BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
666294	CCn1ncc2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C14H23N7OS/c1-2-21-14-12(10-19-21)13(3-6-17-14)18-9-11-4-7-20(8-5-11)23(15,16)22/h3,6,10-11H,2,4-5,7-9H2,1H3,(H,17,18)(H3,15,16,22)	QEBVZXAKWCVQEP-UHFFFAOYSA-N	793308	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 1A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793308&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337526	528824771							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666295	CCn1ncc2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C14H23N7OS/c1-2-21-14-12(10-19-21)13(3-6-17-14)18-9-11-4-7-20(8-5-11)23(15,16)22/h3,6,10-11H,2,4-5,7-9H2,1H3,(H,17,18)(H3,15,16,22)	QEBVZXAKWCVQEP-UHFFFAOYSA-N	793308	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 1A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793308&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337526	528824771							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666296	CCn1ncc2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C14H23N7OS/c1-2-21-14-12(10-19-21)13(3-6-17-14)18-9-11-4-7-20(8-5-11)23(15,16)22/h3,6,10-11H,2,4-5,7-9H2,1H3,(H,17,18)(H3,15,16,22)	QEBVZXAKWCVQEP-UHFFFAOYSA-N	793308	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 1A	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793308&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170337526	528824771							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
666297	CCn1ncc2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C14H23N7OS/c1-2-21-14-12(10-19-21)13(3-6-17-14)18-9-11-4-7-20(8-5-11)23(15,16)22/h3,6,10-11H,2,4-5,7-9H2,1H3,(H,17,18)(H3,15,16,22)	QEBVZXAKWCVQEP-UHFFFAOYSA-N	793308	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 1A	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793308&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170337526	528824771							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666298	N=S(N)(=O)c1ccc(CNc2ccnc3[nH]nc(-c4ccccc4)c23)cc1	InChI=1S/C19H18N6OS/c20-27(21,26)15-8-6-13(7-9-15)12-23-16-10-11-22-19-17(16)18(24-25-19)14-4-2-1-3-5-14/h1-11H,12H2,(H3,20,21,26)(H2,22,23,24,25)	NASINKKRDYXVJE-UHFFFAOYSA-N	793309	4-(((3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzenesulfonimidamide::US20260049084, Compound 1B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793309&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388643	528824772							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666299	N=S(N)(=O)c1ccc(CNc2ccnc3[nH]nc(-c4ccccc4)c23)cc1	InChI=1S/C19H18N6OS/c20-27(21,26)15-8-6-13(7-9-15)12-23-16-10-11-22-19-17(16)18(24-25-19)14-4-2-1-3-5-14/h1-11H,12H2,(H3,20,21,26)(H2,22,23,24,25)	NASINKKRDYXVJE-UHFFFAOYSA-N	793309	4-(((3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzenesulfonimidamide::US20260049084, Compound 1B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793309&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388643	528824772							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666306	N=S(N)(=O)c1ccc(CNc2ccnc3[nH]nc(-c4ccccc4)c23)cc1	InChI=1S/C19H18N6OS/c20-27(21,26)15-8-6-13(7-9-15)12-23-16-10-11-22-19-17(16)18(24-25-19)14-4-2-1-3-5-14/h1-11H,12H2,(H3,20,21,26)(H2,22,23,24,25)	NASINKKRDYXVJE-UHFFFAOYSA-N	793309	4-(((3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzenesulfonimidamide::US20260049084, Compound 1B	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793309&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170388643	528824772							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
666307	N=S(N)(=O)c1ccc(CNc2ccnc3[nH]nc(-c4ccccc4)c23)cc1	InChI=1S/C19H18N6OS/c20-27(21,26)15-8-6-13(7-9-15)12-23-16-10-11-22-19-17(16)18(24-25-19)14-4-2-1-3-5-14/h1-11H,12H2,(H3,20,21,26)(H2,22,23,24,25)	NASINKKRDYXVJE-UHFFFAOYSA-N	793309	4-(((3-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzenesulfonimidamide::US20260049084, Compound 1B	Carbonic anhydrase 2	Homo sapiens		 550							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793309&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170388643	528824772							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666308	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C14H22ClN7OS/c1-2-22-14-12(13(15)20-22)11(3-6-18-14)19-9-10-4-7-21(8-5-10)24(16,17)23/h3,6,10H,2,4-5,7-9H2,1H3,(H,18,19)(H3,16,17,23)	KBIRXDZGISKFNE-UHFFFAOYSA-N	793310	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 1C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793310&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337532	528824773							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666309	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C14H22ClN7OS/c1-2-22-14-12(13(15)20-22)11(3-6-18-14)19-9-10-4-7-21(8-5-10)24(16,17)23/h3,6,10H,2,4-5,7-9H2,1H3,(H,18,19)(H3,16,17,23)	KBIRXDZGISKFNE-UHFFFAOYSA-N	793310	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 1C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793310&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337532	528824773							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666310	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H18N6OS/c1-2-21-15-13(10-20-21)14(7-8-18-15)19-9-11-3-5-12(6-4-11)23(16,17)22/h3-8,10H,2,9H2,1H3,(H,18,19)(H3,16,17,22)	CRQJSLCEAAFZQJ-UHFFFAOYSA-N	793311	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzene sulfonimidamide::US20260049084, Compound 2A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793311&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337530	528824774							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666311	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H18N6OS/c1-2-21-15-13(10-20-21)14(7-8-18-15)19-9-11-3-5-12(6-4-11)23(16,17)22/h3-8,10H,2,9H2,1H3,(H,18,19)(H3,16,17,22)	CRQJSLCEAAFZQJ-UHFFFAOYSA-N	793311	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzene sulfonimidamide::US20260049084, Compound 2A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793311&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337530	528824774							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666312	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H18N6OS/c1-2-21-15-13(10-20-21)14(7-8-18-15)19-9-11-3-5-12(6-4-11)23(16,17)22/h3-8,10H,2,9H2,1H3,(H,18,19)(H3,16,17,22)	CRQJSLCEAAFZQJ-UHFFFAOYSA-N	793311	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzene sulfonimidamide::US20260049084, Compound 2A	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793311&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170337530	528824774							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
666313	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H18N6OS/c1-2-21-15-13(10-20-21)14(7-8-18-15)19-9-11-3-5-12(6-4-11)23(16,17)22/h3-8,10H,2,9H2,1H3,(H,18,19)(H3,16,17,22)	CRQJSLCEAAFZQJ-UHFFFAOYSA-N	793311	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)benzene sulfonimidamide::US20260049084, Compound 2A	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793311&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170337530	528824774							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666314	CCn1nc(Br)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H17BrN6OS/c1-2-22-15-13(14(16)21-22)12(7-8-19-15)20-9-10-3-5-11(6-4-10)24(17,18)23/h3-8H,2,9H2,1H3,(H,19,20)(H3,17,18,23)	VVMUDDUUPAUBII-UHFFFAOYSA-N	793312	4-(((3-bromo-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 2B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793312&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388668	528824775							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666315	CCn1nc(Br)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H17BrN6OS/c1-2-22-15-13(14(16)21-22)12(7-8-19-15)20-9-10-3-5-11(6-4-10)24(17,18)23/h3-8H,2,9H2,1H3,(H,19,20)(H3,17,18,23)	VVMUDDUUPAUBII-UHFFFAOYSA-N	793312	4-(((3-bromo-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 2B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793312&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388668	528824775							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666316	CCn1nc(Br)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H17BrN6OS/c1-2-22-15-13(14(16)21-22)12(7-8-19-15)20-9-10-3-5-11(6-4-10)24(17,18)23/h3-8H,2,9H2,1H3,(H,19,20)(H3,17,18,23)	VVMUDDUUPAUBII-UHFFFAOYSA-N	793312	4-(((3-bromo-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 2B	Carbonic anhydrase 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793312&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170388668	528824775							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
666317	CCn1nc(Br)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H17BrN6OS/c1-2-22-15-13(14(16)21-22)12(7-8-19-15)20-9-10-3-5-11(6-4-10)24(17,18)23/h3-8H,2,9H2,1H3,(H,19,20)(H3,17,18,23)	VVMUDDUUPAUBII-UHFFFAOYSA-N	793312	4-(((3-bromo-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 2B	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793312&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170388668	528824775							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666318	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)cc(-c3ncc[nH]3)nc21	InChI=1S/C18H20N8OS/c1-2-26-18-14(11-24-26)15(9-16(25-18)17-21-7-8-22-17)23-10-12-3-5-13(6-4-12)28(19,20)27/h3-9,11H,2,10H2,1H3,(H,21,22)(H,23,25)(H3,19,20,27)	JCNQFMMPMYFBNI-UHFFFAOYSA-N	793313	4-(((1-ethyl-6-(1H-imidazol-2-yl)-1H-pyrazolo [3,4-b]pyridin-4-yl)amino)methyl)benzene sulfonimidamide::US20260049084, Compound 2C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793313&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388670	528824776							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666319	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)cc(-c3ncc[nH]3)nc21	InChI=1S/C18H20N8OS/c1-2-26-18-14(11-24-26)15(9-16(25-18)17-21-7-8-22-17)23-10-12-3-5-13(6-4-12)28(19,20)27/h3-9,11H,2,10H2,1H3,(H,21,22)(H,23,25)(H3,19,20,27)	JCNQFMMPMYFBNI-UHFFFAOYSA-N	793313	4-(((1-ethyl-6-(1H-imidazol-2-yl)-1H-pyrazolo [3,4-b]pyridin-4-yl)amino)methyl)benzene sulfonimidamide::US20260049084, Compound 2C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793313&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388670	528824776							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666320	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)ncnc21	InChI=1S/C14H17N7OS/c1-2-21-14-12(8-20-21)13(18-9-19-14)17-7-10-3-5-11(6-4-10)23(15,16)22/h3-6,8-9H,2,7H2,1H3,(H3,15,16,22)(H,17,18,19)	BSXGVUSVRXYMOA-UHFFFAOYSA-N	793314	4-(((1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl) amino)methyl)benzenesulfonimidamide::US20260049084, Compound 2D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793314&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388671	528824777							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666321	CCn1ncc2c(NCc3ccc(S(=N)(N)=O)cc3)ncnc21	InChI=1S/C14H17N7OS/c1-2-21-14-12(8-20-21)13(18-9-19-14)17-7-10-3-5-11(6-4-10)23(15,16)22/h3-6,8-9H,2,7H2,1H3,(H3,15,16,22)(H,17,18,19)	BSXGVUSVRXYMOA-UHFFFAOYSA-N	793314	4-(((1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl) amino)methyl)benzenesulfonimidamide::US20260049084, Compound 2D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793314&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388671	528824777							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666322	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793315	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid2061012	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793315&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824778							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666323	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793315	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid2061013	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793315&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824778							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
666327	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793315	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3A	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793315&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824778							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
666328	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793315	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3A	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC			US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793315&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824778							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683932	C#CCn1nc(Cl)c2c(NCc3c(F)cc(S(N)(=O)=NC)cc3F)ccnc21	InChI=1S/C17H15ClF2N6OS/c1-3-6-26-17-15(16(18)25-26)14(4-5-23-17)24-9-11-12(19)7-10(8-13(11)20)28(21,27)22-2/h1,4-5,7-8H,6,9H2,2H3,(H,23,24)(H2,21,22,27)	ZXEVRGPMVWLOLC-UHFFFAOYSA-N	793316	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluoro-N-methylbenzenesulfonimidamide::US20260049084, Compound 3B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793316&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388705	528824779							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683933	C#CCn1nc(Cl)c2c(NCc3c(F)cc(S(N)(=O)=NC)cc3F)ccnc21	InChI=1S/C17H15ClF2N6OS/c1-3-6-26-17-15(16(18)25-26)14(4-5-23-17)24-9-11-12(19)7-10(8-13(11)20)28(21,27)22-2/h1,4-5,7-8H,6,9H2,2H3,(H,23,24)(H2,21,22,27)	ZXEVRGPMVWLOLC-UHFFFAOYSA-N	793316	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluoro-N-methylbenzenesulfonimidamide::US20260049084, Compound 3B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793316&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388705	528824779							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683934	C#CCn1nc(Cl)c2c(N(C)Cc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C18H19ClN6OS/c1-4-11-25-18-16(17(19)23-25)15(9-10-22-18)24(3)12-13-5-7-14(8-6-13)27(20,26)21-2/h1,5-10H,11-12H2,2-3H3,(H2,20,21,26)	IQMJBGPBJHQADN-UHFFFAOYSA-N	793317	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)(methyl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793317&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388706	528824780							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683935	C#CCn1nc(Cl)c2c(N(C)Cc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C18H19ClN6OS/c1-4-11-25-18-16(17(19)23-25)15(9-10-22-18)24(3)12-13-5-7-14(8-6-13)27(20,26)21-2/h1,5-10H,11-12H2,2-3H3,(H2,20,21,26)	IQMJBGPBJHQADN-UHFFFAOYSA-N	793317	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)(methyl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793317&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388706	528824780							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683936	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H17N7OS/c1-2-23-16-14(10-21-23)15(7-8-19-16)20-9-12-3-5-13(6-4-12)25(18,24)22-11-17/h3-8,10H,2,9H2,1H3,(H,19,20)(H2,18,22,24)	XVZVWJRZNKNXFD-UHFFFAOYSA-N	793318	N'-cyano-4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 3D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793318&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337531	528824781							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683937	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H17N7OS/c1-2-23-16-14(10-21-23)15(7-8-19-16)20-9-12-3-5-13(6-4-12)25(18,24)22-11-17/h3-8,10H,2,9H2,1H3,(H,19,20)(H2,18,22,24)	XVZVWJRZNKNXFD-UHFFFAOYSA-N	793318	N'-cyano-4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 3D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793318&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337531	528824781							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683938	CCn1ncc2c(NCc3ccc([S@@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793319	(S)-4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793319&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824782							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683939	CCn1ncc2c(NCc3ccc([S@@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793319	(S)-4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793319&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824782							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683940	CCn1ncc2c(NCc3ccc([S@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793320	(R)-4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793320&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824783							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683941	CCn1ncc2c(NCc3ccc([S@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H20N6OS/c1-3-22-16-14(11-21-22)15(8-9-19-16)20-10-12-4-6-13(7-5-12)24(17,23)18-2/h4-9,11H,3,10H2,1-2H3,(H,19,20)(H2,17,18,23)	ALYOPJYFPWYZKU-UHFFFAOYSA-N	793320	(R)-4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 3F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793320&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337528	528824783							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683942	CCn1ncc2c(NCC3CCN(S(C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793321	1-ethyl-N-((1-(S-methylsulfonimidoyl)piperidin- 4-yl)methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 4A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793321&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337520	528824784							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683943	CCn1ncc2c(NCC3CCN(S(C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793321	1-ethyl-N-((1-(S-methylsulfonimidoyl)piperidin- 4-yl)methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 4A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793321&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337520	528824784							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683944	CCn1ncc2c(NCC3CCN(S(C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793321	1-ethyl-N-((1-(S-methylsulfonimidoyl)piperidin- 4-yl)methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 4A	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793321&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170337520	528824784							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
683945	CCn1ncc2c(NCC3CCN(S(C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793321	1-ethyl-N-((1-(S-methylsulfonimidoyl)piperidin- 4-yl)methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 4A	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793321&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170337520	528824784							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683946	CCn1ncc2c(Nc3ccc(S(N)(=O)=NCC4CC4)cc3)ccnc21	InChI=1S/C18H22N6OS/c1-2-24-18-16(12-21-24)17(9-10-20-18)23-14-5-7-15(8-6-14)26(19,25)22-11-13-3-4-13/h5-10,12-13H,2-4,11H2,1H3,(H,20,23)(H2,19,22,25)	MNUNFYXOUVPBDL-UHFFFAOYSA-N	793322	N'-(cyclopropylmethyl)-4-((1-ethyl-1H-pyrazolo [3,4-b]pyridin-4-yl)amino) benzenesulfonimidamide::US20260049084, Compound 5A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793322&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337523	528824785							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683947	CCn1ncc2c(Nc3ccc(S(N)(=O)=NCC4CC4)cc3)ccnc21	InChI=1S/C18H22N6OS/c1-2-24-18-16(12-21-24)17(9-10-20-18)23-14-5-7-15(8-6-14)26(19,25)22-11-13-3-4-13/h5-10,12-13H,2-4,11H2,1H3,(H,20,23)(H2,19,22,25)	MNUNFYXOUVPBDL-UHFFFAOYSA-N	793322	N'-(cyclopropylmethyl)-4-((1-ethyl-1H-pyrazolo [3,4-b]pyridin-4-yl)amino) benzenesulfonimidamide::US20260049084, Compound 5A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793322&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337523	528824785							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683948	CCn1ncc2c(Nc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C15H18N6OS/c1-3-21-15-13(10-19-21)14(8-9-18-15)20-11-4-6-12(7-5-11)23(16,22)17-2/h4-10H,3H2,1-2H3,(H,18,20)(H2,16,17,22)	IAHRYNNEPVHPHJ-UHFFFAOYSA-N	793323	4-((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)-N'-methylbenzenesulfonimidamide::US20260049084, Compound 5B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793323&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388789	528824786							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683949	CCn1ncc2c(Nc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C15H18N6OS/c1-3-21-15-13(10-19-21)14(8-9-18-15)20-11-4-6-12(7-5-11)23(16,22)17-2/h4-10H,3H2,1-2H3,(H,18,20)(H2,16,17,22)	IAHRYNNEPVHPHJ-UHFFFAOYSA-N	793323	4-((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl) amino)-N'-methylbenzenesulfonimidamide::US20260049084, Compound 5B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793323&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388789	528824786							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683950	CCn1nc(Cl)c2c(Nc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C14H15ClN6OS/c1-2-21-14-12(13(15)20-21)11(7-8-18-14)19-9-3-5-10(6-4-9)23(16,17)22/h3-8H,2H2,1H3,(H,18,19)(H3,16,17,22)	ZCGNUNGSZFULTH-UHFFFAOYSA-N	793324	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)benzenesulfonimidamide::US20260049084, Compound 5C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793324&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583444	528824787							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683951	CCn1nc(Cl)c2c(Nc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C14H15ClN6OS/c1-2-21-14-12(13(15)20-21)11(7-8-18-14)19-9-3-5-10(6-4-9)23(16,17)22/h3-8H,2H2,1H3,(H,18,19)(H3,16,17,22)	ZCGNUNGSZFULTH-UHFFFAOYSA-N	793324	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)benzenesulfonimidamide::US20260049084, Compound 5C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793324&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583444	528824787							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683952	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C15H17ClN6OS/c1-3-22-15-13(14(16)21-22)12(8-9-19-15)20-10-4-6-11(7-5-10)24(17,23)18-2/h4-9H,3H2,1-2H3,(H,19,20)(H2,17,18,23)	ZXBQLZGHBGLFOF-UHFFFAOYSA-N	793325	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-methylbenzenesulfonimidamide::US20260049084, Compound 5D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793325&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583431	528824788							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683953	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C15H17ClN6OS/c1-3-22-15-13(14(16)21-22)12(8-9-19-15)20-10-4-6-11(7-5-10)24(17,23)18-2/h4-9H,3H2,1-2H3,(H,19,20)(H2,17,18,23)	ZXBQLZGHBGLFOF-UHFFFAOYSA-N	793325	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-methylbenzenesulfonimidamide::US20260049084, Compound 5D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793325&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583431	528824788							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683954	CCN=S(N)(=O)c1ccc(Nc2ccnc3c2c(Cl)nn3CC)cc1	InChI=1S/C16H19ClN6OS/c1-3-20-25(18,24)12-7-5-11(6-8-12)21-13-9-10-19-16-14(13)15(17)22-23(16)4-2/h5-10H,3-4H2,1-2H3,(H,19,21)(H2,18,20,24)	AONNBQFEJHLFKD-UHFFFAOYSA-N	793326	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-ethylbenzenesulfonimidamide::US20260049084, Compound 5E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793326&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583412	528824789							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683955	CCN=S(N)(=O)c1ccc(Nc2ccnc3c2c(Cl)nn3CC)cc1	InChI=1S/C16H19ClN6OS/c1-3-20-25(18,24)12-7-5-11(6-8-12)21-13-9-10-19-16-14(13)15(17)22-23(16)4-2/h5-10H,3-4H2,1-2H3,(H,19,21)(H2,18,20,24)	AONNBQFEJHLFKD-UHFFFAOYSA-N	793326	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-ethylbenzenesulfonimidamide::US20260049084, Compound 5E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793326&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583412	528824789							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683956	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NCC4CC4)cc3)ccnc21	InChI=1S/C18H21ClN6OS/c1-2-25-18-16(17(19)24-25)15(9-10-21-18)23-13-5-7-14(8-6-13)27(20,26)22-11-12-3-4-12/h5-10,12H,2-4,11H2,1H3,(H,21,23)(H2,20,22,26)	CYDUAQQCXNIQPZ-UHFFFAOYSA-N	793327	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-(cyclopropylmethyl)benzene sulfonimidamide::US20260049084, Compound 5F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793327&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583442	528824790							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683957	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NCC4CC4)cc3)ccnc21	InChI=1S/C18H21ClN6OS/c1-2-25-18-16(17(19)24-25)15(9-10-21-18)23-13-5-7-14(8-6-13)27(20,26)22-11-12-3-4-12/h5-10,12H,2-4,11H2,1H3,(H,21,23)(H2,20,22,26)	CYDUAQQCXNIQPZ-UHFFFAOYSA-N	793327	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-(cyclopropylmethyl)benzene sulfonimidamide::US20260049084, Compound 5F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793327&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583442	528824790							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683958	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C15H14ClN7OS/c1-2-23-15-13(14(16)22-23)12(7-8-19-15)21-10-3-5-11(6-4-10)25(18,24)20-9-17/h3-8H,2H2,1H3,(H,19,21)(H2,18,20,24)	DDNHBVBLAILHLM-UHFFFAOYSA-N	793328	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-cyanobenzenesulfonimidamide::US20260049084, Compound 5G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793328&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388826	528824791							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683959	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C15H14ClN7OS/c1-2-23-15-13(14(16)22-23)12(7-8-19-15)21-10-3-5-11(6-4-10)25(18,24)20-9-17/h3-8H,2H2,1H3,(H,19,21)(H2,18,20,24)	DDNHBVBLAILHLM-UHFFFAOYSA-N	793328	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'-cyanobenzenesulfonimidamide::US20260049084, Compound 5G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793328&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388826	528824791							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683960	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC(C)C)cc3)ccnc21	InChI=1S/C17H21ClN6OS/c1-4-24-17-15(16(18)22-24)14(9-10-20-17)21-12-5-7-13(8-6-12)26(19,25)23-11(2)3/h5-11H,4H2,1-3H3,(H,20,21)(H2,19,23,25)	MZHHOOJLUFQEGR-UHFFFAOYSA-N	793329	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'- isopropylbenzenesulfonimidamide::US20260049084, Compound 5H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793329&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388849	528824792							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683961	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC(C)C)cc3)ccnc21	InChI=1S/C17H21ClN6OS/c1-4-24-17-15(16(18)22-24)14(9-10-20-17)21-12-5-7-13(8-6-12)26(19,25)23-11(2)3/h5-11H,4H2,1-3H3,(H,20,21)(H2,19,23,25)	MZHHOOJLUFQEGR-UHFFFAOYSA-N	793329	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'- isopropylbenzenesulfonimidamide::US20260049084, Compound 5H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793329&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388849	528824792							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683962	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC4CC4)cc3)ccnc21	InChI=1S/C17H19ClN6OS/c1-2-24-17-15(16(18)22-24)14(9-10-20-17)21-11-5-7-13(8-6-11)26(19,25)23-12-3-4-12/h5-10,12H,2-4H2,1H3,(H,20,21)(H2,19,23,25)	ISHTXDGUSRVOJP-UHFFFAOYSA-N	793330	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'- cyclopropylbenzenesulfonimidamide::US20260049084, Compound 5I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793330&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388850	528824793							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683963	CCn1nc(Cl)c2c(Nc3ccc(S(N)(=O)=NC4CC4)cc3)ccnc21	InChI=1S/C17H19ClN6OS/c1-2-24-17-15(16(18)22-24)14(9-10-20-17)21-11-5-7-13(8-6-11)26(19,25)23-12-3-4-12/h5-10,12H,2-4H2,1H3,(H,20,21)(H2,19,23,25)	ISHTXDGUSRVOJP-UHFFFAOYSA-N	793330	4-((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)-N'- cyclopropylbenzenesulfonimidamide::US20260049084, Compound 5I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793330&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388850	528824793							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683964	C#CCn1nc(Cl)c2c(NCc3ccc([S@](C)(=N)=O)cc3)ccnc21	InChI=1S/C17H16ClN5OS/c1-3-10-23-17-15(16(18)22-23)14(8-9-20-17)21-11-12-4-6-13(7-5-12)25(2,19)24/h1,4-9,19H,10-11H2,2H3,(H,20,21)	LNMVQZAYPLGWOX-UHFFFAOYSA-N	793331	(R)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl) phenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 6A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793331&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583450	528824794							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683965	C#CCn1nc(Cl)c2c(NCc3ccc([S@](C)(=N)=O)cc3)ccnc21	InChI=1S/C17H16ClN5OS/c1-3-10-23-17-15(16(18)22-23)14(8-9-20-17)21-11-12-4-6-13(7-5-12)25(2,19)24/h1,4-9,19H,10-11H2,2H3,(H,20,21)	LNMVQZAYPLGWOX-UHFFFAOYSA-N	793331	(R)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl) phenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 6A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793331&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583450	528824794							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683966	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](C)(=N)=O)cc3)ccnc21	InChI=1S/C17H16ClN5OS/c1-3-10-23-17-15(16(18)22-23)14(8-9-20-17)21-11-12-4-6-13(7-5-12)25(2,19)24/h1,4-9,19H,10-11H2,2H3,(H,20,21)	LNMVQZAYPLGWOX-UHFFFAOYSA-N	793332	(S)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl) phenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 6B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793332&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388852	528824795							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683967	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](C)(=N)=O)cc3)ccnc21	InChI=1S/C17H16ClN5OS/c1-3-10-23-17-15(16(18)22-23)14(8-9-20-17)21-11-12-4-6-13(7-5-12)25(2,19)24/h1,4-9,19H,10-11H2,2H3,(H,20,21)	LNMVQZAYPLGWOX-UHFFFAOYSA-N	793332	(S)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl) phenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 6B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793332&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388852	528824795							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683968	CCn1ncc2c(OCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H19N5O2S/c1-3-21-16-14(10-20-21)15(8-9-19-16)23-11-12-4-6-13(7-5-12)24(17,22)18-2/h4-10H,3,11H2,1-2H3,(H2,17,18,22)	YHVKZDAJKZRATG-UHFFFAOYSA-N	793333	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy) methyl)-N'-methylbenzenesulfonimidamide::US20260049084, Compound 7A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793333&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337535	528824796							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683969	CCn1ncc2c(OCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H19N5O2S/c1-3-21-16-14(10-20-21)15(8-9-19-16)23-11-12-4-6-13(7-5-12)24(17,22)18-2/h4-10H,3,11H2,1-2H3,(H2,17,18,22)	YHVKZDAJKZRATG-UHFFFAOYSA-N	793333	4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy) methyl)-N'-methylbenzenesulfonimidamide::US20260049084, Compound 7A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793333&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337535	528824796							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683970	CS(=N)(=O)c1ccc(COc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H14ClN5O2S/c1-25(19,23)12-4-2-11(3-5-12)10-24-13-6-8-20-16-14(13)15(17)21-22(16)9-7-18/h2-6,8,19H,9-10H2,1H3	WBVIQBRAOFOUBN-UHFFFAOYSA-N	793334	2-(3-chloro-4-((4-(S-methylsulfonimidoyl) benzyl)oxy)-1H-pyrazolo[3,4-b]pyridin-1-yl) acetonitrile::US20260049084, Compound 8A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793334&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337524	528824797							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683971	CS(=N)(=O)c1ccc(COc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H14ClN5O2S/c1-25(19,23)12-4-2-11(3-5-12)10-24-13-6-8-20-16-14(13)15(17)21-22(16)9-7-18/h2-6,8,19H,9-10H2,1H3	WBVIQBRAOFOUBN-UHFFFAOYSA-N	793334	2-(3-chloro-4-((4-(S-methylsulfonimidoyl) benzyl)oxy)-1H-pyrazolo[3,4-b]pyridin-1-yl) acetonitrile::US20260049084, Compound 8A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793334&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337524	528824797							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683972	C#CCn1nc(Cl)c2c(N(C)Cc3ccc(S(C)(=N)=O)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)22-24)15(9-10-21-18)23(2)12-13-5-7-14(8-6-13)26(3,20)25/h1,5-10,20H,11-12H2,2-3H3	SGIOJOFULWVFBS-UHFFFAOYSA-N	793335	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H-pyrazolo [3,4-b]pyridin-4-yl)(methyl)amino)methyl) phenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793335&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583401	528824798							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683973	C#CCn1nc(Cl)c2c(N(C)Cc3ccc(S(C)(=N)=O)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)22-24)15(9-10-21-18)23(2)12-13-5-7-14(8-6-13)26(3,20)25/h1,5-10,20H,11-12H2,2-3H3	SGIOJOFULWVFBS-UHFFFAOYSA-N	793335	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H-pyrazolo [3,4-b]pyridin-4-yl)(methyl)amino)methyl) phenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793335&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583401	528824798							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683974	C#CCn1nc(Cl)c2c(N(C)Cc3ccc([S@](C)(=N)=O)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)22-24)15(9-10-21-18)23(2)12-13-5-7-14(8-6-13)26(3,20)25/h1,5-10,20H,11-12H2,2-3H3	SGIOJOFULWVFBS-UHFFFAOYSA-N	793336	(R)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)(methyl)amino)methyl)phenyl)(imino)(methyl)- lambda6-sulfanone::US20260049084, Compound 9B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793336&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422857	528824799							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683975	C#CCn1nc(Cl)c2c(N(C)Cc3ccc([S@](C)(=N)=O)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)22-24)15(9-10-21-18)23(2)12-13-5-7-14(8-6-13)26(3,20)25/h1,5-10,20H,11-12H2,2-3H3	SGIOJOFULWVFBS-UHFFFAOYSA-N	793336	(R)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)(methyl)amino)methyl)phenyl)(imino)(methyl)- lambda6-sulfanone::US20260049084, Compound 9B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793336&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422857	528824799							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683976	C#CCn1nc(Cl)c2c(N(C)Cc3ccc([S@@](C)(=N)=O)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)22-24)15(9-10-21-18)23(2)12-13-5-7-14(8-6-13)26(3,20)25/h1,5-10,20H,11-12H2,2-3H3	SGIOJOFULWVFBS-UHFFFAOYSA-N	793337	(S)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)(methyl)amino)methyl)phenyl)(imino)(methyl)- lambda6-sulfanone::US20260049084, Compound 9C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793337&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422858	528824800							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683977	C#CCn1nc(Cl)c2c(N(C)Cc3ccc([S@@](C)(=N)=O)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)22-24)15(9-10-21-18)23(2)12-13-5-7-14(8-6-13)26(3,20)25/h1,5-10,20H,11-12H2,2-3H3	SGIOJOFULWVFBS-UHFFFAOYSA-N	793337	(S)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)(methyl)amino)methyl)phenyl)(imino)(methyl)- lambda6-sulfanone::US20260049084, Compound 9C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793337&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422858	528824800							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683978	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=N)=O)cc3)ccnc21	InChI=1S/C17H16ClN5OS/c1-3-10-23-17-15(16(18)22-23)14(8-9-20-17)21-11-12-4-6-13(7-5-12)25(2,19)24/h1,4-9,19H,10-11H2,2H3,(H,20,21)	LNMVQZAYPLGWOX-UHFFFAOYSA-N	793338	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)phenyl)(imino)(methyl)-lambda6- sulfanone::US20260049084, Compound 9D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793338&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337518	528824801							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683979	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=N)=O)cc3)ccnc21	InChI=1S/C17H16ClN5OS/c1-3-10-23-17-15(16(18)22-23)14(8-9-20-17)21-11-12-4-6-13(7-5-12)25(2,19)24/h1,4-9,19H,10-11H2,2H3,(H,20,21)	LNMVQZAYPLGWOX-UHFFFAOYSA-N	793338	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)phenyl)(imino)(methyl)-lambda6- sulfanone::US20260049084, Compound 9D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793338&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337518	528824801							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683980	CCn1ncc2c(NCc3ccc(S(C)(=N)=O)cc3)ccnc21	InChI=1S/C16H19N5OS/c1-3-21-16-14(11-20-21)15(8-9-18-16)19-10-12-4-6-13(7-5-12)23(2,17)22/h4-9,11,17H,3,10H2,1-2H3,(H,18,19)	KFIOWUQSHUOMBI-UHFFFAOYSA-N	793339	(4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)phenyl)(imino)(methyl)-lambda6- sulfanone::US20260049084, Compound 9E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793339&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388925	528824802							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683981	CCn1ncc2c(NCc3ccc(S(C)(=N)=O)cc3)ccnc21	InChI=1S/C16H19N5OS/c1-3-21-16-14(11-20-21)15(8-9-18-16)19-10-12-4-6-13(7-5-12)23(2,17)22/h4-9,11,17H,3,10H2,1-2H3,(H,18,19)	KFIOWUQSHUOMBI-UHFFFAOYSA-N	793339	(4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)phenyl)(imino)(methyl)-lambda6- sulfanone::US20260049084, Compound 9E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793339&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388925	528824802							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683982	CS(=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H15ClN6OS/c1-25(19,24)12-4-2-11(3-5-12)10-21-13-6-8-20-16-14(13)15(17)22-23(16)9-7-18/h2-6,8,19H,9-10H2,1H3,(H,20,21)	HUSGORMMDCKWLG-UHFFFAOYSA-N	793340	2-(3-chloro-4-((4-(S- methylsulfonimidoyl)benzyl)amino)-1H- pyrazolo[3,4-b]pyridin-1-yl)acetonitrile::US20260049084, Compound 9F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793340&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388959	528824803							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683983	CS(=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H15ClN6OS/c1-25(19,24)12-4-2-11(3-5-12)10-21-13-6-8-20-16-14(13)15(17)22-23(16)9-7-18/h2-6,8,19H,9-10H2,1H3,(H,20,21)	HUSGORMMDCKWLG-UHFFFAOYSA-N	793340	2-(3-chloro-4-((4-(S- methylsulfonimidoyl)benzyl)amino)-1H- pyrazolo[3,4-b]pyridin-1-yl)acetonitrile::US20260049084, Compound 9F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793340&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388959	528824803							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683984	C[S@](=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H15ClN6OS/c1-25(19,24)12-4-2-11(3-5-12)10-21-13-6-8-20-16-14(13)15(17)22-23(16)9-7-18/h2-6,8,19H,9-10H2,1H3,(H,20,21)	HUSGORMMDCKWLG-UHFFFAOYSA-N	793341	(S)-2-(3-chloro-4-((4-(S-methylsulfonimidoyl) benzyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl) acetonitrile::US20260049084, Compound 9G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793341&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921754	528824804							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683985	C[S@](=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H15ClN6OS/c1-25(19,24)12-4-2-11(3-5-12)10-21-13-6-8-20-16-14(13)15(17)22-23(16)9-7-18/h2-6,8,19H,9-10H2,1H3,(H,20,21)	HUSGORMMDCKWLG-UHFFFAOYSA-N	793341	(S)-2-(3-chloro-4-((4-(S-methylsulfonimidoyl) benzyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl) acetonitrile::US20260049084, Compound 9G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793341&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921754	528824804							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683986	C[S@@](=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H15ClN6OS/c1-25(19,24)12-4-2-11(3-5-12)10-21-13-6-8-20-16-14(13)15(17)22-23(16)9-7-18/h2-6,8,19H,9-10H2,1H3,(H,20,21)	HUSGORMMDCKWLG-UHFFFAOYSA-N	793342	(R)-2-(3-chloro-4-((4-(S- methylsulfonimidoyl)benzyl)amino)-1H- pyrazolo[3,4-b]pyridin-1-yl)acetonitrile::US20260049084, Compound 9H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793342&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388960	528824805							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683987	C[S@@](=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H15ClN6OS/c1-25(19,24)12-4-2-11(3-5-12)10-21-13-6-8-20-16-14(13)15(17)22-23(16)9-7-18/h2-6,8,19H,9-10H2,1H3,(H,20,21)	HUSGORMMDCKWLG-UHFFFAOYSA-N	793342	(R)-2-(3-chloro-4-((4-(S- methylsulfonimidoyl)benzyl)amino)-1H- pyrazolo[3,4-b]pyridin-1-yl)acetonitrile::US20260049084, Compound 9H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793342&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388960	528824805							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
683988	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(=O)CCOC)cc3)ccnc21	InChI=1S/C18H22ClN5O2S/c1-3-24-18-16(17(19)23-24)15(8-9-21-18)22-12-13-4-6-14(7-5-13)27(20,25)11-10-26-2/h4-9,20H,3,10-12H2,1-2H3,(H,21,22)	MSTKPXNFKVNVRF-UHFFFAOYSA-N	793343	(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797304	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793343&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388994	528824806							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714460	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(=O)CCOC)cc3)ccnc21	InChI=1S/C18H22ClN5O2S/c1-3-24-18-16(17(19)23-24)15(8-9-21-18)22-12-13-4-6-14(7-5-13)27(20,25)11-10-26-2/h4-9,20H,3,10-12H2,1-2H3,(H,21,22)	MSTKPXNFKVNVRF-UHFFFAOYSA-N	793343	(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793343&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388994	528824806							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714462	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(=O)CC4CC4)cc3)ccnc21	InChI=1S/C19H22ClN5OS/c1-2-25-19-17(18(20)24-25)16(9-10-22-19)23-11-13-5-7-15(8-6-13)27(21,26)12-14-3-4-14/h5-10,14,21H,2-4,11-12H2,1H3,(H,22,23)	WVQIDIHTNVKYBN-UHFFFAOYSA-N	793344	(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl) (cyclopropylmethyl)(imino)-lambda6-sulfanone::US20260049084, Compound 9J	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793344&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388996	528824807							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714464	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(=O)CC4CC4)cc3)ccnc21	InChI=1S/C19H22ClN5OS/c1-2-25-19-17(18(20)24-25)16(9-10-22-19)23-11-13-5-7-15(8-6-13)27(21,26)12-14-3-4-14/h5-10,14,21H,2-4,11-12H2,1H3,(H,22,23)	WVQIDIHTNVKYBN-UHFFFAOYSA-N	793344	(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl) (cyclopropylmethyl)(imino)-lambda6-sulfanone::US20260049084, Compound 9J	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793344	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793344&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388996	528824807							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714466	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(=O)CC)cc3)ccnc21	InChI=1S/C17H20ClN5OS/c1-3-23-17-15(16(18)22-23)14(9-10-20-17)21-11-12-5-7-13(8-6-12)25(19,24)4-2/h5-10,19H,3-4,11H2,1-2H3,(H,20,21)	ZBNFJZRASOJICY-UHFFFAOYSA-N	793345	(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridine-4-yl)amino)methyl)phenyl)(ethyl) (imino)-lambda6-sulfanone::US20260049084, Compound 9K	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793345&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170388997	528824808							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714468	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(=O)CC)cc3)ccnc21	InChI=1S/C17H20ClN5OS/c1-3-23-17-15(16(18)22-23)14(9-10-20-17)21-11-12-5-7-13(8-6-12)25(19,24)4-2/h5-10,19H,3-4,11H2,1-2H3,(H,20,21)	ZBNFJZRASOJICY-UHFFFAOYSA-N	793345	(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridine-4-yl)amino)methyl)phenyl)(ethyl) (imino)-lambda6-sulfanone::US20260049084, Compound 9K	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793345&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170388997	528824808							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714470	CCn1nc(Cl)c2c(NCc3ccc([S@](C)(=N)=O)cc3)ccnc21	InChI=1S/C16H18ClN5OS/c1-3-22-16-14(15(17)21-22)13(8-9-19-16)20-10-11-4-6-12(7-5-11)24(2,18)23/h4-9,18H,3,10H2,1-2H3,(H,19,20)	QZQNQQUTHXLNJG-UHFFFAOYSA-N	793346	(R)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino) (methyl)-lambda6-sulfanone::US20260049084, Compound 9L	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793346&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583488	528824809							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714472	CCn1nc(Cl)c2c(NCc3ccc([S@](C)(=N)=O)cc3)ccnc21	InChI=1S/C16H18ClN5OS/c1-3-22-16-14(15(17)21-22)13(8-9-19-16)20-10-11-4-6-12(7-5-11)24(2,18)23/h4-9,18H,3,10H2,1-2H3,(H,19,20)	QZQNQQUTHXLNJG-UHFFFAOYSA-N	793346	(R)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino) (methyl)-lambda6-sulfanone::US20260049084, Compound 9L	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793346&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583488	528824809							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714474	CCn1nc(Cl)c2c(NCc3ccc([S@@](C)(=N)=O)cc3)ccnc21	InChI=1S/C16H18ClN5OS/c1-3-22-16-14(15(17)21-22)13(8-9-19-16)20-10-11-4-6-12(7-5-11)24(2,18)23/h4-9,18H,3,10H2,1-2H3,(H,19,20)	QZQNQQUTHXLNJG-UHFFFAOYSA-N	793347	(S)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino) (methyl)-lambda6-sulfanone::US20260049084, Compound 9M	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793347&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422859	528824810							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714476	CCn1nc(Cl)c2c(NCc3ccc([S@@](C)(=N)=O)cc3)ccnc21	InChI=1S/C16H18ClN5OS/c1-3-22-16-14(15(17)21-22)13(8-9-19-16)20-10-11-4-6-12(7-5-11)24(2,18)23/h4-9,18H,3,10H2,1-2H3,(H,19,20)	QZQNQQUTHXLNJG-UHFFFAOYSA-N	793347	(S)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino) (methyl)-lambda6-sulfanone::US20260049084, Compound 9M	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793347&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422859	528824810							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714478	CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)CCOC)cc3)ccnc21	InChI=1S/C18H22ClN5O2S/c1-3-24-18-16(17(19)23-24)15(8-9-21-18)22-12-13-4-6-14(7-5-13)27(20,25)11-10-26-2/h4-9,20H,3,10-12H2,1-2H3,(H,21,22)	MSTKPXNFKVNVRF-UHFFFAOYSA-N	793348	R)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9N	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793348&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583486	528824811							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714480	CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)CCOC)cc3)ccnc21	InChI=1S/C18H22ClN5O2S/c1-3-24-18-16(17(19)23-24)15(8-9-21-18)22-12-13-4-6-14(7-5-13)27(20,25)11-10-26-2/h4-9,20H,3,10-12H2,1-2H3,(H,21,22)	MSTKPXNFKVNVRF-UHFFFAOYSA-N	793348	R)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9N	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793348&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583486	528824811							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714482	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H15ClFN5OS/c1-3-8-24-17-15(16(18)23-24)14(6-7-21-17)22-10-11-4-5-12(9-13(11)19)26(2,20)25/h1,4-7,9,20H,8,10H2,2H3,(H,21,22)	NDIAEHXATMZGTC-UHFFFAOYSA-N	793349	(S)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9O	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793349&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422860	528824812							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714484	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H15ClFN5OS/c1-3-8-24-17-15(16(18)23-24)14(6-7-21-17)22-10-11-4-5-12(9-13(11)19)26(2,20)25/h1,4-7,9,20H,8,10H2,2H3,(H,21,22)	NDIAEHXATMZGTC-UHFFFAOYSA-N	793349	(S)-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9O	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793349&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422860	528824812							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714486	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H15ClFN5OS/c1-3-8-24-17-15(16(18)23-24)14(6-7-21-17)22-10-11-4-5-12(9-13(11)19)26(2,20)25/h1,4-7,9,20H,8,10H2,2H3,(H,21,22)	NDIAEHXATMZGTC-UHFFFAOYSA-N	793350	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-3- fluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9P	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793350&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422860	528824813							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714488	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H15ClFN5OS/c1-3-8-24-17-15(16(18)23-24)14(6-7-21-17)22-10-11-4-5-12(9-13(11)19)26(2,20)25/h1,4-7,9,20H,8,10H2,2H3,(H,21,22)	NDIAEHXATMZGTC-UHFFFAOYSA-N	793350	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-3- fluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9P	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793350&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422860	528824813							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714490	C#CCn1nc(Cl)c2c(NCc3c(F)cc([S@@](C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H14ClF2N5OS/c1-3-6-25-17-15(16(18)24-25)14(4-5-22-17)23-9-11-12(19)7-10(8-13(11)20)27(2,21)26/h1,4-5,7-8,21H,6,9H2,2H3,(H,22,23)	FHRZJGFJTYFMRJ-UHFFFAOYSA-N	793351	(S)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9Q	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793351&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422861	528824814							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714492	C#CCn1nc(Cl)c2c(NCc3c(F)cc([S@@](C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H14ClF2N5OS/c1-3-6-25-17-15(16(18)24-25)14(4-5-22-17)23-9-11-12(19)7-10(8-13(11)20)27(2,21)26/h1,4-5,7-8,21H,6,9H2,2H3,(H,22,23)	FHRZJGFJTYFMRJ-UHFFFAOYSA-N	793351	(S)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9Q	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793351&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422861	528824814							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714494	C#CCn1nc(Cl)c2c(NCc3c(F)cc([S@](C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H14ClF2N5OS/c1-3-6-25-17-15(16(18)24-25)14(4-5-22-17)23-9-11-12(19)7-10(8-13(11)20)27(2,21)26/h1,4-5,7-8,21H,6,9H2,2H3,(H,22,23)	FHRZJGFJTYFMRJ-UHFFFAOYSA-N	793352	(R)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9R	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793352&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422862	528824815							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714496	C#CCn1nc(Cl)c2c(NCc3c(F)cc([S@](C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H14ClF2N5OS/c1-3-6-25-17-15(16(18)24-25)14(4-5-22-17)23-9-11-12(19)7-10(8-13(11)20)27(2,21)26/h1,4-5,7-8,21H,6,9H2,2H3,(H,22,23)	FHRZJGFJTYFMRJ-UHFFFAOYSA-N	793352	(R)-(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9R	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793352&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422862	528824815							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714498	C#CCn1nc(Cl)c2c(NCc3c(F)cc(S(C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H14ClF2N5OS/c1-3-6-25-17-15(16(18)24-25)14(4-5-22-17)23-9-11-12(19)7-10(8-13(11)20)27(2,21)26/h1,4-5,7-8,21H,6,9H2,2H3,(H,22,23)	FHRZJGFJTYFMRJ-UHFFFAOYSA-N	793353	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9S	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793353&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422863	528824816							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714500	C#CCn1nc(Cl)c2c(NCc3c(F)cc(S(C)(=N)=O)cc3F)ccnc21	InChI=1S/C17H14ClF2N5OS/c1-3-6-25-17-15(16(18)24-25)14(4-5-22-17)23-9-11-12(19)7-10(8-13(11)20)27(2,21)26/h1,4-5,7-8,21H,6,9H2,2H3,(H,22,23)	FHRZJGFJTYFMRJ-UHFFFAOYSA-N	793353	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-3,5- difluorophenyl)(imino)(methyl)-lambda6-sulfanone::US20260049084, Compound 9S	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793353&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422863	528824816							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714502	CCn1ncc2c(NCc3ccc(S(=N)(=O)CCOC)cc3)ccnc21	InChI=1S/C18H23N5O2S/c1-3-23-18-16(13-22-23)17(8-9-20-18)21-12-14-4-6-15(7-5-14)26(19,24)11-10-25-2/h4-9,13,19H,3,10-12H2,1-2H3,(H,20,21)	AXEQPRYOSJWCHJ-UHFFFAOYSA-N	793354	(4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)-phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9T	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793354&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389084	528824817							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714504	CCn1ncc2c(NCc3ccc(S(=N)(=O)CCOC)cc3)ccnc21	InChI=1S/C18H23N5O2S/c1-3-23-18-16(13-22-23)17(8-9-20-18)21-12-14-4-6-15(7-5-14)26(19,24)11-10-25-2/h4-9,13,19H,3,10-12H2,1-2H3,(H,20,21)	AXEQPRYOSJWCHJ-UHFFFAOYSA-N	793354	(4-(((1-ethyl-1H-pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)-phenyl)(imino)(2- methoxyethyl)-lambda6-sulfanone::US20260049084, Compound 9T	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793354&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389084	528824817							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714506	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=O)=NC)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)23-24)15(9-10-21-18)22-12-13-5-7-14(8-6-13)26(3,25)20-2/h1,5-10H,11-12H2,2-3H3,(H,21,22)	CNNMYQMWPXAUHD-UHFFFAOYSA-N	793355	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)phenyl)(methyl)(methylimino)- lambda6-sulfanone::US20260049084, Compound 10A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793355&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583484	528824818							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714508	C#CCn1nc(Cl)c2c(NCc3ccc(S(C)(=O)=NC)cc3)ccnc21	InChI=1S/C18H18ClN5OS/c1-4-11-24-18-16(17(19)23-24)15(9-10-21-18)22-12-13-5-7-14(8-6-13)26(3,25)20-2/h1,5-10H,11-12H2,2-3H3,(H,21,22)	CNNMYQMWPXAUHD-UHFFFAOYSA-N	793355	(4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)phenyl)(methyl)(methylimino)- lambda6-sulfanone::US20260049084, Compound 10A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793355&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583484	528824818							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714510	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](=N)(=O)NC)cc3)ccnc21	InChI=1S/C17H17ClN6OS/c1-3-10-24-17-15(16(18)23-24)14(8-9-21-17)22-11-12-4-6-13(7-5-12)26(19,25)20-2/h1,4-9H,10-11H2,2H3,(H,21,22)(H2,19,20,25)	DCOFEGZMHSLJER-UHFFFAOYSA-N	793356	(R)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- methylbenzenesulfonimidamide::US20260049084, Compound 10B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793356&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389115	528824819							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714512	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](=N)(=O)NC)cc3)ccnc21	InChI=1S/C17H17ClN6OS/c1-3-10-24-17-15(16(18)23-24)14(8-9-21-17)22-11-12-4-6-13(7-5-12)26(19,25)20-2/h1,4-9H,10-11H2,2H3,(H,21,22)(H2,19,20,25)	DCOFEGZMHSLJER-UHFFFAOYSA-N	793356	(R)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- methylbenzenesulfonimidamide::US20260049084, Compound 10B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793356&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389115	528824819							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714514	C#CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)NC)cc3)ccnc21	InChI=1S/C17H17ClN6OS/c1-3-10-24-17-15(16(18)23-24)14(8-9-21-17)22-11-12-4-6-13(7-5-12)26(19,25)20-2/h1,4-9H,10-11H2,2H3,(H,21,22)(H2,19,20,25)	DCOFEGZMHSLJER-UHFFFAOYSA-N	793357	(S)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- methylbenzenesulfonimidamide::US20260049084, Compound 10C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793357&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389115	528824820							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714516	C#CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)NC)cc3)ccnc21	InChI=1S/C17H17ClN6OS/c1-3-10-24-17-15(16(18)23-24)14(8-9-21-17)22-11-12-4-6-13(7-5-12)26(19,25)20-2/h1,4-9H,10-11H2,2H3,(H,21,22)(H2,19,20,25)	DCOFEGZMHSLJER-UHFFFAOYSA-N	793357	(S)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- methylbenzenesulfonimidamide::US20260049084, Compound 10C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793357&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389115	528824820							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714518	CN=S(C)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C17H17ClN6OS/c1-20-26(2,25)13-5-3-12(4-6-13)11-22-14-7-9-21-17-15(14)16(18)23-24(17)10-8-19/h3-7,9H,10-11H2,1-2H3,(H,21,22)	UYWMOCLXWOFMKE-UHFFFAOYSA-N	793358	US20260049084, Compound 10D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793358&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389118	528824821							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714520	CN=S(C)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C17H17ClN6OS/c1-20-26(2,25)13-5-3-12(4-6-13)11-22-14-7-9-21-17-15(14)16(18)23-24(17)10-8-19/h3-7,9H,10-11H2,1-2H3,(H,21,22)	UYWMOCLXWOFMKE-UHFFFAOYSA-N	793358	US20260049084, Compound 10D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793358&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389118	528824821							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714522	CN[S@@](=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H16ClN7OS/c1-20-26(19,25)12-4-2-11(3-5-12)10-22-13-6-8-21-16-14(13)15(17)23-24(16)9-7-18/h2-6,8H,9-10H2,1H3,(H,21,22)(H2,19,20,25)	XOXNJUVGKYTZRP-UHFFFAOYSA-N	793359	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- methylbenzenesulfonimidamide::US20260049084, Compound 10F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793359&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583419	528824822							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714524	CN[S@@](=N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H16ClN7OS/c1-20-26(19,25)12-4-2-11(3-5-12)10-22-13-6-8-21-16-14(13)15(17)23-24(16)9-7-18/h2-6,8H,9-10H2,1H3,(H,21,22)(H2,19,20,25)	XOXNJUVGKYTZRP-UHFFFAOYSA-N	793359	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- methylbenzenesulfonimidamide::US20260049084, Compound 10F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793359&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583419	528824822							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714526	C#CCn1nc(Cl)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C16H15ClN6OS/c1-2-9-23-16-14(15(17)22-23)13(7-8-20-16)21-10-11-3-5-12(6-4-11)25(18,19)24/h1,3-8H,9-10H2,(H,20,21)(H3,18,19,24)	MHWLDHMEBUYREG-UHFFFAOYSA-N	793360	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 11A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793360&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389166	528824823							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714528	C#CCn1nc(Cl)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C16H15ClN6OS/c1-2-9-23-16-14(15(17)22-23)13(7-8-20-16)21-10-11-3-5-12(6-4-11)25(18,19)24/h1,3-8H,9-10H2,(H,20,21)(H3,18,19,24)	MHWLDHMEBUYREG-UHFFFAOYSA-N	793360	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 11A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793360&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389166	528824823							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714530	N#CCn1nc(Cl)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H14ClN7OS/c16-14-13-12(5-7-20-15(13)23(22-14)8-6-17)21-9-10-1-3-11(4-2-10)25(18,19)24/h1-5,7H,8-9H2,(H,20,21)(H3,18,19,24)	KYCNHRQDCIWSRL-UHFFFAOYSA-N	793361	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 11B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793361&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389167	528824824							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714532	N#CCn1nc(Cl)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H14ClN7OS/c16-14-13-12(5-7-20-15(13)23(22-14)8-6-17)21-9-10-1-3-11(4-2-10)25(18,19)24/h1-5,7H,8-9H2,(H,20,21)(H3,18,19,24)	KYCNHRQDCIWSRL-UHFFFAOYSA-N	793361	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 11B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793361&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389167	528824824							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714533	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H17ClN6OS/c1-2-22-15-13(14(16)21-22)12(7-8-19-15)20-9-10-3-5-11(6-4-10)24(17,18)23/h3-8H,2,9H2,1H3,(H,19,20)(H3,17,18,23)	JLANRKZJDHCQEV-UHFFFAOYSA-N	793362	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 11C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793362&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389226	528824825							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714535	CCn1nc(Cl)c2c(NCc3ccc(S(=N)(N)=O)cc3)ccnc21	InChI=1S/C15H17ClN6OS/c1-2-22-15-13(14(16)21-22)12(7-8-19-15)20-9-10-3-5-11(6-4-10)24(17,18)23/h3-8H,2,9H2,1H3,(H,19,20)(H3,17,18,23)	JLANRKZJDHCQEV-UHFFFAOYSA-N	793362	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 11C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793362&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389226	528824825							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714537	C#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C17H17ClN6OS/c1-3-10-24-17-15(16(18)23-24)14(8-9-21-17)22-11-12-4-6-13(7-5-12)26(19,25)20-2/h1,4-9H,10-11H2,2H3,(H,21,22)(H2,19,20,25)	DCOFEGZMHSLJER-UHFFFAOYSA-N	793363	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 12A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793363&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583472	528824826							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714539	C#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC)cc3)ccnc21	InChI=1S/C17H17ClN6OS/c1-3-10-24-17-15(16(18)23-24)14(8-9-21-17)22-11-12-4-6-13(7-5-12)26(19,25)20-2/h1,4-9H,10-11H2,2H3,(H,21,22)(H2,19,20,25)	DCOFEGZMHSLJER-UHFFFAOYSA-N	793363	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 12A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793363&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583472	528824826							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714541	CN=S(N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H16ClN7OS/c1-20-26(19,25)12-4-2-11(3-5-12)10-22-13-6-8-21-16-14(13)15(17)23-24(16)9-7-18/h2-6,8H,9-10H2,1H3,(H,21,22)(H2,19,20,25)	XOXNJUVGKYTZRP-UHFFFAOYSA-N	793364	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 12B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793364&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389227	528824827							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714543	CN=S(N)(=O)c1ccc(CNc2ccnc3c2c(Cl)nn3CC#N)cc1	InChI=1S/C16H16ClN7OS/c1-20-26(19,25)12-4-2-11(3-5-12)10-22-13-6-8-21-16-14(13)15(17)23-24(16)9-7-18/h2-6,8H,9-10H2,1H3,(H,21,22)(H2,19,20,25)	XOXNJUVGKYTZRP-UHFFFAOYSA-N	793364	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- methylbenzenesulfonimidamide::US20260049084, Compound 12B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793364&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389227	528824827							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714545	CCn1nc(Cl)c2c(NCc3ccc([S@@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H19ClN6OS/c1-3-23-16-14(15(17)22-23)13(8-9-20-16)21-10-11-4-6-12(7-5-11)25(18,24)19-2/h4-9H,3,10H2,1-2H3,(H,20,21)(H2,18,19,24)	NIFUSKHCWUNDGZ-UHFFFAOYSA-N	793365	(S)-4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)-N'-methyl benzenesulfonimidamide::US20260049084, Compound 12C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793365&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583409	528824828							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714547	CCn1nc(Cl)c2c(NCc3ccc([S@@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H19ClN6OS/c1-3-23-16-14(15(17)22-23)13(8-9-20-16)21-10-11-4-6-12(7-5-11)25(18,24)19-2/h4-9H,3,10H2,1-2H3,(H,20,21)(H2,18,19,24)	NIFUSKHCWUNDGZ-UHFFFAOYSA-N	793365	(S)-4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)-N'-methyl benzenesulfonimidamide::US20260049084, Compound 12C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793365&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583409	528824828							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714549	CCn1nc(Cl)c2c(NCc3ccc([S@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H19ClN6OS/c1-3-23-16-14(15(17)22-23)13(8-9-20-16)21-10-11-4-6-12(7-5-11)25(18,24)19-2/h4-9H,3,10H2,1-2H3,(H,20,21)(H2,18,19,24)	NIFUSKHCWUNDGZ-UHFFFAOYSA-N	793366	(R)-4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)-N'-methyl benzenesulfonimidamide::US20260049084, Compound 12D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793366&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583409	528824829							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714551	CCn1nc(Cl)c2c(NCc3ccc([S@](N)(=O)=NC)cc3)ccnc21	InChI=1S/C16H19ClN6OS/c1-3-23-16-14(15(17)22-23)13(8-9-20-16)21-10-11-4-6-12(7-5-11)25(18,24)19-2/h4-9H,3,10H2,1-2H3,(H,20,21)(H2,18,19,24)	NIFUSKHCWUNDGZ-UHFFFAOYSA-N	793366	(R)-4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)-N'-methyl benzenesulfonimidamide::US20260049084, Compound 12D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793366&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583409	528824829							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714553	CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NCC(F)(F)F)cc3)ccnc21	InChI=1S/C17H18ClF3N6OS/c1-2-27-16-14(15(18)26-27)13(7-8-23-16)24-9-11-3-5-12(6-4-11)29(22,28)25-10-17(19,20)21/h3-8H,2,9-10H2,1H3,(H,23,24)(H2,22,25,28)	IGADNWQSIUHEGC-UHFFFAOYSA-N	793367	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)-N'-(2,2,2-trifluoroethyl) benzenesulfonimidamide::US20260049084, Compound 12E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793367&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583487	528824830							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714555	CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NCC(F)(F)F)cc3)ccnc21	InChI=1S/C17H18ClF3N6OS/c1-2-27-16-14(15(18)26-27)13(7-8-23-16)24-9-11-3-5-12(6-4-11)29(22,28)25-10-17(19,20)21/h3-8H,2,9-10H2,1H3,(H,23,24)(H2,22,25,28)	IGADNWQSIUHEGC-UHFFFAOYSA-N	793367	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)-N'-(2,2,2-trifluoroethyl) benzenesulfonimidamide::US20260049084, Compound 12E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793367&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583487	528824830							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714557	CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H16ClN7OS/c1-2-24-16-14(15(17)23-24)13(7-8-20-16)21-9-11-3-5-12(6-4-11)26(19,25)22-10-18/h3-8H,2,9H2,1H3,(H,20,21)(H2,19,22,25)	YZCVBGSLHHDBHD-UHFFFAOYSA-N	793368	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)-N'-(2,2,2-trifluoroethyl) benzenesulfonimidamide::US20260049084, Compound 12F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793368&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583460	528824831							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714559	CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H16ClN7OS/c1-2-24-16-14(15(17)23-24)13(7-8-20-16)21-9-11-3-5-12(6-4-11)26(19,25)22-10-18/h3-8H,2,9H2,1H3,(H,20,21)(H2,19,22,25)	YZCVBGSLHHDBHD-UHFFFAOYSA-N	793368	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)-N'-(2,2,2-trifluoroethyl) benzenesulfonimidamide::US20260049084, Compound 12F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793368&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583460	528824831							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714561	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H17N7OS/c1-2-23-16-14(10-21-23)15(7-8-19-16)20-9-12-3-5-13(6-4-12)25(18,24)22-11-17/h3-8,10H,2,9H2,1H3,(H,19,20)(H2,18,22,24)	XVZVWJRZNKNXFD-UHFFFAOYSA-N	793369	N'-cyano-4-(((1-ethyl-1H-pyrazolo[3,4- b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 12G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793369&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337531	528824832							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714563	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H17N7OS/c1-2-23-16-14(10-21-23)15(7-8-19-16)20-9-12-3-5-13(6-4-12)25(18,24)22-11-17/h3-8,10H,2,9H2,1H3,(H,19,20)(H2,18,22,24)	XVZVWJRZNKNXFD-UHFFFAOYSA-N	793369	N'-cyano-4-(((1-ethyl-1H-pyrazolo[3,4- b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 12G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793369&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337531	528824832							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714565	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H17N7OS/c1-2-23-16-14(10-21-23)15(7-8-19-16)20-9-12-3-5-13(6-4-12)25(18,24)22-11-17/h3-8,10H,2,9H2,1H3,(H,19,20)(H2,18,22,24)	XVZVWJRZNKNXFD-UHFFFAOYSA-N	793369	N'-cyano-4-(((1-ethyl-1H-pyrazolo[3,4- b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 12G	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793369&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170337531	528824832							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714567	CCn1ncc2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H17N7OS/c1-2-23-16-14(10-21-23)15(7-8-19-16)20-9-12-3-5-13(6-4-12)25(18,24)22-11-17/h3-8,10H,2,9H2,1H3,(H,19,20)(H2,18,22,24)	XVZVWJRZNKNXFD-UHFFFAOYSA-N	793369	N'-cyano-4-(((1-ethyl-1H-pyrazolo[3,4- b]pyridin-4- yl)amino)methyl)benzenesulfonimidamide::US20260049084, Compound 12G	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793369&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170337531	528824832							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714569	N#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H13ClN8OS/c17-15-14-13(5-7-21-16(14)25(24-15)8-6-18)22-9-11-1-3-12(4-2-11)27(20,26)23-10-19/h1-5,7H,8-9H2,(H,21,22)(H2,20,23,26)	OJAFVNOUEMKPTI-UHFFFAOYSA-N	793370	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793370&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583443	528824833							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714571	N#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H13ClN8OS/c17-15-14-13(5-7-21-16(14)25(24-15)8-6-18)22-9-11-1-3-12(4-2-11)27(20,26)23-10-19/h1-5,7H,8-9H2,(H,21,22)(H2,20,23,26)	OJAFVNOUEMKPTI-UHFFFAOYSA-N	793370	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793370&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583443	528824833							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714573	N#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H13ClN8OS/c17-15-14-13(5-7-21-16(14)25(24-15)8-6-18)22-9-11-1-3-12(4-2-11)27(20,26)23-10-19/h1-5,7H,8-9H2,(H,21,22)(H2,20,23,26)	OJAFVNOUEMKPTI-UHFFFAOYSA-N	793370	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12H	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793370&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170583443	528824833							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714575	N#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C16H13ClN8OS/c17-15-14-13(5-7-21-16(14)25(24-15)8-6-18)22-9-11-1-3-12(4-2-11)27(20,26)23-10-19/h1-5,7H,8-9H2,(H,21,22)(H2,20,23,26)	OJAFVNOUEMKPTI-UHFFFAOYSA-N	793370	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12H	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793370&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170583443	528824833							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714577	C#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793371	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793371&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583408	528824834							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714579	C#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793371	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793371&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583408	528824834							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714581	C#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793371	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12I	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793371&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170583408	528824834							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714583	C#CCn1nc(Cl)c2c(NCc3ccc(S(N)(=O)=NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793371	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanobenzenesulfonimidamide::US20260049084, Compound 12I	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793371&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170583408	528824834							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714585	C#CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793372	(R)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12J	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793372&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824835							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714587	C#CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793372	(R)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12J	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793372&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824835							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714589	C#CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793372	(R)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12J	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793372&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824835							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714591	C#CCn1nc(Cl)c2c(NCc3ccc([S@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793372	(R)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12J	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793372&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824835							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714593	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793373	(S)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12K	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793373&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824836							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714595	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793373	(S)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12K	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793373&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824836							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714597	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793373	(S)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12K	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793373&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824836							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714599	C#CCn1nc(Cl)c2c(NCc3ccc([S@@](=N)(=O)NC#N)cc3)ccnc21	InChI=1S/C17H14ClN7OS/c1-2-9-25-17-15(16(18)24-25)14(7-8-21-17)22-10-12-3-5-13(6-4-12)27(20,26)23-11-19/h1,3-8H,9-10H2,(H,21,22)(H2,20,23,26)	SPGDDLJHXNWTSW-UHFFFAOYSA-N	793373	(S)-4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N- cyanobenzenesulfonimidamide::US20260049084, Compound 12K	Carbonic anhydrase 2	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793373&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170583495	528824836							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714601	C#CCn1nc(Cl)c2c(NCC3CCN(S(C)(=N)=O)CC3)ccnc21	InChI=1S/C16H21ClN6OS/c1-3-8-23-16-14(15(17)21-23)13(4-7-19-16)20-11-12-5-9-22(10-6-12)25(2,18)24/h1,4,7,12,18H,5-6,8-11H2,2H3,(H,19,20)	JELFIFFZMPTUJO-UHFFFAOYSA-N	793374	3-chloro-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1- (prop-2-yn-1-yl)-1H-pyrazolo[3,4-b]pyridin-4- amine::US20260049084, Compound 13A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793374&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583420	528824837							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714603	C#CCn1nc(Cl)c2c(NCC3CCN(S(C)(=N)=O)CC3)ccnc21	InChI=1S/C16H21ClN6OS/c1-3-8-23-16-14(15(17)21-23)13(4-7-19-16)20-11-12-5-9-22(10-6-12)25(2,18)24/h1,4,7,12,18H,5-6,8-11H2,2H3,(H,19,20)	JELFIFFZMPTUJO-UHFFFAOYSA-N	793374	3-chloro-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1- (prop-2-yn-1-yl)-1H-pyrazolo[3,4-b]pyridin-4- amine::US20260049084, Compound 13A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793374&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583420	528824837							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714605	C#CCn1nc(Cl)c2c(NCC3CCN([S@](C)(=N)=O)CC3)ccnc21	InChI=1S/C16H21ClN6OS/c1-3-8-23-16-14(15(17)21-23)13(4-7-19-16)20-11-12-5-9-22(10-6-12)25(2,18)24/h1,4,7,12,18H,5-6,8-11H2,2H3,(H,19,20)	JELFIFFZMPTUJO-UHFFFAOYSA-N	793375	(S)-3-chloro-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1- (prop-2-yn-1-yl)-1H-pyrazolo[3,4-b]pyridin-4- amine::US20260049084, Compound 13B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793375&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583416	528824838							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714607	C#CCn1nc(Cl)c2c(NCC3CCN([S@](C)(=N)=O)CC3)ccnc21	InChI=1S/C16H21ClN6OS/c1-3-8-23-16-14(15(17)21-23)13(4-7-19-16)20-11-12-5-9-22(10-6-12)25(2,18)24/h1,4,7,12,18H,5-6,8-11H2,2H3,(H,19,20)	JELFIFFZMPTUJO-UHFFFAOYSA-N	793375	(S)-3-chloro-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1- (prop-2-yn-1-yl)-1H-pyrazolo[3,4-b]pyridin-4- amine::US20260049084, Compound 13B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793375&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583416	528824838							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714609	C#CCn1nc(Cl)c2c(NCC3CCN([S@@](C)(=N)=O)CC3)ccnc21	InChI=1S/C16H21ClN6OS/c1-3-8-23-16-14(15(17)21-23)13(4-7-19-16)20-11-12-5-9-22(10-6-12)25(2,18)24/h1,4,7,12,18H,5-6,8-11H2,2H3,(H,19,20)	JELFIFFZMPTUJO-UHFFFAOYSA-N	793376	(R)-3-chloro-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1- (prop-2-yn-1-yl)-1H-pyrazolo[3,4-b]pyridin-4- amine::US20260049084, Compound 13C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793376&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921759	528824839							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714611	C#CCn1nc(Cl)c2c(NCC3CCN([S@@](C)(=N)=O)CC3)ccnc21	InChI=1S/C16H21ClN6OS/c1-3-8-23-16-14(15(17)21-23)13(4-7-19-16)20-11-12-5-9-22(10-6-12)25(2,18)24/h1,4,7,12,18H,5-6,8-11H2,2H3,(H,19,20)	JELFIFFZMPTUJO-UHFFFAOYSA-N	793376	(R)-3-chloro-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1- (prop-2-yn-1-yl)-1H-pyrazolo[3,4-b]pyridin-4- amine::US20260049084, Compound 13C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793376&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921759	528824839							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714613	CS(=N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H20ClN7OS/c1-25(18,24)22-7-3-11(4-8-22)10-20-12-2-6-19-15-13(12)14(16)21-23(15)9-5-17/h2,6,11,18H,3-4,7-10H2,1H3,(H,19,20)	MURUWWQMOBALRX-UHFFFAOYSA-N	793377	US20260049084, Compound 13D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793377&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583454	528824840							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714615	CS(=N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H20ClN7OS/c1-25(18,24)22-7-3-11(4-8-22)10-20-12-2-6-19-15-13(12)14(16)21-23(15)9-5-17/h2,6,11,18H,3-4,7-10H2,1H3,(H,19,20)	MURUWWQMOBALRX-UHFFFAOYSA-N	793377	US20260049084, Compound 13D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793377&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583454	528824840							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714617	C[S@@](=N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H20ClN7OS/c1-25(18,24)22-7-3-11(4-8-22)10-20-12-2-6-19-15-13(12)14(16)21-23(15)9-5-17/h2,6,11,18H,3-4,7-10H2,1H3,(H,19,20)	MURUWWQMOBALRX-UHFFFAOYSA-N	793378	(S)-2-(3-chloro-4-(((1-(S- methylsulfonimidoyl)piperidin-4-yl) methyl)amino)-1H-pyrazolo[3,4-b] pyridine-1-yl)acetonitrile::US20260049084, Compound 13E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793378&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389452	528824841							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714619	C[S@@](=N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H20ClN7OS/c1-25(18,24)22-7-3-11(4-8-22)10-20-12-2-6-19-15-13(12)14(16)21-23(15)9-5-17/h2,6,11,18H,3-4,7-10H2,1H3,(H,19,20)	MURUWWQMOBALRX-UHFFFAOYSA-N	793378	(S)-2-(3-chloro-4-(((1-(S- methylsulfonimidoyl)piperidin-4-yl) methyl)amino)-1H-pyrazolo[3,4-b] pyridine-1-yl)acetonitrile::US20260049084, Compound 13E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793378&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389452	528824841							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714621	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCO)CC3)ccnc21	InChI=1S/C16H25ClN6O2S/c1-2-23-16-14(15(17)21-23)13(3-6-19-16)20-11-12-4-7-22(8-5-12)26(18,25)10-9-24/h3,6,12,18,24H,2,4-5,7-11H2,1H3,(H,19,20)	SAGHEAOYSVWGCY-UHFFFAOYSA-N	793379	2-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)ethan-1-ol::US20260049084, Compound 14A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793379&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389479	528824842							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714623	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCO)CC3)ccnc21	InChI=1S/C16H25ClN6O2S/c1-2-23-16-14(15(17)21-23)13(3-6-19-16)20-11-12-4-7-22(8-5-12)26(18,25)10-9-24/h3,6,12,18,24H,2,4-5,7-11H2,1H3,(H,19,20)	SAGHEAOYSVWGCY-UHFFFAOYSA-N	793379	2-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)ethan-1-ol::US20260049084, Compound 14A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793379&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389479	528824842							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714625	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCOC)CC3)ccnc21	InChI=1S/C17H27ClN6O2S/c1-3-24-17-15(16(18)22-24)14(4-7-20-17)21-12-13-5-8-23(9-6-13)27(19,25)11-10-26-2/h4,7,13,19H,3,5-6,8-12H2,1-2H3,(H,20,21)	ISFUONWMZSJMMI-UHFFFAOYSA-N	793380	3-chloro-1-ethyl-N-((1-(2- methoxyethylsulfonimidoyl)piperidin-4- yl)methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793380&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389510	528824843							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714627	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCOC)CC3)ccnc21	InChI=1S/C17H27ClN6O2S/c1-3-24-17-15(16(18)22-24)14(4-7-20-17)21-12-13-5-8-23(9-6-13)27(19,25)11-10-26-2/h4,7,13,19H,3,5-6,8-12H2,1-2H3,(H,20,21)	ISFUONWMZSJMMI-UHFFFAOYSA-N	793380	3-chloro-1-ethyl-N-((1-(2- methoxyethylsulfonimidoyl)piperidin-4- yl)methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793380&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389510	528824843							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714629	CCn1nc(Cl)c2c(NCC3CCN([S@@](=N)(=O)CCOC)CC3)ccnc21	InChI=1S/C17H27ClN6O2S/c1-3-24-17-15(16(18)22-24)14(4-7-20-17)21-12-13-5-8-23(9-6-13)27(19,25)11-10-26-2/h4,7,13,19H,3,5-6,8-12H2,1-2H3,(H,20,21)	ISFUONWMZSJMMI-UHFFFAOYSA-N	793381	(R)-3-chloro-1-ethyl-N-((1-(2- methoxyethylsulfonimidoyl)piperidin-4-yl) methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793381&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921761	528824844							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714631	CCn1nc(Cl)c2c(NCC3CCN([S@@](=N)(=O)CCOC)CC3)ccnc21	InChI=1S/C17H27ClN6O2S/c1-3-24-17-15(16(18)22-24)14(4-7-20-17)21-12-13-5-8-23(9-6-13)27(19,25)11-10-26-2/h4,7,13,19H,3,5-6,8-12H2,1-2H3,(H,20,21)	ISFUONWMZSJMMI-UHFFFAOYSA-N	793381	(R)-3-chloro-1-ethyl-N-((1-(2- methoxyethylsulfonimidoyl)piperidin-4-yl) methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793381&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921761	528824844							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714633	CCn1nc(Cl)c2c(NCC3CCN([S@](=N)(=O)CCOC)CC3)ccnc21	InChI=1S/C17H27ClN6O2S/c1-3-24-17-15(16(18)22-24)14(4-7-20-17)21-12-13-5-8-23(9-6-13)27(19,25)11-10-26-2/h4,7,13,19H,3,5-6,8-12H2,1-2H3,(H,20,21)	ISFUONWMZSJMMI-UHFFFAOYSA-N	793382	(S)-3-chloro-1-ethyl-N-((1-(2- methoxyethylsulfonimidoyl)piperidin-4-yl) methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793382&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921770	528824845							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714635	CCn1nc(Cl)c2c(NCC3CCN([S@](=N)(=O)CCOC)CC3)ccnc21	InChI=1S/C17H27ClN6O2S/c1-3-24-17-15(16(18)22-24)14(4-7-20-17)21-12-13-5-8-23(9-6-13)27(19,25)11-10-26-2/h4,7,13,19H,3,5-6,8-12H2,1-2H3,(H,20,21)	ISFUONWMZSJMMI-UHFFFAOYSA-N	793382	(S)-3-chloro-1-ethyl-N-((1-(2- methoxyethylsulfonimidoyl)piperidin-4-yl) methyl)-1H-pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793382&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921770	528824845							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714637	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCC#N)CC3)ccnc21	InChI=1S/C17H24ClN7OS/c1-2-25-17-15(16(18)23-25)14(4-8-21-17)22-12-13-5-9-24(10-6-13)27(20,26)11-3-7-19/h4,8,13,20H,2-3,5-6,9-12H2,1H3,(H,21,22)	FWCLGSLMTZCBHV-UHFFFAOYSA-N	793383	3-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)propanenitrile::US20260049084, Compound 14E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793383&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389541	528824846							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714639	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCC#N)CC3)ccnc21	InChI=1S/C17H24ClN7OS/c1-2-25-17-15(16(18)23-25)14(4-8-21-17)22-12-13-5-9-24(10-6-13)27(20,26)11-3-7-19/h4,8,13,20H,2-3,5-6,9-12H2,1H3,(H,21,22)	FWCLGSLMTZCBHV-UHFFFAOYSA-N	793383	3-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)propanenitrile::US20260049084, Compound 14E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793383&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389541	528824846							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714641	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCC#N)CC3)ccnc21	InChI=1S/C17H24ClN7OS/c1-2-25-17-15(16(18)23-25)14(4-8-21-17)22-12-13-5-9-24(10-6-13)27(20,26)11-3-7-19/h4,8,13,20H,2-3,5-6,9-12H2,1H3,(H,21,22)	FWCLGSLMTZCBHV-UHFFFAOYSA-N	793383	3-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)propanenitrile::US20260049084, Compound 14E	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793383&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170389541	528824846							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714643	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCC#N)CC3)ccnc21	InChI=1S/C17H24ClN7OS/c1-2-25-17-15(16(18)23-25)14(4-8-21-17)22-12-13-5-9-24(10-6-13)27(20,26)11-3-7-19/h4,8,13,20H,2-3,5-6,9-12H2,1H3,(H,21,22)	FWCLGSLMTZCBHV-UHFFFAOYSA-N	793383	3-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)propanenitrile::US20260049084, Compound 14E	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793383&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170389541	528824846							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714645	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCC(=O)O)CC3)ccnc21	InChI=1S/C17H25ClN6O3S/c1-2-24-17-15(16(18)22-24)13(3-7-20-17)21-11-12-4-8-23(9-5-12)28(19,27)10-6-14(25)26/h3,7,12,19H,2,4-6,8-11H2,1H3,(H,20,21)(H,25,26)	WOILXPREPRXHLS-UHFFFAOYSA-N	793384	3-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)propanoic acid::US20260049084, Compound 14F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793384&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583463	528824847							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714647	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCC(=O)O)CC3)ccnc21	InChI=1S/C17H25ClN6O3S/c1-2-24-17-15(16(18)22-24)13(3-7-20-17)21-11-12-4-8-23(9-5-12)28(19,27)10-6-14(25)26/h3,7,12,19H,2,4-6,8-11H2,1H3,(H,20,21)(H,25,26)	WOILXPREPRXHLS-UHFFFAOYSA-N	793384	3-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)propanoic acid::US20260049084, Compound 14F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793384&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583463	528824847							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714649	CCn1ncc2c(NCC3CCN([S@@](C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793385	I-1-ethyl-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1H- pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793385&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921819	528824848							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714651	CCn1ncc2c(NCC3CCN([S@@](C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793385	I-1-ethyl-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1H- pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793385&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921819	528824848							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714653	CCn1ncc2c(NCC3CCN([S@](C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793386	(S)-1-ethyl-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1H- pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793386&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921783	528824849							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714655	CCn1ncc2c(NCC3CCN([S@](C)(=N)=O)CC3)ccnc21	InChI=1S/C15H24N6OS/c1-3-21-15-13(11-19-21)14(4-7-17-15)18-10-12-5-8-20(9-6-12)23(2,16)22/h4,7,11-12,16H,3,5-6,8-10H2,1-2H3,(H,17,18)	HSKWIYGLVUGUHM-UHFFFAOYSA-N	793386	(S)-1-ethyl-N-((1-(S- methylsulfonimidoyl)piperidin-4-yl)methyl)-1H- pyrazolo[3,4-b]pyridin-4-amine::US20260049084, Compound 14H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793386&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921783	528824849							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714657	C#CCn1nc(Cl)c2c(NCC3CCN([S@@](C)(=O)=NC#N)CC3)ccnc21	InChI=1S/C17H20ClN7OS/c1-3-8-25-17-15(16(18)23-25)14(4-7-20-17)21-11-13-5-9-24(10-6-13)27(2,26)22-12-19/h1,4,7,13H,5-6,8-11H2,2H3,(H,20,21)	ILKXDSASSDNQSH-UHFFFAOYSA-N	793387	(S)-N-((4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)piperidin-1-yl)(methyl)(oxo)- lambda6-sulfaneylidene)cyanamide::US20260049084, Compound 14I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793387&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583475	528824850							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714659	C#CCn1nc(Cl)c2c(NCC3CCN([S@@](C)(=O)=NC#N)CC3)ccnc21	InChI=1S/C17H20ClN7OS/c1-3-8-25-17-15(16(18)23-25)14(4-7-20-17)21-11-13-5-9-24(10-6-13)27(2,26)22-12-19/h1,4,7,13H,5-6,8-11H2,2H3,(H,20,21)	ILKXDSASSDNQSH-UHFFFAOYSA-N	793387	(S)-N-((4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)piperidin-1-yl)(methyl)(oxo)- lambda6-sulfaneylidene)cyanamide::US20260049084, Compound 14I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793387&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583475	528824850							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714661	C#CCn1nc(Cl)c2c(NCC3CCN([S@](C)(=O)=NC#N)CC3)ccnc21	InChI=1S/C17H20ClN7OS/c1-3-8-25-17-15(16(18)23-25)14(4-7-20-17)21-11-13-5-9-24(10-6-13)27(2,26)22-12-19/h1,4,7,13H,5-6,8-11H2,2H3,(H,20,21)	ILKXDSASSDNQSH-UHFFFAOYSA-N	793388	(R)-N-((4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)piperidin-1-yl)(methyl)(oxo)- lambda6-sulfaneylidene)cyanamide::US20260049084, Compound 14J	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793388&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			178422864	528824851							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714663	C#CCn1nc(Cl)c2c(NCC3CCN([S@](C)(=O)=NC#N)CC3)ccnc21	InChI=1S/C17H20ClN7OS/c1-3-8-25-17-15(16(18)23-25)14(4-7-20-17)21-11-13-5-9-24(10-6-13)27(2,26)22-12-19/h1,4,7,13H,5-6,8-11H2,2H3,(H,20,21)	ILKXDSASSDNQSH-UHFFFAOYSA-N	793388	(R)-N-((4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)piperidin-1-yl)(methyl)(oxo)- lambda6-sulfaneylidene)cyanamide::US20260049084, Compound 14J	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793388&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			178422864	528824851							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714665	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCNC(C)=O)CC3)ccnc21	InChI=1S/C18H28ClN7O2S/c1-3-26-18-16(17(19)24-26)15(4-7-22-18)23-12-14-5-9-25(10-6-14)29(20,28)11-8-21-13(2)27/h4,7,14,20H,3,5-6,8-12H2,1-2H3,(H,21,27)(H,22,23)	FKKCXGZGNXECQO-UHFFFAOYSA-N	793389	N-(2-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)ethyl)acetamide::US20260049084, Compound 14K	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793389&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389630	528824852							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714667	CCn1nc(Cl)c2c(NCC3CCN(S(=N)(=O)CCNC(C)=O)CC3)ccnc21	InChI=1S/C18H28ClN7O2S/c1-3-26-18-16(17(19)24-26)15(4-7-22-18)23-12-14-5-9-25(10-6-14)29(20,28)11-8-21-13(2)27/h4,7,14,20H,3,5-6,8-12H2,1-2H3,(H,21,27)(H,22,23)	FKKCXGZGNXECQO-UHFFFAOYSA-N	793389	N-(2-(4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b] pyridin-4-yl)amino)methyl)piperidine-1- sulfonimidoyl)ethyl)acetamide::US20260049084, Compound 14K	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793389&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389630	528824852							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714669	CN=S(N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793390	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793390&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824853							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714671	CN=S(N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793390	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793390&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824853							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714673	N#CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793391	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793391&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824854							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714675	N#CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793391	4-(((3-chloro-1-(cyanomethyl)-1H-pyrazolo[3,4- b]pyridin-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15B	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793391&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824854							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714677	CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC)CC3)ccnc21	InChI=1S/C15H24ClN7OS/c1-3-23-15-13(14(16)21-23)12(4-7-19-15)20-10-11-5-8-22(9-6-11)25(17,24)18-2/h4,7,11H,3,5-6,8-10H2,1-2H3,(H,19,20)(H2,17,18,24)	WHUCWCBOOBGUJT-UHFFFAOYSA-N	793392	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)-N'-methylpiperidine-1- sulfonimidamide::US20260049084, Compound 15C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793392&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389664	528824855							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714679	CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC)CC3)ccnc21	InChI=1S/C15H24ClN7OS/c1-3-23-15-13(14(16)21-23)12(4-7-19-15)20-10-11-5-8-22(9-6-11)25(17,24)18-2/h4,7,11H,3,5-6,8-10H2,1-2H3,(H,19,20)(H2,17,18,24)	WHUCWCBOOBGUJT-UHFFFAOYSA-N	793392	4-(((3-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridin- 4-yl)amino)methyl)-N'-methylpiperidine-1- sulfonimidamide::US20260049084, Compound 15C	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793392&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389664	528824855							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714681	C#CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC)CC3)ccnc21	InChI=1S/C16H22ClN7OS/c1-3-8-24-16-14(15(17)22-24)13(4-7-20-16)21-11-12-5-9-23(10-6-12)26(18,25)19-2/h1,4,7,12H,5-6,8-11H2,2H3,(H,20,21)(H2,18,19,25)	AWDSBIHELVFTHZ-UHFFFAOYSA-N	793393	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793393&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170583466	528824856							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714683	C#CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC)CC3)ccnc21	InChI=1S/C16H22ClN7OS/c1-3-8-24-16-14(15(17)22-24)13(4-7-20-16)21-11-12-5-9-23(10-6-12)26(18,25)19-2/h1,4,7,12H,5-6,8-11H2,2H3,(H,20,21)(H2,18,19,25)	AWDSBIHELVFTHZ-UHFFFAOYSA-N	793393	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15D	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 55							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793393&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170583466	528824856							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714685	C#CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC)CC3)ccnc21	InChI=1S/C16H22ClN7OS/c1-3-8-24-16-14(15(17)22-24)13(4-7-20-16)21-11-12-5-9-23(10-6-12)26(18,25)19-2/h1,4,7,12H,5-6,8-11H2,2H3,(H,20,21)(H2,18,19,25)	AWDSBIHELVFTHZ-UHFFFAOYSA-N	793393	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15D	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793393&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170583466	528824856							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714687	C#CCn1nc(Cl)c2c(NCC3CCN(S(N)(=O)=NC)CC3)ccnc21	InChI=1S/C16H22ClN7OS/c1-3-8-24-16-14(15(17)22-24)13(4-7-20-16)21-11-12-5-9-23(10-6-12)26(18,25)19-2/h1,4,7,12H,5-6,8-11H2,2H3,(H,20,21)(H2,18,19,25)	AWDSBIHELVFTHZ-UHFFFAOYSA-N	793393	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15D	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793393&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170583466	528824856							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714689	N#CCn1nc(Cl)c2c(NCC3CCN([S@@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793394	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793394&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824857							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714691	N#CCn1nc(Cl)c2c(NCC3CCN([S@@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793394	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15E	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793394&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824857							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714693	N#CCn1nc(Cl)c2c(NCC3CCN([S@@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793394	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15E	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793394&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824857							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714695	N#CCn1nc(Cl)c2c(NCC3CCN([S@@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793394	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridine-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15E	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793394&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824857							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714697	N#CCn1nc(Cl)c2c(NCC3CCN([S@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793395	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793395&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824858							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714699	N#CCn1nc(Cl)c2c(NCC3CCN([S@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793395	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15F	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793395&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824858							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714701	N#CCn1nc(Cl)c2c(NCC3CCN([S@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793395	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15F	Carbonic anhydrase 1	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793395&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824858							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714703	N#CCn1nc(Cl)c2c(NCC3CCN([S@](N)(=O)=NC#N)CC3)ccnc21	InChI=1S/C15H18ClN9OS/c16-14-13-12(1-5-20-15(13)25(23-14)8-4-17)21-9-11-2-6-24(7-3-11)27(19,26)22-10-18/h1,5,11H,2-3,6-9H2,(H,20,21)(H2,19,22,26)	ULXZDOUUPMUGPY-UHFFFAOYSA-N	793395	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- cyanopiperidine-1-sulfonimidamide::US20260049084, Compound 15F	Carbonic anhydrase 2	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793395&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170389665	528824858							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714705	CN=[S@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793396	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793396&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824859							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714707	CN=[S@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793396	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15G	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793396&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824859							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714709	CN=[S@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793396	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15G	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793396&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824859							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714711	CN=[S@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793396	(S)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15G	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793396&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824859							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714713	CN=[S@@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793397	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793397&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824860							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714715	CN=[S@@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793397	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15H	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793397&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824860							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714717	CN=[S@@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793397	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15H	Carbonic anhydrase 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793397&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824860							1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF	9RV0,9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4	Carbonic anhydrase 1	CAH1_HUMAN	P00915																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
714719	CN=[S@@](N)(=O)N1CCC(CNc2ccnc3c2c(Cl)nn3CC#N)CC1	InChI=1S/C15H21ClN8OS/c1-19-26(18,25)23-7-3-11(4-8-23)10-21-12-2-6-20-15-13(12)14(16)22-24(15)9-5-17/h2,6,11H,3-4,7-10H2,1H3,(H,20,21)(H2,18,19,25)	PYNKWAHZYQTTQD-UHFFFAOYSA-N	793397	(R)-4-(((3-chloro-1-(cyanomethyl)-1H- pyrazolo[3,4-b]pyridin-4-yl)amino)methyl)-N'- methylpiperidine-1-sulfonimidamide::US20260049084, Compound 15H	Carbonic anhydrase 2	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793397&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search			170389632	528824860							1	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK	8ZWV,8C0Q,6EQU,9TYE,9SNC,9SNB,9RUZ,9RFO,9RFL,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6	Carbonic anhydrase 2	CAH2_HUMAN	P00918	B2R7G8 Q6FI12 Q96ET9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714721	C#CCn1nc(Cl)c2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C15H20ClN7OS/c1-2-7-23-15-13(14(16)21-23)12(3-6-19-15)20-10-11-4-8-22(9-5-11)25(17,18)24/h1,3,6,11H,4-5,7-10H2,(H,19,20)(H3,17,18,24)	NMWFZYVADZLBSS-UHFFFAOYSA-N	793398	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 15I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		<10							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793398&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			177921764	528824861							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714723	C#CCn1nc(Cl)c2c(NCC3CCN(S(=N)(N)=O)CC3)ccnc21	InChI=1S/C15H20ClN7OS/c1-2-7-23-15-13(14(16)21-23)12(3-6-19-15)20-10-11-4-8-22(9-5-11)25(17,18)24/h1,3,6,11H,4-5,7-10H2,(H,19,20)(H3,17,18,24)	NMWFZYVADZLBSS-UHFFFAOYSA-N	793398	4-(((3-chloro-1-(prop-2-yn-1-yl)-1H- pyrazolo[3,4-b]pyridin-4- yl)amino)methyl)piperidine-1-sulfonimidamide::US20260049084, Compound 15I	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		 550							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793398&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			177921764	528824861							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714725	CCn1ncc2c(Oc3ccc(S(N)(=O)=NCC4CC4)cc3)ccnc21	InChI=1S/C18H21N5O2S/c1-2-23-18-16(12-21-23)17(9-10-20-18)25-14-5-7-15(8-6-14)26(19,24)22-11-13-3-4-13/h5-10,12-13H,2-4,11H2,1H3,(H2,19,22,24)	INFWAIQMDZYMTQ-UHFFFAOYSA-N	793399	N'-(cyclopropylmethyl)-4-((1-ethyl-1H-pyrazolo [3,4-b]pyridin-4-yl)oxy)benzenesulfonimidamide::US20260049084, Compound 16A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793399&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search			170337536	528824862							1	MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED	6WFJ,6WEW,6WEV,6WEU,6WET	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1_HUMAN	P22413	Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
714727	CCn1ncc2c(Oc3ccc(S(N)(=O)=NCC4CC4)cc3)ccnc21	InChI=1S/C18H21N5O2S/c1-2-23-18-16(12-21-23)17(9-10-20-18)25-14-5-7-15(8-6-14)26(19,24)22-11-13-3-4-13/h5-10,12-13H,2-4,11H2,1H3,(H2,19,22,24)	INFWAIQMDZYMTQ-UHFFFAOYSA-N	793399	N'-(cyclopropylmethyl)-4-((1-ethyl-1H-pyrazolo [3,4-b]pyridin-4-yl)oxy)benzenesulfonimidamide::US20260049084, Compound 16A	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	Homo sapiens		>1000							US Patent		10.7270/Q24M99JC		aid1797834	US20260049084	ROWBOTTOM, MW; LU, K; MICHELS, T; KASEM, M	2/19/2026	7/1/2026	Gossamer Bio Services	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=793399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006725&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=793399&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+3&column=ki&startPg=0&Increment=50&submit=Search			170337536	528824862							1	MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI	6C01,9NIR	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3_HUMAN	O14638	Q5JTL3