BDBM50660474 CHEMBL6150603

SMILES COc1cn(Cc2cc(-c3ccc(N)nc3F)ccn2)c(=O)cc1-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=SLYRYQGKFIGQJP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50660474   

TargetCoagulation factor XI(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human FXIa using p-Glu-Pro-Arg-pNA.HCl as substrate incubated for 30 mins followed by substrate addition and measured after 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 222nMAssay Description:Inhibition of PKal (unknown origin) using H-D-Pro-Phe-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of thrombin (unknown origin) using H-D-Phe-Pip-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTissue-type plasminogen activator(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tPA (unknown origin) using H-D-Ile-Pro-Arg-pNA-2HCl as substrate incubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-Ile-Glu(gamma-OR)-Gly-Arg-pNA.HCl as substrate incubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetChymotrypsinogen B2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of chymotrypsin (unknown origin) using N-Suc-Ala-Ala-Pro-Phe-pNA as substrate incubated for 30 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FXa (unknown origin) using Z-D-Arg-Gly-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPlasminogen(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of plasmin (unknown origin) using PyroGlu-Phe-Lys-pNA.HCl as substrate incubated for 30 mins followed by substrate addition and measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCoagulation factor XII(Human)
Hefei University of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660474BDBM50660474(CHEMBL6150603)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FXIIa (unknown origin) using H-D-ProPhe-Arg-pNA.2HCl as substrate incubated for 30 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed