21-17-12-14(13-4-2-1-3-5-13)6-7-15(17)16(20(22,23)24)8-10-30(26,29)11-9-18(25)19(27)28/h1-7,12,16,18,26H,8-11,25H2,(H,27,28)	URSASXPMNDSVFC-UHFFFAOYSA-N	790679	US20260034094, Compound 315	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790679&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396143	N=S(=O)(CCC(c1ccc(Oc2ccccc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H23F3N2O4S/c21-20(22,23)17(10-12-30(25,28)13-11-18(24)19(26)27)14-6-8-16(9-7-14)29-15-4-2-1-3-5-15/h1-9,17-18,25H,10-13,24H2,(H,26,27)	WYGJXWVXVMKDME-UHFFFAOYSA-N	790680	US20260034094, Compound 316	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790680&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396144	N=S(=O)(CCC(c1ccc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C19H20Cl2F3N3O3S/c20-12-2-3-13(15(21)9-12)11-1-4-17(27-10-11)14(19(22,23)24)5-7-31(26,30)8-6-16(25)18(28)29/h1-4,9-10,14,16,26H,5-8,25H2,(H,28,29)	XWEXHAKZMHFINZ-UHFFFAOYSA-N	790681	US20260034094, Compound 317	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790681&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396145	N=S(=O)(CCC(c1ccc(Oc2ccc(Cl)cc2Cl)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H21Cl2F3N2O4S/c21-13-3-6-18(16(22)11-13)31-14-4-1-12(2-5-14)15(20(23,24)25)7-9-32(27,30)10-8-17(26)19(28)29/h1-6,11,15,17,27H,7-10,26H2,(H,28,29)	DUFXBVRAZSYJGP-UHFFFAOYSA-N	790682	US20260034094, Compound 318	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790682&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396146	COCC(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F	InChI=1S/C10H19F3N2O4S/c1-19-6-7(10(11,12)13)2-4-20(15,18)5-3-8(14)9(16)17/h7-8,15H,2-6,14H2,1H3,(H,16,17)	MXFJXWIYCQFOTE-UHFFFAOYSA-N	790683	US20260034094, Compound 319	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790683&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396147	N=S(=O)(CCC(CO)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C9H17F3N2O4S/c10-9(11,12)6(5-15)1-3-19(14,18)4-2-7(13)8(16)17/h6-7,14-15H,1-5,13H2,(H,16,17)	GWBCEHOIDLAJDR-UHFFFAOYSA-N	790684	US20260034094, Compound 320	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790684&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396148	COCC(C)(C)CCS(=N)(=O)CC[C@H](N)C(=O)O	InChI=1S/C11H24N2O4S/c1-11(2,8-17-3)5-7-18(13,16)6-4-9(12)10(14)15/h9,13H,4-8,12H2,1-3H3,(H,14,15)	PYMSPVXFDKCHMX-UHFFFAOYSA-N	790685	US20260034094, Compound 321	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790685&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396149	CC(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-8(17,9(10,11)12)3-5-19(14,18)4-2-6(13)7(15)16/h6,14,17H,2-5,13H2,1H3,(H,15,16)	SQLALGOQTMEDGJ-UHFFFAOYSA-N	790686	US20260034094, Compound 322	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790686&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396150	CC(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-8(17,9(10,11)12)3-5-19(14,18)4-2-6(13)7(15)16/h6,14,17H,2-5,13H2,1H3,(H,15,16)	SQLALGOQTMEDGJ-UHFFFAOYSA-N	790687	US20260034094, Compound 323	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790687&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396151	CC(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-8(17,9(10,11)12)3-5-19(14,18)4-2-6(13)7(15)16/h6,14,17H,2-5,13H2,1H3,(H,15,16)	SQLALGOQTMEDGJ-UHFFFAOYSA-N	790688	US20260034094, Compound 324	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790688&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396152	CC(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C9H17F3N2O4S/c1-8(17,9(10,11)12)3-5-19(14,18)4-2-6(13)7(15)16/h6,14,17H,2-5,13H2,1H3,(H,15,16)	SQLALGOQTMEDGJ-UHFFFAOYSA-N	790689	US20260034094, Compound 325	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790689&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396153	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)C(F)(F)F	InChI=1S/C8H15F3N2O4S/c9-8(10,11)6(14)2-4-18(13,17)3-1-5(12)7(15)16/h5-6,13-14H,1-4,12H2,(H,15,16)	DKJFFPCIWXTSGY-UHFFFAOYSA-N	790690	US20260034094, Compound 326	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790690&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396154	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)C(F)(F)F	InChI=1S/C8H15F3N2O4S/c9-8(10,11)6(14)2-4-18(13,17)3-1-5(12)7(15)16/h5-6,13-14H,1-4,12H2,(H,15,16)	DKJFFPCIWXTSGY-UHFFFAOYSA-N	790691	US20260034094, Compound 327	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790691&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396155	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)C(F)(F)F	InChI=1S/C8H15F3N2O4S/c9-8(10,11)6(14)2-4-18(13,17)3-1-5(12)7(15)16/h5-6,13-14H,1-4,12H2,(H,15,16)	DKJFFPCIWXTSGY-UHFFFAOYSA-N	790692	US20260034094, Compound 328	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790692&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396156	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)C(F)(F)F	InChI=1S/C8H15F3N2O4S/c9-8(10,11)6(14)2-4-18(13,17)3-1-5(12)7(15)16/h5-6,13-14H,1-4,12H2,(H,15,16)	DKJFFPCIWXTSGY-UHFFFAOYSA-N	790693	US20260034094, Compound 329	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790693&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396157	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(OC(F)(F)F)cc1)C(F)(F)F	InChI=1S/C15H18F6N2O5S/c16-14(17,18)13(26,6-8-29(23,27)7-5-11(22)12(24)25)9-1-3-10(4-2-9)28-15(19,20)21/h1-4,11,23,26H,5-8,22H2,(H,24,25)	YODPVCIURRZWAZ-UHFFFAOYSA-N	790694	US20260034094, Compound 330	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790694&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396158	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cc2ccccc2cn1)C(F)(F)F	InChI=1S/C17H20F3N3O4S/c18-17(19,20)16(26,6-8-28(22,27)7-5-13(21)15(24)25)14-9-11-3-1-2-4-12(11)10-23-14/h1-4,9-10,13,22,26H,5-8,21H2,(H,24,25)	TVMGXPHRSHLTOX-UHFFFAOYSA-N	790695	US20260034094, Compound 331	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790695&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396159	NC(CC[S@SP3](=O)(=O)CCC(O)(c1cc2ccccc2cn1)C(F)(F)F)C(=O)O	InChI=1S/C17H19F3N2O5S/c18-17(19,20)16(25,6-8-28(26,27)7-5-13(21)15(23)24)14-9-11-3-1-2-4-12(11)10-22-14/h1-4,9-10,13,25H,5-8,21H2,(H,23,24)	QGCHRSRSPCUDIU-UHFFFAOYSA-N	790696	US20260034094, Compound 332	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790696&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396160	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C(=O)O)C(F)(F)F	InChI=1S/C9H15F3N2O6S/c10-9(11,12)8(19,7(17)18)2-4-21(14,20)3-1-5(13)6(15)16/h5,14,19H,1-4,13H2,(H,15,16)(H,17,18)	YPEXAOPLWAEGKA-UHFFFAOYSA-N	790697	US20260034094, Compound 333	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790697&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396161	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(Oc2ccccc2)cc1)C(F)(F)F	InChI=1S/C20H23F3N2O5S/c21-20(22,23)19(28,11-13-31(25,29)12-10-17(24)18(26)27)14-6-8-16(9-7-14)30-15-4-2-1-3-5-15/h1-9,17,25,28H,10-13,24H2,(H,26,27)	XLLOGKNKHCKUOL-UHFFFAOYSA-N	790698	US20260034094, Compound 334	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790698&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396162	N=[S@SP2](=O)(CCCC(O)(c1ccc(-c2ccccc2)cc1)C(F)(F)F)CCC(N)C(=O)O	InChI=1S/C21H25F3N2O4S/c22-21(23,24)20(29,12-4-13-31(26,30)14-11-18(25)19(27)28)17-9-7-16(8-10-17)15-5-2-1-3-6-15/h1-3,5-10,18,26,29H,4,11-14,25H2,(H,27,28)	OPBYRLFGUWVTBN-UHFFFAOYSA-N	790699	US20260034094, Compound 335	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790699&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396163	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccn(-c2ccc(Cl)cc2Cl)n1)C(F)(F)F	InChI=1S/C17H19Cl2F3N4O4S/c18-10-1-2-13(11(19)9-10)26-6-3-14(25-26)16(29,17(20,21)22)5-8-31(24,30)7-4-12(23)15(27)28/h1-3,6,9,12,24,29H,4-5,7-8,23H2,(H,27,28)	ULRXSHJJGRYXSC-UHFFFAOYSA-N	790700	US20260034094, Compound 336	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790700&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396164	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cc(-c2ccc(Cl)cc2Cl)cs1)C(F)(F)F	InChI=1S/C18H19Cl2F3N2O4S2/c19-11-1-2-12(13(20)8-11)10-7-15(30-9-10)17(28,18(21,22)23)4-6-31(25,29)5-3-14(24)16(26)27/h1-2,7-9,14,25,28H,3-6,24H2,(H,26,27)	GLUOVZOFIPSURZ-UHFFFAOYSA-N	790701	US20260034094, Compound 337	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790701&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396165	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(C(F)(F)F)cc1)C(F)(F)F	InChI=1S/C15H18F6N2O4S/c16-14(17,18)10-3-1-9(2-4-10)13(26,15(19,20)21)6-8-28(23,27)7-5-11(22)12(24)25/h1-4,11,23,26H,5-8,22H2,(H,24,25)	YCNKVYCDPNSKCX-UHFFFAOYSA-N	790702	US20260034094, Compound 338	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790702&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396166	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(OC2CCCCC2)cc1)C(F)(F)F	InChI=1S/C20H29F3N2O5S/c21-20(22,23)19(28,11-13-31(25,29)12-10-17(24)18(26)27)14-6-8-16(9-7-14)30-15-4-2-1-3-5-15/h6-9,15,17,25,28H,1-5,10-13,24H2,(H,26,27)	XGXMTKMEPJIRCU-UHFFFAOYSA-N	790703	US20260034094, Compound 339	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790703&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396167	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)([C@H]1CC[C@H](c2ccc(Cl)cc2Cl)CC1)C(F)(F)F	InChI=1S/C20H27Cl2F3N2O4S/c21-14-5-6-15(16(22)11-14)12-1-3-13(4-2-12)19(30,20(23,24)25)8-10-32(27,31)9-7-17(26)18(28)29/h5-6,11-13,17,27,30H,1-4,7-10,26H2,(H,28,29)	DTXBDSGPZZORET-UHFFFAOYSA-N	790704	US20260034094, Compound 340	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790704&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396168	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)([C@H]1CC[C@@H](c2ccc(Cl)cc2Cl)CC1)C(F)(F)F	InChI=1S/C20H27Cl2F3N2O4S/c21-14-5-6-15(16(22)11-14)12-1-3-13(4-2-12)19(30,20(23,24)25)8-10-32(27,31)9-7-17(26)18(28)29/h5-6,11-13,17,27,30H,1-4,7-10,26H2,(H,28,29)	DTXBDSGPZZORET-UHFFFAOYSA-N	790705	US20260034094, Compound 341	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790705&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396169	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(Oc2ccc(Cl)cc2Cl)cc1)C(F)(F)F	InChI=1S/C20H21Cl2F3N2O5S/c21-13-3-6-17(15(22)11-13)32-14-4-1-12(2-5-14)19(30,20(23,24)25)8-10-33(27,31)9-7-16(26)18(28)29/h1-6,11,16,27,30H,7-10,26H2,(H,28,29)	AARMNNFODOZTLB-UHFFFAOYSA-N	790706	US20260034094, Compound 342	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790706&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396170	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1nc2ccccc2[nH]1)C(F)(F)F	InChI=1S/C15H19F3N4O4S/c16-15(17,18)14(25,13-21-10-3-1-2-4-11(10)22-13)6-8-27(20,26)7-5-9(19)12(23)24/h1-4,9,20,25H,5-8,19H2,(H,21,22)(H,23,24)	UEAXYEVXAFWYFS-UHFFFAOYSA-N	790707	US20260034094, Compound 343	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790707&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174248372	528498494							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396171	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1nccs1)C(F)(F)F	InChI=1S/C11H16F3N3O4S2/c12-11(13,14)10(20,9-17-3-4-22-9)2-6-23(16,21)5-1-7(15)8(18)19/h3-4,7,16,20H,1-2,5-6,15H2,(H,18,19)	XVJDZICAEHJPLZ-UHFFFAOYSA-N	790708	US20260034094, Compound 344	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790708&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396172	N=[S@](=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccccc1)C(F)(F)F	InChI=1S/C14H19F3N2O4S/c15-14(16,17)13(22,10-4-2-1-3-5-10)7-9-24(19,23)8-6-11(18)12(20)21/h1-5,11,19,22H,6-9,18H2,(H,20,21)	SKHOBHFKCRSPGY-UHFFFAOYSA-N	790709	US20260034094, Compound 345	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790709&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396173	N=[S@](=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccccc1)C(F)(F)F	InChI=1S/C14H19F3N2O4S/c15-14(16,17)13(22,10-4-2-1-3-5-10)7-9-24(19,23)8-6-11(18)12(20)21/h1-5,11,19,22H,6-9,18H2,(H,20,21)	SKHOBHFKCRSPGY-UHFFFAOYSA-N	790710	US20260034094, Compound 346	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790710&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396174	N=[S@@](=O)(CC[C@H](N)C(=O)O)CC[C@@](O)(c1ccccc1)C(F)(F)F	InChI=1S/C14H19F3N2O4S/c15-14(16,17)13(22,10-4-2-1-3-5-10)7-9-24(19,23)8-6-11(18)12(20)21/h1-5,11,19,22H,6-9,18H2,(H,20,21)	SKHOBHFKCRSPGY-UHFFFAOYSA-N	790711	US20260034094, Compound 347	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790711&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396175	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccccc1)C(F)(F)F	InChI=1S/C14H19F3N2O4S/c15-14(16,17)13(22,10-4-2-1-3-5-10)7-9-24(19,23)8-6-11(18)12(20)21/h1-5,11,19,22H,6-9,18H2,(H,20,21)	SKHOBHFKCRSPGY-UHFFFAOYSA-N	790712	US20260034094, Compound 348	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790712&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396176	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(C1CC1)C(F)(F)F	InChI=1S/C11H19F3N2O4S/c12-11(13,14)10(19,7-1-2-7)4-6-21(16,20)5-3-8(15)9(17)18/h7-8,16,19H,1-6,15H2,(H,17,18)	NCCIIPJOWNXBDF-UHFFFAOYSA-N	790713	US20260034094, Compound 349	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790713&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396177	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccccn1)C(F)(F)F	InChI=1S/C13H18F3N3O4S/c14-13(15,16)12(22,10-3-1-2-6-19-10)5-8-24(18,23)7-4-9(17)11(20)21/h1-3,6,9,18,22H,4-5,7-8,17H2,(H,20,21)	SUCCZNXCHKVGRH-UHFFFAOYSA-N	790714	US20260034094, Compound 350	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790714&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396178	N[C@@H](CCS(=O)(=O)CCC(O)(c1ccccn1)C(F)(F)F)C(=O)O	InChI=1S/C13H17F3N2O5S/c14-13(15,16)12(21,10-3-1-2-6-18-10)5-8-24(22,23)7-4-9(17)11(19)20/h1-3,6,9,21H,4-5,7-8,17H2,(H,19,20)	WAUWKHROESYHQN-UHFFFAOYSA-N	790715	US20260034094, Compound 351	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790715&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396179	CCC(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C10H19F3N2O4S/c1-2-9(18,10(11,12)13)4-6-20(15,19)5-3-7(14)8(16)17/h7,15,18H,2-6,14H2,1H3,(H,16,17)	JOHLGODJAZBTAD-UHFFFAOYSA-N	790716	US20260034094, Compound 352	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790716&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396180	CC(C)C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F	InChI=1S/C11H21F3N2O4S/c1-7(2)10(19,11(12,13)14)4-6-21(16,20)5-3-8(15)9(17)18/h7-8,16,19H,3-6,15H2,1-2H3,(H,17,18)	QOCQKMFMCPFQEJ-UHFFFAOYSA-N	790717	US20260034094, Compound 353	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790717&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396181	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(Cc1ccccc1)C(F)(F)F	InChI=1S/C15H21F3N2O4S/c16-15(17,18)14(23,10-11-4-2-1-3-5-11)7-9-25(20,24)8-6-12(19)13(21)22/h1-5,12,20,23H,6-10,19H2,(H,21,22)	JDLMSZNJLVKBFJ-UHFFFAOYSA-N	790718	US20260034094, Compound 354	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790718&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396182	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C1CCCCC1)C(F)(F)F	InChI=1S/C14H25F3N2O4S/c15-14(16,17)13(22,10-4-2-1-3-5-10)7-9-24(19,23)8-6-11(18)12(20)21/h10-11,19,22H,1-9,18H2,(H,20,21)	FUSOELKAINSETA-UHFFFAOYSA-N	790719	US20260034094, Compound 355	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790719&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396183	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C1CCCC1)C(F)(F)F	InChI=1S/C13H23F3N2O4S/c14-13(15,16)12(21,9-3-1-2-4-9)6-8-23(18,22)7-5-10(17)11(19)20/h9-10,18,21H,1-8,17H2,(H,19,20)	JMRAEIFDGLWSRT-UHFFFAOYSA-N	790720	US20260034094, Compound 356	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790720&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396184	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C1CCC1)C(F)(F)F	InChI=1S/C12H21F3N2O4S/c13-12(14,15)11(20,8-2-1-3-8)5-7-22(17,21)6-4-9(16)10(18)19/h8-9,17,20H,1-7,16H2,(H,18,19)	SNLUWDOZQOXARL-UHFFFAOYSA-N	790721	US20260034094, Compound 357	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790721&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396185	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ncc(-c2ccccc2)[nH]1)C(F)(F)F	InChI=1S/C17H21F3N4O4S/c18-17(19,20)16(27,7-9-29(22,28)8-6-12(21)14(25)26)15-23-10-13(24-15)11-4-2-1-3-5-11/h1-5,10,12,22,27H,6-9,21H2,(H,23,24)(H,25,26)	UYTPIBNIOYJFNO-UHFFFAOYSA-N	790722	US20260034094, Compound 358	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790722&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174247360	528498509							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396186	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C(F)(F)F)C12CC(C1)C2	InChI=1S/C13H21F3N2O4S/c14-13(15,16)12(21,11-5-8(6-11)7-11)2-4-23(18,22)3-1-9(17)10(19)20/h8-9,18,21H,1-7,17H2,(H,19,20)	DSYMNVDNXLICHI-UHFFFAOYSA-N	790723	US20260034094, Compound 359	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790723&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396187	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1cc2cc[nH]c2cn1)C(F)(F)F	InChI=1S/C15H19F3N4O4S/c16-15(17,18)14(25,12-7-9-1-4-21-11(9)8-22-12)3-6-27(20,26)5-2-10(19)13(23)24/h1,4,7-8,10,20-21,25H,2-3,5-6,19H2,(H,23,24)	NYHLMNNEGLTHLB-UHFFFAOYSA-N	790724	US20260034094, Compound 360	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790724&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174254282	528498511							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396188	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cccnc1)C(F)(F)F	InChI=1S/C13H18F3N3O4S/c14-13(15,16)12(22,9-2-1-5-19-8-9)4-7-24(18,23)6-3-10(17)11(20)21/h1-2,5,8,10,18,22H,3-4,6-7,17H2,(H,20,21)	XOVRRHOLVZYSOD-UHFFFAOYSA-N	790725	US20260034094, Compound 361	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790725&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396189	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccncc1)C(F)(F)F	InChI=1S/C13H18F3N3O4S/c14-13(15,16)12(22,9-1-5-19-6-2-9)4-8-24(18,23)7-3-10(17)11(20)21/h1-2,5-6,10,18,22H,3-4,7-8,17H2,(H,20,21)	VPFIGFIJFZEKDA-UHFFFAOYSA-N	790726	US20260034094, Compound 362	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790726&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396190	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ncccn1)C(F)(F)F	InChI=1S/C12H17F3N4O4S/c13-12(14,15)11(22,10-18-4-1-5-19-10)3-7-24(17,23)6-2-8(16)9(20)21/h1,4-5,8,17,22H,2-3,6-7,16H2,(H,20,21)	BGTSRVYZFIDDLR-UHFFFAOYSA-N	790727	US20260034094, Compound 363	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790727&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396191	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccnc(C(F)(F)F)c1)C(F)(F)F	InChI=1S/C14H17F6N3O4S/c15-13(16,17)10-7-8(1-4-23-10)12(26,14(18,19)20)3-6-28(22,27)5-2-9(21)11(24)25/h1,4,7,9,22,26H,2-3,5-6,21H2,(H,24,25)	HVSJUALMTJECGM-UHFFFAOYSA-N	790728	US20260034094, Compound 364	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790728&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396192	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(C(F)(F)F)nc1)C(F)(F)F	InChI=1S/C14H17F6N3O4S/c15-13(16,17)10-2-1-8(7-23-10)12(26,14(18,19)20)4-6-28(22,27)5-3-9(21)11(24)25/h1-2,7,9,22,26H,3-6,21H2,(H,24,25)	QAIKQCXICASXLC-UHFFFAOYSA-N	790729	US20260034094, Compound 365	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790729&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396193	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cnc(-c2ccc(Cl)cc2Cl)nc1)C(F)(F)F	InChI=1S/C18H19Cl2F3N4O4S/c19-11-1-2-12(13(20)7-11)15-26-8-10(9-27-15)17(30,18(21,22)23)4-6-32(25,31)5-3-14(24)16(28)29/h1-2,7-9,14,25,30H,3-6,24H2,(H,28,29)	HLFXJUUZORABMV-UHFFFAOYSA-N	790730	US20260034094, Compound 366	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790730&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396194	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cnc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C18H19Cl2F3N4O4S/c19-10-1-2-11(12(20)7-10)14-8-27-15(9-26-14)17(30,18(21,22)23)4-6-32(25,31)5-3-13(24)16(28)29/h1-2,7-9,13,25,30H,3-6,24H2,(H,28,29)	XPHVCTTUKIRDPH-UHFFFAOYSA-N	790731	US20260034094, Compound 367	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790731&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396195	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccon1)C(F)(F)F	InChI=1S/C11H16F3N3O5S/c12-11(13,14)10(20,8-1-4-22-17-8)3-6-23(16,21)5-2-7(15)9(18)19/h1,4,7,16,20H,2-3,5-6,15H2,(H,18,19)	YUUPJMZXOHGBNS-UHFFFAOYSA-N	790732	US20260034094, Compound 368	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790732&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396196	N[C@@H](CCS(=O)(=O)CCC(O)(c1ccon1)C(F)(F)F)C(=O)O	InChI=1S/C11H15F3N2O6S/c12-11(13,14)10(19,8-1-4-22-16-8)3-6-23(20,21)5-2-7(15)9(17)18/h1,4,7,19H,2-3,5-6,15H2,(H,17,18)	YCYLKVJSQYAZCE-UHFFFAOYSA-N	790733	US20260034094, Compound 369	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790733&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396197	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccsn1)C(F)(F)F	InChI=1S/C11H16F3N3O4S2/c12-11(13,14)10(20,8-1-4-22-17-8)3-6-23(16,21)5-2-7(15)9(18)19/h1,4,7,16,20H,2-3,5-6,15H2,(H,18,19)	DELZDDOANLWNEA-UHFFFAOYSA-N	790734	US20260034094, Compound 370	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790734&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396198	N[C@@H](CCS(=O)(=O)CCC(O)(c1ccsn1)C(F)(F)F)C(=O)O	InChI=1S/C11H15F3N2O5S2/c12-11(13,14)10(19,8-1-4-22-16-8)3-6-23(20,21)5-2-7(15)9(17)18/h1,4,7,19H,2-3,5-6,15H2,(H,17,18)	JRAZRDDPBOKJCX-UHFFFAOYSA-N	790735	US20260034094, Compound 371	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790735&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396199	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(Oc2ccccc2)cn1)C(F)(F)F	InChI=1S/C19H22F3N3O5S/c20-19(21,22)18(28,9-11-31(24,29)10-8-15(23)17(26)27)16-7-6-14(12-25-16)30-13-4-2-1-3-5-13/h1-7,12,15,24,28H,8-11,23H2,(H,26,27)	NNNMNRHYTBNCES-UHFFFAOYSA-N	790736	US20260034094, Compound 372	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790736&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396200	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc2ccccc2n1)C(F)(F)F	InChI=1S/C17H20F3N3O4S/c18-17(19,20)16(26,8-10-28(22,27)9-7-12(21)15(24)25)14-6-5-11-3-1-2-4-13(11)23-14/h1-6,12,22,26H,7-10,21H2,(H,24,25)	DUXYHZIICSRXNG-UHFFFAOYSA-N	790737	US20260034094, Compound 373	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790737&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396201	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ncc2ccccc2n1)C(F)(F)F	InChI=1S/C16H19F3N4O4S/c17-16(18,19)15(26,6-8-28(21,27)7-5-11(20)13(24)25)14-22-9-10-3-1-2-4-12(10)23-14/h1-4,9,11,21,26H,5-8,20H2,(H,24,25)	WXUHKVZOHGHYSR-UHFFFAOYSA-N	790738	US20260034094, Compound 374	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790738&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396202	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1nsc2ccccc12)C(F)(F)F	InChI=1S/C15H18F3N3O4S2/c16-15(17,18)14(24,12-9-3-1-2-4-11(9)26-21-12)6-8-27(20,25)7-5-10(19)13(22)23/h1-4,10,20,24H,5-8,19H2,(H,22,23)	PZSMRPBXABAOEP-UHFFFAOYSA-N	790739	US20260034094, Compound 375	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790739&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396203	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cc(-c2ccccc2)sn1)C(F)(F)F	InChI=1S/C17H20F3N3O4S2/c18-17(19,20)16(26,7-9-29(22,27)8-6-12(21)15(24)25)14-10-13(28-23-14)11-4-2-1-3-5-11/h1-5,10,12,22,26H,6-9,21H2,(H,24,25)	VGNKJPYITILTET-UHFFFAOYSA-N	790740	US20260034094, Compound 376	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790740&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396204	N[C@@H](CCS(=O)(=O)CCC(O)(c1cc(-c2ccccc2)sn1)C(F)(F)F)C(=O)O	InChI=1S/C17H19F3N2O5S2/c18-17(19,20)16(25,7-9-29(26,27)8-6-12(21)15(23)24)14-10-13(28-22-14)11-4-2-1-3-5-11/h1-5,10,12,25H,6-9,21H2,(H,23,24)	UGADMFCAOPWCTM-UHFFFAOYSA-N	790741	US20260034094, Compound 377	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790741&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396205	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cc(-c2ccccc2)on1)C(F)(F)F	InChI=1S/C17H20F3N3O5S/c18-17(19,20)16(26,7-9-29(22,27)8-6-12(21)15(24)25)14-10-13(28-23-14)11-4-2-1-3-5-11/h1-5,10,12,22,26H,6-9,21H2,(H,24,25)	VOFTUJTWQDOFDF-UHFFFAOYSA-N	790742	US20260034094, Compound 378	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790742&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396206	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C1CCN(c2ccc(Cl)cc2Cl)CC1)C(F)(F)F	InChI=1S/C19H26Cl2F3N3O4S/c20-13-1-2-16(14(21)11-13)27-7-3-12(4-8-27)18(30,19(22,23)24)6-10-32(26,31)9-5-15(25)17(28)29/h1-2,11-12,15,26,30H,3-10,25H2,(H,28,29)	PTULLMOIPZYKDJ-UHFFFAOYSA-N	790743	US20260034094, Compound 379	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790743&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396207	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(Oc2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C19H20Cl2F3N3O5S/c20-11-1-3-15(13(21)9-11)32-12-2-4-16(27-10-12)18(30,19(22,23)24)6-8-33(26,31)7-5-14(25)17(28)29/h1-4,9-10,14,26,30H,5-8,25H2,(H,28,29)	IISIMDAIHFWRRK-UHFFFAOYSA-N	790744	US20260034094, Compound 380	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790744&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396208	N=S(=O)(CCC(C1CCCCC1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H25F3N2O3S/c15-14(16,17)11(10-4-2-1-3-5-10)6-8-23(19,22)9-7-12(18)13(20)21/h10-12,19H,1-9,18H2,(H,20,21)	AVSPNJDOQUQUTK-UHFFFAOYSA-N	790745	US20260034094, Compound 381	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790745&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396209	N=S(=O)(CCC(C1CCCC1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C13H23F3N2O3S/c14-13(15,16)10(9-3-1-2-4-9)5-7-22(18,21)8-6-11(17)12(19)20/h9-11,18H,1-8,17H2,(H,19,20)	CYTURFWYYHOEIP-UHFFFAOYSA-N	790746	US20260034094, Compound 382	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790746&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396210	N=S(=O)(CCC(C1CCC1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C12H21F3N2O3S/c13-12(14,15)9(8-2-1-3-8)4-6-21(17,20)7-5-10(16)11(18)19/h8-10,17H,1-7,16H2,(H,18,19)	YWIMPWHSWVMJPV-UHFFFAOYSA-N	790747	US20260034094, Compound 383	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790747&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396211	N=S(=O)(CCC(C(F)(F)F)C12CC(C1)C2)CC[C@H](N)C(=O)O	InChI=1S/C13H21F3N2O3S/c14-13(15,16)10(12-5-8(6-12)7-12)2-4-22(18,21)3-1-9(17)11(19)20/h8-10,18H,1-7,17H2,(H,19,20)	SNMRHINQZWRFNN-UHFFFAOYSA-N	790748	US20260034094, Compound 384	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790748&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396212	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2cccc(F)c2)CCC1	InChI=1S/C16H23FN2O3S/c17-13-4-1-3-12(11-13)16(6-2-7-16)8-10-23(19,22)9-5-14(18)15(20)21/h1,3-4,11,14,19H,2,5-10,18H2,(H,20,21)	ZRTCNESOOQNUJY-UHFFFAOYSA-N	790749	US20260034094, Compound 385	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790749&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396213	N=S(=O)(CCC(c1ccc2[nH]ncc2c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C15H19F3N4O3S/c16-15(17,18)11(9-1-2-13-10(7-9)8-21-22-13)3-5-26(20,25)6-4-12(19)14(23)24/h1-2,7-8,11-12,20H,3-6,19H2,(H,21,22)(H,23,24)	TZUOQKOYJZKZRG-UHFFFAOYSA-N	790750	US20260034094, Compound 386	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790750&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770334	528498537							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396214	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccccn2)CCC1	InChI=1S/C15H23N3O3S/c16-12(14(19)20)5-10-22(17,21)11-8-15(6-3-7-15)13-4-1-2-9-18-13/h1-2,4,9,12,17H,3,5-8,10-11,16H2,(H,19,20)	NARBXQHHCHKYNJ-UHFFFAOYSA-N	790751	US20260034094, Compound 387	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790751&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396215	N=[S@@](=O)(CC[C@H](N)C(=O)O)CCC1(c2ccccn2)CCC1	InChI=1S/C15H23N3O3S/c16-12(14(19)20)5-10-22(17,21)11-8-15(6-3-7-15)13-4-1-2-9-18-13/h1-2,4,9,12,17H,3,5-8,10-11,16H2,(H,19,20)	NARBXQHHCHKYNJ-UHFFFAOYSA-N	790752	US20260034094, Compound 388	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790752&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396216	N=[S@](=O)(CC[C@H](N)C(=O)O)CCC1(c2ccccn2)CCC1	InChI=1S/C15H23N3O3S/c16-12(14(19)20)5-10-22(17,21)11-8-15(6-3-7-15)13-4-1-2-9-18-13/h1-2,4,9,12,17H,3,5-8,10-11,16H2,(H,19,20)	NARBXQHHCHKYNJ-UHFFFAOYSA-N	790753	US20260034094, Compound 389	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790753&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396217	N[C@@H](CCS(=O)(=O)CCC1(c2ccccn2)CCC1)C(=O)O	InChI=1S/C15H22N2O4S/c16-12(14(18)19)5-10-22(20,21)11-8-15(6-3-7-15)13-4-1-2-9-17-13/h1-2,4,9,12H,3,5-8,10-11,16H2,(H,18,19)	QSHVUNACWYXPDU-UHFFFAOYSA-N	790754	US20260034094, Compound 390	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790754&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396218	N=S(=O)(CCC(c1ccc(-c2ccccc2)cc1O)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H23F3N2O4S/c21-20(22,23)16(8-10-30(25,29)11-9-17(24)19(27)28)15-7-6-14(12-18(15)26)13-4-2-1-3-5-13/h1-7,12,16-17,25-26H,8-11,24H2,(H,27,28)	TUUQOKSKUSRIJR-UHFFFAOYSA-N	790755	US20260034094, Compound 391	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790755&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396219	N=[S@@](=O)(CC[C@H](N)C(=O)O)CCC1(c2ccccc2)CCC1	InChI=1S/C16H24N2O3S/c17-14(15(19)20)7-11-22(18,21)12-10-16(8-4-9-16)13-5-2-1-3-6-13/h1-3,5-6,14,18H,4,7-12,17H2,(H,19,20)	VNXVGGGLUGGXMB-UHFFFAOYSA-N	790756	US20260034094, Compound 392	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790756&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396220	N=S(=O)(CCC(c1ccc2[nH]nnc2c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H18F3N5O3S/c15-14(16,17)9(8-1-2-11-12(7-8)21-22-20-11)3-5-26(19,25)6-4-10(18)13(23)24/h1-2,7,9-10,19H,3-6,18H2,(H,23,24)(H,20,21,22)	SWNJSXUPBNRQBT-UHFFFAOYSA-N	790757	US20260034094, Compound 393	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790757&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			174247513	528498544							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396221	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccc3[nH]ncc3c2)CCC1	InChI=1S/C17H24N4O3S/c18-14(16(22)23)4-8-25(19,24)9-7-17(5-1-6-17)13-2-3-15-12(10-13)11-20-21-15/h2-3,10-11,14,19H,1,4-9,18H2,(H,20,21)(H,22,23)	CLKUHLMHJLGPGU-UHFFFAOYSA-N	790758	US20260034094, Compound 394	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790758&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170769944	528498545							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396222	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccc3[nH]nnc3c2)CCC1	InChI=1S/C16H23N5O3S/c17-12(15(22)23)4-8-25(18,24)9-7-16(5-1-6-16)11-2-3-13-14(10-11)20-21-19-13/h2-3,10,12,18H,1,4-9,17H2,(H,22,23)(H,19,20,21)	HGMKGXXKJAAGMP-UHFFFAOYSA-N	790759	US20260034094, Compound 395	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790759&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			178348148	528498546							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396223	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccc3[nH]cnc3c2)CCC1	InChI=1S/C17H24N4O3S/c18-13(16(22)23)4-8-25(19,24)9-7-17(5-1-6-17)12-2-3-14-15(10-12)21-11-20-14/h2-3,10-11,13,19H,1,4-9,18H2,(H,20,21)(H,22,23)	XMRMKAIUSSZVKN-UHFFFAOYSA-N	790760	US20260034094, Compound 396	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790760&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			178348149	528498547							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396224	N=S(=O)(CCC(c1ccccc1O)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H19F3N2O4S/c15-14(16,17)10(9-3-1-2-4-12(9)20)5-7-24(19,23)8-6-11(18)13(21)22/h1-4,10-11,19-20H,5-8,18H2,(H,21,22)	SSKORXSFAHOEQG-UHFFFAOYSA-N	790761	US20260034094, Compound 397	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790761&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396225	COc1ccccc1C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F	InChI=1S/C15H21F3N2O4S/c1-24-13-5-3-2-4-10(13)11(15(16,17)18)6-8-25(20,23)9-7-12(19)14(21)22/h2-5,11-12,20H,6-9,19H2,1H3,(H,21,22)	OOUMOSDEWIEGQQ-UHFFFAOYSA-N	790762	US20260034094, Compound 398	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790762&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396226	N=S(=O)(CCC(c1ccc2[nH]cnc2c1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C15H19F3N4O3S/c16-15(17,18)10(9-1-2-12-13(7-9)22-8-21-12)3-5-26(20,25)6-4-11(19)14(23)24/h1-2,7-8,10-11,20H,3-6,19H2,(H,21,22)(H,23,24)	BTMKQJIHNFJNQY-UHFFFAOYSA-N	790763	US20260034094, Compound 399	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790763&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search			170770025	528498550							1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396227	COc1ccc(-c2ccc(C3(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC3)cc2)c(Cl)c1	InChI=1S/C23H29ClN2O4S/c1-30-18-7-8-19(20(24)15-18)16-3-5-17(6-4-16)23(10-2-11-23)12-14-31(26,29)13-9-21(25)22(27)28/h3-8,15,21,26H,2,9-14,25H2,1H3,(H,27,28)	QAVCYXSJHPZQIM-UHFFFAOYSA-N	790764	US20260034094, Compound 400	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790764&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396228	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccc(-c3ccc(O)cc3Cl)cc2)CCC1	InChI=1S/C22H27ClN2O4S/c23-19-14-17(26)6-7-18(19)15-2-4-16(5-3-15)22(9-1-10-22)11-13-30(25,29)12-8-20(24)21(27)28/h2-7,14,20,25-26H,1,8-13,24H2,(H,27,28)	SRCLXBYMSGARLM-UHFFFAOYSA-N	790765	US20260034094, Compound 401	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790765&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396229	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccc(-c3ccc(Cl)cc3Cl)cc2)CCC1	InChI=1S/C22H26Cl2N2O3S/c23-17-6-7-18(19(24)14-17)15-2-4-16(5-3-15)22(9-1-10-22)11-13-30(26,29)12-8-20(25)21(27)28/h2-7,14,20,26H,1,8-13,25H2,(H,27,28)	QBKRLZQDPMOFKA-UHFFFAOYSA-N	790766	US20260034094, Compound 402	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790766&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396230	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ccc(Oc3ccc(Cl)cc3Cl)cc2)CCC1	InChI=1S/C22H26Cl2N2O4S/c23-16-4-7-20(18(24)14-16)30-17-5-2-15(3-6-17)22(9-1-10-22)11-13-31(26,29)12-8-19(25)21(27)28/h2-7,14,19,26H,1,8-13,25H2,(H,27,28)	XXLBLANVBDDGJM-UHFFFAOYSA-N	790767	US20260034094, Compound 403	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790767&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396231	N=S(=O)(CCC(n1nccn1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C10H16F3N5O3S/c11-10(12,13)8(18-16-3-4-17-18)2-6-22(15,21)5-1-7(14)9(19)20/h3-4,7-8,15H,1-2,5-6,14H2,(H,19,20)	QABVPEHRGMBFET-UHFFFAOYSA-N	790768	US20260034094, Compound 404	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790768&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396232	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(n2nccn2)CCC1	InChI=1S/C12H21N5O3S/c13-10(11(18)19)2-8-21(14,20)9-5-12(3-1-4-12)17-15-6-7-16-17/h6-7,10,14H,1-5,8-9,13H2,(H,18,19)	SKENPYDFCSJFHB-UHFFFAOYSA-N	790769	US20260034094, Compound 405	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790769&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396233	Cc1cnn(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)n1	InChI=1S/C11H18F3N5O3S/c1-7-6-17-19(18-7)9(11(12,13)14)3-5-23(16,22)4-2-8(15)10(20)21/h6,8-9,16H,2-5,15H2,1H3,(H,20,21)	FKDJGUDNCFYQHO-UHFFFAOYSA-N	790770	US20260034094, Compound 406	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790770&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396234	N=S(=O)(CCC(n1ncc(-c2ccccn2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C15H19F3N6O3S/c16-15(17,18)13(5-8-28(20,27)7-4-10(19)14(25)26)24-22-9-12(23-24)11-3-1-2-6-21-11/h1-3,6,9-10,13,20H,4-5,7-8,19H2,(H,25,26)	PSSONKOTBKTBKU-UHFFFAOYSA-N	790771	US20260034094, Compound 407	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790771&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396235	N=S(=O)(CCC(n1ncc(-c2cccnc2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C15H19F3N6O3S/c16-15(17,18)13(4-7-28(20,27)6-3-11(19)14(25)26)24-22-9-12(23-24)10-2-1-5-21-8-10/h1-2,5,8-9,11,13,20H,3-4,6-7,19H2,(H,25,26)	DMXDOJPIPDXSNK-UHFFFAOYSA-N	790772	US20260034094, Compound 408	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790772&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396236	N=S(=O)(CCC(n1ncc(-c2ccccc2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C16H20F3N5O3S/c17-16(18,19)14(7-9-28(21,27)8-6-12(20)15(25)26)24-22-10-13(23-24)11-4-2-1-3-5-11/h1-5,10,12,14,21H,6-9,20H2,(H,25,26)	BATSFWMZEDXUQU-UHFFFAOYSA-N	790773	US20260034094, Compound 409	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790773&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396237	N=S(=O)(CCC(n1nc2ccccc2n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H18F3N5O3S/c15-14(16,17)12(22-20-10-3-1-2-4-11(10)21-22)6-8-26(19,25)7-5-9(18)13(23)24/h1-4,9,12,19H,5-8,18H2,(H,23,24)	CECOZRUZAXVRRR-UHFFFAOYSA-N	790774	US20260034094, Compound 410	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790774&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396238	N=S(=O)(CCC(n1cccn1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C11H17F3N4O3S/c12-11(13,14)9(18-5-1-4-17-18)3-7-22(16,21)6-2-8(15)10(19)20/h1,4-5,8-9,16H,2-3,6-7,15H2,(H,19,20)	SDXDRGKQZKQUSU-UHFFFAOYSA-N	790775	US20260034094, Compound 411	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790775&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396239	Cc1ccn(C(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)n1	InChI=1S/C12H19F3N4O3S/c1-8-2-5-19(18-8)10(12(13,14)15)4-7-23(17,22)6-3-9(16)11(20)21/h2,5,9-10,17H,3-4,6-7,16H2,1H3,(H,20,21)	CWLPYLZJPJJENA-UHFFFAOYSA-N	790776	US20260034094, Compound 412	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790776&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396240	N=S(=O)(CCC(n1ccc(C2CC2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C14H21F3N4O3S/c15-14(16,17)12(21-6-3-11(20-21)9-1-2-9)5-8-25(19,24)7-4-10(18)13(22)23/h3,6,9-10,12,19H,1-2,4-5,7-8,18H2,(H,22,23)	LOLJJIJSGAPRCD-UHFFFAOYSA-N	790777	US20260034094, Compound 413	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790777&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396241	N=S(=O)(CCC(n1ccc(-c2cccnc2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C16H20F3N5O3S/c17-16(18,19)14(5-9-28(21,27)8-4-12(20)15(25)26)24-7-3-13(23-24)11-2-1-6-22-10-11/h1-3,6-7,10,12,14,21H,4-5,8-9,20H2,(H,25,26)	MOQADCFPYTVEDE-UHFFFAOYSA-N	790778	US20260034094, Compound 414	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790778&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396242	N=S(=O)(CCC(n1ccc(-c2ccccn2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C16H20F3N5O3S/c17-16(18,19)14(6-10-28(21,27)9-5-11(20)15(25)26)24-8-4-13(23-24)12-3-1-2-7-22-12/h1-4,7-8,11,14,21H,5-6,9-10,20H2,(H,25,26)	OZWFYYOKQOSSEQ-UHFFFAOYSA-N	790779	US20260034094, Compound 415	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790779&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396243	N=S(=O)(CCC(n1ccc(-c2ccccc2)n1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C17H21F3N4O3S/c18-17(19,20)15(8-11-28(22,27)10-7-13(21)16(25)26)24-9-6-14(23-24)12-4-2-1-3-5-12/h1-6,9,13,15,22H,7-8,10-11,21H2,(H,25,26)	MFEDFGBLDMNTSU-UHFFFAOYSA-N	790780	US20260034094, Compound 416	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790780&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396244	Cc1cnn(C2(CCS(=N)(=O)CC[C@H](N)C(=O)O)CCC2)n1	InChI=1S/C13H23N5O3S/c1-10-9-16-18(17-10)13(4-2-5-13)6-8-22(15,21)7-3-11(14)12(19)20/h9,11,15H,2-8,14H2,1H3,(H,19,20)	IKTFWLVKBMCPEV-UHFFFAOYSA-N	790781	US20260034094, Compound 417	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790781&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396245	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(n2ncc(-c3ccccn3)n2)CCC1	InChI=1S/C17H24N6O3S/c18-13(16(24)25)5-10-27(19,26)11-8-17(6-3-7-17)23-21-12-15(22-23)14-4-1-2-9-20-14/h1-2,4,9,12-13,19H,3,5-8,10-11,18H2,(H,24,25)	GKWDUTOANSWLSS-UHFFFAOYSA-N	790782	US20260034094, Compound 418	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790782&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396246	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(n2ncc(-c3cccnc3)n2)CCC1	InChI=1S/C17H24N6O3S/c18-14(16(24)25)4-9-27(19,26)10-7-17(5-2-6-17)23-21-12-15(22-23)13-3-1-8-20-11-13/h1,3,8,11-12,14,19H,2,4-7,9-10,18H2,(H,24,25)	SSFMJKMLKFQALT-UHFFFAOYSA-N	790783	US20260034094, Compound 419	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790783&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396247	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(n2ncc(-c3ccccc3)n2)CCC1	InChI=1S/C18H25N5O3S/c19-15(17(24)25)7-11-27(20,26)12-10-18(8-4-9-18)23-21-13-16(22-23)14-5-2-1-3-6-14/h1-3,5-6,13,15,20H,4,7-12,19H2,(H,24,25)	SZWWGKZPTNJVQY-UHFFFAOYSA-N	790784	US20260034094, Compound 420	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790784&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396248	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(n2nc3ccccc3n2)CCC1	InChI=1S/C16H23N5O3S/c17-12(15(22)23)6-10-25(18,24)11-9-16(7-3-8-16)21-19-13-4-1-2-5-14(13)20-21/h1-2,4-5,12,18H,3,6-11,17H2,(H,22,23)	PMZALONHYSEGJJ-UHFFFAOYSA-N	790785	US20260034094, Compound 421	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790785&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396249	CC(CCS(=N)(=O)CC[C@H](N)C(=O)O)n1ncc(-c2ccccc2Cl)n1	InChI=1S/C16H22ClN5O3S/c1-11(6-8-26(19,25)9-7-14(18)16(23)24)22-20-10-15(21-22)12-4-2-3-5-13(12)17/h2-5,10-11,14,19H,6-9,18H2,1H3,(H,23,24)	XEGYPOMTOCZNAX-UHFFFAOYSA-N	790786	US20260034094, Compound 422	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790786&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396250	N=S(=O)(CCC(N1CCN(c2ccc(Cl)cc2Cl)CC1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C18H25Cl2F3N4O3S/c19-12-1-2-15(13(20)11-12)26-5-7-27(8-6-26)16(18(21,22)23)4-10-31(25,30)9-3-14(24)17(28)29/h1-2,11,14,16,25H,3-10,24H2,(H,28,29)	XISFUDPERNWKEB-UHFFFAOYSA-N	790787	US20260034094, Compound 423	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790787&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396251	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccccc2)cc1)C(F)(F)F	InChI=1S/C20H23F3N2O4S/c21-20(22,23)19(28,11-13-30(25,29)12-10-17(24)18(26)27)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17,25,28H,10-13,24H2,(H,26,27)	MQFHUHDYPLNLJN-UHFFFAOYSA-N	790788	US20260034094, Compound 424	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790788&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396252	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccc3ccc(=O)oc3c2)cc1)C(F)(F)F	InChI=1S/C23H23F3N2O6S/c24-23(25,26)22(32,10-12-35(28,33)11-9-18(27)21(30)31)17-6-3-14(4-7-17)16-2-1-15-5-8-20(29)34-19(15)13-16/h1-8,13,18,28,32H,9-12,27H2,(H,30,31)	AEJRMGUQFOCRPM-UHFFFAOYSA-N	790789	US20260034094, Compound 425	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790789&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396253	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-n2cccn2)cc1)C(F)(F)F	InChI=1S/C17H21F3N4O4S/c18-17(19,20)16(27,7-11-29(22,28)10-6-14(21)15(25)26)12-2-4-13(5-3-12)24-9-1-8-23-24/h1-5,8-9,14,22,27H,6-7,10-11,21H2,(H,25,26)	MCNAYLRJZOZPGJ-UHFFFAOYSA-N	790790	US20260034094, Compound 426	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790790&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396254	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cc1)C(F)(F)F	InChI=1S/C20H21Cl2F3N2O4S/c21-14-5-6-15(16(22)11-14)12-1-3-13(4-2-12)19(30,20(23,24)25)8-10-32(27,31)9-7-17(26)18(28)29/h1-6,11,17,27,30H,7-10,26H2,(H,28,29)	BOADPFSLHGINCN-UHFFFAOYSA-N	790791	US20260034094, Compound 427	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790791&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396255	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cc1)C(F)(F)F	InChI=1S/C20H21Cl2F3N2O4S/c21-14-5-6-15(16(22)11-14)12-1-3-13(4-2-12)19(30,20(23,24)25)8-10-32(27,31)9-7-17(26)18(28)29/h1-6,11,17,27,30H,7-10,26H2,(H,28,29)	BOADPFSLHGINCN-UHFFFAOYSA-N	790792	US20260034094, Compound 428	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790792&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396256	Cc1ccccc1-c1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H25F3N2O4S/c1-14-4-2-3-5-17(14)15-6-8-16(9-7-15)20(29,21(22,23)24)11-13-31(26,30)12-10-18(25)19(27)28/h2-9,18,26,29H,10-13,25H2,1H3,(H,27,28)	AWZRTTZZVNDGSV-UHFFFAOYSA-N	790793	US20260034094, Compound 429	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790793&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396257	Cc1cc(Cl)ccc1-c1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C21H24ClF3N2O4S/c1-13-12-16(22)6-7-17(13)14-2-4-15(5-3-14)20(30,21(23,24)25)9-11-32(27,31)10-8-18(26)19(28)29/h2-7,12,18,27,30H,8-11,26H2,1H3,(H,28,29)	OVCUKLDCFVHGEC-UHFFFAOYSA-N	790794	US20260034094, Compound 430	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790794&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396258	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2)cc1)C(F)(F)F	InChI=1S/C20H22ClF3N2O4S/c21-16-7-3-14(4-8-16)13-1-5-15(6-2-13)19(29,20(22,23)24)10-12-31(26,30)11-9-17(25)18(27)28/h1-8,17,26,29H,9-12,25H2,(H,27,28)	QKXLKAHECWYRET-UHFFFAOYSA-N	790795	US20260034094, Compound 431	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790795&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396259	Cc1ccc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(Cl)c1	InChI=1S/C21H24ClF3N2O4S/c1-13-2-7-16(17(22)12-13)14-3-5-15(6-4-14)20(30,21(23,24)25)9-11-32(27,31)10-8-18(26)19(28)29/h2-7,12,18,27,30H,8-11,26H2,1H3,(H,28,29)	PILKOGHMCKGTOR-UHFFFAOYSA-N	790796	US20260034094, Compound 432	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790796&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396260	Cn1ncc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)cc1=O	InChI=1S/C19H23F3N4O5S/c1-26-16(27)10-13(11-25-26)12-2-4-14(5-3-12)18(30,19(20,21)22)7-9-32(24,31)8-6-15(23)17(28)29/h2-5,10-11,15,24,30H,6-9,23H2,1H3,(H,28,29)	FPOUDDBJCBJXJB-UHFFFAOYSA-N	790797	US20260034094, Compound 433	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790797&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396261	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccccc2O)cc1)C(F)(F)F	InChI=1S/C20H23F3N2O5S/c21-20(22,23)19(29,10-12-31(25,30)11-9-16(24)18(27)28)14-7-5-13(6-8-14)15-3-1-2-4-17(15)26/h1-8,16,25-26,29H,9-12,24H2,(H,27,28)	UCQAMOFGGNTTLC-UHFFFAOYSA-N	790798	US20260034094, Compound 434	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790798&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396262	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1cccc(-c2ccccc2)c1)C(F)(F)F	InChI=1S/C20H23F3N2O4S/c21-20(22,23)19(28,10-12-30(25,29)11-9-17(24)18(26)27)16-8-4-7-15(13-16)14-5-2-1-3-6-14/h1-8,13,17,25,28H,9-12,24H2,(H,26,27)	VHTIOFJPVNZHPC-UHFFFAOYSA-N	790799	US20260034094, Compound 435	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790799&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396263	Cc1cc(F)ccc1-c1ccc(C(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)(C(F)(F)F)C(F)(F)F)cc1	InChI=1S/C22H23F7N2O3S/c1-13-12-16(23)6-7-17(13)14-2-4-15(5-3-14)20(21(24,25)26,22(27,28)29)9-11-35(31,34)10-8-18(30)19(32)33/h2-7,12,18,31H,8-11,30H2,1H3,(H,32,33)	REPASVSHXBKEOR-UHFFFAOYSA-N	790800	US20260034094, Compound 436	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790800&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396264	Cc1ccc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(F)c1	InChI=1S/C21H24F4N2O4S/c1-13-2-7-16(17(22)12-13)14-3-5-15(6-4-14)20(30,21(23,24)25)9-11-32(27,31)10-8-18(26)19(28)29/h2-7,12,18,27,30H,8-11,26H2,1H3,(H,28,29)	HRYCNJOWBNHSLW-UHFFFAOYSA-N	790801	US20260034094, Compound 437	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790801&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396265	Cc1ccc(-c2ccc(C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F)cc2)c(C)c1	InChI=1S/C22H27F3N2O4S/c1-14-3-8-18(15(2)13-14)16-4-6-17(7-5-16)21(30,22(23,24)25)10-12-32(27,31)11-9-19(26)20(28)29/h3-8,13,19,27,30H,9-12,26H2,1-2H3,(H,28,29)	HOGYBDUAJUIHRZ-UHFFFAOYSA-N	790802	US20260034094, Compound 438	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790802&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396266	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccc(C(F)(F)F)cc2C(F)(F)F)cc1)C(F)(F)F	InChI=1S/C22H21F9N2O4S/c23-20(24,25)14-5-6-15(16(11-14)21(26,27)28)12-1-3-13(4-2-12)19(36,22(29,30)31)8-10-38(33,37)9-7-17(32)18(34)35/h1-6,11,17,33,36H,7-10,32H2,(H,34,35)	JCBXVNNHIAAILB-UHFFFAOYSA-N	790803	US20260034094, Compound 439	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790803&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396267	COc1cc(OC(F)(F)F)ccc1-c1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C22H24F6N2O6S/c1-35-18-12-15(36-22(26,27)28)6-7-16(18)13-2-4-14(5-3-13)20(33,21(23,24)25)9-11-37(30,34)10-8-17(29)19(31)32/h2-7,12,17,30,33H,8-11,29H2,1H3,(H,31,32)	HNVVHOSELRWLST-UHFFFAOYSA-N	790804	US20260034094, Compound 440	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790804&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396268	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccc(C(F)(F)F)cc2Cl)cc1)C(F)(F)F	InChI=1S/C21H21ClF6N2O4S/c22-16-11-14(20(23,24)25)5-6-15(16)12-1-3-13(4-2-12)19(33,21(26,27)28)8-10-35(30,34)9-7-17(29)18(31)32/h1-6,11,17,30,33H,7-10,29H2,(H,31,32)	XLHNPJFSCJSEIS-UHFFFAOYSA-N	790805	US20260034094, Compound 441	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790805&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396269	CS(=O)(=O)c2ccc(c1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1)c(Cl)c2	InChI=1S/C21H24ClF3N2O6S2/c1-34(31,32)15-6-7-16(17(22)12-15)13-2-4-14(5-3-13)20(30,21(23,24)25)9-11-35(27,33)10-8-18(26)19(28)29/h2-7,12,18,27,30H,8-11,26H2,1H3,(H,28,29)	OVHGUEXCVOPFJV-UHFFFAOYSA-N	790806	US20260034094, Compound 442	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790806&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396270	Cc1cc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)ccc1-c1ccc(Cl)cc1Cl	InChI=1S/C21H23Cl2F3N2O4S/c1-12-10-13(2-4-15(12)16-5-3-14(22)11-17(16)23)20(31,21(24,25)26)7-9-33(28,32)8-6-18(27)19(29)30/h2-5,10-11,18,28,31H,6-9,27H2,1H3,(H,29,30)	KAFQLXFUGHJSHE-UHFFFAOYSA-N	790807	US20260034094, Compound 443	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790807&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396271	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2cccc3ccccc23)cc1)C(F)(F)F	InChI=1S/C24H25F3N2O4S/c25-24(26,27)23(32,13-15-34(29,33)14-12-21(28)22(30)31)18-10-8-17(9-11-18)20-7-3-5-16-4-1-2-6-19(16)20/h1-11,21,29,32H,12-15,28H2,(H,30,31)	RCZBWIHRRURAQI-UHFFFAOYSA-N	790808	US20260034094, Compound 444	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790808&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396272	CC(C)(C)c1nnc(-c2ccc(C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F)cc2)o1	InChI=1S/C20H27F3N4O5S/c1-18(2,3)17-27-26-15(32-17)12-4-6-13(7-5-12)19(30,20(21,22)23)9-11-33(25,31)10-8-14(24)16(28)29/h4-7,14,25,30H,8-11,24H2,1-3H3,(H,28,29)	AWKJKULNDVRBSN-UHFFFAOYSA-N	790809	US20260034094, Compound 445	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790809&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396273	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(NC(=O)c2ccsc2)cc1)C(F)(F)F	InChI=1S/C19H22F3N3O5S2/c20-19(21,22)18(29,7-10-32(24,30)9-6-15(23)17(27)28)13-1-3-14(4-2-13)25-16(26)12-5-8-31-11-12/h1-5,8,11,15,24,29H,6-7,9-10,23H2,(H,25,26)(H,27,28)	FAMWBOBFVLLXMU-UHFFFAOYSA-N	790810	US20260034094, Compound 446	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790810&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396274	Cc1cc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c(C)o1	InChI=1S/C20H25F3N2O5S/c1-12-11-16(13(2)30-12)14-3-5-15(6-4-14)19(28,20(21,22)23)8-10-31(25,29)9-7-17(24)18(26)27/h3-6,11,17,25,28H,7-10,24H2,1-2H3,(H,26,27)	PWZHYTVFAXJNLL-UHFFFAOYSA-N	790811	US20260034094, Compound 447	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790811&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396275	Cc1noc(C)c1-c1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C19H24F3N3O5S/c1-11-16(12(2)30-25-11)13-3-5-14(6-4-13)18(28,19(20,21)22)8-10-31(24,29)9-7-15(23)17(26)27/h3-6,15,24,28H,7-10,23H2,1-2H3,(H,26,27)	CJHFIVBJFZEWKH-UHFFFAOYSA-N	790812	US20260034094, Compound 448	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790812&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396276	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cc1OC(F)(F)F)C(F)(F)F	InChI=1S/C21H20Cl2F6N2O5S/c22-12-2-3-13(15(23)10-12)11-1-4-14(17(9-11)36-21(27,28)29)19(34,20(24,25)26)6-8-37(31,35)7-5-16(30)18(32)33/h1-4,9-10,16,31,34H,5-8,30H2,(H,32,33)	GKDJODFSRJOWKD-UHFFFAOYSA-N	790813	US20260034094, Compound 449	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790813&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396277	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cc1F)C(F)(F)F	InChI=1S/C20H20Cl2F4N2O4S/c21-12-2-3-13(15(22)10-12)11-1-4-14(16(23)9-11)19(31,20(24,25)26)6-8-33(28,32)7-5-17(27)18(29)30/h1-4,9-10,17,28,31H,5-8,27H2,(H,29,30)	HSLXTDDOJXADEO-UHFFFAOYSA-N	790814	US20260034094, Compound 450	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790814&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396278	CCOc1cccc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)c1	InChI=1S/C22H27F3N2O5S/c1-2-32-18-5-3-4-16(14-18)15-6-8-17(9-7-15)21(30,22(23,24)25)11-13-33(27,31)12-10-19(26)20(28)29/h3-9,14,19,27,30H,2,10-13,26H2,1H3,(H,28,29)	STZKSGUFADWWMK-UHFFFAOYSA-N	790815	US20260034094, Compound 451	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790815&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396279	Cc1ccc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2C#N)cc1	InChI=1S/C22H24F3N3O4S/c1-14-2-4-15(5-3-14)18-7-6-17(12-16(18)13-26)21(31,22(23,24)25)9-11-33(28,32)10-8-19(27)20(29)30/h2-7,12,19,28,31H,8-11,27H2,1H3,(H,29,30)	LULQTLUJNKSONE-UHFFFAOYSA-N	790816	US20260034094, Compound 452	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790816&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396280	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(O)c(F)c2)cc1)C(F)(F)F	InChI=1S/C20H22F4N2O5S/c21-15-11-13(3-6-17(15)27)12-1-4-14(5-2-12)19(30,20(22,23)24)8-10-32(26,31)9-7-16(25)18(28)29/h1-6,11,16,26-27,30H,7-10,25H2,(H,28,29)	YZFMJRDUZBHLIF-UHFFFAOYSA-N	790817	US20260034094, Compound 453	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790817&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396281	N#Cc1cc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)ccc1O	InChI=1S/C21H22F3N3O5S/c22-21(23,24)20(31,8-10-33(27,32)9-7-17(26)19(29)30)16-4-1-13(2-5-16)14-3-6-18(28)15(11-14)12-25/h1-6,11,17,27-28,31H,7-10,26H2,(H,29,30)	RIDYCVVFDDZRHV-UHFFFAOYSA-N	790818	US20260034094, Compound 454	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790818&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396282	Cc1cc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)ccc1-c1ccc(O)c(F)c1	InChI=1S/C21H24F4N2O5S/c1-12-10-14(3-4-15(12)13-2-5-18(28)16(22)11-13)20(31,21(23,24)25)7-9-33(27,32)8-6-17(26)19(29)30/h2-5,10-11,17,27-28,31H,6-9,26H2,1H3,(H,29,30)	ZTNUTCLOIHCFRF-UHFFFAOYSA-N	790819	US20260034094, Compound 455	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790819&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396283	CC(C)(C)c1cc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc2)ccc1O	InChI=1S/C24H31F3N2O5S/c1-22(2,3)18-14-16(6-9-20(18)30)15-4-7-17(8-5-15)23(33,24(25,26)27)11-13-35(29,34)12-10-19(28)21(31)32/h4-9,14,19,29-30,33H,10-13,28H2,1-3H3,(H,31,32)	WQTCVNMSLRWUPN-UHFFFAOYSA-N	790820	US20260034094, Compound 456	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790820&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396284	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(Cc2ccc(Cl)cc2Cl)cc1)C(F)(F)F	InChI=1S/C21H23Cl2F3N2O4S/c22-16-6-3-14(17(23)12-16)11-13-1-4-15(5-2-13)20(31,21(24,25)26)8-10-33(28,32)9-7-18(27)19(29)30/h1-6,12,18,28,31H,7-11,27H2,(H,29,30)	AGIDRMXCQPWAHX-UHFFFAOYSA-N	790821	US20260034094, Compound 457	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790821&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396285	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(OC(F)(F)F)cc2O)cc1)C(F)(F)F	InChI=1S/C21H22F6N2O6S/c22-20(23,24)19(33,8-10-36(29,34)9-7-16(28)18(31)32)13-3-1-12(2-4-13)15-6-5-14(11-17(15)30)35-21(25,26)27/h1-6,11,16,29-30,33H,7-10,28H2,(H,31,32)	HHLBAJORRCTFFP-UHFFFAOYSA-N	790822	US20260034094, Compound 458	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790822&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396286	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccccc2)cn1)C(F)(F)F	InChI=1S/C19H22F3N3O4S/c20-19(21,22)18(28,9-11-30(24,29)10-8-15(23)17(26)27)16-7-6-14(12-25-16)13-4-2-1-3-5-13/h1-7,12,15,24,28H,8-11,23H2,(H,26,27)	DQEVGEFUZZKQDN-UHFFFAOYSA-N	790823	US20260034094, Compound 459	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790823&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396287	NC(CC[S@SP3](=O)(=O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F)C(=O)O	InChI=1S/C19H19Cl2F3N2O5S/c20-12-2-3-13(14(21)9-12)11-1-4-16(26-10-11)18(29,19(22,23)24)6-8-32(30,31)7-5-15(25)17(27)28/h1-4,9-10,15,29H,5-8,25H2,(H,27,28)	WMEMSWGFKLQEMR-UHFFFAOYSA-N	790824	US20260034094, Compound 460	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790824&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396288	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(C2CCCC2)cn1)C(F)(F)F	InChI=1S/C18H26F3N3O4S/c19-18(20,21)17(27,8-10-29(23,28)9-7-14(22)16(25)26)15-6-5-13(11-24-15)12-3-1-2-4-12/h5-6,11-12,14,23,27H,1-4,7-10,22H2,(H,25,26)	ARZKEGYETVUZSY-UHFFFAOYSA-N	790825	US20260034094, Compound 461	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790825&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396289	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ncc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C18H19Cl2F3N4O4S/c19-11-1-2-12(13(20)7-11)10-8-26-16(27-9-10)17(30,18(21,22)23)4-6-32(25,31)5-3-14(24)15(28)29/h1-2,7-9,14,25,30H,3-6,24H2,(H,28,29)	BVTIAPXCNNIELB-UHFFFAOYSA-N	790826	US20260034094, Compound 462	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790826&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396290	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C19H20Cl2F3N3O4S/c20-12-2-3-13(14(21)9-12)11-1-4-16(27-10-11)18(30,19(22,23)24)6-8-32(26,31)7-5-15(25)17(28)29/h1-4,9-10,15,26,30H,5-8,25H2,(H,28,29)	FIDUUUFSAFSDLH-UHFFFAOYSA-N	790827	US20260034094, Compound 463	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790827&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396291	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C19H20Cl2F3N3O4S/c20-12-2-3-13(14(21)9-12)11-1-4-16(27-10-11)18(30,19(22,23)24)6-8-32(26,31)7-5-15(25)17(28)29/h1-4,9-10,15,26,30H,5-8,25H2,(H,28,29)	FIDUUUFSAFSDLH-UHFFFAOYSA-N	790828	US20260034094, Compound 464	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790828&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396292	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C19H20Cl2F3N3O4S/c20-12-2-3-13(14(21)9-12)11-1-4-16(27-10-11)18(30,19(22,23)24)6-8-32(26,31)7-5-15(25)17(28)29/h1-4,9-10,15,26,30H,5-8,25H2,(H,28,29)	FIDUUUFSAFSDLH-UHFFFAOYSA-N	790829	US20260034094, Compound 465	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790829&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396293	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C19H20Cl2F3N3O4S/c20-12-2-3-13(14(21)9-12)11-1-4-16(27-10-11)18(30,19(22,23)24)6-8-32(26,31)7-5-15(25)17(28)29/h1-4,9-10,15,26,30H,5-8,25H2,(H,28,29)	FIDUUUFSAFSDLH-UHFFFAOYSA-N	790830	US20260034094, Compound 466	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790830&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396294	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ncc(-c2ccccc2)cn1)C(F)(F)F	InChI=1S/C18H21F3N4O4S/c19-18(20,21)17(28,7-9-30(23,29)8-6-14(22)15(26)27)16-24-10-13(11-25-16)12-4-2-1-3-5-12/h1-5,10-11,14,23,28H,6-9,22H2,(H,26,27)	UUYJTXAOZBKHKJ-UHFFFAOYSA-N	790831	US20260034094, Compound 467	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790831&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396295	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ncc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F	InChI=1S/C18H19Cl2F3N4O4S/c19-11-1-2-12(13(20)7-11)10-8-26-16(27-9-10)17(30,18(21,22)23)4-6-32(25,31)5-3-14(24)15(28)29/h1-2,7-9,14,25,30H,3-6,24H2,(H,28,29)	BVTIAPXCNNIELB-UHFFFAOYSA-N	790832	US20260034094, Compound 468	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790832&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396296	N[C@@H](CCSCCC(O)(c1ncc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F)C(=O)O	InChI=1S/C18H18Cl2F3N3O3S/c19-11-1-2-12(13(20)7-11)10-8-25-16(26-9-10)17(29,18(21,22)23)4-6-30-5-3-14(24)15(27)28/h1-2,7-9,14,29H,3-6,24H2,(H,27,28)	PGEURRGUIOFBJL-UHFFFAOYSA-N	790833	US20260034094, Compound 469	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790833&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396297	N[C@@H](CCS(=O)(=O)CCC(O)(c1ncc(-c2ccc(Cl)cc2Cl)cn1)C(F)(F)F)C(=O)O	InChI=1S/C18H18Cl2F3N3O5S/c19-11-1-2-12(13(20)7-11)10-8-25-16(26-9-10)17(29,18(21,22)23)4-6-32(30,31)5-3-14(24)15(27)28/h1-2,7-9,14,29H,3-6,24H2,(H,27,28)	AFFLGWCJUUGGRW-UHFFFAOYSA-N	790834	US20260034094, Compound 470	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790834&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396298	Cc1ccccc1-c1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)nc1	InChI=1S/C20H24F3N3O4S/c1-13-4-2-3-5-15(13)14-6-7-17(26-12-14)19(29,20(21,22)23)9-11-31(25,30)10-8-16(24)18(27)28/h2-7,12,16,25,29H,8-11,24H2,1H3,(H,27,28)	CQULJZMWJHJEPR-UHFFFAOYSA-N	790835	US20260034094, Compound 471	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790835&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396299	Cn1cc(-c2ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)nc2)cn1	InChI=1S/C17H22F3N5O4S/c1-25-10-12(9-24-25)11-2-3-14(23-8-11)16(28,17(18,19)20)5-7-30(22,29)6-4-13(21)15(26)27/h2-3,8-10,13,22,28H,4-7,21H2,1H3,(H,26,27)	SMTVBAXAFIWSBE-UHFFFAOYSA-N	790836	US20260034094, Compound 472	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790836&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396300	Cc1cc(F)ccc1-c1cnc(C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F)nc1	InChI=1S/C19H22F4N4O4S/c1-11-8-13(20)2-3-14(11)12-9-26-17(27-10-12)18(30,19(21,22)23)5-7-32(25,31)6-4-15(24)16(28)29/h2-3,8-10,15,25,30H,4-7,24H2,1H3,(H,28,29)	CVTUWGQYOGMWLF-UHFFFAOYSA-N	790837	US20260034094, Compound 473	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790837&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396301	Cc1cc(Cl)ccc1-c1cnc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)nc1	InChI=1S/C19H22ClF3N4O4S/c1-11-8-13(20)2-3-14(11)12-9-26-17(27-10-12)18(30,19(21,22)23)5-7-32(25,31)6-4-15(24)16(28)29/h2-3,8-10,15,25,30H,4-7,24H2,1H3,(H,28,29)	LISJTAZHISVKEV-UHFFFAOYSA-N	790838	US20260034094, Compound 474	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790838&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396302	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(C2CC2)cn1)C(F)(F)F	InChI=1S/C16H22F3N3O4S/c17-16(18,19)15(25,13-4-3-11(9-22-13)10-1-2-10)6-8-27(21,26)7-5-12(20)14(23)24/h3-4,9-10,12,21,25H,1-2,5-8,20H2,(H,23,24)	LTBOVXXENHAOLV-UHFFFAOYSA-N	790839	US20260034094, Compound 475	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790839&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396303	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(C2CCCCC2)cn1)C(F)(F)F	InChI=1S/C19H28F3N3O4S/c20-19(21,22)18(28,9-11-30(24,29)10-8-15(23)17(26)27)16-7-6-14(12-25-16)13-4-2-1-3-5-13/h6-7,12-13,15,24,28H,1-5,8-11,23H2,(H,26,27)	IAWNZJIUPSQZES-UHFFFAOYSA-N	790840	US20260034094, Compound 476	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790840&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396304	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(-c2ccc(F)cc2F)cn1)C(F)(F)F	InChI=1S/C19H20F5N3O4S/c20-12-2-3-13(14(21)9-12)11-1-4-16(27-10-11)18(30,19(22,23)24)6-8-32(26,31)7-5-15(25)17(28)29/h1-4,9-10,15,26,30H,5-8,25H2,(H,28,29)	RKDASLYNHGDFLI-UHFFFAOYSA-N	790841	US20260034094, Compound 477	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790841&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396305	Cc1cc(Cl)ccc1-c1ccc(C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F)nc1	InChI=1S/C20H23ClF3N3O4S/c1-12-10-14(21)3-4-15(12)13-2-5-17(27-11-13)19(30,20(22,23)24)7-9-32(26,31)8-6-16(25)18(28)29/h2-5,10-11,16,26,30H,6-9,25H2,1H3,(H,28,29)	HWCZVNGISDZMJT-UHFFFAOYSA-N	790842	US20260034094, Compound 478	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790842&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396306	Cc1cc(F)ccc1-c1ccc(C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F)nc1	InChI=1S/C20H23F4N3O4S/c1-12-10-14(21)3-4-15(12)13-2-5-17(27-11-13)19(30,20(22,23)24)7-9-32(26,31)8-6-16(25)18(28)29/h2-5,10-11,16,26,30H,6-9,25H2,1H3,(H,28,29)	BTPNPCGKDMDIMD-UHFFFAOYSA-N	790843	US20260034094, Compound 479	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790843&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396307	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2cnco2)cn1)C(F)(F)F	InChI=1S/C16H19F3N4O5S/c17-16(18,19)15(26,4-6-29(21,27)5-3-11(20)14(24)25)13-2-1-10(7-23-13)12-8-22-9-28-12/h1-2,7-9,11,21,26H,3-6,20H2,(H,24,25)	OPWAPHBWQQVHGY-UHFFFAOYSA-N	790844	US20260034094, Compound 480	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790844&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396308	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(-c2ccco2)cn1)C(F)(F)F	InChI=1S/C17H20F3N3O5S/c18-17(19,20)16(26,6-9-29(22,27)8-5-12(21)15(24)25)14-4-3-11(10-23-14)13-2-1-7-28-13/h1-4,7,10,12,22,26H,5-6,8-9,21H2,(H,24,25)	YABKLVOCRJLBGW-UHFFFAOYSA-N	790845	US20260034094, Compound 481	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790845&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396309	CCCCS(=N)(=O)CC[C@H](N)C(=O)OCC	InChI=1S/C10H22N2O3S/c1-3-5-7-16(12,14)8-6-9(11)10(13)15-4-2/h9,12H,3-8,11H2,1-2H3	GGPNMSKUYXMFQZ-UHFFFAOYSA-N	790846	US20260034094, Compound 482	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790846&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396310	CCCCS(=N)(=O)CC[C@H](N)C(=O)OC(C)(C)C	InChI=1S/C12H26N2O3S/c1-5-6-8-18(14,16)9-7-10(13)11(15)17-12(2,3)4/h10,14H,5-9,13H2,1-4H3	NGXAGWIKSPTDIV-UHFFFAOYSA-N	790847	US20260034094, Compound 483	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790847&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396311	CCC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCCC(F)(F)F	InChI=1S/C13H25F3N2O3S/c1-4-12(2,3)21-11(19)10(17)6-9-22(18,20)8-5-7-13(14,15)16/h10,18H,4-9,17H2,1-3H3	DFAIFILZHPFCNY-UHFFFAOYSA-N	790848	US20260034094, Compound 484	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790848&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396312	CCCCOC(=O)C(N)CC[S@SP3](=N)(=O)CCC(O)(c1ccc(-c2ccc(Cl)cc2Cl)cc1)C(F)(F)F	InChI=1S/C24H29Cl2F3N2O4S/c1-2-3-12-35-22(32)21(30)10-13-36(31,34)14-11-23(33,24(27,28)29)17-6-4-16(5-7-17)19-9-8-18(25)15-20(19)26/h4-9,15,21,31,33H,2-3,10-14,30H2,1H3	RIASVGFVEZHSPP-UHFFFAOYSA-N	790849	US20260034094, Compound 485	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790849&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396313	CCOC(=O)C(N)CC[S@SP3](=N)(=O)CCC(O)C(F)(F)F	InChI=1S/C10H19F3N2O4S/c1-2-19-9(17)7(14)3-5-20(15,18)6-4-8(16)10(11,12)13/h7-8,15-16H,2-6,14H2,1H3	FSCQZXBKQBIJJQ-UHFFFAOYSA-N	790850	US20260034094, Compound 486	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790850&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396314	CCOC(=O)C(N)CC[S@SP3](=N)(=O)CCC(C)(O)C(F)(F)F	InChI=1S/C11H21F3N2O4S/c1-3-20-9(17)8(15)4-6-21(16,19)7-5-10(2,18)11(12,13)14/h8,16,18H,3-7,15H2,1-2H3	IJIZHGDDSDIKIH-UHFFFAOYSA-N	790851	US20260034094, Compound 487	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790851&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396315	CCOC(=O)[C@@H](N)CC[S@@](=N)(=O)CC[C@](O)(c1ccccc1)C(F)(F)F	InChI=1S/C16H23F3N2O4S/c1-2-25-14(22)13(20)8-10-26(21,24)11-9-15(23,16(17,18)19)12-6-4-3-5-7-12/h3-7,13,21,23H,2,8-11,20H2,1H3	GQOAOYPMGUKSBF-UHFFFAOYSA-N	790852	US20260034094, Compound 488	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790852&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396316	CC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCC(O)C(F)(F)F	InChI=1S/C12H23F3N2O4S/c1-11(2,3)21-10(19)8(16)4-6-22(17,20)7-5-9(18)12(13,14)15/h8-9,17-18H,4-7,16H2,1-3H3	UCVAJJVTOGNSNN-UHFFFAOYSA-N	790853	US20260034094, Compound 489	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790853&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396317	CC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCC(O)C(F)(F)F	InChI=1S/C12H23F3N2O4S/c1-11(2,3)21-10(19)8(16)4-6-22(17,20)7-5-9(18)12(13,14)15/h8-9,17-18H,4-7,16H2,1-3H3	UCVAJJVTOGNSNN-UHFFFAOYSA-N	790854	US20260034094, Compound 490	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790854&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396318	CC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCC(O)C(F)(F)F	InChI=1S/C12H23F3N2O4S/c1-11(2,3)21-10(19)8(16)4-6-22(17,20)7-5-9(18)12(13,14)15/h8-9,17-18H,4-7,16H2,1-3H3	UCVAJJVTOGNSNN-UHFFFAOYSA-N	790855	US20260034094, Compound 491	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790855&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396319	CC(C)(C)OC(=O)C(N)CC[S@SP3](=N)(=O)CCC(O)C(F)(F)F	InChI=1S/C12H23F3N2O4S/c1-11(2,3)21-10(19)8(16)4-6-22(17,20)7-5-9(18)12(13,14)15/h8-9,17-18H,4-7,16H2,1-3H3	UCVAJJVTOGNSNN-UHFFFAOYSA-N	790856	US20260034094, Compound 492	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790856&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396320	C#CCNC(=O)[C@@H](N)CCS(=N)(=O)CCCC	InChI=1S/C11H21N3O2S/c1-3-5-8-17(13,16)9-6-10(12)11(15)14-7-4-2/h2,10,13H,3,5-9,12H2,1H3,(H,14,15)	CVKIVUWURRHRGV-UHFFFAOYSA-N	790857	US20260034094, Compound 493	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790857&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396321	CCC(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ccc(-c2ccc(Cl)cc2Cl)cc1	InChI=1S/C21H26Cl2N2O4S/c1-2-21(28,10-12-30(25,29)11-9-19(24)20(26)27)15-5-3-14(4-6-15)17-8-7-16(22)13-18(17)23/h3-8,13,19,25,28H,2,9-12,24H2,1H3,(H,26,27)	CHXMDPJCEYORFJ-UHFFFAOYSA-N	790858	US20260034094, Compound 494	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790858&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396322	CC/C(=CCS(=N)(=O)CC[C@H](N)C(=O)O)c1ccc(-c2ccc(Cl)cc2Cl)cc1	InChI=1S/C21H24Cl2N2O3S/c1-2-14(9-11-29(25,28)12-10-20(24)21(26)27)15-3-5-16(6-4-15)18-8-7-17(22)13-19(18)23/h3-9,13,20,25H,2,10-12,24H2,1H3,(H,26,27)	LWVVLZQYQZHVFR-UHFFFAOYSA-N	790859	US20260034094, Compound 495	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790859&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396323	NC1CC[S@TB6](=O)(CCC(O)C(F)(F)F)=NC1=O	InChI=1S/C8H13F3N2O3S/c9-8(10,11)6(14)2-4-17(16)3-1-5(12)7(15)13-17/h5-6,14H,1-4,12H2	MNBKPCNXCIECPF-UHFFFAOYSA-N	790860	US20260034094, Compound 496	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790860&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396324	CC(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C1CCC1	InChI=1S/C12H24N2O4S/c1-12(17,9-3-2-4-9)6-8-19(14,18)7-5-10(13)11(15)16/h9-10,14,17H,2-8,13H2,1H3,(H,15,16)	TWABXTBCHPSVNC-UHFFFAOYSA-N	790861	US20260034094, Compound 497	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790861&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396325	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(c2ncc(-c3ccc(Cl)cc3Cl)cn2)CCC1	InChI=1S/C20H24Cl2N4O3S/c21-14-2-3-15(16(22)10-14)13-11-25-19(26-12-13)20(5-1-6-20)7-9-30(24,29)8-4-17(23)18(27)28/h2-3,10-12,17,24H,1,4-9,23H2,(H,27,28)	IYHRGDIKPQMAMX-UHFFFAOYSA-N	790862	US20260034094, Compound 498	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790862&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396326	N=S(=O)(CCC(c1ccc(S(=O)(=O)Nc2ccccc2)cc1)C(F)(F)F)CC[C@H](N)C(=O)O	InChI=1S/C20H24F3N3O5S2/c21-20(22,23)17(10-12-32(25,29)13-11-18(24)19(27)28)14-6-8-16(9-7-14)33(30,31)26-15-4-2-1-3-5-15/h1-9,17-18,25-26H,10-13,24H2,(H,27,28)	QRTKMNICPJQWMC-UHFFFAOYSA-N	790863	US20260034094, Compound 499	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790863&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396327	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC12CC(c3ccc(C(F)(F)F)cc3)(C1)C2(F)F	InChI=1S/C18H21F5N2O3S/c19-17(20,21)12-3-1-11(2-4-12)16-9-15(10-16,18(16,22)23)6-8-29(25,28)7-5-13(24)14(26)27/h1-4,13,25H,5-10,24H2,(H,26,27)	XQSQMHSJYXUUKC-UHFFFAOYSA-N	790864	US20260034094, Compound 500	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790864&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396328	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1ccc(Oc2ccc3ccc(=O)oc3c2)cc1)C(F)(F)F	InChI=1S/C23H23F3N2O7S/c24-23(25,26)22(32,10-12-36(28,33)11-9-18(27)21(30)31)15-3-6-16(7-4-15)34-17-5-1-14-2-8-20(29)35-19(14)13-17/h1-8,13,18,28,32H,9-12,27H2,(H,30,31)	VNACOCPONCXDGF-UHFFFAOYSA-N	790865	US20260034094, Compound 501	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790865&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396329	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(c1nc2ccccc2o1)C(F)(F)F	InChI=1S/C15H18F3N3O5S/c16-15(17,18)14(24,13-21-10-3-1-2-4-11(10)26-13)6-8-27(20,25)7-5-9(19)12(22)23/h1-4,9,20,24H,5-8,19H2,(H,22,23)	WVSBURSBFSMLPH-UHFFFAOYSA-N	790866	US20260034094, Compound 502	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790866&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396330	N=S(=O)(CC[C@H](N)C(=O)O)CCC(O)(C1[C@@H](c2ccccc2)[C@H]1c1ccccc1)C(F)(F)F	InChI=1S/C23H27F3N2O4S/c24-23(25,26)22(31,12-14-33(28,32)13-11-17(27)21(29)30)20-18(15-7-3-1-4-8-15)19(20)16-9-5-2-6-10-16/h1-10,17-20,28,31H,11-14,27H2,(H,29,30)	IUUQGHSRBNZBNY-UHFFFAOYSA-N	790867	US20260034094, Compound 503	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790867&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396331	CC(=O)N(c1ccc(C(O)(CC[S@SP3](=N)(=O)CCC(N)C(=O)O)C(F)(F)F)cc1)c1nccs1	InChI=1S/C19H23F3N4O5S2/c1-12(27)26(17-25-8-9-32-17)14-4-2-13(3-5-14)18(30,19(20,21)22)7-11-33(24,31)10-6-15(23)16(28)29/h2-5,8-9,15,24,30H,6-7,10-11,23H2,1H3,(H,28,29)	XHNSYGCNQLIRCP-UHFFFAOYSA-N	790868	US20260034094, Compound 504	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790868&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396332	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(Nc2nccs2)cc1)C(F)(F)F	InChI=1S/C17H21F3N4O4S2/c18-17(19,20)16(27,6-10-30(22,28)9-5-13(21)14(25)26)11-1-3-12(4-2-11)24-15-23-7-8-29-15/h1-4,7-8,13,22,27H,5-6,9-10,21H2,(H,23,24)(H,25,26)	IEHDMENRCURUKF-UHFFFAOYSA-N	790869	US20260034094, Compound 505	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790869&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396333	CC(=O)Nc1ccc(C(O)(CCS(=N)(=O)CC[C@H](N)C(=O)O)C(F)(F)F)cc1	InChI=1S/C16H22F3N3O5S/c1-10(23)22-12-4-2-11(3-5-12)15(26,16(17,18)19)7-9-28(21,27)8-6-13(20)14(24)25/h2-5,13,21,26H,6-9,20H2,1H3,(H,22,23)(H,24,25)	HTWRFOJMNYATQH-UHFFFAOYSA-N	790870	US20260034094, Compound 506	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790870&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396334	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(O)(c1ccc(N[S@SP3](=O)(=O)c2ccccc2)cc1)C(F)(F)F	InChI=1S/C20H24F3N3O6S2/c21-20(22,23)19(29,11-13-33(25,30)12-10-17(24)18(27)28)14-6-8-15(9-7-14)26-34(31,32)16-4-2-1-3-5-16/h1-9,17,25-26,29H,10-13,24H2,(H,27,28)	VOVNVBOFJCVANL-UHFFFAOYSA-N	790871	US20260034094, Compound 507	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790871&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396335	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(c1ccccc1)(C(F)(F)F)C(F)(F)F	InChI=1S/C15H18F6N2O3S/c16-14(17,18)13(15(19,20)21,10-4-2-1-3-5-10)7-9-27(23,26)8-6-11(22)12(24)25/h1-5,11,23H,6-9,22H2,(H,24,25)	IPPZWLGEHIPYAV-UHFFFAOYSA-N	790872	US20260034094, Compound 508	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790872&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396336	N=[S@SP2](=O)(CCC(N)C(=O)O)CCC(c1ccc(-c2ccccc2)cc1)(C(F)(F)F)C(F)(F)F	InChI=1S/C21H22F6N2O3S/c22-20(23,24)19(21(25,26)27,11-13-33(29,32)12-10-17(28)18(30)31)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17,29H,10-13,28H2,(H,30,31)	CZLRUWYJFHBUMZ-UHFFFAOYSA-N	790873	US20260034094, Compound 509	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790873&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396337	N=S(=O)(CC[C@H](N)C(=O)O)CCC(c1ccc(-c2ccc(Cl)cc2Cl)cc1)(C(F)(F)F)C(F)(F)F	InChI=1S/C21H20Cl2F6N2O3S/c22-14-5-6-15(16(23)11-14)12-1-3-13(4-2-12)19(20(24,25)26,21(27,28)29)8-10-35(31,34)9-7-17(30)18(32)33/h1-6,11,17,31H,7-10,30H2,(H,32,33)	VAKKEUAIXQKABF-UHFFFAOYSA-N	790874	US20260034094, Compound 510	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790874&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396338	N=S(=O)(CC[C@H](N)C(=O)O)CCC1(C(F)(F)F)OCc2ccccc21	InChI=1S/C15H19F3N2O4S/c16-15(17,18)14(11-4-2-1-3-10(11)9-24-14)6-8-25(20,23)7-5-12(19)13(21)22/h1-4,12,20H,5-9,19H2,(H,21,22)	QXFZDJOKCZMCIW-UHFFFAOYSA-N	790875	US20260034094, Compound 511	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790875&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396339	N[C@@H](CCS(=O)(=O)CCC1(C(F)(F)F)OC(=O)c2ccccc21)C(=O)O	InChI=1S/C15H16F3NO6S/c16-15(17,18)14(10-4-2-1-3-9(10)13(22)25-14)6-8-26(23,24)7-5-11(19)12(20)21/h1-4,11H,5-8,19H2,(H,20,21)	RATKQJUJLWDZSF-UHFFFAOYSA-N	790876	US20260034094, Compound 512	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790876&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396340	CC(O)(CCS(=O)(=O)CC[C@H](N)C(=O)O)c1ccc(-c2ccc(Cl)cc2Cl)cn1	InChI=1S/C19H22Cl2N2O5S/c1-19(26,7-9-29(27,28)8-6-16(22)18(24)25)17-5-2-12(11-23-17)14-4-3-13(20)10-15(14)21/h2-5,10-11,16,26H,6-9,22H2,1H3,(H,24,25)	OHGNXDLXAUCTJZ-UHFFFAOYSA-N	790877	US20260034094, Compound 513	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790877&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396341	CC(O)(CCS(=O)(=O)CC[C@H](N)C(=O)O)c1ccc(-c2ccccc2)cn1	InChI=1S/C19H24N2O5S/c1-19(24,10-12-27(25,26)11-9-16(20)18(22)23)17-8-7-15(13-21-17)14-5-3-2-4-6-14/h2-8,13,16,24H,9-12,20H2,1H3,(H,22,23)	AEZGEPZISLQBRP-UHFFFAOYSA-N	790878	US20260034094, Compound 514	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		 1010000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790878&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396342	N=[S@@](=O)(CC[C@H](N)C(=O)O)CCC1(CO)CCC1	InChI=1S/C11H22N2O4S/c12-9(10(15)16)2-6-18(13,17)7-5-11(8-14)3-1-4-11/h9,13-14H,1-8,12H2,(H,15,16)	MWUUBTCNCBRGRN-UHFFFAOYSA-N	790879	US20260034094, Compound 515	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		<20000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=790879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=790879&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
396343	N[C@@H](CCS(=O)(=O)CCC(O)C(F)(F)F)C(=O)O	InChI=1S/C8H14F3NO5S/c9-8(10,11)6(13)2-4-18(16,17)3-1-5(12)7(14)15/h5-6,13H,1-4,12H2,(H,14,15)	VLKHCCGSKUROME-UHFFFAOYSA-N	791603	US20260034094, Compound 516	Glutamate--cysteine ligase catalytic subunit	Homo sapiens		>2000000							US Patent		10.7270/Q21Z497Z		aid1802770	US20260034094	Furst, L; Eaton, JR., JK; Hynes, JR., J; Sistla, RK; Yan, L	2/5/2026	6/18/2026	Kojin Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001646&target=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791603&enzyme=Glutamate--cysteine+ligase+catalytic+subunit&column=ki&startPg=0&Increment=50&submit=Search											1	MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN		Glutamate--cysteine ligase catalytic subunit	GSH1_HUMAN	P48506	Q14399