BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
557559	O=C(c1c(O)cc(O)cc1OCc2ncccn2)N3CCCC3	InChI=1S/C16H17N3O4/c20-11-8-12(21)15(16(22)19-6-1-2-7-19)13(9-11)23-10-14-17-4-3-5-18-14/h3-5,8-9,20-21H,1-2,6-7,10H2	IJVNUJLALBRYGV-UHFFFAOYSA-N	792780	[2,4-dihydroxy-6-(pyrimidin-2-ylmethoxy)phenyl]-pyrrolidin-1-yl-methanone::US12552758, Example 1	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792780&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159550	528824296							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557561	O=C(c1c(O)cc(O)cc1OCc2ncccn2)N3CCCC3	InChI=1S/C16H17N3O4/c20-11-8-12(21)15(16(22)19-6-1-2-7-19)13(9-11)23-10-14-17-4-3-5-18-14/h3-5,8-9,20-21H,1-2,6-7,10H2	IJVNUJLALBRYGV-UHFFFAOYSA-N	792780	[2,4-dihydroxy-6-(pyrimidin-2-ylmethoxy)phenyl]-pyrrolidin-1-yl-methanone::US12552758, Example 1	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792780&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159550	528824296							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557563	O=C(c1c(O)cc(O)cc1OC2CCCC2)N3CCCC3	InChI=1S/C16H21NO4/c18-11-9-13(19)15(16(20)17-7-3-4-8-17)14(10-11)21-12-5-1-2-6-12/h9-10,12,18-19H,1-8H2	KCCWUSRTNPVXCA-UHFFFAOYSA-N	792782	[2-(cyclopentoxy)-4,6-dihydroxy-phenyl]-pyrrolidin-1-yl-methanone::US12552758, Example 2	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792782&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			163702368	528824298							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557565	O=C(c1c(O)cc(O)cc1OC2CCCC2)N3CCCC3	InChI=1S/C16H21NO4/c18-11-9-13(19)15(16(20)17-7-3-4-8-17)14(10-11)21-12-5-1-2-6-12/h9-10,12,18-19H,1-8H2	KCCWUSRTNPVXCA-UHFFFAOYSA-N	792782	[2-(cyclopentoxy)-4,6-dihydroxy-phenyl]-pyrrolidin-1-yl-methanone::US12552758, Example 2	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792782&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			163702368	528824298							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557567	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCCC1	InChI=1S/C18H19NO4/c20-14-10-15(21)17(18(22)19-8-4-5-9-19)16(11-14)23-12-13-6-2-1-3-7-13/h1-3,6-7,10-11,20-21H,4-5,8-9,12H2	ZZWWPFCVDODIJK-UHFFFAOYSA-N	792784	(2-benzyloxy- 4,6-dihydroxy- phenyl)- pyrrolidin-1-yl- methanone::US12552758, Example 3	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792784&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159498	528824300							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557569	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCCC1	InChI=1S/C18H19NO4/c20-14-10-15(21)17(18(22)19-8-4-5-9-19)16(11-14)23-12-13-6-2-1-3-7-13/h1-3,6-7,10-11,20-21H,4-5,8-9,12H2	ZZWWPFCVDODIJK-UHFFFAOYSA-N	792784	(2-benzyloxy- 4,6-dihydroxy- phenyl)- pyrrolidin-1-yl- methanone::US12552758, Example 3	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792784&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159498	528824300							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557571	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1Cc2ccccc2C1	InChI=1S/C22H19NO4/c24-18-10-19(25)21(20(11-18)27-14-15-6-2-1-3-7-15)22(26)23-12-16-8-4-5-9-17(16)13-23/h1-11,24-25H,12-14H2	ILJZCWWJYXSPTG-UHFFFAOYSA-N	792785	(2-benzyloxy- 4,6-dihydroxy- phenyl)- isoindolin-2-yl- methanone::US12552758, Example 4	DNA mismatch repair protein Mlh1			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792785&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159512	528824301							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557573	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1Cc2ccccc2C1	InChI=1S/C22H19NO4/c24-18-10-19(25)21(20(11-18)27-14-15-6-2-1-3-7-15)22(26)23-12-16-8-4-5-9-17(16)13-23/h1-11,24-25H,12-14H2	ILJZCWWJYXSPTG-UHFFFAOYSA-N	792785	(2-benzyloxy- 4,6-dihydroxy- phenyl)- isoindolin-2-yl- methanone::US12552758, Example 4	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792785&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159512	528824301							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557575	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCCCC1	InChI=1S/C19H21NO4/c21-15-11-16(22)18(19(23)20-9-5-2-6-10-20)17(12-15)24-13-14-7-3-1-4-8-14/h1,3-4,7-8,11-12,21-22H,2,5-6,9-10,13H2	ZOBPLQIWHWJLOO-UHFFFAOYSA-N	792786	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(1- piperidyl) methanone::US12552758, Example 5	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792786&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159528	528824302							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557577	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCCCC1	InChI=1S/C19H21NO4/c21-15-11-16(22)18(19(23)20-9-5-2-6-10-20)17(12-15)24-13-14-7-3-1-4-8-14/h1,3-4,7-8,11-12,21-22H,2,5-6,9-10,13H2	ZOBPLQIWHWJLOO-UHFFFAOYSA-N	792786	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(1- piperidyl) methanone::US12552758, Example 5	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792786&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159528	528824302							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557579	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CC[C@H](O)C1	InChI=1S/C18H19NO5/c20-13-6-7-19(10-13)18(23)17-15(22)8-14(21)9-16(17)24-11-12-4-2-1-3-5-12/h1-5,8-9,13,20-22H,6-7,10-11H2	DHYYYNSVEINJNZ-UHFFFAOYSA-N	792787	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3S)-3- hydroxypyrrolidin- 1-yl]methanone::US12552758, Example 6	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792787&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159434	528824303							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557581	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CC[C@H](O)C1	InChI=1S/C18H19NO5/c20-13-6-7-19(10-13)18(23)17-15(22)8-14(21)9-16(17)24-11-12-4-2-1-3-5-12/h1-5,8-9,13,20-22H,6-7,10-11H2	DHYYYNSVEINJNZ-UHFFFAOYSA-N	792787	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3S)-3- hydroxypyrrolidin- 1-yl]methanone::US12552758, Example 6	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792787&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159434	528824303							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557583	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CC[C@@H](O)C1	InChI=1S/C18H19NO5/c20-13-6-7-19(10-13)18(23)17-15(22)8-14(21)9-16(17)24-11-12-4-2-1-3-5-12/h1-5,8-9,13,20-22H,6-7,10-11H2	DHYYYNSVEINJNZ-UHFFFAOYSA-N	792788	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3R)-3- hydroxypyrrolidin- 1-yl]methanone::US12552758, Example 7	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792788&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159547	528824304							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557585	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CC[C@@H](O)C1	InChI=1S/C18H19NO5/c20-13-6-7-19(10-13)18(23)17-15(22)8-14(21)9-16(17)24-11-12-4-2-1-3-5-12/h1-5,8-9,13,20-22H,6-7,10-11H2	DHYYYNSVEINJNZ-UHFFFAOYSA-N	792788	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3R)-3- hydroxypyrrolidin- 1-yl]methanone::US12552758, Example 7	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792788&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159547	528824304							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557587	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCC[C@@H](O)C1	InChI=1S/C19H21NO5/c21-14-7-4-8-20(11-14)19(24)18-16(23)9-15(22)10-17(18)25-12-13-5-2-1-3-6-13/h1-3,5-6,9-10,14,21-23H,4,7-8,11-12H2	FHEICJYTFPKXOS-UHFFFAOYSA-N	792789	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3R)-3- hydroxy-1- piperidyl] methanone::US12552758, Example 8	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792789&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159505	528824305							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557589	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCC[C@@H](O)C1	InChI=1S/C19H21NO5/c21-14-7-4-8-20(11-14)19(24)18-16(23)9-15(22)10-17(18)25-12-13-5-2-1-3-6-13/h1-3,5-6,9-10,14,21-23H,4,7-8,11-12H2	FHEICJYTFPKXOS-UHFFFAOYSA-N	792789	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3R)-3- hydroxy-1- piperidyl] methanone::US12552758, Example 8	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792789&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159505	528824305							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557591	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCC[C@H](O)C1	InChI=1S/C19H21NO5/c21-14-7-4-8-20(11-14)19(24)18-16(23)9-15(22)10-17(18)25-12-13-5-2-1-3-6-13/h1-3,5-6,9-10,14,21-23H,4,7-8,11-12H2	FHEICJYTFPKXOS-UHFFFAOYSA-N	792790	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3S)-3- hydroxy-1- piperidyl] methanone::US12552758, Example 9	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792790&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159508	528824306							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557593	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCC[C@H](O)C1	InChI=1S/C19H21NO5/c21-14-7-4-8-20(11-14)19(24)18-16(23)9-15(22)10-17(18)25-12-13-5-2-1-3-6-13/h1-3,5-6,9-10,14,21-23H,4,7-8,11-12H2	FHEICJYTFPKXOS-UHFFFAOYSA-N	792790	(2-benzyloxy- 4,6-dihydroxy- phenyl)-[(3S)-3- hydroxy-1- piperidyl] methanone::US12552758, Example 9	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792790&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159508	528824306							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557595	Cc1c(O)cc(O)c(C(=O)N2CCCC2)c1OCc1ccccc1	InChI=1S/C19H21NO4/c1-13-15(21)11-16(22)17(19(23)20-9-5-6-10-20)18(13)24-12-14-7-3-2-4-8-14/h2-4,7-8,11,21-22H,5-6,9-10,12H2,1H3	NBQGAVWHWPAPGQ-UHFFFAOYSA-N	792791	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- pyrrolidin-1-yl- methanone::US12552758, Example 10	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792791&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159524	528824307							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
557597	Cc1c(O)cc(O)c(C(=O)N2CCCC2)c1OCc1ccccc1	InChI=1S/C19H21NO4/c1-13-15(21)11-16(22)17(19(23)20-9-5-6-10-20)18(13)24-12-14-7-3-2-4-8-14/h2-4,7-8,11,21-22H,5-6,9-10,12H2,1H3	NBQGAVWHWPAPGQ-UHFFFAOYSA-N	792791	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- pyrrolidin-1-yl- methanone::US12552758, Example 10	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792791&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159524	528824307							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558144	CCc1c(O)cc(O)c(C(=O)N2CCCC2)c1OCc1ccccc1	InChI=1S/C20H23NO4/c1-2-15-16(22)12-17(23)18(20(24)21-10-6-7-11-21)19(15)25-13-14-8-4-3-5-9-14/h3-5,8-9,12,22-23H,2,6-7,10-11,13H2,1H3	QENCOSSGOMDQHB-UHFFFAOYSA-N	792792	(2-benzyloxy-3- ethyl-4,6- dihydroxy- phenyl)- pyrrolidin-1-yl- methanone::US12552758, Example 11	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792792&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159445	528824308							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558146	CCc1c(O)cc(O)c(C(=O)N2CCCC2)c1OCc1ccccc1	InChI=1S/C20H23NO4/c1-2-15-16(22)12-17(23)18(20(24)21-10-6-7-11-21)19(15)25-13-14-8-4-3-5-9-14/h3-5,8-9,12,22-23H,2,6-7,10-11,13H2,1H3	QENCOSSGOMDQHB-UHFFFAOYSA-N	792792	(2-benzyloxy-3- ethyl-4,6- dihydroxy- phenyl)- pyrrolidin-1-yl- methanone::US12552758, Example 11	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792792&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159445	528824308							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558148	O=C(c1c(O)cc(O)cc1OCc1ccccn1)N1CCCC1	InChI=1S/C17H18N2O4/c20-13-9-14(21)16(17(22)19-7-3-4-8-19)15(10-13)23-11-12-5-1-2-6-18-12/h1-2,5-6,9-10,20-21H,3-4,7-8,11H2	YEGGNTJLXWGYCT-UHFFFAOYSA-N	792793	[2,4-dihydroxy- 6-(2- pyridylmethoxy) phenyl]- pyrrolidin-1-yl- methanone::US12552758, Example 12	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792793&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159439	528824309							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558150	O=C(c1c(O)cc(O)cc1OCc1ccccn1)N1CCCC1	InChI=1S/C17H18N2O4/c20-13-9-14(21)16(17(22)19-7-3-4-8-19)15(10-13)23-11-12-5-1-2-6-18-12/h1-2,5-6,9-10,20-21H,3-4,7-8,11H2	YEGGNTJLXWGYCT-UHFFFAOYSA-N	792793	[2,4-dihydroxy- 6-(2- pyridylmethoxy) phenyl]- pyrrolidin-1-yl- methanone::US12552758, Example 12	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792793&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159439	528824309							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558152	CC(Oc1cc(O)cc(O)c1C(=O)N1CCCC1)c1ccccc1	InChI=1S/C19H21NO4/c1-13(14-7-3-2-4-8-14)24-17-12-15(21)11-16(22)18(17)19(23)20-9-5-6-10-20/h2-4,7-8,11-13,21-22H,5-6,9-10H2,1H3	JMPGPZJRIWWHGI-UHFFFAOYSA-N	792794	[2,4-dihydroxy- 6-1- phenylethoxy] phenyl]-pyrrolidin- 1-yl-methanone ISOMER 1::US12552758, Example 13	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792794&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			169917382	528824310							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558154	CC(Oc1cc(O)cc(O)c1C(=O)N1CCCC1)c1ccccc1	InChI=1S/C19H21NO4/c1-13(14-7-3-2-4-8-14)24-17-12-15(21)11-16(22)18(17)19(23)20-9-5-6-10-20/h2-4,7-8,11-13,21-22H,5-6,9-10H2,1H3	JMPGPZJRIWWHGI-UHFFFAOYSA-N	792794	[2,4-dihydroxy- 6-1- phenylethoxy] phenyl]-pyrrolidin- 1-yl-methanone ISOMER 1::US12552758, Example 13	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792794&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			169917382	528824310							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558156	CC(Oc1cc(O)cc(O)c1C(=O)N1CCCC1)c1ccccc1	InChI=1S/C19H21NO4/c1-13(14-7-3-2-4-8-14)24-17-12-15(21)11-16(22)18(17)19(23)20-9-5-6-10-20/h2-4,7-8,11-13,21-22H,5-6,9-10H2,1H3	JMPGPZJRIWWHGI-UHFFFAOYSA-N	792795	[2,4-dihydroxy- 6-1- phenylethoxy] phenyl]-pyrrolidin- 1-yl-methanone ISOMER 2::US12552758, Example 14	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792795&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			169917382	528824311							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558158	CC(Oc1cc(O)cc(O)c1C(=O)N1CCCC1)c1ccccc1	InChI=1S/C19H21NO4/c1-13(14-7-3-2-4-8-14)24-17-12-15(21)11-16(22)18(17)19(23)20-9-5-6-10-20/h2-4,7-8,11-13,21-22H,5-6,9-10H2,1H3	JMPGPZJRIWWHGI-UHFFFAOYSA-N	792795	[2,4-dihydroxy- 6-1- phenylethoxy] phenyl]-pyrrolidin- 1-yl-methanone ISOMER 2::US12552758, Example 14	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792795&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			169917382	528824311							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558160	O=C(c1c(O)cc(O)cc1OCc1ccc(F)cc1)N1CCCC1	InChI=1S/C18H18FNO4/c19-13-5-3-12(4-6-13)11-24-16-10-14(21)9-15(22)17(16)18(23)20-7-1-2-8-20/h3-6,9-10,21-22H,1-2,7-8,11H2	CTVVHAMBNYMSRX-UHFFFAOYSA-N	792796	[2-[(4- fluorophenyl) methoxy]-4,6- dihydroxy- phenyl]- pyrrolidin-1-yl- methanone::US12552758, Example 15	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792796&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159536	528824312							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558162	O=C(c1c(O)cc(O)cc1OCc1ccc(F)cc1)N1CCCC1	InChI=1S/C18H18FNO4/c19-13-5-3-12(4-6-13)11-24-16-10-14(21)9-15(22)17(16)18(23)20-7-1-2-8-20/h3-6,9-10,21-22H,1-2,7-8,11H2	CTVVHAMBNYMSRX-UHFFFAOYSA-N	792796	[2-[(4- fluorophenyl) methoxy]-4,6- dihydroxy- phenyl]- pyrrolidin-1-yl- methanone::US12552758, Example 15	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792796&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159536	528824312							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558164	COc1ccc(COc2cc(O)cc(O)c2C(=O)N2CCCC2)cc1	InChI=1S/C19H21NO5/c1-24-15-6-4-13(5-7-15)12-25-17-11-14(21)10-16(22)18(17)19(23)20-8-2-3-9-20/h4-7,10-11,21-22H,2-3,8-9,12H2,1H3	MMVACNPKKNOSQR-UHFFFAOYSA-N	792797	[2,4-dihydroxy- 6-[(4- methoxyphenyl) methoxy]phenyl]- pyrrolidin-1-yl- methanone::US12552758, Example 16	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792797&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159544	528824313							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558166	COc1ccc(COc2cc(O)cc(O)c2C(=O)N2CCCC2)cc1	InChI=1S/C19H21NO5/c1-24-15-6-4-13(5-7-15)12-25-17-11-14(21)10-16(22)18(17)19(23)20-8-2-3-9-20/h4-7,10-11,21-22H,2-3,8-9,12H2,1H3	MMVACNPKKNOSQR-UHFFFAOYSA-N	792797	[2,4-dihydroxy- 6-[(4- methoxyphenyl) methoxy]phenyl]- pyrrolidin-1-yl- methanone::US12552758, Example 16	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792797&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159544	528824313							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558168	Cc1cccc(COc2cc(O)cc(O)c2C(=O)N2CCCC2)c1	InChI=1S/C19H21NO4/c1-13-5-4-6-14(9-13)12-24-17-11-15(21)10-16(22)18(17)19(23)20-7-2-3-8-20/h4-6,9-11,21-22H,2-3,7-8,12H2,1H3	IBRVNEBWGWDDOE-UHFFFAOYSA-N	792798	[2,4-dihydroxy- 6-(m- tolylmethoxy) phenyl]-pyrrolidin- 1-yl-methanone::US12552758, Example 17	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792798&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159474	528824314							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558170	Cc1cccc(COc2cc(O)cc(O)c2C(=O)N2CCCC2)c1	InChI=1S/C19H21NO4/c1-13-5-4-6-14(9-13)12-24-17-11-15(21)10-16(22)18(17)19(23)20-7-2-3-8-20/h4-6,9-11,21-22H,2-3,7-8,12H2,1H3	IBRVNEBWGWDDOE-UHFFFAOYSA-N	792798	[2,4-dihydroxy- 6-(m- tolylmethoxy) phenyl]-pyrrolidin- 1-yl-methanone::US12552758, Example 17	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792798&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159474	528824314							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558172	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1Cc2cccnc2C1	InChI=1S/C21H18N2O4/c24-16-9-18(25)20(19(10-16)27-13-14-5-2-1-3-6-14)21(26)23-11-15-7-4-8-22-17(15)12-23/h1-10,24-25H,11-13H2	UJXHETTYJMZTQC-UHFFFAOYSA-N	792799	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5,7- dihydropyrrolo[3,4- b]pyridin-6- yl)methanone::US12552758, Example 18	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792799&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159456	528824315							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558174	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1Cc2cccnc2C1	InChI=1S/C21H18N2O4/c24-16-9-18(25)20(19(10-16)27-13-14-5-2-1-3-6-14)21(26)23-11-15-7-4-8-22-17(15)12-23/h1-10,24-25H,11-13H2	UJXHETTYJMZTQC-UHFFFAOYSA-N	792799	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5,7- dihydropyrrolo[3,4- b]pyridin-6- yl)methanone::US12552758, Example 18	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792799&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159456	528824315							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558176	COc1cccc2c1CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C23H21NO5/c1-28-20-9-5-8-16-12-24(13-18(16)20)23(27)22-19(26)10-17(25)11-21(22)29-14-15-6-3-2-4-7-15/h2-11,25-26H,12-14H2,1H3	IHUCWMWXWJGHNJ-UHFFFAOYSA-N	792800	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(4- methoxyisoindolin- 2-yl)methanone::US12552758, Example 19	DNA mismatch repair protein Mlh1			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792800&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159484	528824316							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558178	COc1cccc2c1CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C23H21NO5/c1-28-20-9-5-8-16-12-24(13-18(16)20)23(27)22-19(26)10-17(25)11-21(22)29-14-15-6-3-2-4-7-15/h2-11,25-26H,12-14H2,1H3	IHUCWMWXWJGHNJ-UHFFFAOYSA-N	792800	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(4- methoxyisoindolin- 2-yl)methanone::US12552758, Example 19	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792800&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159484	528824316							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558180	O=C(c1c(O)cc(O)cc1OCc1ccncn1)N1CCCC1	InChI=1S/C16H17N3O4/c20-12-7-13(21)15(16(22)19-5-1-2-6-19)14(8-12)23-9-11-3-4-17-10-18-11/h3-4,7-8,10,20-21H,1-2,5-6,9H2	KZWWLIDEXDQOJU-UHFFFAOYSA-N	792801	[2,4-dihydroxy- 6-(pyrimidin-4- ylmethoxy)phenyl]- pyrrolidin-1- yl-methanone::US12552758, Example 20	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792801&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159537	528824317							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558182	O=C(c1c(O)cc(O)cc1OCc1ccncn1)N1CCCC1	InChI=1S/C16H17N3O4/c20-12-7-13(21)15(16(22)19-5-1-2-6-19)14(8-12)23-9-11-3-4-17-10-18-11/h3-4,7-8,10,20-21H,1-2,5-6,9H2	KZWWLIDEXDQOJU-UHFFFAOYSA-N	792801	[2,4-dihydroxy- 6-(pyrimidin-4- ylmethoxy)phenyl]- pyrrolidin-1- yl-methanone::US12552758, Example 20	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792801&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159537	528824317							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558186	O=C(c1c(O)cc(O)cc1OCc1cc[nH]n1)N1CCCC1	InChI=1S/C15H17N3O4/c19-11-7-12(20)14(15(21)18-5-1-2-6-18)13(8-11)22-9-10-3-4-16-17-10/h3-4,7-8,19-20H,1-2,5-6,9H2,(H,16,17)	NFCHHTAOMMDDCF-UHFFFAOYSA-N	792802	(2-((1H-pyrazol- 3-yl)methoxy)- 4,6- dihydroxyphenyl) (pyrrolidin-1- yl)methanone::US12552758, Example 21	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792802&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168796316	528824318							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558188	O=C(c1c(O)cc(O)cc1OCc1cc[nH]n1)N1CCCC1	InChI=1S/C15H17N3O4/c19-11-7-12(20)14(15(21)18-5-1-2-6-18)13(8-11)22-9-10-3-4-16-17-10/h3-4,7-8,19-20H,1-2,5-6,9H2,(H,16,17)	NFCHHTAOMMDDCF-UHFFFAOYSA-N	792802	(2-((1H-pyrazol- 3-yl)methoxy)- 4,6- dihydroxyphenyl) (pyrrolidin-1- yl)methanone::US12552758, Example 21	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792802&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168796316	528824318							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558190	O=C(c1c(O)cc(O)cc1OCc1c[nH]nn1)N1CCCC1	InChI=1S/C14H16N4O4/c19-10-5-11(20)13(14(21)18-3-1-2-4-18)12(6-10)22-8-9-7-15-17-16-9/h5-7,19-20H,1-4,8H2,(H,15,16,17)	WUIADAKHNFELCP-UHFFFAOYSA-N	792803	[2,4-dihydroxy- 6-(1H-triazol-4- ylmethoxy)phenyl]- pyrrolidin-1- yl-methanone::[2,4-dihydroxy-6-(1H-triazol-4-ylmethoxy)phenyl]-pyrrolidin-1-yl-methanone::US12552758, Example 22	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792803&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159517	528824319							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558192	O=C(c1c(O)cc(O)cc1OCc1c[nH]nn1)N1CCCC1	InChI=1S/C14H16N4O4/c19-10-5-11(20)13(14(21)18-3-1-2-4-18)12(6-10)22-8-9-7-15-17-16-9/h5-7,19-20H,1-4,8H2,(H,15,16,17)	WUIADAKHNFELCP-UHFFFAOYSA-N	792803	[2,4-dihydroxy- 6-(1H-triazol-4- ylmethoxy)phenyl]- pyrrolidin-1- yl-methanone::[2,4-dihydroxy-6-(1H-triazol-4-ylmethoxy)phenyl]-pyrrolidin-1-yl-methanone::US12552758, Example 22	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792803&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159517	528824319							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558194	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1Cc2ccc(Br)cc2C1	InChI=1S/C22H18BrNO4/c23-17-7-6-15-11-24(12-16(15)8-17)22(27)21-19(26)9-18(25)10-20(21)28-13-14-4-2-1-3-5-14/h1-10,25-26H,11-13H2	NHMUPLMXFABKLG-UHFFFAOYSA-N	792804	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5- bromoisoindolin- 2-yl)methanone::US12552758, Example 23	DNA mismatch repair protein Mlh1			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792804&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159442	528824320							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558196	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1Cc2ccc(Br)cc2C1	InChI=1S/C22H18BrNO4/c23-17-7-6-15-11-24(12-16(15)8-17)22(27)21-19(26)9-18(25)10-20(21)28-13-14-4-2-1-3-5-14/h1-10,25-26H,11-13H2	NHMUPLMXFABKLG-UHFFFAOYSA-N	792804	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5- bromoisoindolin- 2-yl)methanone::US12552758, Example 23	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792804&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159442	528824320							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558198	COC(=O)c1ccc2c(c1)CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C24H21NO6/c1-30-24(29)16-7-8-17-12-25(13-18(17)9-16)23(28)22-20(27)10-19(26)11-21(22)31-14-15-5-3-2-4-6-15/h2-11,26-27H,12-14H2,1H3	NHKCMKUOVMZXCJ-UHFFFAOYSA-N	792805	methyl 2-(2- benzyloxy-4,6- dihydroxy- benzoyl)isoindoline- 5-carboxylate::US12552758, Example 24	DNA mismatch repair protein Mlh1			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792805&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159451	528824321							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558200	COC(=O)c1ccc2c(c1)CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C24H21NO6/c1-30-24(29)16-7-8-17-12-25(13-18(17)9-16)23(28)22-20(27)10-19(26)11-21(22)31-14-15-5-3-2-4-6-15/h2-11,26-27H,12-14H2,1H3	NHKCMKUOVMZXCJ-UHFFFAOYSA-N	792805	methyl 2-(2- benzyloxy-4,6- dihydroxy- benzoyl)isoindoline- 5-carboxylate::US12552758, Example 24	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792805&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159451	528824321							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558202	COc1ccc2c(c1)CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C23H21NO5/c1-28-19-8-7-16-12-24(13-17(16)9-19)23(27)22-20(26)10-18(25)11-21(22)29-14-15-5-3-2-4-6-15/h2-11,25-26H,12-14H2,1H3	PFCDZICMCYZFER-UHFFFAOYSA-N	792806	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5- methoxyisoindolin- 2-yl)methanone::US12552758, Example 25	DNA mismatch repair protein Mlh1			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792806&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159497	528824322							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558204	COc1ccc2c(c1)CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C23H21NO5/c1-28-19-8-7-16-12-24(13-17(16)9-19)23(27)22-20(26)10-18(25)11-21(22)29-14-15-5-3-2-4-6-15/h2-11,25-26H,12-14H2,1H3	PFCDZICMCYZFER-UHFFFAOYSA-N	792806	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5- methoxyisoindolin- 2-yl)methanone::US12552758, Example 25	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792806&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159497	528824322							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558206	COc1cc2c(cc1OC)CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C24H23NO6/c1-29-20-8-16-12-25(13-17(16)9-21(20)30-2)24(28)23-19(27)10-18(26)11-22(23)31-14-15-6-4-3-5-7-15/h3-11,26-27H,12-14H2,1-2H3	GZYCWYLGQSMOCG-UHFFFAOYSA-N	792807	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5,6- dimethoxyisoindolin- 2-yl)methanone::US12552758, Example 26	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792807&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159448	528824323							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558208	COc1cc2c(cc1OC)CN(C(=O)c1c(O)cc(O)cc1OCc1ccccc1)C2	InChI=1S/C24H23NO6/c1-29-20-8-16-12-25(13-17(16)9-21(20)30-2)24(28)23-19(27)10-18(26)11-22(23)31-14-15-6-4-3-5-7-15/h3-11,26-27H,12-14H2,1-2H3	GZYCWYLGQSMOCG-UHFFFAOYSA-N	792807	(2-benzyloxy- 4,6-dihydroxy- phenyl)-(5,6- dimethoxyisoindolin- 2-yl)methanone::US12552758, Example 26	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792807&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159448	528824323							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558210	CC(Oc1cc(O)cc(O)c1C(=O)N1Cc2ccccc2C1)c1ccccc1	InChI=1S/C23H21NO4/c1-15(16-7-3-2-4-8-16)28-21-12-19(25)11-20(26)22(21)23(27)24-13-17-9-5-6-10-18(17)14-24/h2-12,15,25-26H,13-14H2,1H3	UTZXIGPNXTUYCI-UHFFFAOYSA-N	792808	[2,4-dihydroxy- 6-(1- phenylethoxy) phenyl]-isoindolin- 2-yl-methanone::US12552758, Example 27	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792808&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168796390	528824324							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558212	CC(Oc1cc(O)cc(O)c1C(=O)N1Cc2ccccc2C1)c1ccccc1	InChI=1S/C23H21NO4/c1-15(16-7-3-2-4-8-16)28-21-12-19(25)11-20(26)22(21)23(27)24-13-17-9-5-6-10-18(17)14-24/h2-12,15,25-26H,13-14H2,1H3	UTZXIGPNXTUYCI-UHFFFAOYSA-N	792808	[2,4-dihydroxy- 6-(1- phenylethoxy) phenyl]-isoindolin- 2-yl-methanone::US12552758, Example 27	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792808&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168796390	528824324							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558214	COc1ccc2c(c1)CN(C(=O)c1c(O)cc(O)cc1OC(C)c1ccccc1)C2	InChI=1S/C24H23NO5/c1-15(16-6-4-3-5-7-16)30-22-12-19(26)11-21(27)23(22)24(28)25-13-17-8-9-20(29-2)10-18(17)14-25/h3-12,15,26-27H,13-14H2,1-2H3	XOQBFGKNVVUASA-UHFFFAOYSA-N	792809	[2,4-dihydroxy- 6-(1- phenylethoxy) phenyl]-(5- methoxyisoindolin- 2-yl)methanone::US12552758, Example 28	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792809&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168796400	528824325							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558216	COc1ccc2c(c1)CN(C(=O)c1c(O)cc(O)cc1OC(C)c1ccccc1)C2	InChI=1S/C24H23NO5/c1-15(16-6-4-3-5-7-16)30-22-12-19(26)11-21(27)23(22)24(28)25-13-17-8-9-20(29-2)10-18(17)14-25/h3-12,15,26-27H,13-14H2,1-2H3	XOQBFGKNVVUASA-UHFFFAOYSA-N	792809	[2,4-dihydroxy- 6-(1- phenylethoxy) phenyl]-(5- methoxyisoindolin- 2-yl)methanone::US12552758, Example 28	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792809&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168796400	528824325							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558218	COc1cc2c(cc1OC)CN(C(=O)c1c(O)cc(O)cc1OC(C)c1ccccc1)C2	InChI=1S/C25H25NO6/c1-15(16-7-5-4-6-8-16)32-23-12-19(27)11-20(28)24(23)25(29)26-13-17-9-21(30-2)22(31-3)10-18(17)14-26/h4-12,15,27-28H,13-14H2,1-3H3	BMIWZXHAIFFSEP-UHFFFAOYSA-N	792810	[2,4-dihydroxy- 6-(1- phenylethoxy) phenyl]-(5,6- dimethoxyisoindolin- 2-yl)methanone::US12552758, Example 29	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792810&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168796391	528824326							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558220	COc1cc2c(cc1OC)CN(C(=O)c1c(O)cc(O)cc1OC(C)c1ccccc1)C2	InChI=1S/C25H25NO6/c1-15(16-7-5-4-6-8-16)32-23-12-19(27)11-20(28)24(23)25(29)26-13-17-9-21(30-2)22(31-3)10-18(17)14-26/h4-12,15,27-28H,13-14H2,1-3H3	BMIWZXHAIFFSEP-UHFFFAOYSA-N	792810	[2,4-dihydroxy- 6-(1- phenylethoxy) phenyl]-(5,6- dimethoxyisoindolin- 2-yl)methanone::US12552758, Example 29	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792810&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168796391	528824326							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558222	Cc1c(O)cc(O)c(C(=O)N2Cc3cccnc3C2)c1OCc1ccccc1	InChI=1S/C22H20N2O4/c1-14-18(25)10-19(26)20(21(14)28-13-15-6-3-2-4-7-15)22(27)24-11-16-8-5-9-23-17(16)12-24/h2-10,25-26H,11-13H2,1H3	PSUPHQBQGADPJS-UHFFFAOYSA-N	792811	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (5,7- dihydropyrrolo[3,4- b]pyridin-6- yl)methanone::US12552758, Example 30	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792811&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159533	528824327							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558224	Cc1c(O)cc(O)c(C(=O)N2Cc3cccnc3C2)c1OCc1ccccc1	InChI=1S/C22H20N2O4/c1-14-18(25)10-19(26)20(21(14)28-13-15-6-3-2-4-7-15)22(27)24-11-16-8-5-9-23-17(16)12-24/h2-10,25-26H,11-13H2,1H3	PSUPHQBQGADPJS-UHFFFAOYSA-N	792811	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (5,7- dihydropyrrolo[3,4- b]pyridin-6- yl)methanone::US12552758, Example 30	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792811&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159533	528824327							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558226	Cc1cccc(COc2c(C)c(O)cc(O)c2C(=O)N2Cc3cccnc3C2)c1	InChI=1S/C23H22N2O4/c1-14-5-3-6-16(9-14)13-29-22-15(2)19(26)10-20(27)21(22)23(28)25-11-17-7-4-8-24-18(17)12-25/h3-10,26-27H,11-13H2,1-2H3	KZURVNOEJFALSQ-UHFFFAOYSA-N	792812	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [4,6-dihydroxy- 3-methyl-2-(m- tolylmethoxy) phenyl]methanone::US12552758, Example 31	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792812&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159545	528824328							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558228	Cc1cccc(COc2c(C)c(O)cc(O)c2C(=O)N2Cc3cccnc3C2)c1	InChI=1S/C23H22N2O4/c1-14-5-3-6-16(9-14)13-29-22-15(2)19(26)10-20(27)21(22)23(28)25-11-17-7-4-8-24-18(17)12-25/h3-10,26-27H,11-13H2,1-2H3	KZURVNOEJFALSQ-UHFFFAOYSA-N	792812	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [4,6-dihydroxy- 3-methyl-2-(m- tolylmethoxy) phenyl]methanone::US12552758, Example 31	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792812&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159545	528824328							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558230	Cc1cccc(COc2cc(O)cc(O)c2C(=O)N2Cc3cccnc3C2)c1	InChI=1S/C22H20N2O4/c1-14-4-2-5-15(8-14)13-28-20-10-17(25)9-19(26)21(20)22(27)24-11-16-6-3-7-23-18(16)12-24/h2-10,25-26H,11-13H2,1H3	ZDFWVJWVJGMBHM-UHFFFAOYSA-N	792813	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [2,4-dihydroxy- 6-(m- tolylmethoxy) phenyl]methanone::US12552758, Example 32	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792813&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159514	528824329							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558232	Cc1cccc(COc2cc(O)cc(O)c2C(=O)N2Cc3cccnc3C2)c1	InChI=1S/C22H20N2O4/c1-14-4-2-5-15(8-14)13-28-20-10-17(25)9-19(26)21(20)22(27)24-11-16-6-3-7-23-18(16)12-24/h2-10,25-26H,11-13H2,1H3	ZDFWVJWVJGMBHM-UHFFFAOYSA-N	792813	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [2,4-dihydroxy- 6-(m- tolylmethoxy) phenyl]methanone::US12552758, Example 32	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792813&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159514	528824329							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558234	Cc1c(O)cc(O)c(C(=O)N2Cc3cccnc3C2)c1OCc1ccccn1	InChI=1S/C21H19N3O4/c1-13-17(25)9-18(26)19(20(13)28-12-15-6-2-3-7-22-15)21(27)24-10-14-5-4-8-23-16(14)11-24/h2-9,25-26H,10-12H2,1H3	CVRDJSOKEWWPIR-UHFFFAOYSA-N	792814	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]methanone::US12552758, Example 33	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792814&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159450	528824330							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558236	Cc1c(O)cc(O)c(C(=O)N2Cc3cccnc3C2)c1OCc1ccccn1	InChI=1S/C21H19N3O4/c1-13-17(25)9-18(26)19(20(13)28-12-15-6-2-3-7-22-15)21(27)24-10-14-5-4-8-23-16(14)11-24/h2-9,25-26H,10-12H2,1H3	CVRDJSOKEWWPIR-UHFFFAOYSA-N	792814	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]methanone::US12552758, Example 33	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792814&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159450	528824330							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558238	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C2)c1OCc1ccccn1	InChI=1S/C22H20N2O4/c1-14-18(25)10-19(26)20(21(14)28-13-17-8-4-5-9-23-17)22(27)24-11-15-6-2-3-7-16(15)12-24/h2-10,25-26H,11-13H2,1H3	PCEPHNVQTIJFPW-UHFFFAOYSA-N	792815	[4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]- isoindolin-2-yl- methanone::US12552758, Example 34	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795883	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792815&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159491	528824331							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558549	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C2)c1OCc1ccccn1	InChI=1S/C22H20N2O4/c1-14-18(25)10-19(26)20(21(14)28-13-17-8-4-5-9-23-17)22(27)24-11-15-6-2-3-7-16(15)12-24/h2-10,25-26H,11-13H2,1H3	PCEPHNVQTIJFPW-UHFFFAOYSA-N	792815	[4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]- isoindolin-2-yl- methanone::US12552758, Example 34	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792815&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159491	528824331							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558550	O=C(c1c(O)cc(O)cc1OCc1ccccn1)N1Cc2cccnc2C1	InChI=1S/C20H17N3O4/c24-15-8-17(25)19(18(9-15)27-12-14-5-1-2-6-21-14)20(26)23-10-13-4-3-7-22-16(13)11-23/h1-9,24-25H,10-12H2	MPODZGIYKQFNHS-UHFFFAOYSA-N	792816	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [2,4-dihydroxy- 6-(2- pyridylmethoxy) phenyl]methanone::US12552758, Example 35	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792816&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159435	528824332							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558551	O=C(c1c(O)cc(O)cc1OCc1ccccn1)N1Cc2cccnc2C1	InChI=1S/C20H17N3O4/c24-15-8-17(25)19(18(9-15)27-12-14-5-1-2-6-21-14)20(26)23-10-13-4-3-7-22-16(13)11-23/h1-9,24-25H,10-12H2	MPODZGIYKQFNHS-UHFFFAOYSA-N	792816	5,7- dihydropyrrolo[3,4- b]pyridin-6-yl- [2,4-dihydroxy- 6-(2- pyridylmethoxy) phenyl]methanone::US12552758, Example 35	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792816&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159435	528824332							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558552	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccccc1	InChI=1S/C24H23NO4/c1-16-20(26)13-21(27)22(23(16)29-15-17-7-3-2-4-8-17)24(28)25-12-11-18-9-5-6-10-19(18)14-25/h2-10,13,26-27H,11-12,14-15H2,1H3	FGYPOMBGBGRMDC-UHFFFAOYSA-N	792817	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (3,4-dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 36	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792817&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159446	528824333							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558553	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccccc1	InChI=1S/C24H23NO4/c1-16-20(26)13-21(27)22(23(16)29-15-17-7-3-2-4-8-17)24(28)25-12-11-18-9-5-6-10-19(18)14-25/h2-10,13,26-27H,11-12,14-15H2,1H3	FGYPOMBGBGRMDC-UHFFFAOYSA-N	792817	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (3,4-dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 36	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792817&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159446	528824333							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558554	O=C(c1c(O)cc(O)cc1OCc1ccccn1)N1Cc2ccccc2C1	InChI=1S/C21H18N2O4/c24-17-9-18(25)20(19(10-17)27-13-16-7-3-4-8-22-16)21(26)23-11-14-5-1-2-6-15(14)12-23/h1-10,24-25H,11-13H2	JKSKJOWSRCIXLO-UHFFFAOYSA-N	792818	[2,4-dihydroxy- 6-(2- pyridylmethoxy) phenyl]- isoindolin-2-yl- methanone::US12552758, Example 37	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792818&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159507	528824334							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558555	O=C(c1c(O)cc(O)cc1OCc1ccccn1)N1Cc2ccccc2C1	InChI=1S/C21H18N2O4/c24-17-9-18(25)20(19(10-17)27-13-16-7-3-4-8-22-16)21(26)23-11-14-5-1-2-6-15(14)12-23/h1-10,24-25H,11-13H2	JKSKJOWSRCIXLO-UHFFFAOYSA-N	792818	[2,4-dihydroxy- 6-(2- pyridylmethoxy) phenyl]- isoindolin-2-yl- methanone::US12552758, Example 37	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792818&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159507	528824334							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558556	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(Br)c3C2)c1OCc1ccccc1	InChI=1S/C23H20BrNO4/c1-14-19(26)10-20(27)21(22(14)29-13-15-6-3-2-4-7-15)23(28)25-11-16-8-5-9-18(24)17(16)12-25/h2-10,26-27H,11-13H2,1H3	NJYCHZAPPHVFPB-UHFFFAOYSA-N	792819	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (4- bromoisoindolin- 2-yl)methanone::US12552758, Example 38	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792819&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159480	528824335							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558557	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(Br)c3C2)c1OCc1ccccc1	InChI=1S/C23H20BrNO4/c1-14-19(26)10-20(27)21(22(14)29-13-15-6-3-2-4-7-15)23(28)25-11-16-8-5-9-18(24)17(16)12-25/h2-10,26-27H,11-13H2,1H3	NJYCHZAPPHVFPB-UHFFFAOYSA-N	792819	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (4- bromoisoindolin- 2-yl)methanone::US12552758, Example 38	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792819&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159480	528824335							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558558	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(CO)c3C2)c1OCc1ccccc1	InChI=1S/C24H23NO5/c1-15-20(27)10-21(28)22(23(15)30-14-16-6-3-2-4-7-16)24(29)25-11-17-8-5-9-18(13-26)19(17)12-25/h2-10,26-28H,11-14H2,1H3	OGMVAAVSTBYEBO-UHFFFAOYSA-N	792820	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- [4- (hydroxymethyl) isoindolin-2- yl]methanone::US12552758, Example 39	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792820&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159526	528824336							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558559	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(CO)c3C2)c1OCc1ccccc1	InChI=1S/C24H23NO5/c1-15-20(27)10-21(28)22(23(15)30-14-16-6-3-2-4-7-16)24(29)25-11-17-8-5-9-18(13-26)19(17)12-25/h2-10,26-28H,11-14H2,1H3	OGMVAAVSTBYEBO-UHFFFAOYSA-N	792820	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- [4- (hydroxymethyl) isoindolin-2- yl]methanone::US12552758, Example 39	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792820&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159526	528824336							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558560	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c1OCc1ccccc1	InChI=1S/C29H33N3O4/c1-20-25(33)15-26(34)27(28(20)36-19-21-6-4-3-5-7-21)29(35)32-17-23-9-8-22(14-24(23)18-32)16-31-12-10-30(2)11-13-31/h3-9,14-15,33-34H,10-13,16-19H2,1-2H3	PEMJUHDJPUMTCH-UHFFFAOYSA-N	792821	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- [5-[(4- methylpiperazin- 1-yl)methyl] isoindolin-2- yl]methanone::US12552758, Example 40	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792821&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159468	528824337							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558561	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c1OCc1ccccc1	InChI=1S/C29H33N3O4/c1-20-25(33)15-26(34)27(28(20)36-19-21-6-4-3-5-7-21)29(35)32-17-23-9-8-22(14-24(23)18-32)16-31-12-10-30(2)11-13-31/h3-9,14-15,33-34H,10-13,16-19H2,1-2H3	PEMJUHDJPUMTCH-UHFFFAOYSA-N	792821	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- [5-[(4- methylpiperazin- 1-yl)methyl] isoindolin-2- yl]methanone::US12552758, Example 40	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792821&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159468	528824337							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558562	COc1ccc2c(c1)CCN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H25NO5/c1-16-21(27)13-22(28)23(24(16)31-15-17-6-4-3-5-7-17)25(29)26-11-10-18-12-20(30-2)9-8-19(18)14-26/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3	RDDMMSAXTJNZCY-UHFFFAOYSA-N	792822	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (6-methoxy-3,4- dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 41	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792822&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159489	528824338							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558563	COc1ccc2c(c1)CCN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H25NO5/c1-16-21(27)13-22(28)23(24(16)31-15-17-6-4-3-5-7-17)25(29)26-11-10-18-12-20(30-2)9-8-19(18)14-26/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3	RDDMMSAXTJNZCY-UHFFFAOYSA-N	792822	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (6-methoxy-3,4- dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 41	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792822&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159489	528824338							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558564	Cc1c(O)cc(O)c(C(=O)N2CCc3ccncc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)11-20(27)21(22(15)29-14-16-5-3-2-4-6-16)23(28)25-10-8-17-7-9-24-12-18(17)13-25/h2-7,9,11-12,26-27H,8,10,13-14H2,1H3	GTQKVWJOVYMNKT-UHFFFAOYSA-N	792823	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (3,4-dihydro-1H- 2,7- naphthyridin-2- yl)methanone::US12552758, Example 42	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792823&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159510	528824339							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558565	Cc1c(O)cc(O)c(C(=O)N2CCc3ccncc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)11-20(27)21(22(15)29-14-16-5-3-2-4-6-16)23(28)25-10-8-17-7-9-24-12-18(17)13-25/h2-7,9,11-12,26-27H,8,10,13-14H2,1H3	GTQKVWJOVYMNKT-UHFFFAOYSA-N	792823	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (3,4-dihydro-1H- 2,7- naphthyridin-2- yl)methanone::US12552758, Example 42	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792823&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159510	528824339							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558566	Cc1c(O)cc(O)c(C(=O)N2CCc3cnccc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)11-20(27)21(22(15)29-14-16-5-3-2-4-6-16)23(28)25-10-8-17-12-24-9-7-18(17)13-25/h2-7,9,11-12,26-27H,8,10,13-14H2,1H3	MQYXFGPGHCBBIZ-UHFFFAOYSA-N	792824	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (3,4-dihydro-1H- 2,6- naphthyridin-2- yl)methanone::US12552758, Example 43	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792824&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159551	528824340							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558567	Cc1c(O)cc(O)c(C(=O)N2CCc3cnccc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)11-20(27)21(22(15)29-14-16-5-3-2-4-6-16)23(28)25-10-8-17-12-24-9-7-18(17)13-25/h2-7,9,11-12,26-27H,8,10,13-14H2,1H3	MQYXFGPGHCBBIZ-UHFFFAOYSA-N	792824	(2-benzyloxy- 4,6-dihydroxy-3- methyl-phenyl)- (3,4-dihydro-1H- 2,6- naphthyridin-2- yl)methanone::US12552758, Example 43	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792824&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159551	528824340							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558568	Cc1cccc(COc2c(C)c(O)cc(O)c2C(=O)N2CCc3ccccc3C2)c1	InChI=1S/C25H25NO4/c1-16-6-5-7-18(12-16)15-30-24-17(2)21(27)13-22(28)23(24)25(29)26-11-10-19-8-3-4-9-20(19)14-26/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3	WDEQMHVFMPNNBY-UHFFFAOYSA-N	792825	3,4-dihydro-1H- isoquinolin-2-yl- [4,6-dihydroxy- 3-methyl-2-(m- tolylmethoxy) phenyl]methanone::US12552758, Example 44	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792825&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159477	528824341							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558569	Cc1cccc(COc2c(C)c(O)cc(O)c2C(=O)N2CCc3ccccc3C2)c1	InChI=1S/C25H25NO4/c1-16-6-5-7-18(12-16)15-30-24-17(2)21(27)13-22(28)23(24)25(29)26-11-10-19-8-3-4-9-20(19)14-26/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3	WDEQMHVFMPNNBY-UHFFFAOYSA-N	792825	3,4-dihydro-1H- isoquinolin-2-yl- [4,6-dihydroxy- 3-methyl-2-(m- tolylmethoxy) phenyl]methanone::US12552758, Example 44	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792825&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159477	528824341							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558570	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccccn1	InChI=1S/C23H22N2O4/c1-15-19(26)12-20(27)21(22(15)29-14-18-8-4-5-10-24-18)23(28)25-11-9-16-6-2-3-7-17(16)13-25/h2-8,10,12,26-27H,9,11,13-14H2,1H3	QNGJOSRAPXWJDT-UHFFFAOYSA-N	792826	3,4-dihydro-1H- isoquinolin-2-yl- [4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]methanone::US12552758, Example 45	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792826&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159518	528824342							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558571	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccccn1	InChI=1S/C23H22N2O4/c1-15-19(26)12-20(27)21(22(15)29-14-18-8-4-5-10-24-18)23(28)25-11-9-16-6-2-3-7-17(16)13-25/h2-8,10,12,26-27H,9,11,13-14H2,1H3	QNGJOSRAPXWJDT-UHFFFAOYSA-N	792826	3,4-dihydro-1H- isoquinolin-2-yl- [4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]methanone::US12552758, Example 45	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792826&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159518	528824342							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558572	COc1ccc2c(c1)CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccn1)CC2	InChI=1S/C24H24N2O5/c1-15-20(27)12-21(28)22(23(15)31-14-18-5-3-4-9-25-18)24(29)26-10-8-16-6-7-19(30-2)11-17(16)13-26/h3-7,9,11-12,27-28H,8,10,13-14H2,1-2H3	NPSDBORBSNWEKB-UHFFFAOYSA-N	792827	[4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]-(7- methoxy-3,4- dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 46	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792827&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159535	528824343							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558573	COc1ccc2c(c1)CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccn1)CC2	InChI=1S/C24H24N2O5/c1-15-20(27)12-21(28)22(23(15)31-14-18-5-3-4-9-25-18)24(29)26-10-8-16-6-7-19(30-2)11-17(16)13-26/h3-7,9,11-12,27-28H,8,10,13-14H2,1-2H3	NPSDBORBSNWEKB-UHFFFAOYSA-N	792827	[4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]-(7- methoxy-3,4- dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 46	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792827&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159535	528824343							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558574	COc1ccc2c(c1)CCN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccn1)C2	InChI=1S/C24H24N2O5/c1-15-20(27)12-21(28)22(23(15)31-14-18-5-3-4-9-25-18)24(29)26-10-8-16-11-19(30-2)7-6-17(16)13-26/h3-7,9,11-12,27-28H,8,10,13-14H2,1-2H3	FCMFXDVDVZFZHR-UHFFFAOYSA-N	792828	[4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]-(6- methoxy-3,4- dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 47	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792828&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159539	528824344							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558575	COc1ccc2c(c1)CCN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccn1)C2	InChI=1S/C24H24N2O5/c1-15-20(27)12-21(28)22(23(15)31-14-18-5-3-4-9-25-18)24(29)26-10-8-16-11-19(30-2)7-6-17(16)13-26/h3-7,9,11-12,27-28H,8,10,13-14H2,1-2H3	FCMFXDVDVZFZHR-UHFFFAOYSA-N	792828	[4,6-dihydroxy- 3-methyl-2-(2- pyridylmethoxy) phenyl]-(6- methoxy-3,4- dihydro-1H- isoquinolin-2- yl)methanone::US12552758, Example 47	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792828&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159539	528824344							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558576	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccc(F)cc1	InChI=1S/C24H22FNO4/c1-15-20(27)12-21(28)22(23(15)30-14-16-6-8-19(25)9-7-16)24(29)26-11-10-17-4-2-3-5-18(17)13-26/h2-9,12,27-28H,10-11,13-14H2,1H3	WWDFIKBWXZPKFJ-UHFFFAOYSA-N	792829	3,4-dihydro-1H- isoquinolin-2-yl- [2-[(4- fluorophenyl) methoxy]-4,6- dihydroxy-3- methyl- phenyl]methanone::US12552758, Example 48	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792829&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159548	528824345							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558577	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccc(F)cc1	InChI=1S/C24H22FNO4/c1-15-20(27)12-21(28)22(23(15)30-14-16-6-8-19(25)9-7-16)24(29)26-11-10-17-4-2-3-5-18(17)13-26/h2-9,12,27-28H,10-11,13-14H2,1H3	WWDFIKBWXZPKFJ-UHFFFAOYSA-N	792829	3,4-dihydro-1H- isoquinolin-2-yl- [2-[(4- fluorophenyl) methoxy]-4,6- dihydroxy-3- methyl- phenyl]methanone::US12552758, Example 48	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792829&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159548	528824345							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558578	CN1CCN(Cc2ccc3c(c2)CN(C(=O)c2c(O)cc(O)cc2OCc2ccccc2)C3)CC1	InChI=1S/C28H31N3O4/c1-29-9-11-30(12-10-29)16-21-7-8-22-17-31(18-23(22)13-21)28(34)27-25(33)14-24(32)15-26(27)35-19-20-5-3-2-4-6-20/h2-8,13-15,32-33H,9-12,16-19H2,1H3	SEPUSNIDUHVROH-UHFFFAOYSA-N	792830	(2-(benzyloxy)- 4,6- dihydroxyphenyl) (5-((4- methylpiperazin- 1-yl)methyl) isoindolin-2- yl)methanone::US12552758, Example 49	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792830&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159504	528824346							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558579	CN1CCN(Cc2ccc3c(c2)CN(C(=O)c2c(O)cc(O)cc2OCc2ccccc2)C3)CC1	InChI=1S/C28H31N3O4/c1-29-9-11-30(12-10-29)16-21-7-8-22-17-31(18-23(22)13-21)28(34)27-25(33)14-24(32)15-26(27)35-19-20-5-3-2-4-6-20/h2-8,13-15,32-33H,9-12,16-19H2,1H3	SEPUSNIDUHVROH-UHFFFAOYSA-N	792830	(2-(benzyloxy)- 4,6- dihydroxyphenyl) (5-((4- methylpiperazin- 1-yl)methyl) isoindolin-2- yl)methanone::US12552758, Example 49	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792830&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159504	528824346							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558580	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(N)c3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-14-19(26)10-20(27)21(22(14)29-13-15-6-3-2-4-7-15)23(28)25-11-16-8-5-9-18(24)17(16)12-25/h2-10,26-27H,11-13,24H2,1H3	NBMPFMVIFAZABZ-UHFFFAOYSA-N	792831	(4- aminoisoindolin- 2-yl)(2- (benzyloxy)-4,6- dihydroxy-3- methylphenyl) methanone::US12552758, Example 50	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792831&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159511	528824347							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558581	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(N)c3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-14-19(26)10-20(27)21(22(14)29-13-15-6-3-2-4-7-15)23(28)25-11-16-8-5-9-18(24)17(16)12-25/h2-10,26-27H,11-13,24H2,1H3	NBMPFMVIFAZABZ-UHFFFAOYSA-N	792831	(4- aminoisoindolin- 2-yl)(2- (benzyloxy)-4,6- dihydroxy-3- methylphenyl) methanone::US12552758, Example 50	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792831&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159511	528824347							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558582	C=Cc1cccc2c1CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H23NO4/c1-3-18-10-7-11-19-13-26(14-20(18)19)25(29)23-22(28)12-21(27)16(2)24(23)30-15-17-8-5-4-6-9-17/h3-12,27-28H,1,13-15H2,2H3	QQUPGFFDRHMCGC-UHFFFAOYSA-N	792832	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- vinylisoindolin- 2-yl)methanone::US12552758, Example 51	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792832&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159443	528824348							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558583	C=Cc1cccc2c1CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H23NO4/c1-3-18-10-7-11-19-13-26(14-20(18)19)25(29)23-22(28)12-21(27)16(2)24(23)30-15-17-8-5-4-6-9-17/h3-12,27-28H,1,13-15H2,2H3	QQUPGFFDRHMCGC-UHFFFAOYSA-N	792832	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- vinylisoindolin- 2-yl)methanone::US12552758, Example 51	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792832&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159443	528824348							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558584	COc4ccc3CCN(C(=O)c1c(O)cc(O)c(C)c1OCc2ccccc2)Cc3c4	InChI=1S/C25H25NO5/c1-16-21(27)13-22(28)23(24(16)31-15-17-6-4-3-5-7-17)25(29)26-11-10-18-8-9-20(30-2)12-19(18)14-26/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3	VSCQFOUXCWPDEF-UHFFFAOYSA-N	792833	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7- methoxy-3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 52	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792833&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159502	528824349							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558585	COc4ccc3CCN(C(=O)c1c(O)cc(O)c(C)c1OCc2ccccc2)Cc3c4	InChI=1S/C25H25NO5/c1-16-21(27)13-22(28)23(24(16)31-15-17-6-4-3-5-7-17)25(29)26-11-10-18-8-9-20(30-2)12-19(18)14-26/h3-9,12-13,27-28H,10-11,14-15H2,1-2H3	VSCQFOUXCWPDEF-UHFFFAOYSA-N	792833	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7- methoxy-3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 52	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792833&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159502	528824349							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558586	Cc1c(O)cc(O)c(C(=O)N2CCc3cccnc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)12-20(27)21(22(15)29-14-16-6-3-2-4-7-16)23(28)25-11-9-17-8-5-10-24-18(17)13-25/h2-8,10,12,26-27H,9,11,13-14H2,1H3	XOGXWCBHVSHGML-UHFFFAOYSA-N	792834	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5,8- dihydro-1,7- naphthyridin- 7(6H)- yl)methanone::US12552758, Example 53	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792834&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159503	528824350							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558587	Cc1c(O)cc(O)c(C(=O)N2CCc3cccnc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)12-20(27)21(22(15)29-14-16-6-3-2-4-7-16)23(28)25-11-9-17-8-5-10-24-18(17)13-25/h2-8,10,12,26-27H,9,11,13-14H2,1H3	XOGXWCBHVSHGML-UHFFFAOYSA-N	792834	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5,8- dihydro-1,7- naphthyridin- 7(6H)- yl)methanone::US12552758, Example 53	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792834&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159503	528824350							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558588	Cc1c(O)cc(O)c(C(=O)N2CCc3ncccc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)12-20(27)21(22(15)29-14-16-6-3-2-4-7-16)23(28)25-11-9-18-17(13-25)8-5-10-24-18/h2-8,10,12,26-27H,9,11,13-14H2,1H3	CBZVWMSHAJBURQ-UHFFFAOYSA-N	792835	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7,8- dihydro-1,6- naphthyridin- 6(5H)- yl)methanone::US12552758, Example 54	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792835&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159534	528824351							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558589	Cc1c(O)cc(O)c(C(=O)N2CCc3ncccc3C2)c1OCc1ccccc1	InChI=1S/C23H22N2O4/c1-15-19(26)12-20(27)21(22(15)29-14-16-6-3-2-4-7-16)23(28)25-11-9-18-17(13-25)8-5-10-24-18/h2-8,10,12,26-27H,9,11,13-14H2,1H3	CBZVWMSHAJBURQ-UHFFFAOYSA-N	792835	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7,8- dihydro-1,6- naphthyridin- 6(5H)- yl)methanone::US12552758, Example 54	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792835&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159534	528824351							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558590	Cc1c(O)cc(O)c(C(=O)N2CCc3ncncc3C2)c1OCc1ccccc1	InChI=1S/C22H21N3O4/c1-14-18(26)9-19(27)20(21(14)29-12-15-5-3-2-4-6-15)22(28)25-8-7-17-16(11-25)10-23-13-24-17/h2-6,9-10,13,26-27H,7-8,11-12H2,1H3	RNDQUBOBLVWURO-UHFFFAOYSA-N	792836	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7,8- dihydropyrido[4,3- d]pyrimidin- 6(5H)- yl)methanone::US12552758, Example 55	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792836&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159486	528824352							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558591	Cc1c(O)cc(O)c(C(=O)N2CCc3ncncc3C2)c1OCc1ccccc1	InChI=1S/C22H21N3O4/c1-14-18(26)9-19(27)20(21(14)29-12-15-5-3-2-4-6-15)22(28)25-8-7-17-16(11-25)10-23-13-24-17/h2-6,9-10,13,26-27H,7-8,11-12H2,1H3	RNDQUBOBLVWURO-UHFFFAOYSA-N	792836	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7,8- dihydropyrido[4,3- d]pyrimidin- 6(5H)- yl)methanone::US12552758, Example 55	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792836&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159486	528824352							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558592	Cc1c(O)cc(O)c(C(=O)N2CCc3cncnc3C2)c1OCc1ccccc1	InChI=1S/C22H21N3O4/c1-14-18(26)9-19(27)20(21(14)29-12-15-5-3-2-4-6-15)22(28)25-8-7-16-10-23-13-24-17(16)11-25/h2-6,9-10,13,26-27H,7-8,11-12H2,1H3	GZGUNFZDYUTCFT-UHFFFAOYSA-N	792837	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5,8- dihydropyrido[3,4- d]pyrimidin- 7(6H)- yl)methanone::US12552758, Example 56	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792837&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159509	528824353							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558593	Cc1c(O)cc(O)c(C(=O)N2CCc3cncnc3C2)c1OCc1ccccc1	InChI=1S/C22H21N3O4/c1-14-18(26)9-19(27)20(21(14)29-12-15-5-3-2-4-6-15)22(28)25-8-7-16-10-23-13-24-17(16)11-25/h2-6,9-10,13,26-27H,7-8,11-12H2,1H3	GZGUNFZDYUTCFT-UHFFFAOYSA-N	792837	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5,8- dihydropyrido[3,4- d]pyrimidin- 7(6H)- yl)methanone::US12552758, Example 56	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792837&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159509	528824353							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558594	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccn(C)n1	InChI=1S/C22H23N3O4/c1-14-18(26)11-19(27)20(21(14)29-13-17-8-9-24(2)23-17)22(28)25-10-7-15-5-3-4-6-16(15)12-25/h3-6,8-9,11,26-27H,7,10,12-13H2,1-2H3	ATCSVXDGYMDFIQ-UHFFFAOYSA-N	792838	(3,4- dihydroisoquinolin- 2(1H)-yl)(4,6- dihydroxy-3- methyl-2-((1- methyl-1H- pyrazol-3- yl)methoxy)phenyl) methanone::US12552758, Example 57	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792838&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159529	528824354							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558595	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2)c1OCc1ccn(C)n1	InChI=1S/C22H23N3O4/c1-14-18(26)11-19(27)20(21(14)29-13-17-8-9-24(2)23-17)22(28)25-10-7-15-5-3-4-6-16(15)12-25/h3-6,8-9,11,26-27H,7,10,12-13H2,1-2H3	ATCSVXDGYMDFIQ-UHFFFAOYSA-N	792838	(3,4- dihydroisoquinolin- 2(1H)-yl)(4,6- dihydroxy-3- methyl-2-((1- methyl-1H- pyrazol-3- yl)methoxy)phenyl) methanone::US12552758, Example 57	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792838&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159529	528824354							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558596	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCc2ccccc2C1	InChI=1S/C23H21NO4/c25-19-12-20(26)22(21(13-19)28-15-16-6-2-1-3-7-16)23(27)24-11-10-17-8-4-5-9-18(17)14-24/h1-9,12-13,25-26H,10-11,14-15H2	MAZZPFQWHXTUIS-UHFFFAOYSA-N	792839	(2-(benzyloxy)- 4,6- dihydroxyphenyl) (3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 58	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792839&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159449	528824355							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558597	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCc2ccccc2C1	InChI=1S/C23H21NO4/c25-19-12-20(26)22(21(13-19)28-15-16-6-2-1-3-7-16)23(27)24-11-10-17-8-4-5-9-18(17)14-24/h1-9,12-13,25-26H,10-11,14-15H2	MAZZPFQWHXTUIS-UHFFFAOYSA-N	792839	(2-(benzyloxy)- 4,6- dihydroxyphenyl) (3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 58	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792839&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159449	528824355							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558598	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C2)c1OCc1ccccc1	InChI=1S/C23H21NO4/c1-15-19(25)11-20(26)21(22(15)28-14-16-7-3-2-4-8-16)23(27)24-12-17-9-5-6-10-18(17)13-24/h2-11,25-26H,12-14H2,1H3	ZOILVIJLSKJUQN-UHFFFAOYSA-N	792840	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl) (isoindolin-2- yl)methanone::US12552758, Example 59	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792840&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159465	528824356							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558599	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C2)c1OCc1ccccc1	InChI=1S/C23H21NO4/c1-15-19(25)11-20(26)21(22(15)28-14-16-7-3-2-4-8-16)23(27)24-12-17-9-5-6-10-18(17)13-24/h2-11,25-26H,12-14H2,1H3	ZOILVIJLSKJUQN-UHFFFAOYSA-N	792840	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl) (isoindolin-2- yl)methanone::US12552758, Example 59	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792840&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159465	528824356							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558600	Cc1c(O)cc(O)c(C(=O)N2CCc3ccc(CN(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C27H30N2O4/c1-18-23(30)14-24(31)25(26(18)33-17-19-7-5-4-6-8-19)27(32)29-12-11-21-10-9-20(15-28(2)3)13-22(21)16-29/h4-10,13-14,30-31H,11-12,15-17H2,1-3H3	RAMNDFXEOMQFTL-UHFFFAOYSA-N	792841	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7- ((dimethylamino) methyl)-3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 60	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792841&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159523	528824357							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558601	Cc1c(O)cc(O)c(C(=O)N2CCc3ccc(CN(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C27H30N2O4/c1-18-23(30)14-24(31)25(26(18)33-17-19-7-5-4-6-8-19)27(32)29-12-11-21-10-9-20(15-28(2)3)13-22(21)16-29/h4-10,13-14,30-31H,11-12,15-17H2,1-3H3	RAMNDFXEOMQFTL-UHFFFAOYSA-N	792841	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(7- ((dimethylamino) methyl)-3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 60	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792841&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159523	528824357							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558602	Cc1c(O)cc(O)c(C(=O)N2CCc3cc(CN(C)C)ccc3C2)c1OCc1ccccc1	InChI=1S/C27H30N2O4/c1-18-23(30)14-24(31)25(26(18)33-17-19-7-5-4-6-8-19)27(32)29-12-11-21-13-20(15-28(2)3)9-10-22(21)16-29/h4-10,13-14,30-31H,11-12,15-17H2,1-3H3	BLSCXXJVYHZKLA-UHFFFAOYSA-N	792842	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(6- ((dimethylamino) methyl)-3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 61	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792842&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159522	528824358							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558603	Cc1c(O)cc(O)c(C(=O)N2CCc3cc(CN(C)C)ccc3C2)c1OCc1ccccc1	InChI=1S/C27H30N2O4/c1-18-23(30)14-24(31)25(26(18)33-17-19-7-5-4-6-8-19)27(32)29-12-11-21-13-20(15-28(2)3)9-10-22(21)16-29/h4-10,13-14,30-31H,11-12,15-17H2,1-3H3	BLSCXXJVYHZKLA-UHFFFAOYSA-N	792842	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(6- ((dimethylamino) methyl)-3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 61	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792842&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159522	528824358							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558604	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C[C@H]2CO)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)12-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-13-19-10-6-5-9-18(19)11-20(26)14-27/h2-10,12,20,27-29H,11,13-15H2,1H3	RTKCGHBYOZDIKU-UHFFFAOYSA-N	792843	(S)-(2- (Benzyloxy)-4,6- dihydroxy-3- methylphenyl)(3- (hydroxymethyl)- 3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 62	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792843&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159530	528824359							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558605	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C[C@H]2CO)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)12-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-13-19-10-6-5-9-18(19)11-20(26)14-27/h2-10,12,20,27-29H,11,13-15H2,1H3	RTKCGHBYOZDIKU-UHFFFAOYSA-N	792843	(S)-(2- (Benzyloxy)-4,6- dihydroxy-3- methylphenyl)(3- (hydroxymethyl)- 3,4- dihydroisoquinolin- 2(1H)- yl)methanone::US12552758, Example 62	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792843&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159530	528824359							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558606	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C2CO)c1OCc1ccccc1	InChI=1S/C24H23NO5/c1-15-20(27)11-21(28)22(23(15)30-14-16-7-3-2-4-8-16)24(29)25-12-17-9-5-6-10-18(17)19(25)13-26/h2-11,19,26-28H,12-14H2,1H3	GZPZNNSQIDFASH-UHFFFAOYSA-N	792844	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(1- (hydroxymethyl) isoindolin-2- yl)methanone::US12552758, Example 63	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792844&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159481	528824360							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558607	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C2CO)c1OCc1ccccc1	InChI=1S/C24H23NO5/c1-15-20(27)11-21(28)22(23(15)30-14-16-7-3-2-4-8-16)24(29)25-12-17-9-5-6-10-18(17)19(25)13-26/h2-11,19,26-28H,12-14H2,1H3	GZPZNNSQIDFASH-UHFFFAOYSA-N	792844	(2-(benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(1- (hydroxymethyl) isoindolin-2- yl)methanone::US12552758, Example 63	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792844&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159481	528824360							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558608	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C[C@@H]2CO)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)12-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-13-19-10-6-5-9-18(19)11-20(26)14-27/h2-10,12,20,27-29H,11,13-15H2,1H3	RTKCGHBYOZDIKU-UHFFFAOYSA-N	792845	(R)-(2- (benzyloxy)-4,6- dihydroxy-3- methylphenyl)(3- (hydroxymethyl)-3,4- dihydroisoquinolin- 2(1H)-yl)methanone::US12552758, Example 64	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792845&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159441	528824361							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558609	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C[C@@H]2CO)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)12-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-13-19-10-6-5-9-18(19)11-20(26)14-27/h2-10,12,20,27-29H,11,13-15H2,1H3	RTKCGHBYOZDIKU-UHFFFAOYSA-N	792845	(R)-(2- (benzyloxy)-4,6- dihydroxy-3- methylphenyl)(3- (hydroxymethyl)-3,4- dihydroisoquinolin- 2(1H)-yl)methanone::US12552758, Example 64	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792845&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159441	528824361							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558610	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2CO)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)13-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-12-11-18-9-5-6-10-19(18)20(26)14-27/h2-10,13,20,27-29H,11-12,14-15H2,1H3	IYXIQJIEYRSVIP-UHFFFAOYSA-N	792846	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(1- (hydroxymethyl)-3,4- dihydroisoquinolin- 2(1H)-yl)methanone::US12552758, Example 65	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792846&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159519	528824362							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558611	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc3C2CO)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)13-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-12-11-18-9-5-6-10-19(18)20(26)14-27/h2-10,13,20,27-29H,11-12,14-15H2,1H3	IYXIQJIEYRSVIP-UHFFFAOYSA-N	792846	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(1- (hydroxymethyl)-3,4- dihydroisoquinolin- 2(1H)-yl)methanone::US12552758, Example 65	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792846&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159519	528824362							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558612	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C(CO)C2)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)11-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-12-18-9-5-6-10-20(18)19(13-26)14-27/h2-11,19,27-29H,12-15H2,1H3	XVHXLUPTRSIHHN-UHFFFAOYSA-N	792847	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- (hydroxymethyl)-3,4- dihydroisoquinolin- 2(1H)-yl)methanone::US12552758, Example 66	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792847&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159470	528824363							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558613	Cc1c(O)cc(O)c(C(=O)N2Cc3ccccc3C(CO)C2)c1OCc1ccccc1	InChI=1S/C25H25NO5/c1-16-21(28)11-22(29)23(24(16)31-15-17-7-3-2-4-8-17)25(30)26-12-18-9-5-6-10-20(18)19(13-26)14-27/h2-11,19,27-29H,12-15H2,1H3	XVHXLUPTRSIHHN-UHFFFAOYSA-N	792847	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- (hydroxymethyl)-3,4- dihydroisoquinolin- 2(1H)-yl)methanone::US12552758, Example 66	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792847&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159470	528824363							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558614	Cc1c(O)cc(O)c(C(=O)N2CCOc3ccccc32)c1OCc1ccccc1	InChI=1S/C23H21NO5/c1-15-18(25)13-19(26)21(22(15)29-14-16-7-3-2-4-8-16)23(27)24-11-12-28-20-10-6-5-9-17(20)24/h2-10,13,25-26H,11-12,14H2,1H3	MSVQJNWOMZBJLU-UHFFFAOYSA-N	792848	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(2,3- dihydro-4H- benzo[b][1,4] oxazin-4- yl)methanone::US12552758, Example 67	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792848&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159525	528824364							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558615	Cc1c(O)cc(O)c(C(=O)N2CCOc3ccccc32)c1OCc1ccccc1	InChI=1S/C23H21NO5/c1-15-18(25)13-19(26)21(22(15)29-14-16-7-3-2-4-8-16)23(27)24-11-12-28-20-10-6-5-9-17(20)24/h2-10,13,25-26H,11-12,14H2,1H3	MSVQJNWOMZBJLU-UHFFFAOYSA-N	792848	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(2,3- dihydro-4H- benzo[b][1,4] oxazin-4- yl)methanone::US12552758, Example 67	Mismatch repair endonuclease PMS2			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792848&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159525	528824364							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558616	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C26H28N2O4/c1-17-22(29)12-23(30)24(25(17)32-16-18-7-5-4-6-8-18)26(31)28-14-20-10-9-19(13-27(2)3)11-21(20)15-28/h4-12,29-30H,13-16H2,1-3H3	UBKAKFDOHVNBAP-UHFFFAOYSA-N	792849	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5- ((dimethylamino) methyl)isoindolin- 2-yl)methanone::US12552758, Example 68	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792849&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159457	528824365							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558617	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C26H28N2O4/c1-17-22(29)12-23(30)24(25(17)32-16-18-7-5-4-6-8-18)26(31)28-14-20-10-9-19(13-27(2)3)11-21(20)15-28/h4-12,29-30H,13-16H2,1-3H3	UBKAKFDOHVNBAP-UHFFFAOYSA-N	792849	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5- ((dimethylamino) methyl)isoindolin- 2-yl)methanone::US12552758, Example 68	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792849&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159457	528824365							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558618	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCOCC4)cc3C2)c1OCc1ccccc1	InChI=1S/C28H30N2O5/c1-19-24(31)14-25(32)26(27(19)35-18-20-5-3-2-4-6-20)28(33)30-16-22-8-7-21(13-23(22)17-30)15-29-9-11-34-12-10-29/h2-8,13-14,31-32H,9-12,15-18H2,1H3	ZTMUAUVJOQEWPH-UHFFFAOYSA-N	792850	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5- (morpholinomethyl) isoindolin-2- yl)methanone::US12552758, Example 69	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792850&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159436	528824366							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558619	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCOCC4)cc3C2)c1OCc1ccccc1	InChI=1S/C28H30N2O5/c1-19-24(31)14-25(32)26(27(19)35-18-20-5-3-2-4-6-20)28(33)30-16-22-8-7-21(13-23(22)17-30)15-29-9-11-34-12-10-29/h2-8,13-14,31-32H,9-12,15-18H2,1H3	ZTMUAUVJOQEWPH-UHFFFAOYSA-N	792850	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(5- (morpholinomethyl) isoindolin-2- yl)methanone::US12552758, Example 69	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792850&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159436	528824366							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558620	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc32)c1OCc1ccccc1	InChI=1S/C23H21NO4/c1-15-19(25)13-20(26)21(22(15)28-14-16-7-3-2-4-8-16)23(27)24-12-11-17-9-5-6-10-18(17)24/h2-10,13,25-26H,11-12,14H2,1H3	XRLNPTBNVHEASQ-UHFFFAOYSA-N	792851	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl) (indolin-1- yl)methanone::US12552758, Example 70	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792851&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159482	528824367							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558621	Cc1c(O)cc(O)c(C(=O)N2CCc3ccccc32)c1OCc1ccccc1	InChI=1S/C23H21NO4/c1-15-19(25)13-20(26)21(22(15)28-14-16-7-3-2-4-8-16)23(27)24-12-11-17-9-5-6-10-18(17)24/h2-10,13,25-26H,11-12,14H2,1H3	XRLNPTBNVHEASQ-UHFFFAOYSA-N	792851	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl) (indolin-1- yl)methanone::US12552758, Example 70	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792851&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159482	528824367							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558622	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCc2ccccc21	InChI=1S/C22H19NO4/c24-17-12-19(25)21(20(13-17)27-14-15-6-2-1-3-7-15)22(26)23-11-10-16-8-4-5-9-18(16)23/h1-9,12-13,24-25H,10-11,14H2	MLTOWXFAHONDOI-UHFFFAOYSA-N	792852	(2-(Benzyloxy)-4,6- dihydroxyphenyl) (indolin-1- yl)methanone::US12552758, Example 71	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792852&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159479	528824368							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558623	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCc2ccccc21	InChI=1S/C22H19NO4/c24-17-12-19(25)21(20(13-17)27-14-15-6-2-1-3-7-15)22(26)23-11-10-16-8-4-5-9-18(16)23/h1-9,12-13,24-25H,10-11,14H2	MLTOWXFAHONDOI-UHFFFAOYSA-N	792852	(2-(Benzyloxy)-4,6- dihydroxyphenyl) (indolin-1- yl)methanone::US12552758, Example 71	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792852&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159479	528824368							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558624	Cc1c(O)cc(O)c(C(=O)N2CCCc3ccccc32)c1OCc1ccccc1	InChI=1S/C24H23NO4/c1-16-20(26)14-21(27)22(23(16)29-15-17-8-3-2-4-9-17)24(28)25-13-7-11-18-10-5-6-12-19(18)25/h2-6,8-10,12,14,26-27H,7,11,13,15H2,1H3	DQVILYMMYSBBNM-UHFFFAOYSA-N	792853	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl) (3,4- dihydroquinolin- 1(2H)- yl)methanone::US12552758, Example 72	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792853&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159538	528824369							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558625	Cc1c(O)cc(O)c(C(=O)N2CCCc3ccccc32)c1OCc1ccccc1	InChI=1S/C24H23NO4/c1-16-20(26)14-21(27)22(23(16)29-15-17-8-3-2-4-9-17)24(28)25-13-7-11-18-10-5-6-12-19(18)25/h2-6,8-10,12,14,26-27H,7,11,13,15H2,1H3	DQVILYMMYSBBNM-UHFFFAOYSA-N	792853	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl) (3,4- dihydroquinolin- 1(2H)- yl)methanone::US12552758, Example 72	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792853&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159538	528824369							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558626	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCCc2ccccc21	InChI=1S/C23H21NO4/c25-18-13-20(26)22(21(14-18)28-15-16-7-2-1-3-8-16)23(27)24-12-6-10-17-9-4-5-11-19(17)24/h1-5,7-9,11,13-14,25-26H,6,10,12,15H2	FDJLWPMTTYRPOJ-UHFFFAOYSA-N	792854	(2-(Benzyloxy)- 4,6- dihydroxyphenyl) (3,4- dihydroquinolin- 1(2H)- yl)methanone::US12552758, Example 73	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792854&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159437	528824370							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558627	O=C(c1c(O)cc(O)cc1OCc1ccccc1)N1CCCc2ccccc21	InChI=1S/C23H21NO4/c25-18-13-20(26)22(21(14-18)28-15-16-7-2-1-3-8-16)23(27)24-12-6-10-17-9-4-5-11-19(17)24/h1-5,7-9,11,13-14,25-26H,6,10,12,15H2	FDJLWPMTTYRPOJ-UHFFFAOYSA-N	792854	(2-(Benzyloxy)- 4,6- dihydroxyphenyl) (3,4- dihydroquinolin- 1(2H)- yl)methanone::US12552758, Example 73	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792854&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159437	528824370							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558628	Cc1c(O)cc(O)c(C(=O)N2Cc3ccncc3C2)c1OCc1ccccc1	InChI=1S/C22H20N2O4/c1-14-18(25)9-19(26)20(21(14)28-13-15-5-3-2-4-6-15)22(27)24-11-16-7-8-23-10-17(16)12-24/h2-10,25-26H,11-13H2,1H3	BHUFHSQADNKBJQ-UHFFFAOYSA-N	792855	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(1,3- dihydro-2H- pyrrolo[3,4- c]pyridin-2- yl)methanone::US12552758, Example 74	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792855&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159463	528824371							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558629	Cc1c(O)cc(O)c(C(=O)N2Cc3ccncc3C2)c1OCc1ccccc1	InChI=1S/C22H20N2O4/c1-14-18(25)9-19(26)20(21(14)28-13-15-5-3-2-4-6-15)22(27)24-11-16-7-8-23-10-17(16)12-24/h2-10,25-26H,11-13H2,1H3	BHUFHSQADNKBJQ-UHFFFAOYSA-N	792855	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(1,3- dihydro-2H- pyrrolo[3,4- c]pyridin-2- yl)methanone::US12552758, Example 74	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792855&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159463	528824371							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558630	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(CN4CCN(C)CC4)c3C2)c1OCc1ccccc1	InChI=1S/C29H33N3O4/c1-20-25(33)15-26(34)27(28(20)36-19-21-7-4-3-5-8-21)29(35)32-17-23-10-6-9-22(24(23)18-32)16-31-13-11-30(2)12-14-31/h3-10,15,33-34H,11-14,16-19H2,1-2H3	DVMPACUWAXCCHD-UHFFFAOYSA-N	792856	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- ((4- methylpiperazin-1- yl)methyl)isoindolin- 2-yl)methanone::US12552758, Example 75	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792856&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159452	528824372							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558631	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(CN4CCN(C)CC4)c3C2)c1OCc1ccccc1	InChI=1S/C29H33N3O4/c1-20-25(33)15-26(34)27(28(20)36-19-21-7-4-3-5-8-21)29(35)32-17-23-10-6-9-22(24(23)18-32)16-31-13-11-30(2)12-14-31/h3-10,15,33-34H,11-14,16-19H2,1-2H3	DVMPACUWAXCCHD-UHFFFAOYSA-N	792856	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- ((4- methylpiperazin-1- yl)methyl)isoindolin- 2-yl)methanone::US12552758, Example 75	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792856&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159452	528824372							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558632	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(CN4CCOCC4)c3C2)c1OCc1ccccc1	InChI=1S/C28H30N2O5/c1-19-24(31)14-25(32)26(27(19)35-18-20-6-3-2-4-7-20)28(33)30-16-22-9-5-8-21(23(22)17-30)15-29-10-12-34-13-11-29/h2-9,14,31-32H,10-13,15-18H2,1H3	QTQIJSDPHXZELZ-UHFFFAOYSA-N	792857	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- (morpholinomethyl) isoindolin-2- yl)methanone::US12552758, Example 76	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792857&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159546	528824373							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558633	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(CN4CCOCC4)c3C2)c1OCc1ccccc1	InChI=1S/C28H30N2O5/c1-19-24(31)14-25(32)26(27(19)35-18-20-6-3-2-4-7-20)28(33)30-16-22-9-5-8-21(23(22)17-30)15-29-10-12-34-13-11-29/h2-9,14,31-32H,10-13,15-18H2,1H3	QTQIJSDPHXZELZ-UHFFFAOYSA-N	792857	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- (morpholinomethyl) isoindolin-2- yl)methanone::US12552758, Example 76	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792857&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159546	528824373							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558634	Cc1c(O)cc(O)c(C(=O)N2CCc3ccc(C(=O)N(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-22(30)14-23(31)24(25(17)34-16-18-7-5-4-6-8-18)27(33)29-12-11-19-9-10-20(13-21(19)15-29)26(32)28(2)3/h4-10,13-14,30-31H,11-12,15-16H2,1-3H3	NVIDOBBRDDUMCM-UHFFFAOYSA-N	792858	2-(2- (Benzyloxy)-4,6- dihydroxy-3- methylbenzoyl)- N,N-dimethyl- 1,2,3,4- tetrahydroisoquinoline- 7-carboxamide::US12552758, Example 77	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792858&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159495	528824374							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558635	Cc1c(O)cc(O)c(C(=O)N2CCc3ccc(C(=O)N(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-22(30)14-23(31)24(25(17)34-16-18-7-5-4-6-8-18)27(33)29-12-11-19-9-10-20(13-21(19)15-29)26(32)28(2)3/h4-10,13-14,30-31H,11-12,15-16H2,1-3H3	NVIDOBBRDDUMCM-UHFFFAOYSA-N	792858	2-(2- (Benzyloxy)-4,6- dihydroxy-3- methylbenzoyl)- N,N-dimethyl- 1,2,3,4- tetrahydroisoquinoline- 7-carboxamide::US12552758, Example 77	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792858&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159495	528824374							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558636	Cc1c(O)cc(O)c(C(=O)N2CCc3cc(C(=O)N(C)C)ccc3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-22(30)14-23(31)24(25(17)34-16-18-7-5-4-6-8-18)27(33)29-12-11-19-13-20(26(32)28(2)3)9-10-21(19)15-29/h4-10,13-14,30-31H,11-12,15-16H2,1-3H3	CAIWKGOHFGAEFA-UHFFFAOYSA-N	792859	2-(2- (benzyloxy)-4,6- dihydroxy-3- methylbenzoyl)- N,N-dimethyl- 1,2,3,4- tetrahydroisoquinoline- 6-carboxamide::US12552758, Example 78	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792859&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159483	528824375							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558637	Cc1c(O)cc(O)c(C(=O)N2CCc3cc(C(=O)N(C)C)ccc3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-22(30)14-23(31)24(25(17)34-16-18-7-5-4-6-8-18)27(33)29-12-11-19-13-20(26(32)28(2)3)9-10-21(19)15-29/h4-10,13-14,30-31H,11-12,15-16H2,1-3H3	CAIWKGOHFGAEFA-UHFFFAOYSA-N	792859	2-(2- (benzyloxy)-4,6- dihydroxy-3- methylbenzoyl)- N,N-dimethyl- 1,2,3,4- tetrahydroisoquinoline- 6-carboxamide::US12552758, Example 78	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792859&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159483	528824375							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558638	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(NC4CCOC4)c3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-23(30)12-24(31)25(26(17)34-15-18-6-3-2-4-7-18)27(32)29-13-19-8-5-9-22(21(19)14-29)28-20-10-11-33-16-20/h2-9,12,20,28,30-31H,10-11,13-16H2,1H3	PASZBQIANMZXIF-UHFFFAOYSA-N	792860	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- ((tetrahydrofuran-3- yl)amino)isoindolin- 2-yl)methanone::US12552758, Example 79	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792860&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159513	528824376							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558639	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(NC4CCOC4)c3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-23(30)12-24(31)25(26(17)34-15-18-6-3-2-4-7-18)27(32)29-13-19-8-5-9-22(21(19)14-29)28-20-10-11-33-16-20/h2-9,12,20,28,30-31H,10-11,13-16H2,1H3	PASZBQIANMZXIF-UHFFFAOYSA-N	792860	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- ((tetrahydrofuran-3- yl)amino)isoindolin- 2-yl)methanone::US12552758, Example 79	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792860&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159513	528824376							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558640	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(NC4COC4)c3C2)c1OCc1ccccc1	InChI=1S/C26H26N2O5/c1-16-22(29)10-23(30)24(25(16)33-13-17-6-3-2-4-7-17)26(31)28-11-18-8-5-9-21(20(18)12-28)27-19-14-32-15-19/h2-10,19,27,29-30H,11-15H2,1H3	HMZMAPXZLZSKIA-UHFFFAOYSA-N	792861	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- (oxetan-3- ylamino)isoindolin- 2-yl)methanone::US12552758, Example 80	DNA mismatch repair protein Mlh1			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792861&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159542	528824377							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558641	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(NC4COC4)c3C2)c1OCc1ccccc1	InChI=1S/C26H26N2O5/c1-16-22(29)10-23(30)24(25(16)33-13-17-6-3-2-4-7-17)26(31)28-11-18-8-5-9-21(20(18)12-28)27-19-14-32-15-19/h2-10,19,27,29-30H,11-15H2,1H3	HMZMAPXZLZSKIA-UHFFFAOYSA-N	792861	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4- (oxetan-3- ylamino)isoindolin- 2-yl)methanone::US12552758, Example 80	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792861&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159542	528824377							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558642	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(N4CCCC(O)C4)c3C2)c1OCc1ccccc1	InChI=1S/C28H30N2O5/c1-18-24(32)13-25(33)26(27(18)35-17-19-7-3-2-4-8-19)28(34)30-14-20-9-5-11-23(22(20)16-30)29-12-6-10-21(31)15-29/h2-5,7-9,11,13,21,31-33H,6,10,12,14-17H2,1H3	CWGHCJLBLRAJSQ-UHFFFAOYSA-N	792862	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4-(3- hydroxypiperidin- 1-yl)isoindolin- 2-yl)methanone::US12552758, Example 81	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792862&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159473	528824378							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558643	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(N4CCCC(O)C4)c3C2)c1OCc1ccccc1	InChI=1S/C28H30N2O5/c1-18-24(32)13-25(33)26(27(18)35-17-19-7-3-2-4-8-19)28(34)30-14-20-9-5-11-23(22(20)16-30)29-12-6-10-21(31)15-29/h2-5,7-9,11,13,21,31-33H,6,10,12,14-17H2,1H3	CWGHCJLBLRAJSQ-UHFFFAOYSA-N	792862	(2-(Benzyloxy)- 4,6-dihydroxy-3- methylphenyl)(4-(3- hydroxypiperidin- 1-yl)isoindolin- 2-yl)methanone::US12552758, Example 81	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792862&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159473	528824378							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558644	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(C#N)c3C2)c1OCc1ccccc1	InChI=1S/C24H20N2O4/c1-15-20(27)10-21(28)22(23(15)30-14-16-6-3-2-4-7-16)24(29)26-12-18-9-5-8-17(11-25)19(18)13-26/h2-10,27-28H,12-14H2,1H3	PACJPNFVCYDZDV-UHFFFAOYSA-N	792863	2-(2-(benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)isoindoline-4-carbonitrile::US12552758, Example 82	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792863&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159447	528824379							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558645	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(C#N)c3C2)c1OCc1ccccc1	InChI=1S/C24H20N2O4/c1-15-20(27)10-21(28)22(23(15)30-14-16-6-3-2-4-7-16)24(29)26-12-18-9-5-8-17(11-25)19(18)13-26/h2-10,27-28H,12-14H2,1H3	PACJPNFVCYDZDV-UHFFFAOYSA-N	792863	2-(2-(benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)isoindoline-4-carbonitrile::US12552758, Example 82	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792863&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159447	528824379							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558646	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(C(=O)N(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C26H26N2O5/c1-16-21(29)12-22(30)23(24(16)33-15-17-7-5-4-6-8-17)26(32)28-13-19-10-9-18(11-20(19)14-28)25(31)27(2)3/h4-12,29-30H,13-15H2,1-3H3	WHOIIWKXEZQINS-UHFFFAOYSA-N	792864	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N,N-dimethylisoindoline-5-carboxamide::US12552758, Example 83	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792864&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159488	528824380							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558647	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(C(=O)N(C)C)cc3C2)c1OCc1ccccc1	InChI=1S/C26H26N2O5/c1-16-21(29)12-22(30)23(24(16)33-15-17-7-5-4-6-8-17)26(32)28-13-19-10-9-18(11-20(19)14-28)25(31)27(2)3/h4-12,29-30H,13-15H2,1-3H3	WHOIIWKXEZQINS-UHFFFAOYSA-N	792864	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N,N-dimethylisoindoline-5-carboxamide::US12552758, Example 83	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792864&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159488	528824380							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558648	CNC(=O)c1ccc2c(c1)CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H24N2O5/c1-15-20(28)11-21(29)22(23(15)32-14-16-6-4-3-5-7-16)25(31)27-12-18-9-8-17(24(30)26-2)10-19(18)13-27/h3-11,28-29H,12-14H2,1-2H3,(H,26,30)	RSSRZHGGCYLYKB-UHFFFAOYSA-N	792865	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N-methylisoindoline-5-carboxamide::US12552758, Example 84	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792865&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168796305	528824381							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558649	CNC(=O)c1ccc2c(c1)CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H24N2O5/c1-15-20(28)11-21(29)22(23(15)32-14-16-6-4-3-5-7-16)25(31)27-12-18-9-8-17(24(30)26-2)10-19(18)13-27/h3-11,28-29H,12-14H2,1-2H3,(H,26,30)	RSSRZHGGCYLYKB-UHFFFAOYSA-N	792865	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N-methylisoindoline-5-carboxamide::US12552758, Example 84	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792865&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168796305	528824381							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558650	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(C(=O)N(C)C)c3C2)c1OCc1ccccc1	InChI=1S/C26H26N2O5/c1-16-21(29)12-22(30)23(24(16)33-15-17-8-5-4-6-9-17)26(32)28-13-18-10-7-11-19(20(18)14-28)25(31)27(2)3/h4-12,29-30H,13-15H2,1-3H3	MGUMTGPVVVNUDU-UHFFFAOYSA-N	792866	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N,N-dimethylisoindoline-4-carboxamide::US12552758, Example 85	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792866&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159455	528824382							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558651	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(C(=O)N(C)C)c3C2)c1OCc1ccccc1	InChI=1S/C26H26N2O5/c1-16-21(29)12-22(30)23(24(16)33-15-17-8-5-4-6-9-17)26(32)28-13-18-10-7-11-19(20(18)14-28)25(31)27(2)3/h4-12,29-30H,13-15H2,1-3H3	MGUMTGPVVVNUDU-UHFFFAOYSA-N	792866	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N,N-dimethylisoindoline-4-carboxamide::US12552758, Example 85	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792866&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159455	528824382							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558652	CNC(=O)C1=CC=CC2CN(C(=O)c3c(O)cc(O)c(C)c3OCc3ccccc3)CC12	InChI=1S/C25H26N2O5/c1-15-20(28)11-21(29)22(23(15)32-14-16-7-4-3-5-8-16)25(31)27-12-17-9-6-10-18(19(17)13-27)24(30)26-2/h3-11,17,19,28-29H,12-14H2,1-2H3,(H,26,30)	LNKGGPCJVVQYHN-UHFFFAOYSA-N	792867	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N-methylisoindoline-4-carboxamide::US12552758, Example 86	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792867&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			178422833	528824383							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558653	CNC(=O)C1=CC=CC2CN(C(=O)c3c(O)cc(O)c(C)c3OCc3ccccc3)CC12	InChI=1S/C25H26N2O5/c1-15-20(28)11-21(29)22(23(15)32-14-16-7-4-3-5-8-16)25(31)27-12-17-9-6-10-18(19(17)13-27)24(30)26-2/h3-11,17,19,28-29H,12-14H2,1-2H3,(H,26,30)	LNKGGPCJVVQYHN-UHFFFAOYSA-N	792867	2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)-N-methylisoindoline-4-carboxamide::US12552758, Example 86	Mismatch repair endonuclease PMS2			 5500							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792867&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			178422833	528824383							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558654	CC(=O)Nc1cccc2c1CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H24N2O5/c1-15-21(29)11-22(30)23(24(15)32-14-17-7-4-3-5-8-17)25(31)27-12-18-9-6-10-20(19(18)13-27)26-16(2)28/h3-11,29-30H,12-14H2,1-2H3,(H,26,28)	HAMDLCKHQAIHLG-UHFFFAOYSA-N	792868	N-(2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)isoindolin-4-yl)acetamide::US12552758, Example 87	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792868&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159466	528824384							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558655	CC(=O)Nc1cccc2c1CN(C(=O)c1c(O)cc(O)c(C)c1OCc1ccccc1)C2	InChI=1S/C25H24N2O5/c1-15-21(29)11-22(30)23(24(15)32-14-17-7-4-3-5-8-17)25(31)27-12-18-9-6-10-20(19(18)13-27)26-16(2)28/h3-11,29-30H,12-14H2,1-2H3,(H,26,28)	HAMDLCKHQAIHLG-UHFFFAOYSA-N	792868	N-(2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)isoindolin-4-yl)acetamide::US12552758, Example 87	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792868&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159466	528824384							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558656	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(OC4CCOC4)c3C2)c1OCc1ccccc1	InChI=1S/C27H27NO6/c1-17-22(29)12-23(30)25(26(17)33-15-18-6-3-2-4-7-18)27(31)28-13-19-8-5-9-24(21(19)14-28)34-20-10-11-32-16-20/h2-9,12,20,29-30H,10-11,13-16H2,1H3	WYYXKCQGQSZFFQ-UHFFFAOYSA-N	792869	((2-(Benzyloxy)-4,6-dihydroxy-3-methylphenyl)(4-((tetrahydrofuran-3-yl)oxy)isoindolin-2-yl)methanone::(2-(Benzyloxy)-4,6-dihydroxy-3-methylphenyl)(4-((tetrahydrofuran-3-yl)oxy)isoindolin-2-yl)methanone::US12552758, Example 88	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792869&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159475	528824385							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558657	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(OC4CCOC4)c3C2)c1OCc1ccccc1	InChI=1S/C27H27NO6/c1-17-22(29)12-23(30)25(26(17)33-15-18-6-3-2-4-7-18)27(31)28-13-19-8-5-9-24(21(19)14-28)34-20-10-11-32-16-20/h2-9,12,20,29-30H,10-11,13-16H2,1H3	WYYXKCQGQSZFFQ-UHFFFAOYSA-N	792869	((2-(Benzyloxy)-4,6-dihydroxy-3-methylphenyl)(4-((tetrahydrofuran-3-yl)oxy)isoindolin-2-yl)methanone::(2-(Benzyloxy)-4,6-dihydroxy-3-methylphenyl)(4-((tetrahydrofuran-3-yl)oxy)isoindolin-2-yl)methanone::US12552758, Example 88	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792869&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159475	528824385							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558658	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(OCC4CNC4)c3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-22(30)10-23(31)25(26(17)34-15-18-6-3-2-4-7-18)27(32)29-13-20-8-5-9-24(21(20)14-29)33-16-19-11-28-12-19/h2-10,19,28,30-31H,11-16H2,1H3	BAJZTYWLPQIARW-UHFFFAOYSA-N	792870	(4-(Azetidin-3-yl methoxy) isoindolin-2-yl) (2-(benzyloxy)-4,6-dihydroxy-3-methylphenyl)methanone::(4-(Azetidin-3-ylmethoxy)isoindolin-2-yl)(2-(benzyloxy)-4,6-dihydroxy-3-methylphenyl)methanone::US12552758, Example 89	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792870&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159543	528824386							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558659	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(OCC4CNC4)c3C2)c1OCc1ccccc1	InChI=1S/C27H28N2O5/c1-17-22(30)10-23(31)25(26(17)34-15-18-6-3-2-4-7-18)27(32)29-13-20-8-5-9-24(21(20)14-29)33-16-19-11-28-12-19/h2-10,19,28,30-31H,11-16H2,1H3	BAJZTYWLPQIARW-UHFFFAOYSA-N	792870	(4-(Azetidin-3-yl methoxy) isoindolin-2-yl) (2-(benzyloxy)-4,6-dihydroxy-3-methylphenyl)methanone::(4-(Azetidin-3-ylmethoxy)isoindolin-2-yl)(2-(benzyloxy)-4,6-dihydroxy-3-methylphenyl)methanone::US12552758, Example 89	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792870&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159543	528824386							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558660	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(OCc4cncnc4)c3C2)c1OCc1ccccc1	InChI=1S/C28H25N3O5/c1-18-23(32)10-24(33)26(27(18)36-15-19-6-3-2-4-7-19)28(34)31-13-21-8-5-9-25(22(21)14-31)35-16-20-11-29-17-30-12-20/h2-12,17,32-33H,13-16H2,1H3	HNJYQBZELQHBFF-UHFFFAOYSA-N	792871	(2-(Benzyloxy)-4,6-dihydroxy-3-methylphenyl)(4-(pyrimidin-5-ylmethoxy)isoindolin-2-yl)methanone::US12552758, Example 90	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792871&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159532	528824387							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558661	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(OCc4cncnc4)c3C2)c1OCc1ccccc1	InChI=1S/C28H25N3O5/c1-18-23(32)10-24(33)26(27(18)36-15-19-6-3-2-4-7-19)28(34)31-13-21-8-5-9-25(22(21)14-31)35-16-20-11-29-17-30-12-20/h2-12,17,32-33H,13-16H2,1H3	HNJYQBZELQHBFF-UHFFFAOYSA-N	792871	(2-(Benzyloxy)-4,6-dihydroxy-3-methylphenyl)(4-(pyrimidin-5-ylmethoxy)isoindolin-2-yl)methanone::US12552758, Example 90	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792871&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159532	528824387							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558662	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(N4CC(C#N)C4)c3C2)c1OCc1ccccc1	InChI=1S/C27H25N3O4/c1-17-23(31)10-24(32)25(26(17)34-16-18-6-3-2-4-7-18)27(33)30-14-20-8-5-9-22(21(20)15-30)29-12-19(11-28)13-29/h2-10,19,31-32H,12-16H2,1H3	IPGWQGDRQGEMRP-UHFFFAOYSA-N	792872	1-(2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)isoindolin-4-yl)azetidine-3-carbonitrile::US12552758, Example 91	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792872&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159492	528824388							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558663	Cc1c(O)cc(O)c(C(=O)N2Cc3cccc(N4CC(C#N)C4)c3C2)c1OCc1ccccc1	InChI=1S/C27H25N3O4/c1-17-23(31)10-24(32)25(26(17)34-16-18-6-3-2-4-7-18)27(33)30-14-20-8-5-9-22(21(20)15-30)29-12-19(11-28)13-29/h2-10,19,31-32H,12-16H2,1H3	IPGWQGDRQGEMRP-UHFFFAOYSA-N	792872	1-(2-(2-(Benzyloxy)-4,6-dihydroxy-3-methylbenzoyl)isoindolin-4-yl)azetidine-3-carbonitrile::US12552758, Example 91	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792872&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159492	528824388							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558664	COc1c(C)c(O)cc(O)c1C(=O)N1Cc2ccc(CN3CCN(C)CC3)cc2C1	InChI=1S/C23H29N3O4/c1-15-19(27)11-20(28)21(22(15)30-3)23(29)26-13-17-5-4-16(10-18(17)14-26)12-25-8-6-24(2)7-9-25/h4-5,10-11,27-28H,6-9,12-14H2,1-3H3	ZREIVVPUEUEQRL-UHFFFAOYSA-N	792873	(4,6-Dihydroxy-2-methoxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 92	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792873&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159506	528824389							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558665	COc1c(C)c(O)cc(O)c1C(=O)N1Cc2ccc(CN3CCN(C)CC3)cc2C1	InChI=1S/C23H29N3O4/c1-15-19(27)11-20(28)21(22(15)30-3)23(29)26-13-17-5-4-16(10-18(17)14-26)12-25-8-6-24(2)7-9-25/h4-5,10-11,27-28H,6-9,12-14H2,1-3H3	ZREIVVPUEUEQRL-UHFFFAOYSA-N	792873	(4,6-Dihydroxy-2-methoxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 92	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792873&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159506	528824389							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558666	CCOc1c(C)c(O)cc(O)c1C(=O)N1Cc2ccc(CN3CCN(C)CC3)cc2C1	InChI=1S/C24H31N3O4/c1-4-31-23-16(2)20(28)12-21(29)22(23)24(30)27-14-18-6-5-17(11-19(18)15-27)13-26-9-7-25(3)8-10-26/h5-6,11-12,28-29H,4,7-10,13-15H2,1-3H3	XKTMZKJBTNCSGB-UHFFFAOYSA-N	792874	(2-Ethoxy-4,6-dihydroxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 93	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792874&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159493	528824390							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558667	CCOc1c(C)c(O)cc(O)c1C(=O)N1Cc2ccc(CN3CCN(C)CC3)cc2C1	InChI=1S/C24H31N3O4/c1-4-31-23-16(2)20(28)12-21(29)22(23)24(30)27-14-18-6-5-17(11-19(18)15-27)13-26-9-7-25(3)8-10-26/h5-6,11-12,28-29H,4,7-10,13-15H2,1-3H3	XKTMZKJBTNCSGB-UHFFFAOYSA-N	792874	(2-Ethoxy-4,6-dihydroxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 93	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792874&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159493	528824390							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558668	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c1OCC1CCCCC1	InChI=1S/C29H39N3O4/c1-20-25(33)15-26(34)27(28(20)36-19-21-6-4-3-5-7-21)29(35)32-17-23-9-8-22(14-24(23)18-32)16-31-12-10-30(2)11-13-31/h8-9,14-15,21,33-34H,3-7,10-13,16-19H2,1-2H3	QOIGGSIZFRXCNK-UHFFFAOYSA-N	792875	(2-(Cyclohexylmethoxy)-4,6-dihydroxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 94	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792875&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159472	528824391							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558669	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c1OCC1CCCCC1	InChI=1S/C29H39N3O4/c1-20-25(33)15-26(34)27(28(20)36-19-21-6-4-3-5-7-21)29(35)32-17-23-9-8-22(14-24(23)18-32)16-31-12-10-30(2)11-13-31/h8-9,14-15,21,33-34H,3-7,10-13,16-19H2,1-2H3	QOIGGSIZFRXCNK-UHFFFAOYSA-N	792875	(2-(Cyclohexylmethoxy)-4,6-dihydroxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 94	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792875&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159472	528824391							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558670	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c1OCC1CC1	InChI=1S/C26H33N3O4/c1-17-22(30)12-23(31)24(25(17)33-16-18-3-4-18)26(32)29-14-20-6-5-19(11-21(20)15-29)13-28-9-7-27(2)8-10-28/h5-6,11-12,18,30-31H,3-4,7-10,13-16H2,1-2H3	UNVZMLXJVXTRPV-UHFFFAOYSA-N	792876	(2-(Cyclopropylmethoxy)-4,6-dihydroxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 95	DNA mismatch repair protein Mlh1			>10000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2123&target=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792876&enzyme=DNA+mismatch+repair+protein+Mlh1&column=ki&startPg=0&Increment=50&submit=Search			168159476	528824392							1	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRKALKNPSEEYGKILEVVGRYSVHNAGISFSVKKQGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESTSLRKAIETVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEMVKSTTSLTSSSTSGSSDKVYAHQMVRTDSREQKLDAFLQPLSKPLSSQPQAIVTEDKTDISSGRARQQDEEMLELPAPAEVAAKNQSLEGDTTKGTSEMSEKRGPTSSNPRKRHREDSDVEMVEDDSRKEMTAACTPRRRIINLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFTEDGNILQLANLPDLYKVFERC	4P7A,9R9M,3RBN,9P4B,9P5C,9P51	DNA mismatch repair protein Mlh1	MLH1_HUMAN	P40692	B4DI13 B4DQ11 E9PCU2																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
558671	Cc1c(O)cc(O)c(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c1OCC1CC1	InChI=1S/C26H33N3O4/c1-17-22(30)12-23(31)24(25(17)33-16-18-3-4-18)26(32)29-14-20-6-5-19(11-21(20)15-29)13-28-9-7-27(2)8-10-28/h5-6,11-12,18,30-31H,3-4,7-10,13-16H2,1-2H3	UNVZMLXJVXTRPV-UHFFFAOYSA-N	792876	(2-(Cyclopropylmethoxy)-4,6-dihydroxy-3-methylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone::US12552758, Example 95	Mismatch repair endonuclease PMS2			<1000							US Patent		10.7270/Q2JS9WD2		aid1795887	US12552758	Blagg, J; Roffey, J; Drysdale, M; Winship, P; Clark, D	2/17/2026	6/29/2026	Neophore	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1797&target=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792876&enzyme=Mismatch+repair+endonuclease+PMS2&column=ki&startPg=0&Increment=50&submit=Search			168159476	528824392							1	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN	7RCK,1H7U,1H7S,9S89,1EA6	Mismatch repair endonuclease PMS2	PMS2_HUMAN	P54278	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2