BDBM50669007 CHEMBL6192725

SMILES Cc1cc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)cc(C)c1-n1cccc(CCN[C@H]2CC[C@H](O)CC2)c1=O

InChI Key InChIKey=GECMZHHEDPUNDQ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50669007   

TargetCoagulation factor X(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of factor Xa (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProthrombin(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of factor IIa (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProthrombin(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 30nMAssay Description:Inhibition of factor IIa (unknown origin) in presence of human plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCoagulation factor X(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 35nMAssay Description:Inhibition of factor Xa (unknown origin) in presence of human plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProthrombin(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 40nMAssay Description:Inhibition of human factor IIa using Boc-Val-Pro-Arg-AMC as substrate measured for 20 mins in presence of minipig plasma by ecarin reagent based assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCoagulation factor X(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 70nMAssay Description:Inhibition of human factor Xa using Methoxycarbonyl-D-Nle-Gly-Arg-pNA as substrate measured for 20 mins in presence of minipig plasma by RVV reagent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCoagulation factor X(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 150nMAssay Description:Inhibition of human factor Xa using Methoxycarbonyl-D-Nle-Gly-Arg-pNA as substrate measured for 20 mins in presence of rabbit plasma by RVV reagent b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProthrombin(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 270nMAssay Description:Inhibition of human factor IIa using Boc-Val-Pro-Arg-AMC as substrate measured for 20 mins in presence of rabbit plasma by ecarin reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProthrombin(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 370nMAssay Description:Inhibition of factor IIa generation in human plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of factor XIa (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTrypsin(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPlasminogen(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of plasmin (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTissue-type plasminogen activator(Human)
Germany.F. Hoffmann-La Roche Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50669007BDBM50669007(CHEMBL6192725)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of TPA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed