BDBM50618483 CHEMBL5419358

SMILES COc1cc2c(cc1Nc1nc(Nc3ccccc3S(=O)(=O)N(C)C)c3c(-c4cccnc4)c[nH]c3n1)CN(C)CC2

InChI Key InChIKey=UVFANRIFEXGNPK-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50618483   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human HPK1 using myelin basic protein and [gamma33P]ATP as substrate incubated for 40 mins in presence of Mg/ATP by radiometric scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of HPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of HPK1 (unknown origin) by [gamma-33p]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 12nMAssay Description:Inhibition of HPK1 (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HPK1 (unknown origin) assessed as reduction in SLP76 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetLymphocyte cytosolic protein 2(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of SLP76 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human HPK1 in anti-human CD3 stimulated human Jurkat T cells assessed as inhibition of SLP76 phosphorylation preincubated for 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618483BDBM50618483(CHEMBL5419358)
Affinity DataEC50:  1.19E+3nMAssay Description:Inhibition of human HPK1 in human Jurkat T cells assessed as increase in anti-human CD3 stimulated IL-2 secretion preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed