BDBM100262 2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile ::US20260001868, Compound 1

SMILES Cn1ncc(-c2ccc3c(=O)[nH]cc(CN)c3c2)c1-c1c(F)c(Cl)cc(OC2CC2)c1C#N

InChI Key InChIKey=UTESOWDSXZVOAN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 100262   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Xizang Haisco Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 100262BDBM100262(2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydroisoquinolin...)
Affinity DataIC50: 5.5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Xizang Haisco Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 100262BDBM100262(2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydroisoquinolin...)
Affinity DataIC50: 55nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2026
Entry Details
US Patent