BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 558862 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H23F3N6O2/c1-12-10-27(11-13(2)31-12)16-15(14-6-4-3-5-7-14)25-18(24)29-17(16)26-28(19(29)30)9-8-20(21,22)23/h3-7,12-13H,8-11H2,1-2H3,(H2,24,25) KDXJBMRQWCTPSO-UHFFFAOYSA-N 792956 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-1 Adenosine receptor A1 Homo sapiens >3981 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792956&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760561 528824472 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558863 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H23F3N6O2/c1-12-10-27(11-13(2)31-12)16-15(14-6-4-3-5-7-14)25-18(24)29-17(16)26-28(19(29)30)9-8-20(21,22)23/h3-7,12-13H,8-11H2,1-2H3,(H2,24,25) KDXJBMRQWCTPSO-UHFFFAOYSA-N 792956 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-1 Adenosine receptor A2a Homo sapiens 5.01 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792956&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760561 528824472 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558864 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCCF)nc23)C[C@H](C)O1 InChI=1S/C20H25FN6O2/c1-13-11-25(12-14(2)29-13)17-16(15-7-4-3-5-8-15)23-19(22)27-18(17)24-26(20(27)28)10-6-9-21/h3-5,7-8,13-14H,6,9-12H2,1-2H3,(H2,22,23) NCVJVPVNGIRXBX-UHFFFAOYSA-N 792957 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-(3-fluoropropyl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-2 Adenosine receptor A1 Homo sapiens >3162 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792957&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760507 528824473 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558865 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCCF)nc23)C[C@H](C)O1 InChI=1S/C20H25FN6O2/c1-13-11-25(12-14(2)29-13)17-16(15-7-4-3-5-8-15)23-19(22)27-18(17)24-26(20(27)28)10-6-9-21/h3-5,7-8,13-14H,6,9-12H2,1-2H3,(H2,22,23) NCVJVPVNGIRXBX-UHFFFAOYSA-N 792957 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-(3-fluoropropyl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-2 Adenosine receptor A2a Homo sapiens 158 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792957&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760507 528824473 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558866 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H24F2N6O2/c1-12-10-26(11-13(2)30-12)17-16(14-6-4-3-5-7-14)24-19(23)28-18(17)25-27(20(28)29)9-8-15(21)22/h3-7,12-13,15H,8-11H2,1-2H3,(H2,23,24) KTEUQRPEFHJWKI-UHFFFAOYSA-N 792958 5-amino-2-(3,3-difluoropropyl)-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-3 Adenosine receptor A1 Homo sapiens >3981 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792958&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760573 528824474 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558867 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H24F2N6O2/c1-12-10-26(11-13(2)30-12)17-16(14-6-4-3-5-7-14)24-19(23)28-18(17)25-27(20(28)29)9-8-15(21)22/h3-7,12-13,15H,8-11H2,1-2H3,(H2,23,24) KTEUQRPEFHJWKI-UHFFFAOYSA-N 792958 5-amino-2-(3,3-difluoropropyl)-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-3 Adenosine receptor A2a Homo sapiens 79.4 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792958&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760573 528824474 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558868 CCCn1nc2c(N3C[C@@H](C)O[C@@H](C)C3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C20H26N6O2/c1-4-10-25-20(27)26-18(23-25)17(24-11-13(2)28-14(3)12-24)16(22-19(26)21)15-8-6-5-7-9-15/h5-9,13-14H,4,10-12H2,1-3H3,(H2,21,22) OZGHBVPPBMZZJK-UHFFFAOYSA-N 792959 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-propyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-4 Adenosine receptor A1 Homo sapiens >3162 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792959&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767952 528824475 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558869 CCCn1nc2c(N3C[C@@H](C)O[C@@H](C)C3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C20H26N6O2/c1-4-10-25-20(27)26-18(23-25)17(24-11-13(2)28-14(3)12-24)16(22-19(26)21)15-8-6-5-7-9-15/h5-9,13-14H,4,10-12H2,1-3H3,(H2,21,22) OZGHBVPPBMZZJK-UHFFFAOYSA-N 792959 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-propyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-4 Adenosine receptor A2a Homo sapiens 63.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792959&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767952 528824475 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558870 C[C@@H]1CN(c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H22F4N6O2/c1-11-9-28(10-12(2)32-11)16-15(13-3-5-14(21)6-4-13)26-18(25)30-17(16)27-29(19(30)31)8-7-20(22,23)24/h3-6,11-12H,7-10H2,1-2H3,(H2,25,26) IDCIUJASVHRYBH-UHFFFAOYSA-N 792960 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-(4-fluorophenyl)-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-5 Adenosine receptor A1 Homo sapiens >3162 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792960&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760592 528824476 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558871 C[C@@H]1CN(c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H22F4N6O2/c1-11-9-28(10-12(2)32-11)16-15(13-3-5-14(21)6-4-13)26-18(25)30-17(16)27-29(19(30)31)8-7-20(22,23)24/h3-6,11-12H,7-10H2,1-2H3,(H2,25,26) IDCIUJASVHRYBH-UHFFFAOYSA-N 792960 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-(4-fluorophenyl)-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-5 Adenosine receptor A2a Homo sapiens 50.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792960&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760592 528824476 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558872 CCCn1nc2c(N3C[C@@H](C)O[C@@H](C)C3)c(-c3ccc(F)cc3)nc(N)n2c1=O InChI=1S/C20H25FN6O2/c1-4-9-26-20(28)27-18(24-26)17(25-10-12(2)29-13(3)11-25)16(23-19(27)22)14-5-7-15(21)8-6-14/h5-8,12-13H,4,9-11H2,1-3H3,(H2,22,23) OVGHXZIIIAAPCB-UHFFFAOYSA-N 792961 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-(4-fluorophenyl)-2-propyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-6 Adenosine receptor A1 Homo sapiens 398 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792961&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760571 528824477 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558873 CCCn1nc2c(N3C[C@@H](C)O[C@@H](C)C3)c(-c3ccc(F)cc3)nc(N)n2c1=O InChI=1S/C20H25FN6O2/c1-4-9-26-20(28)27-18(24-26)17(25-10-12(2)29-13(3)11-25)16(23-19(27)22)14-5-7-15(21)8-6-14/h5-8,12-13H,4,9-11H2,1-3H3,(H2,22,23) OVGHXZIIIAAPCB-UHFFFAOYSA-N 792961 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-(4-fluorophenyl)-2-propyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-6 Adenosine receptor A2a Homo sapiens 126 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792961&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760571 528824477 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558874 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@@H]4CCCN4C)nc23)C[C@H](C)O1 InChI=1S/C23H31N7O2/c1-15-12-28(13-16(2)32-15)20-19(17-8-5-4-6-9-17)25-22(24)30-21(20)26-29(23(30)31)14-18-10-7-11-27(18)3/h4-6,8-9,15-16,18H,7,10-14H2,1-3H3,(H2,24,25) BQOVGGOUTKJLTF-UHFFFAOYSA-N 792962 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-7 Adenosine receptor A1 Homo sapiens 1995 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792962&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 157431440 528824478 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558875 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@@H]4CCCN4C)nc23)C[C@H](C)O1 InChI=1S/C23H31N7O2/c1-15-12-28(13-16(2)32-15)20-19(17-8-5-4-6-9-17)25-22(24)30-21(20)26-29(23(30)31)14-18-10-7-11-27(18)3/h4-6,8-9,15-16,18H,7,10-14H2,1-3H3,(H2,24,25) BQOVGGOUTKJLTF-UHFFFAOYSA-N 792962 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(2S)-1-methylpyrrolidin-2-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-7 Adenosine receptor A2a Homo sapiens 158 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792962&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 157431440 528824478 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558876 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4CCCO4)nc23)C[C@H](C)O1 InChI=1S/C22H28N6O3/c1-14-11-26(12-15(2)31-14)19-18(16-7-4-3-5-8-16)24-21(23)28-20(19)25-27(22(28)29)13-17-9-6-10-30-17/h3-5,7-8,14-15,17H,6,9-13H2,1-2H3,(H2,23,24) WGKKOVUFCBDNKZ-UHFFFAOYSA-N 792963 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-[[(2R)-tetrahydrofuran-2-yl]methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-8 Adenosine receptor A1 Homo sapiens >1995 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792963&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767977 528824479 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558877 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4CCCO4)nc23)C[C@H](C)O1 InChI=1S/C22H28N6O3/c1-14-11-26(12-15(2)31-14)19-18(16-7-4-3-5-8-16)24-21(23)28-20(19)25-27(22(28)29)13-17-9-6-10-30-17/h3-5,7-8,14-15,17H,6,9-13H2,1-2H3,(H2,23,24) WGKKOVUFCBDNKZ-UHFFFAOYSA-N 792963 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-[[(2R)-tetrahydrofuran-2-yl]methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-8 Adenosine receptor A2a Homo sapiens 10.0 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792963&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767977 528824479 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558878 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCN4CCCCC4)nc23)C[C@H](C)O1 InChI=1S/C24H33N7O2/c1-17-15-29(16-18(2)33-17)21-20(19-9-5-3-6-10-19)26-23(25)31-22(21)27-30(24(31)32)14-13-28-11-7-4-8-12-28/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3,(H2,25,26) JUDXDAMNCSGJED-UHFFFAOYSA-N 792964 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-[2-(1-piperidyl)ethyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-9 Adenosine receptor A1 Homo sapiens >3162 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792964&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767981 528824480 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558879 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCN4CCCCC4)nc23)C[C@H](C)O1 InChI=1S/C24H33N7O2/c1-17-15-29(16-18(2)33-17)21-20(19-9-5-3-6-10-19)26-23(25)31-22(21)27-30(24(31)32)14-13-28-11-7-4-8-12-28/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3,(H2,25,26) JUDXDAMNCSGJED-UHFFFAOYSA-N 792964 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-[2-(1-piperidyl)ethyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-9 Adenosine receptor A2a Homo sapiens 200 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792964&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767981 528824480 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558880 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4COCCN4)nc23)C[C@H](C)O1 InChI=1S/C22H29N7O3/c1-14-10-27(11-15(2)32-14)19-18(16-6-4-3-5-7-16)25-21(23)29-20(19)26-28(22(29)30)12-17-13-31-9-8-24-17/h3-7,14-15,17,24H,8-13H2,1-2H3,(H2,23,25) JRAWMIHZSJIXEQ-UHFFFAOYSA-N 792965 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3S)-morpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-10 Adenosine receptor A1 Homo sapiens >3981 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792965&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 158998521 528824481 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558881 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4COCCN4)nc23)C[C@H](C)O1 InChI=1S/C22H29N7O3/c1-14-10-27(11-15(2)32-14)19-18(16-6-4-3-5-7-16)25-21(23)29-20(19)26-28(22(29)30)12-17-13-31-9-8-24-17/h3-7,14-15,17,24H,8-13H2,1-2H3,(H2,23,25) JRAWMIHZSJIXEQ-UHFFFAOYSA-N 792965 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3S)-morpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-10 Adenosine receptor A2a Homo sapiens 126 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792965&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 158998521 528824481 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558882 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@@H]4COCCN4)nc23)C[C@H](C)O1 InChI=1S/C22H29N7O3/c1-14-10-27(11-15(2)32-14)19-18(16-6-4-3-5-7-16)25-21(23)29-20(19)26-28(22(29)30)12-17-13-31-9-8-24-17/h3-7,14-15,17,24H,8-13H2,1-2H3,(H2,23,25) JRAWMIHZSJIXEQ-UHFFFAOYSA-N 792966 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3R)-morpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-11 Adenosine receptor A1 Homo sapiens >2512 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792966&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767982 528824482 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558883 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@@H]4COCCN4)nc23)C[C@H](C)O1 InChI=1S/C22H29N7O3/c1-14-10-27(11-15(2)32-14)19-18(16-6-4-3-5-7-16)25-21(23)29-20(19)26-28(22(29)30)12-17-13-31-9-8-24-17/h3-7,14-15,17,24H,8-13H2,1-2H3,(H2,23,25) JRAWMIHZSJIXEQ-UHFFFAOYSA-N 792966 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3R)-morpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-11 Adenosine receptor A2a Homo sapiens 200 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792966&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767982 528824482 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558884 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4COCCN4C)nc23)C[C@H](C)O1 InChI=1S/C23H31N7O3/c1-15-11-28(12-16(2)33-15)20-19(17-7-5-4-6-8-17)25-22(24)30-21(20)26-29(23(30)31)13-18-14-32-10-9-27(18)3/h4-8,15-16,18H,9-14H2,1-3H3,(H2,24,25) IAAQDZOTKBGLLL-UHFFFAOYSA-N 792967 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3S)-4-methylmorpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-12 Adenosine receptor A1 Homo sapiens >3981 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792967&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166768051 528824483 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558885 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4COCCN4C)nc23)C[C@H](C)O1 InChI=1S/C23H31N7O3/c1-15-11-28(12-16(2)33-15)20-19(17-7-5-4-6-8-17)25-22(24)30-21(20)26-29(23(30)31)13-18-14-32-10-9-27(18)3/h4-8,15-16,18H,9-14H2,1-3H3,(H2,24,25) IAAQDZOTKBGLLL-UHFFFAOYSA-N 792967 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3S)-4-methylmorpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-12 Adenosine receptor A2a Homo sapiens 126 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792967&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166768051 528824483 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558886 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@@H]4COCCN4C)nc23)C[C@H](C)O1 InChI=1S/C23H31N7O3/c1-15-11-28(12-16(2)33-15)20-19(17-7-5-4-6-8-17)25-22(24)30-21(20)26-29(23(30)31)13-18-14-32-10-9-27(18)3/h4-8,15-16,18H,9-14H2,1-3H3,(H2,24,25) IAAQDZOTKBGLLL-UHFFFAOYSA-N 792968 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3R)-4-methylmorpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-13 Adenosine receptor A1 Homo sapiens >3981 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792968&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767973 528824484 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558887 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@@H]4COCCN4C)nc23)C[C@H](C)O1 InChI=1S/C23H31N7O3/c1-15-11-28(12-16(2)33-15)20-19(17-7-5-4-6-8-17)25-22(24)30-21(20)26-29(23(30)31)13-18-14-32-10-9-27(18)3/h4-8,15-16,18H,9-14H2,1-3H3,(H2,24,25) IAAQDZOTKBGLLL-UHFFFAOYSA-N 792968 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[[(3R)-4-methylmorpholin-3-yl]methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-13 Adenosine receptor A2a Homo sapiens 79.4 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792968&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767973 528824484 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558888 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)C[C@H](C)O1 InChI=1S/C23H24FN7O2/c1-14-11-29(12-15(2)33-14)20-19(16-6-4-3-5-7-16)27-22(25)31-21(20)28-30(23(31)32)13-18-9-8-17(24)10-26-18/h3-10,14-15H,11-13H2,1-2H3,(H2,25,27) QKJISDGJUZBGJQ-UHFFFAOYSA-N 792969 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[(5-fluoro-2-pyridyl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-14 Adenosine receptor A1 Homo sapiens 1259 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792969&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767972 528824485 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558889 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)C[C@H](C)O1 InChI=1S/C23H24FN7O2/c1-14-11-29(12-15(2)33-14)20-19(16-6-4-3-5-7-16)27-22(25)31-21(20)28-30(23(31)32)13-18-9-8-17(24)10-26-18/h3-10,14-15H,11-13H2,1-2H3,(H2,25,27) QKJISDGJUZBGJQ-UHFFFAOYSA-N 792969 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[(5-fluoro-2-pyridyl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-14 Adenosine receptor A2a Homo sapiens 12.6 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792969&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767972 528824485 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558890 COc1ncccc1Cn1nc2c(N3C[C@@H](C)O[C@@H](C)C3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H27N7O3/c1-15-12-29(13-16(2)34-15)20-19(17-8-5-4-6-9-17)27-23(25)31-21(20)28-30(24(31)32)14-18-10-7-11-26-22(18)33-3/h4-11,15-16H,12-14H2,1-3H3,(H2,25,27) LEMDGRRAFOZAHN-UHFFFAOYSA-N 792970 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[(2-methoxy-3-pyridyl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-15 Adenosine receptor A1 Homo sapiens 398 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792970&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767971 528824486 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558891 COc1ncccc1Cn1nc2c(N3C[C@@H](C)O[C@@H](C)C3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H27N7O3/c1-15-12-29(13-16(2)34-15)20-19(17-8-5-4-6-9-17)27-23(25)31-21(20)28-30(24(31)32)14-18-10-7-11-26-22(18)33-3/h4-11,15-16H,12-14H2,1-3H3,(H2,25,27) LEMDGRRAFOZAHN-UHFFFAOYSA-N 792970 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[(2-methoxy-3-pyridyl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-15 Adenosine receptor A2a Homo sapiens 3.98 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792970&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767971 528824486 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558892 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4cccnn4)nc23)C[C@H](C)O1 InChI=1S/C22H24N8O2/c1-14-11-28(12-15(2)32-14)19-18(16-7-4-3-5-8-16)25-21(23)30-20(19)27-29(22(30)31)13-17-9-6-10-24-26-17/h3-10,14-15H,11-13H2,1-2H3,(H2,23,25) ZWFHANYQTXKZDJ-UHFFFAOYSA-N 792971 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(pyridazin-3-ylmethyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-16 Adenosine receptor A1 Homo sapiens 794 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792971&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760501 528824487 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558893 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4cccnn4)nc23)C[C@H](C)O1 InChI=1S/C22H24N8O2/c1-14-11-28(12-15(2)32-14)19-18(16-7-4-3-5-8-16)25-21(23)30-20(19)27-29(22(30)31)13-17-9-6-10-24-26-17/h3-10,14-15H,11-13H2,1-2H3,(H2,23,25) ZWFHANYQTXKZDJ-UHFFFAOYSA-N 792971 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(pyridazin-3-ylmethyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-16 Adenosine receptor A2a Homo sapiens 63.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792971&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760501 528824487 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558894 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCc4ccccc4)nc23)C[C@H](C)O1 InChI=1S/C25H28N6O2/c1-17-15-29(16-18(2)33-17)22-21(20-11-7-4-8-12-20)27-24(26)31-23(22)28-30(25(31)32)14-13-19-9-5-3-6-10-19/h3-12,17-18H,13-16H2,1-2H3,(H2,26,27) GSLJGZHYTRMALP-UHFFFAOYSA-N 792972 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(2-phenylethyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-17 Adenosine receptor A1 Homo sapiens >1585 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792972&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760598 528824488 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558895 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCc4ccccc4)nc23)C[C@H](C)O1 InChI=1S/C25H28N6O2/c1-17-15-29(16-18(2)33-17)22-21(20-11-7-4-8-12-20)27-24(26)31-23(22)28-30(25(31)32)14-13-19-9-5-3-6-10-19/h3-12,17-18H,13-16H2,1-2H3,(H2,26,27) GSLJGZHYTRMALP-UHFFFAOYSA-N 792972 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(2-phenylethyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-17 Adenosine receptor A2a Homo sapiens 63.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792972&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760598 528824488 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558896 C[C@@H]1CC(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)=C[C@H](C)O1 InChI=1S/C21H22F3N5O2/c1-12-10-15(11-13(2)31-12)16-17(14-6-4-3-5-7-14)26-19(25)29-18(16)27-28(20(29)30)9-8-21(22,23)24/h3-7,10,12-13H,8-9,11H2,1-2H3,(H2,25,26) OXTRSOVDEBIWBM-UHFFFAOYSA-N 792973 5-amino-8-[(cis)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 2-1 Adenosine receptor A1 Homo sapiens 501 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792973&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767950 528824489 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558897 C[C@@H]1CC(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)=C[C@H](C)O1 InChI=1S/C21H22F3N5O2/c1-12-10-15(11-13(2)31-12)16-17(14-6-4-3-5-7-14)26-19(25)29-18(16)27-28(20(29)30)9-8-21(22,23)24/h3-7,10,12-13H,8-9,11H2,1-2H3,(H2,25,26) OXTRSOVDEBIWBM-UHFFFAOYSA-N 792973 5-amino-8-[(cis)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 2-1 Adenosine receptor A2a Homo sapiens 2.51 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792973&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767950 528824489 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558898 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H23F3N6O2/c1-12-10-27(11-13(2)31-12)16-15(14-6-4-3-5-7-14)25-18(24)29-17(16)26-28(19(29)30)9-8-20(21,22)23/h3-7,12-13H,8-11H2,1-2H3,(H2,24,25) KDXJBMRQWCTPSO-UHFFFAOYSA-N 792974 5-amino-8-[(cis)-2,6-dimethyltetrahydropyran-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 2-2 Adenosine receptor A1 Homo sapiens >3162 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792974&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760561 528824490 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558899 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H23F3N6O2/c1-12-10-27(11-13(2)31-12)16-15(14-6-4-3-5-7-14)25-18(24)29-17(16)26-28(19(29)30)9-8-20(21,22)23/h3-7,12-13H,8-11H2,1-2H3,(H2,24,25) KDXJBMRQWCTPSO-UHFFFAOYSA-N 792974 5-amino-8-[(cis)-2,6-dimethyltetrahydropyran-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 2-2 Adenosine receptor A2a Homo sapiens 39.8 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792974&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760561 528824490 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558900 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc(C)c1O InChI=1S/C25H21FN6O2/c1-14-10-17(11-15(2)22(14)33)20-21(16-6-4-3-5-7-16)29-24(27)32-23(20)30-31(25(32)34)13-19-9-8-18(26)12-28-19/h3-12,33H,13H2,1-2H3,(H2,27,29) OLRADYMAXSEFAN-UHFFFAOYSA-N 792975 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(4-hydroxy-3,5-dimethyl-phenyl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 3-1 Adenosine receptor A1 Homo sapiens 100 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792975&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760468 528824491 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558901 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc(C)c1O InChI=1S/C25H21FN6O2/c1-14-10-17(11-15(2)22(14)33)20-21(16-6-4-3-5-7-16)29-24(27)32-23(20)30-31(25(32)34)13-19-9-8-18(26)12-28-19/h3-12,33H,13H2,1-2H3,(H2,27,29) OLRADYMAXSEFAN-UHFFFAOYSA-N 792975 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(4-hydroxy-3,5-dimethyl-phenyl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 3-1 Adenosine receptor A2a Homo sapiens 0.631 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792975&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760468 528824491 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558902 Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)cc2ocnc12 InChI=1S/C22H16F4N6O2/c1-11-8-13(9-15-17(11)28-10-34-15)16-18(12-2-4-14(23)5-3-12)29-20(27)32-19(16)30-31(21(32)33)7-6-22(24,25)26/h2-5,8-10H,6-7H2,1H3,(H2,27,29) GUGRLSDYHRPSDJ-UHFFFAOYSA-N 792976 5-amino-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-1 Adenosine receptor A1 Homo sapiens 316 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792976&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166767913 528824492 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558903 Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)cc2ocnc12 InChI=1S/C22H16F4N6O2/c1-11-8-13(9-15-17(11)28-10-34-15)16-18(12-2-4-14(23)5-3-12)29-20(27)32-19(16)30-31(21(32)33)7-6-22(24,25)26/h2-5,8-10H,6-7H2,1H3,(H2,27,29) GUGRLSDYHRPSDJ-UHFFFAOYSA-N 792976 5-amino-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-1 Adenosine receptor A2a Homo sapiens 0.501 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792976&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166767913 528824492 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558904 Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(Cc4ccc(Cl)cn4)nc23)cc2ocnc12 InChI=1S/C25H17ClFN7O2/c1-13-8-15(9-19-21(13)30-12-36-19)20-22(14-2-5-17(27)6-3-14)31-24(28)34-23(20)32-33(25(34)35)11-18-7-4-16(26)10-29-18/h2-10,12H,11H2,1H3,(H2,28,31) PMGCVFKYTNFHKN-UHFFFAOYSA-N 792977 5-amino-2-[(5-chloro-2-pyridyl)methyl]-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-2 Adenosine receptor A1 Homo sapiens 63.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792977&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 163872732 528824493 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558905 Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(Cc4ccc(Cl)cn4)nc23)cc2ocnc12 InChI=1S/C25H17ClFN7O2/c1-13-8-15(9-19-21(13)30-12-36-19)20-22(14-2-5-17(27)6-3-14)31-24(28)34-23(20)32-33(25(34)35)11-18-7-4-16(26)10-29-18/h2-10,12H,11H2,1H3,(H2,28,31) PMGCVFKYTNFHKN-UHFFFAOYSA-N 792977 5-amino-2-[(5-chloro-2-pyridyl)methyl]-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-2 Adenosine receptor A2a Homo sapiens 0.158 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792977&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 163872732 528824493 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558906 Cc1ccc(Cn2nc3c(-c4cc(C)c5ncoc5c4)c(-c4ccc(F)cc4)nc(N)n3c2=O)nc1 InChI=1S/C26H20FN7O2/c1-14-3-8-19(29-11-14)12-33-26(35)34-24(32-33)21(17-9-15(2)22-20(10-17)36-13-30-22)23(31-25(34)28)16-4-6-18(27)7-5-16/h3-11,13H,12H2,1-2H3,(H2,28,31) YCLLBMADBFTBBS-UHFFFAOYSA-N 792978 5-amino-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-2-[(5-methyl-2-pyridyl)methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-3 Adenosine receptor A1 Homo sapiens 126 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792978&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760586 528824494 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558907 Cc1ccc(Cn2nc3c(-c4cc(C)c5ncoc5c4)c(-c4ccc(F)cc4)nc(N)n3c2=O)nc1 InChI=1S/C26H20FN7O2/c1-14-3-8-19(29-11-14)12-33-26(35)34-24(32-33)21(17-9-15(2)22-20(10-17)36-13-30-22)23(31-25(34)28)16-4-6-18(27)7-5-16/h3-11,13H,12H2,1-2H3,(H2,28,31) YCLLBMADBFTBBS-UHFFFAOYSA-N 792978 5-amino-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-2-[(5-methyl-2-pyridyl)methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-3 Adenosine receptor A2a Homo sapiens 0.158 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792978&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760586 528824494 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558908 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc2c1N=NC2 InChI=1S/C25H19FN8O/c1-14-9-16(10-17-11-29-31-21(14)17)20-22(15-5-3-2-4-6-15)30-24(27)34-23(20)32-33(25(34)35)13-19-8-7-18(26)12-28-19/h2-10,12H,11,13H2,1H3,(H2,27,30) CFKVXDPOCKMZRN-UHFFFAOYSA-N 792979 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(7-methyl-1H-indazol-5-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-4 Adenosine receptor A1 Homo sapiens 25.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792979&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 169811311 528824495 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558909 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc2c1N=NC2 InChI=1S/C25H19FN8O/c1-14-9-16(10-17-11-29-31-21(14)17)20-22(15-5-3-2-4-6-15)30-24(27)34-23(20)32-33(25(34)35)13-19-8-7-18(26)12-28-19/h2-10,12H,11,13H2,1H3,(H2,27,30) CFKVXDPOCKMZRN-UHFFFAOYSA-N 792979 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(7-methyl-1H-indazol-5-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-4 Adenosine receptor A2a Homo sapiens 0.251 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792979&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 169811311 528824495 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558910 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc2nc[nH]c12 InChI=1S/C25H19FN8O/c1-14-9-16(10-19-21(14)30-13-29-19)20-22(15-5-3-2-4-6-15)31-24(27)34-23(20)32-33(25(34)35)12-18-8-7-17(26)11-28-18/h2-11,13H,12H2,1H3,(H2,27,31)(H,29,30) OFFURUJZFMFNSK-UHFFFAOYSA-N 792980 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(7-methyl-1H-benzimidazol-5-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-5 Adenosine receptor A1 Homo sapiens 100 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792980&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760607 528824496 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558911 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc2nc[nH]c12 InChI=1S/C25H19FN8O/c1-14-9-16(10-19-21(14)30-13-29-19)20-22(15-5-3-2-4-6-15)31-24(27)34-23(20)32-33(25(34)35)12-18-8-7-17(26)11-28-18/h2-11,13H,12H2,1H3,(H2,27,31)(H,29,30) OFFURUJZFMFNSK-UHFFFAOYSA-N 792980 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(7-methyl-1H-benzimidazol-5-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-5 Adenosine receptor A2a Homo sapiens 1.000 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792980&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760607 528824496 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558912 Cc1ocnc1Cn1nc2c(-c3cc(C)c4ncoc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H19N7O3/c1-13-8-16(9-18-20(13)27-12-34-18)19-21(15-6-4-3-5-7-15)28-23(25)31-22(19)29-30(24(31)32)10-17-14(2)33-11-26-17/h3-9,11-12H,10H2,1-2H3,(H2,25,28) ATEIDDSDMLUNLR-UHFFFAOYSA-N 792981 5-amino-8-(4-methyl-1,3-benzoxazol-6-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-6 Adenosine receptor A1 Homo sapiens 7.94 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792981&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 163434365 528824497 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558913 Cc1ocnc1Cn1nc2c(-c3cc(C)c4ncoc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H19N7O3/c1-13-8-16(9-18-20(13)27-12-34-18)19-21(15-6-4-3-5-7-15)28-23(25)31-22(19)29-30(24(31)32)10-17-14(2)33-11-26-17/h3-9,11-12H,10H2,1-2H3,(H2,25,28) ATEIDDSDMLUNLR-UHFFFAOYSA-N 792981 5-amino-8-(4-methyl-1,3-benzoxazol-6-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-6 Adenosine receptor A2a Homo sapiens 0.079 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792981&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 163434365 528824497 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558914 Cc1nc(Cn2nc3c(-c4cc(C)c5ncoc5c4)c(-c4ccc(F)cc4)nc(N)n3c2=O)c(C)o1 InChI=1S/C25H20FN7O3/c1-12-8-16(9-19-21(12)28-11-35-19)20-22(15-4-6-17(26)7-5-15)30-24(27)33-23(20)31-32(25(33)34)10-18-13(2)36-14(3)29-18/h4-9,11H,10H2,1-3H3,(H2,27,30) GTTMMDPYSXFEGR-UHFFFAOYSA-N 792982 5-amino-2-[(2,5-dimethyloxazol-4-yl)methyl]-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-7 Adenosine receptor A1 Homo sapiens 20.0 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792982&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 163596346 528824498 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558915 Cc1nc(Cn2nc3c(-c4cc(C)c5ncoc5c4)c(-c4ccc(F)cc4)nc(N)n3c2=O)c(C)o1 InChI=1S/C25H20FN7O3/c1-12-8-16(9-19-21(12)28-11-35-19)20-22(15-4-6-17(26)7-5-15)30-24(27)33-23(20)31-32(25(33)34)10-18-13(2)36-14(3)29-18/h4-9,11H,10H2,1-3H3,(H2,27,30) GTTMMDPYSXFEGR-UHFFFAOYSA-N 792982 5-amino-2-[(2,5-dimethyloxazol-4-yl)methyl]-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-7 Adenosine receptor A2a Homo sapiens 0.126 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792982&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 163596346 528824498 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558916 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ncc4c3)c(-c3ccc(F)cc3)nc(N)n2c1=O InChI=1S/C24H19FN8O2/c1-12-7-15(8-16-9-28-30-20(12)16)19-21(14-3-5-17(25)6-4-14)29-23(26)33-22(19)31-32(24(33)34)10-18-13(2)35-11-27-18/h3-9,11H,10H2,1-2H3,(H2,26,29)(H,28,30) QIDIKWFLUVGNKC-UHFFFAOYSA-N 792983 5-amino-7-(4-fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-8 Adenosine receptor A1 Homo sapiens 3.98 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792983&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 160423512 528824499 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558917 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ncc4c3)c(-c3ccc(F)cc3)nc(N)n2c1=O InChI=1S/C24H19FN8O2/c1-12-7-15(8-16-9-28-30-20(12)16)19-21(14-3-5-17(25)6-4-14)29-23(26)33-22(19)31-32(24(33)34)10-18-13(2)35-11-27-18/h3-9,11H,10H2,1-2H3,(H2,26,29)(H,28,30) QIDIKWFLUVGNKC-UHFFFAOYSA-N 792983 5-amino-7-(4-fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-8 Adenosine receptor A2a Homo sapiens 0.251 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792983&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 160423512 528824499 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558918 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ncc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H20N8O2/c1-13-8-16(9-17-10-27-29-20(13)17)19-21(15-6-4-3-5-7-15)28-23(25)32-22(19)30-31(24(32)33)11-18-14(2)34-12-26-18/h3-10,12H,11H2,1-2H3,(H2,25,28)(H,27,29) AGAOWKARFSSGOJ-UHFFFAOYSA-N 792984 5-amino-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-9 Adenosine receptor A1 Homo sapiens 1.58 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792984&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760499 528824500 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558919 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ncc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H20N8O2/c1-13-8-16(9-17-10-27-29-20(13)17)19-21(15-6-4-3-5-7-15)28-23(25)32-22(19)30-31(24(32)33)11-18-14(2)34-12-26-18/h3-10,12H,11H2,1-2H3,(H2,25,28)(H,27,29) AGAOWKARFSSGOJ-UHFFFAOYSA-N 792984 5-amino-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-9 Adenosine receptor A2a Homo sapiens 0.079 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792984&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760499 528824500 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558920 [2H]c1c([2H])c([2H])c(-c2nc(N)n3c(=O)n(Cc4ncoc4C)nc3c2-c2cc(C)c3[nH]ncc3c2)c([2H])c1[2H] InChI=1S/C24H20N8O2/c1-13-8-16(9-17-10-27-29-20(13)17)19-21(15-6-4-3-5-7-15)28-23(25)32-22(19)30-31(24(32)33)11-18-14(2)34-12-26-18/h3-10,12H,11H2,1-2H3,(H2,25,28)(H,27,29)/i3D,4D,5D,6D,7D AGAOWKARFSSGOJ-DKFMXDSJSA-N 792985 5-amino-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-(2,3,4,5,6-pentadeuteriophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-10 Adenosine receptor A1 Homo sapiens 2.00 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792985&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760555 528824501 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558921 [2H]c1c([2H])c([2H])c(-c2nc(N)n3c(=O)n(Cc4ncoc4C)nc3c2-c2cc(C)c3[nH]ncc3c2)c([2H])c1[2H] InChI=1S/C24H20N8O2/c1-13-8-16(9-17-10-27-29-20(13)17)19-21(15-6-4-3-5-7-15)28-23(25)32-22(19)30-31(24(32)33)11-18-14(2)34-12-26-18/h3-10,12H,11H2,1-2H3,(H2,25,28)(H,27,29)/i3D,4D,5D,6D,7D AGAOWKARFSSGOJ-DKFMXDSJSA-N 792985 5-amino-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-(2,3,4,5,6-pentadeuteriophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-10 Adenosine receptor A2a Homo sapiens 0.100 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792985&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760555 528824501 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558922 Cc1ocnc1Cn1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C23H17ClN8O2/c1-12-17(26-11-34-12)10-31-23(33)32-21(30-31)18(14-7-15-9-27-29-19(15)16(24)8-14)20(28-22(32)25)13-5-3-2-4-6-13/h2-9,11H,10H2,1H3,(H2,25,28)(H,27,29) RHBPBNHERQWPOD-UHFFFAOYSA-N 792986 5-amino-8-(7-chloro-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-11 Adenosine receptor A1 Homo sapiens 2.00 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792986&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760582 528824502 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558923 Cc1ocnc1Cn1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C23H17ClN8O2/c1-12-17(26-11-34-12)10-31-23(33)32-21(30-31)18(14-7-15-9-27-29-19(15)16(24)8-14)20(28-22(32)25)13-5-3-2-4-6-13/h2-9,11H,10H2,1H3,(H2,25,28)(H,27,29) RHBPBNHERQWPOD-UHFFFAOYSA-N 792986 5-amino-8-(7-chloro-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-11 Adenosine receptor A2a Homo sapiens 0.158 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792986&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760582 528824502 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558924 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ccc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C25H21N7O2/c1-14-10-18(11-17-8-9-27-21(14)17)20-22(16-6-4-3-5-7-16)29-24(26)32-23(20)30-31(25(32)33)12-19-15(2)34-13-28-19/h3-11,13,27H,12H2,1-2H3,(H2,26,29) IQKYEVCSRKBURH-UHFFFAOYSA-N 792987 5-amino-8-(7-methyl-1H-indol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-12 Adenosine receptor A1 Homo sapiens 63.1 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2129&target=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792987&enzyme=Adenosine+receptor+A1&column=ki&startPg=0&Increment=50&submit=Search 166760514 528824503 1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD 7LD4,7LD3,6D9H,5UEN Adenosine receptor A1 AA1R_HUMAN P30542 A6NFY5 A6NGP4 A8K1L3 B3KXQ4 D2CGD0 Q6FHK3 Q8TAM8 558925 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ccc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C25H21N7O2/c1-14-10-18(11-17-8-9-27-21(14)17)20-22(16-6-4-3-5-7-16)29-24(26)32-23(20)30-31(25(32)33)12-19-15(2)34-13-28-19/h3-11,13,27H,12H2,1-2H3,(H2,26,29) IQKYEVCSRKBURH-UHFFFAOYSA-N 792987 5-amino-8-(7-methyl-1H-indol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-12 Adenosine receptor A2a Homo sapiens 0.501 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2130&target=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792987&enzyme=Adenosine+receptor+A2a&column=ki&startPg=0&Increment=50&submit=Search 166760514 528824503 1 MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS 9EEA,9EE9,9EE8,5UIG,9T9P,8JWZ,8JWY,3QAK,3EML,5WF6,5WF5,7T32,5OM4,5OM1,5OLZ,5OLV,5OLO,5OLH,5OLG,5MZJ,9H37,9H2X,8PWN,7ARO,6ZDV,6ZDR,6S0Q,6S0L,6GT3,5NM4,5NM2,5NLX,5N2R,5MZP,5IUB,5IUA,5IU8,5IU7,5IU4 Adenosine receptor A2a AA2AR_HUMAN P29274 B2R7E0 558926 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)C[C@H](C)O1 InChI=1S/C20H23F3N6O2/c1-12-10-27(11-13(2)31-12)16-15(14-6-4-3-5-7-14)25-18(24)29-17(16)26-28(19(29)30)9-8-20(21,22)23/h3-7,12-13H,8-11H2,1-2H3,(H2,24,25) KDXJBMRQWCTPSO-UHFFFAOYSA-N 792956 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-1 Cannabinoid receptor 1 Homo sapiens 33900 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792956&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166760561 528824472 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558927 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(C[C@H]4CCCO4)nc23)C[C@H](C)O1 InChI=1S/C22H28N6O3/c1-14-11-26(12-15(2)31-14)19-18(16-7-4-3-5-8-16)24-21(23)28-20(19)25-27(22(28)29)13-17-9-6-10-30-17/h3-5,7-8,14-15,17H,6,9-13H2,1-2H3,(H2,23,24) WGKKOVUFCBDNKZ-UHFFFAOYSA-N 792963 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-7-phenyl-2-[[(2R)-tetrahydrofuran-2-yl]methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-8 Cannabinoid receptor 1 Homo sapiens 66500 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792963&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166767977 528824479 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558928 C[C@@H]1CN(c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)C[C@H](C)O1 InChI=1S/C23H24FN7O2/c1-14-11-29(12-15(2)33-14)20-19(16-6-4-3-5-7-16)27-22(25)31-21(20)28-30(23(31)32)13-18-9-8-17(24)10-26-18/h3-10,14-15H,11-13H2,1-2H3,(H2,25,27) QKJISDGJUZBGJQ-UHFFFAOYSA-N 792969 5-amino-8-[(cis)-2,6-dimethylmorpholin-4-yl]-2-[(5-fluoro-2-pyridyl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 1-14 Cannabinoid receptor 1 Homo sapiens 9500 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792969&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166767972 528824485 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558929 C[C@@H]1CC(c2c(-c3ccccc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)=C[C@H](C)O1 InChI=1S/C21H22F3N5O2/c1-12-10-15(11-13(2)31-12)16-17(14-6-4-3-5-7-14)26-19(25)29-18(16)27-28(20(29)30)9-8-21(22,23)24/h3-7,10,12-13H,8-9,11H2,1-2H3,(H2,25,26) OXTRSOVDEBIWBM-UHFFFAOYSA-N 792973 5-amino-8-[(cis)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl]-7-phenyl-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 2-1 Cannabinoid receptor 1 Homo sapiens 31500 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792973&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166767950 528824489 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558930 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc(C)c1O InChI=1S/C25H21FN6O2/c1-14-10-17(11-15(2)22(14)33)20-21(16-6-4-3-5-7-16)29-24(27)32-23(20)30-31(25(32)34)13-19-9-8-18(26)12-28-19/h3-12,33H,13H2,1-2H3,(H2,27,29) OLRADYMAXSEFAN-UHFFFAOYSA-N 792975 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(4-hydroxy-3,5-dimethyl-phenyl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 3-1 Cannabinoid receptor 1 Homo sapiens 25200 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792975&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166760468 528824491 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558931 Cc1cc(-c2c(-c3ccc(F)cc3)nc(N)n3c(=O)n(CCC(F)(F)F)nc23)cc2ocnc12 InChI=1S/C22H16F4N6O2/c1-11-8-13(9-15-17(11)28-10-34-15)16-18(12-2-4-14(23)5-3-12)29-20(27)32-19(16)30-31(21(32)33)7-6-22(24,25)26/h2-5,8-10H,6-7H2,1H3,(H2,27,29) GUGRLSDYHRPSDJ-UHFFFAOYSA-N 792976 5-amino-7-(4-fluorophenyl)-8-(4-methyl-1,3-benzoxazol-6-yl)-2-(3,3,3-trifluoropropyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-1 Cannabinoid receptor 1 Homo sapiens 3700 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792976&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166767913 528824492 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558932 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc2c1N=NC2 InChI=1S/C25H19FN8O/c1-14-9-16(10-17-11-29-31-21(14)17)20-22(15-5-3-2-4-6-15)30-24(27)34-23(20)32-33(25(34)35)13-19-8-7-18(26)12-28-19/h2-10,12H,11,13H2,1H3,(H2,27,30) CFKVXDPOCKMZRN-UHFFFAOYSA-N 792979 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(7-methyl-1H-indazol-5-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-4 Cannabinoid receptor 1 Homo sapiens 5500 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792979&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 169811311 528824495 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558933 Cc1cc(-c2c(-c3ccccc3)nc(N)n3c(=O)n(Cc4ccc(F)cn4)nc23)cc2nc[nH]c12 InChI=1S/C25H19FN8O/c1-14-9-16(10-19-21(14)30-13-29-19)20-22(15-5-3-2-4-6-15)31-24(27)34-23(20)32-33(25(34)35)12-18-8-7-17(26)11-28-18/h2-11,13H,12H2,1H3,(H2,27,31)(H,29,30) OFFURUJZFMFNSK-UHFFFAOYSA-N 792980 5-amino-2-[(5-fluoro-2-pyridyl)methyl]-8-(7-methyl-1H-benzimidazol-5-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-5 Cannabinoid receptor 1 Homo sapiens 24400 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792980&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166760607 528824496 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558934 Cc1ocnc1Cn1nc2c(-c3cc(C)c4ncoc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H19N7O3/c1-13-8-16(9-18-20(13)27-12-34-18)19-21(15-6-4-3-5-7-15)28-23(25)31-22(19)29-30(24(31)32)10-17-14(2)33-11-26-17/h3-9,11-12H,10H2,1-2H3,(H2,25,28) ATEIDDSDMLUNLR-UHFFFAOYSA-N 792981 5-amino-8-(4-methyl-1,3-benzoxazol-6-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-6 Cannabinoid receptor 1 Homo sapiens 23000 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792981&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 163434365 528824497 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558935 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ncc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C24H20N8O2/c1-13-8-16(9-17-10-27-29-20(13)17)19-21(15-6-4-3-5-7-15)28-23(25)32-22(19)30-31(24(32)33)11-18-14(2)34-12-26-18/h3-10,12H,11H2,1-2H3,(H2,25,28)(H,27,29) AGAOWKARFSSGOJ-UHFFFAOYSA-N 792984 5-amino-8-(7-methyl-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-9 Cannabinoid receptor 1 Homo sapiens 39100 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792984&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166760499 528824500 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558936 Cc1ocnc1Cn1nc2c(-c3cc(Cl)c4[nH]ncc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C23H17ClN8O2/c1-12-17(26-11-34-12)10-31-23(33)32-21(30-31)18(14-7-15-9-27-29-19(15)16(24)8-14)20(28-22(32)25)13-5-3-2-4-6-13/h2-9,11H,10H2,1H3,(H2,25,28)(H,27,29) RHBPBNHERQWPOD-UHFFFAOYSA-N 792986 5-amino-8-(7-chloro-1H-indazol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-11 Cannabinoid receptor 1 Homo sapiens 2500 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792986&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166760582 528824502 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0 558937 Cc1ocnc1Cn1nc2c(-c3cc(C)c4[nH]ccc4c3)c(-c3ccccc3)nc(N)n2c1=O InChI=1S/C25H21N7O2/c1-14-10-18(11-17-8-9-27-21(14)17)20-22(16-6-4-3-5-7-16)29-24(26)32-23(20)30-31(25(32)33)12-19-15(2)34-13-28-19/h3-11,13,27H,12H2,1-2H3,(H2,26,29) IQKYEVCSRKBURH-UHFFFAOYSA-N 792987 5-amino-8-(7-methyl-1H-indol-5-yl)-2-[(5-methyloxazol-4-yl)methyl]-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-3-one::US12552799, Example 4-12 Cannabinoid receptor 1 Homo sapiens 39600 US Patent 10.7270/Q21V5KZ1 aid1795887 US12552799 Brown, GA; Congreve, MS; Andrews, SP; Mason, JS; Deflorian, F; Swain, NA 2/17/2026 6/29/2026 Nxera Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2136&target=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792987&enzyme=Cannabinoid+receptor+1&column=ki&startPg=0&Increment=50&submit=Search 166760514 528824503 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL 7WV9,23IW,23IV,9ERX,9EGO,9DGI,9B65,9B54,8GHV,8GAG,6N4B,8WU1,8IKH,8IKG Cannabinoid receptor 1 CNR1_HUMAN P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0