BDBM540286 (32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo[1,2-b]pyridazina-1(2,4), 4(3,2)-dipyridina-3(1,2)-pyrrolidinacycloheptaphane::US20260028352, Example I-38

SMILES C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)cnc2O1

InChI Key InChIKey=WFEOFAMMFORTDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540286   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540286BDBM540286((32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540286BDBM540286((32R,6R,E)-45-fluoro-6-methyl-5-oxa-2(3,6)-imidazo...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details
US Patent