BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
348228	C[C@@H]1CN(Cc2c1n(nc2C(=O)Nc3cccc(c3)[C@H](C)O)Cc4ccc(cc4)F)C(=O)c5ccc[nH]5	InChI=1S/C28H28FN5O3/c1-17-14-33(28(37)24-7-4-12-30-24)16-23-25(27(36)31-22-6-3-5-20(13-22)18(2)35)32-34(26(17)23)15-19-8-10-21(29)11-9-19/h3-13,17-18,30,35H,14-16H2,1-2H3,(H,31,36)	IVFDDVKCCBDPQZ-UHFFFAOYSA-N	195601	GSK321::US11376246, Cpd ID GSK321::US11576906, Compound GSK321::US11311527, Cpd ID GSK321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 3.8						25.00 C	Curated from the literature by BindingDB	10.1038/nchembio.1930	10.7270/Q2RR1X2G	26436839	aid1801986		Okoye-Okafor, UC; Bartholdy, B; Cartier, J; Gao, EN; Pietrak, B; Rendina, AR; Rominger, C; Quinn, C; Smallwood, A; Wiggall, KJ; Reif, AJ; Schmidt, SJ; Qi, H; Zhao, H; Joberty, G; Faelth-Savitski, M; Bantscheff, M; Drewes, G; Duraiswami, C; Brady, P; Groy, A; Narayanagari, SR; Antony-Debre, I; Mitchell, K; Wang, HR; Kao, YR; Christopeit, M; Carvajal, L; Barreyro, L; Paietta, E; Makishima, H; Will, B; Concha, N; Adams, ND; Schwartz, B; McCabe, MT; Maciejewski, J; Verma, A; Steidl, U	11/28/2015	10/7/2016	Albert Einstein College of Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=195601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=195601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	59D	5DE1	91864709	318471187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
348235	Cc1cccc(NC(=O)c2nn(Cc3c[nH]cn3)c3CCN(Cc23)C(=O)c2ccc[nH]2)c1	InChI=1S/C23H23N7O2/c1-15-4-2-5-16(10-15)27-22(31)21-18-13-29(23(32)19-6-3-8-25-19)9-7-20(18)30(28-21)12-17-11-24-14-26-17/h2-6,8,10-11,14,25H,7,9,12-13H2,1H3,(H,24,26)(H,27,31)	PYCSPHYSYJHUKG-UHFFFAOYSA-N	195602	GSK990	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 4495						25.00 C	Curated from the literature by BindingDB	10.1038/nchembio.1930	10.7270/Q2RR1X2G	26436839	aid1801986		Okoye-Okafor, UC; Bartholdy, B; Cartier, J; Gao, EN; Pietrak, B; Rendina, AR; Rominger, C; Quinn, C; Smallwood, A; Wiggall, KJ; Reif, AJ; Schmidt, SJ; Qi, H; Zhao, H; Joberty, G; Faelth-Savitski, M; Bantscheff, M; Drewes, G; Duraiswami, C; Brady, P; Groy, A; Narayanagari, SR; Antony-Debre, I; Mitchell, K; Wang, HR; Kao, YR; Christopeit, M; Carvajal, L; Barreyro, L; Paietta, E; Makishima, H; Will, B; Concha, N; Adams, ND; Schwartz, B; McCabe, MT; Maciejewski, J; Verma, A; Steidl, U	11/28/2015	10/7/2016	Albert Einstein College of Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=195602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=195602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			91864706	318471188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
399571	Cc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1	InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)	GZLNOSRHZLTDMT-UHFFFAOYSA-N	228658	rac-ML309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 62							Curated from the literature by BindingDB	10.1074/jbc.M113.511030	10.7270/Q2513X35	24668804	aid1802831		Davis, MI; Gross, S; Shen, M; Straley, KS; Pragani, R; Lea, WA; Popovici-Muller, J; DeLaBarre, B; Artin, E; Thorne, N; Auld, DS; Li, Z; Dang, L; Boxer, MB; Simeonov, A	5/16/2014	5/22/2017	National Institutes of Health	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228658	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			56832449	336948180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
399572	Cc1ccccc1[C@@H](N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1	InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)/t28-/m1/s1	GZLNOSRHZLTDMT-MUUNZHRXSA-N	228659	(+)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-o-tolylacetamide::(+)-ML309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 30							Curated from the literature by BindingDB	10.1074/jbc.M113.511030	10.7270/Q2513X35	24668804	aid1802831		Davis, MI; Gross, S; Shen, M; Straley, KS; Pragani, R; Lea, WA; Popovici-Muller, J; DeLaBarre, B; Artin, E; Thorne, N; Auld, DS; Li, Z; Dang, L; Boxer, MB; Simeonov, A	5/16/2014	5/22/2017	National Institutes of Health	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			124604738	336948181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
399573	Cc1ccccc1[C@H](N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1	InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)/t28-/m0/s1	GZLNOSRHZLTDMT-NDEPHWFRSA-N	228660	(-)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-o-tolylacetamide::(-)-ML309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 15000							Curated from the literature by BindingDB	10.1074/jbc.M113.511030	10.7270/Q2513X35	24668804	aid1802831		Davis, MI; Gross, S; Shen, M; Straley, KS; Pragani, R; Lea, WA; Popovici-Muller, J; DeLaBarre, B; Artin, E; Thorne, N; Auld, DS; Li, Z; Dang, L; Boxer, MB; Simeonov, A	5/16/2014	5/22/2017	National Institutes of Health	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			124604737	336948182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529891	CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O5/c1-25(11-34-12-25)23-21(22(29-35-23)20-16(27)9-14(26)10-17(20)28)24(33)30-8-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-10H,11-12H2,1H3,(H,31,32)/b6-5+	GUUIMFGRPPTLFX-AATRIKPKSA-N	278539	(2E)-3-(1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 56					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278539	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306974	378160133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529893	Cc1cn(C(=O)c2c(noc2C2(C)COC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H19Cl3N2O5/c1-13-10-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(21-16(28)8-15(27)9-17(21)29)30-36-24(22)26(2)11-35-12-26/h3-10H,11-12H2,1-2H3,(H,32,33)/b7-6+	HYWBLOXYWSBDNM-VOTSOKGWSA-N	278540	 (2E)-3-(3-Methyl-1-{[5-(3-methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 47					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278540	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307051	378160134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529895	COC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O6/c1-34-25(11-35-12-25)23-21(22(29-36-23)20-16(27)9-14(26)10-17(20)28)24(33)30-8-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-10H,11-12H2,1H3,(H,31,32)/b6-5+	STYBXRKGHGFUHP-AATRIKPKSA-N	278541	 (2E)-3-(1-{[5-(3-Methoxyoxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 64					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307131	378160135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529897	COC1(COC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3N2O6/c1-13-10-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(21-16(28)8-15(27)9-17(21)29)30-37-24(22)26(35-2)11-36-12-26/h3-10H,11-12H2,1-2H3,(H,32,33)/b7-6+	LEFPHBUXKVVVQR-VOTSOKGWSA-N	278542	 (2E)-3-(1-{[5-(3-Methoxyoxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 56					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307233	378160136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529899	CCC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C26H20Cl2N2O5/c1-2-26(13-34-14-26)24-22(23(29-35-24)21-17(27)6-4-7-18(21)28)25(33)30-12-11-16-15(9-10-20(31)32)5-3-8-19(16)30/h3-12H,2,13-14H2,1H3,(H,31,32)/b10-9+	XEODONMEYPNKSS-MDZDMXLPSA-N	278543	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(3-ethyloxetan-3-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 62					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278543	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307317	378160137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529901	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1C1(F)COC1)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H14Cl3FN2O5/c25-13-8-15(26)19(16(27)9-13)21-20(22(35-29-21)24(28)10-34-11-24)23(33)30-7-6-14-12(4-5-18(31)32)2-1-3-17(14)30/h1-9H,10-11H2,(H,31,32)/b5-4+	TZFJDMKNEHTWGX-SNAWJCMRSA-N	278544	 (2E)-3-(1-{[5-(3-Fluorooxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 151					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278544	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307129	378160138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529903	CC(C)(O)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C24H18Cl2N2O5/c1-24(2,32)22-20(21(27-33-22)19-15(25)6-4-7-16(19)26)23(31)28-12-11-14-13(9-10-18(29)30)5-3-8-17(14)28/h3-12,32H,1-2H3,(H,29,30)/b10-9+	QCJZHAYRCPMVBV-MDZDMXLPSA-N	278545	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(2-hydroxypropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 152					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307053	378160139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529905	CC1(COC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H19Cl3N2O5/c1-27(11-36-12-27)25-23(24(31-37-25)22-17(29)8-15(28)9-18(22)30)26(35)32-10-14-6-5-13(7-20(33)34)16-3-2-4-19(32)21(14)16/h2-4,7-10H,5-6,11-12H2,1H3,(H,33,34)/b13-7+	YTFZGEAFVYSQNL-NTUHNPAUSA-N	278546	 (2E)-[1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid  ::US10040791, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 55					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278546	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307130	378160140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529907	CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)ccnc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H16Cl3N3O5/c1-24(10-34-11-24)21-19(20(29-35-21)18-15(26)8-13(25)9-16(18)27)23(33)30-7-5-14-12(2-3-17(31)32)4-6-28-22(14)30/h2-9H,10-11H2,1H3,(H,31,32)/b3-2+	QXJHSRNWHJVTFC-NSCUHMNNSA-N	278547	 (2E)-3-(1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-pyrrolo[2,3-b]pyridin-4-yl]prop-2-enoic acid   ::US10040791, Example 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 107					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278547	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306978	378160141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529909	Cc1cn(C(=O)c2c(noc2C2(C)CCC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C27H21Cl3N2O4/c1-14-13-32(19-6-3-5-15(21(14)19)7-8-20(33)34)26(35)23-24(22-17(29)11-16(28)12-18(22)30)31-36-25(23)27(2)9-4-10-27/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,33,34)/b8-7+	QHSJEYJOBOUGEC-BQYQJAHWSA-N	278548	(2E)-3-(3-Methyl-1-{[5-(1-methylcyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 179					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278548	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307235	378160142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529911	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cncc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C24H18Cl2FN3O4/c1-12-11-30(16-6-4-5-13(18(12)16)7-8-17(31)32)23(33)20-21(29-34-22(20)24(2,3)27)19-14(25)9-28-10-15(19)26/h4-11H,1-3H3,(H,31,32)/b8-7+	UHDGEPDZTMAVJV-BQYQJAHWSA-N	278549	 (2E)-3-(1-{[3-(3,5-Dichloropyridin-2-yl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 112					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307132	378160143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529913	COC1(CCC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H21Cl3N2O5/c1-37-28(8-3-9-28)26-24(25(32-38-26)23-18(30)11-16(29)12-19(23)31)27(36)33-13-15-7-6-14(10-21(34)35)17-4-2-5-20(33)22(15)17/h2,4-5,10-13H,3,6-9H2,1H3,(H,34,35)/b14-10+	CAZZHNDDRFPVJL-GXDHUFHOSA-N	278550	 (2E)-[1-{[5-(1-Methoxycyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 144					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307052	378160144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529915	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H18Cl3FN2O4/c1-26(2,30)24-22(23(31-36-24)21-16(28)9-14(27)10-17(21)29)25(35)32-11-13-7-6-12(8-19(33)34)15-4-3-5-18(32)20(13)15/h3-5,8-11H,6-7H2,1-2H3,(H,33,34)/b12-8+	MVIGZMHMDFYACG-XYOKQWHBSA-N	278551	 (2E)-[1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzop[cd]indol-5(1H)-ylidene]ethanoic acid  ::US10040791, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 148					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278551	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307134	378160145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529917	COC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C27H21Cl2FN2O5/c1-14-13-32(19-6-3-5-15(21(14)19)7-8-20(33)34)26(35)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(36-2)9-4-10-27/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,33,34)/b8-7+	HCJBIQJBHNAGCT-BQYQJAHWSA-N	278552	 (2E)-3-(1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(1-methoxycyclobutyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl]prop-2-enoic acid  ::US10040791, Example 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 110					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306979	378160146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529919	COC1(CCC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C28H21Cl2FN2O5/c1-37-28(8-3-9-28)26-24(25(32-38-26)23-18(30)11-16(29)12-19(23)31)27(36)33-13-15-7-6-14(10-21(34)35)17-4-2-5-20(33)22(15)17/h2,4-5,10-13H,3,6-9H2,1H3,(H,34,35)/b14-10+	KXHHUBQLBSPFKX-GXDHUFHOSA-N	278553	 (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(1-methoxycyclobutyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 106					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306981	378160147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529921	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C26H18Cl2F2N2O4/c1-26(2,30)24-22(23(31-36-24)21-16(28)9-14(27)10-17(21)29)25(35)32-11-13-7-6-12(8-19(33)34)15-4-3-5-18(32)20(13)15/h3-5,8-11H,6-7H2,1-2H3,(H,33,34)/b12-8+	KKYRFHWXZPWGSG-XYOKQWHBSA-N	278554	 (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 107					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307324	378160148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529923	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2ccc(Cl)c(F)c2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(16-6-4-5-13(18(12)16)7-10-17(32)33)24(34)19-22(30-35-23(19)25(2,3)29)14-8-9-15(26)21(28)20(14)27/h4-11H,1-3H3,(H,32,33)/b10-7+	CASAMGIMEQMXAY-JXMROGBWSA-N	278555	 (2E)-3-(1-{[3-(2,4-Dichloro-3-fluorophenyl-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 201					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307322	378160149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529925	CC(C)(F)c1onc(c1C(=O)n1ccc2c3CC(CCc3ccc12)C(O)=O)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H20Cl3FN2O4/c1-26(2,30)23-21(22(31-36-23)20-17(28)10-14(27)11-18(20)29)24(33)32-8-7-15-16-9-13(25(34)35)4-3-12(16)5-6-19(15)32/h5-8,10-11,13H,3-4,9H2,1-2H3,(H,34,35)	HAFXELMPPKAVQF-UHFFFAOYSA-N	278556	 3-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-6,7,8,9-tetrahydro-3H-Benzo[e]indole-8-carboxylic acid  ::US10040791, Example 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 162					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307237	378160150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529927	CC1(CC(F)(F)C1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H19Cl3F2N2O4/c1-27(11-28(32,33)12-27)25-23(24(34-39-25)22-17(30)8-15(29)9-18(22)31)26(38)35-10-14-6-5-13(7-20(36)37)16-3-2-4-19(35)21(14)16/h2-4,7-10H,5-6,11-12H2,1H3,(H,36,37)/b13-7+	RXFMFDIZFGQVGG-NTUHNPAUSA-N	278557	 (2E)-[1-{[5-(3,3-Difluoro-1-methylcyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-::US10040791, Example 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 169					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307135	378160151							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529929	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1ccc(Cl)c(F)c1Cl	InChI=1S/C26H18Cl2F2N2O4/c1-26(2,30)24-20(23(31-36-24)15-8-9-16(27)22(29)21(15)28)25(35)32-11-13-7-6-12(10-18(33)34)14-4-3-5-17(32)19(13)14/h3-5,8-11H,6-7H2,1-2H3,(H,33,34)/b12-10+	LGQXUYAGLCRTRI-ZRDIBKRKSA-N	278558	 (2E)-[1-{[3-(2,4-Dichloro-3-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 267					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307321	378160152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529931	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl3FN2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	BOOMBLZEOHXPPX-BQYQJAHWSA-N	278559	(2E)-3-(1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 95					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278559	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	7SU	7PJN	130306983	378160153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529933	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O4/c1-25(2,3)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	LCOBXWZHLGWJIZ-BQYQJAHWSA-N	278560	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 189					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278560	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307054	378160154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529935	CC(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C24H18Cl2N2O4/c1-13(2)23-21(22(27-32-23)20-16(25)6-4-7-17(20)26)24(31)28-12-11-15-14(9-10-19(29)30)5-3-8-18(15)28/h3-13H,1-2H3,(H,29,30)/b10-9+	KADGEUCPGOYAHO-MDZDMXLPSA-N	278561	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278561	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307133	378160155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529937	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H20Cl2N2O4/c1-25(2,3)23-21(22(28-33-23)20-16(26)7-5-8-17(20)27)24(32)29-13-12-15-14(10-11-19(30)31)6-4-9-18(15)29/h4-13H,1-3H3,(H,30,31)/b11-10+	PTWCGRGZFAKIRK-ZHACJKMWSA-N	278562	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 182					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278562	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307323	378160156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529939	CC(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H20Cl2N2O4/c1-13(2)24-22(23(28-33-24)21-16(26)7-5-8-17(21)27)25(32)29-12-14(3)20-15(10-11-19(30)31)6-4-9-18(20)29/h4-13H,1-3H3,(H,30,31)/b11-10+	RRZHMFYRBCZLQU-ZHACJKMWSA-N	278563	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 326					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278563	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307055	378160157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529941	CC(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H17Cl3N2O4/c1-12(2)23-21(22(28-33-23)20-16(26)10-14(25)11-17(20)27)24(32)29-9-8-15-13(6-7-19(30)31)4-3-5-18(15)29/h3-12H,1-2H3,(H,30,31)/b7-6+	HJZWUPUKQAOZOL-VOTSOKGWSA-N	278564	 (2E)-3-(1-{[5-(Propan-2-yl)-3-(2,4,6-Trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 253					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307240	378160158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529943	COC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H20Cl2N2O5/c1-25(2,33-3)23-21(22(28-34-23)20-16(26)7-5-8-17(20)27)24(32)29-13-12-15-14(10-11-19(30)31)6-4-9-18(15)29/h4-13H,1-3H3,(H,30,31)/b11-10+	RBYMZTGYWZYCGQ-ZHACJKMWSA-N	278565	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(2-methoxypropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 160					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278565	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307140	378160159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529945	CC(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)ccc(F)c1Cl	InChI=1S/C24H17Cl2FN2O4/c1-12(2)23-20(22(28-33-23)19-15(25)7-8-16(27)21(19)26)24(32)29-11-10-14-13(6-9-18(30)31)4-3-5-17(14)29/h3-12H,1-2H3,(H,30,31)/b9-6+	CEZDLRBULRMOMM-RMKNXTFCSA-N	278566	 (2E)-3-(1-{[3-(2,6-Dichloro-3-fluorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 90					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278566	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306985	378160160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529947	CC(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O4/c1-12(2)24-22(23(29-34-24)21-16(27)9-15(26)10-17(21)28)25(33)30-11-13(3)20-14(7-8-19(31)32)5-4-6-18(20)30/h4-12H,1-3H3,(H,31,32)/b8-7+	MNHSYSZAEPPKAS-BQYQJAHWSA-N	278567	 (2E)-3-(1-{[5-(Propan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 102					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278567	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306988	378160161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529949	CC(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)ccc(F)c1Cl	InChI=1S/C25H19Cl2FN2O4/c1-12(2)24-21(23(29-34-24)20-15(26)8-9-16(28)22(20)27)25(33)30-11-13(3)19-14(7-10-18(31)32)5-4-6-17(19)30/h4-12H,1-3H3,(H,31,32)/b10-7+	TXSKIZGFRWQAPI-JXMROGBWSA-N	278568	 (2E)-3-(1-{[3-(2,6-Dichloro-3-fluorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 114					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306986	378160162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529951	COC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O5/c1-25(2,34-3)23-21(22(29-35-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	NEJDEYZFTDRNEU-BQYQJAHWSA-N	278569	 (2E)-3-(1-{[5-(2-Methoxypropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 57					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307243	378160163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529953	CC(C)(C)c1onc(c1C(=O)N1CCc2c1cccc2\C=C\C(O)=O)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H21Cl3N2O4/c1-25(2,3)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-8,11-12H,9-10H2,1-3H3,(H,31,32)/b8-7+	DHOYKWMMIZQDPN-BQYQJAHWSA-N	278570	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-2,3-dihydro-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 176					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307057	378160164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529955	Cc1cn(C(=O)c2c(noc2C(C)(C)C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl3N2O4/c1-13-12-31(18-7-5-6-14(20(13)18)8-9-19(32)33)25(34)22-23(30-35-24(22)26(2,3)4)21-16(28)10-15(27)11-17(21)29/h5-12H,1-4H3,(H,32,33)/b9-8+	KXPPLODPOGLEGB-CMDGGOBGSA-N	278571	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 193					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278571	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306987	378160165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529957	CC(C)(C)c1noc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O4/c1-25(2,3)23-21(22(34-29-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	TWGYWTMUIXWFOU-BQYQJAHWSA-N	278572	 (2E)-3-(1-{[3-(tert-Butyl)-5-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 364					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307244	378160166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529959	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C25H19Cl2FN2O4/c1-25(2,3)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	XDRGKEBBTDBCJD-BQYQJAHWSA-N	278573	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4-dichloro-6-fluorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 161					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307326	378160167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529961	CC(C)(F)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H16Cl3FN2O4/c1-24(2,28)22-20(21(29-34-22)19-15(26)10-13(25)11-16(19)27)23(33)30-9-8-14-12(6-7-18(31)32)4-3-5-17(14)30/h3-11H,1-2H3,(H,31,32)/b7-6+	USRBFOUUSBSCQL-VOTSOKGWSA-N	278574	 (2E)-3-(1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 109					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307136	378160168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529963	CC1(CC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O4/c1-25(8-9-25)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-7,10-12H,8-9H2,1H3,(H,31,32)/b6-5+	HCDHCLNCWWHWFR-AATRIKPKSA-N	278575	 (2E)-3-(1-{[5-(1-Methylcyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 117					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307247	378160169							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529965	Cc1cc(Cl)c(-c2noc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)C(C)(C)C)c(Cl)c1	InChI=1S/C26H22Cl2N2O4/c1-14-12-17(27)21(18(28)13-14)23-22(24(34-29-23)26(2,3)4)25(33)30-11-10-16-15(8-9-20(31)32)6-5-7-19(16)30/h5-13H,1-4H3,(H,31,32)/b9-8+	POCJZMUEOXWJNG-CMDGGOBGSA-N	278576	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,6-dichloro-4-methylphenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 234					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278576	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307328	378160170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529967	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Br	InChI=1S/C25H20BrClN2O4/c1-25(2,3)23-21(22(28-33-23)20-16(26)7-5-8-17(20)27)24(32)29-13-12-15-14(10-11-19(30)31)6-4-9-18(15)29/h4-13H,1-3H3,(H,30,31)/b11-10+	IMRHNXOLHZPEKS-ZHACJKMWSA-N	278577	 (2E)-3-(1-{[3-(2-Bromo-6-chlorophenyl)-5-(tert-butyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 168					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307249	378160171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529969	CC(C)(C)c1onc(c1C(=O)n1cc(F)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H18Cl3FN2O4/c1-25(2,3)23-21(22(30-35-23)20-14(27)9-13(26)10-15(20)28)24(34)31-11-16(29)19-12(7-8-18(32)33)5-4-6-17(19)31/h4-11H,1-3H3,(H,32,33)/b8-7+	BOIGZCYRGKILGC-BQYQJAHWSA-N	278578	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-fluoro-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 159					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306990	378160172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529971	Cc1cc(Cl)cc(Cl)c1-c1noc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)C(C)(C)C	InChI=1S/C26H22Cl2N2O4/c1-14-12-16(27)13-18(28)21(14)23-22(24(34-29-23)26(2,3)4)25(33)30-11-10-17-15(8-9-20(31)32)6-5-7-19(17)30/h5-13H,1-4H3,(H,31,32)/b9-8+	AATFCJCQCIVGMT-CMDGGOBGSA-N	278579	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4-dichloro-6-methylphenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 280					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307250	378160173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529973	COCC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H21Cl3N2O5/c1-26(2,13-35-3)24-22(23(30-36-24)21-17(28)11-15(27)12-18(21)29)25(34)31-10-9-16-14(7-8-20(32)33)5-4-6-19(16)31/h4-12H,13H2,1-3H3,(H,32,33)/b8-7+	JRUHHIFYIWJNCM-BQYQJAHWSA-N	278580	 (2E)-3-(1-{[5-(1-Methoxy-2-methylpropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 217					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278580	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307137	378160174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529975	Cc1cn(C(=O)c2c(noc2C2(C)CC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H19Cl3N2O4/c1-13-12-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(30-35-24(22)26(2)8-9-26)21-16(28)10-15(27)11-17(21)29/h3-7,10-12H,8-9H2,1-2H3,(H,32,33)/b7-6+	VYFPNWUXLMTAEQ-VOTSOKGWSA-N	278581	 (2E)-3-(3-Methyl-1-{[5-(1-methylcyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 139					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307330	378160175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529977	COC1(CC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O5/c1-34-25(8-9-25)23-21(22(29-35-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-7,10-12H,8-9H2,1H3,(H,31,32)/b6-5+	PXBRVLPBVPDPSB-AATRIKPKSA-N	278582	 (2E)-3-(1-{[5-(1-Methoxycyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 189					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307331	378160176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529979	CC(C)(F)c1onc(c1C(=O)n1cc(F)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H15Cl3F2N2O4/c1-24(2,29)22-20(21(30-35-22)19-13(26)8-12(25)9-14(19)27)23(34)31-10-15(28)18-11(6-7-17(32)33)4-3-5-16(18)31/h3-10H,1-2H3,(H,32,33)/b7-6+	ZWPYXTYCFJBBGS-VOTSOKGWSA-N	278583	 (2E)-3-(3-Fluoro-1-{[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 114					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307138	378160177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529981	CC(C)(F)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C24H16Cl2F2N2O4/c1-24(2,28)22-20(21(29-34-22)19-15(26)10-13(25)11-16(19)27)23(33)30-9-8-14-12(6-7-18(31)32)4-3-5-17(14)30/h3-11H,1-2H3,(H,31,32)/b7-6+	AOYWWPQSXIUJOE-VOTSOKGWSA-N	278584	 (2E)-3-(1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 197					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307141	378160178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529983	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(F)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	BVUMRBVNGXVXSA-BQYQJAHWSA-N	278585	(2E)-3-(1-{[3-(2,4-Dichloro-6- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 98					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307214	378160179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529985	CC(C)(F)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)ccc(F)c12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H15Cl3F2N2O4/c1-24(2,29)22-19(20(30-35-22)18-14(26)9-12(25)10-15(18)27)23(34)31-8-7-13-11(4-6-17(32)33)3-5-16(28)21(13)31/h3-10H,1-2H3,(H,32,33)/b6-4+	MWWIJOCRHKKPLJ-GQCTYLIASA-N	278586	(2E)-3-(1-{[5-(tert-Butyl)-3- (2,4,6-trichlorophenyl)-1,2- oxazole-4-carbonyl]-7- fluoroindol-4-yl]prop-2-enoic acid ::US10040791, Example 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 193					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			132070937	378160180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529987	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(F)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(26)9-14(28)10-16(20)27/h4-11H,1-3H3,(H,32,33)/b8-7+	NYOISIQPEVFIMT-BQYQJAHWSA-N	278587	(2E)-3-(1-{[3-(2,6-Dichloro-4- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 79					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307332	378160181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529989	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2c(F)ccc(\C=C\C(O)=O)c12	InChI=1S/C25H17Cl3F2N2O4/c1-11-10-32(22-16(29)6-4-12(18(11)22)5-7-17(33)34)24(35)20-21(31-36-23(20)25(2,3)30)19-14(27)8-13(26)9-15(19)28/h4-10H,1-3H3,(H,33,34)/b7-5+	XUYRICDZVZLNIE-FNORWQNLSA-N	278588	(2E)-3-(7-Fluoro-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 104					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306989	378160182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529991	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl3FN2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	BOOMBLZEOHXPPX-BQYQJAHWSA-N	278589	(2E)-3-(1-{[5-(1,1- Difluoroethyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 115					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	7SU	7PJN	130306983	378160183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529993	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(F)cccc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H19ClF2N2O4/c1-13-12-30(17-9-4-6-14(19(13)17)10-11-18(31)32)24(33)21-22(29-34-23(21)25(2,3)28)20-15(26)7-5-8-16(20)27/h4-12H,1-3H3,(H,31,32)/b11-10+	DSUHFQCULGTDCW-ZHACJKMWSA-N	278590	(2E)-3-(1-{[3-(2-Chloro-6- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 136					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307062	378160184							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529995	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cccc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H19Cl2FN2O4/c1-13-12-30(17-9-4-6-14(19(13)17)10-11-18(31)32)24(33)21-22(29-34-23(21)25(2,3)28)20-15(26)7-5-8-16(20)27/h4-12H,1-3H3,(H,31,32)/b11-10+	OQWMYJNCGHXCIT-ZHACJKMWSA-N	278591	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 163					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307142	378160185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529997	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(F)cc(Cl)cc2F)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18ClF3N2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	CCWLDTLJVNIOJZ-BQYQJAHWSA-N	278592	(2E)-3-(1-{[3-(4-Chloro-2,6- difluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 109					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307065	378160186							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529999	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(C)cc(Cl)cc2C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C27H24ClFN2O4/c1-14-11-18(28)12-15(2)21(14)24-23(25(35-30-24)27(4,5)29)26(34)31-13-16(3)22-17(9-10-20(32)33)7-6-8-19(22)31/h6-13H,1-5H3,(H,32,33)/b10-9+	HJHDYWCLTZCBAL-MDZDMXLPSA-N	278593	(2E)-3-(1-{[3-(4-Chloro-2,6- dimethylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 125					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307149	378160187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530001	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(C)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl2FN2O4/c1-13-10-16(27)21(17(28)11-13)23-22(24(35-30-23)26(3,4)29)25(34)31-12-14(2)20-15(8-9-19(32)33)6-5-7-18(20)31/h5-12H,1-4H3,(H,32,33)/b9-8+	YJTOZPRYQQAIKI-CMDGGOBGSA-N	278594	(2E)-3-(1-{[3-(2,6-Dichloro-4- methylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 107					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307252	378160188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530003	COC1(CC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3N2O5/c1-13-12-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(21-16(28)10-15(27)11-17(21)29)30-36-24(22)26(35-2)8-9-26/h3-7,10-12H,8-9H2,1-2H3,(H,32,33)/b7-6+	WYBFBZUIZFAUMH-VOTSOKGWSA-N	278595	(2E)-3-(1-{[5-(1- Methoxycyclopropyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 98					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307066	378160189							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530005	COc1cc(Cl)cc(Cl)c1-c1noc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)C(C)(C)F	InChI=1S/C26H21Cl2FN2O5/c1-13-12-31(17-7-5-6-14(20(13)17)8-9-19(32)33)25(34)22-23(30-36-24(22)26(2,3)29)21-16(28)10-15(27)11-18(21)35-4/h5-12H,1-4H3,(H,32,33)/b9-8+	CKRCXEPSLCTCII-CMDGGOBGSA-N	278596	(2E)-3-(1-{[3-(2,4-Dichloro-6- methoxyphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 178					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307067	378160190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530007	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(C)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl2FN2O4/c1-13-10-16(27)11-17(28)21(13)23-22(24(35-30-23)26(3,4)29)25(34)31-12-14(2)20-15(8-9-19(32)33)6-5-7-18(20)31/h5-12H,1-4H3,(H,32,33)/b9-8+	UTTTVQJNSHYJMM-CMDGGOBGSA-N	278597	(2E)-3-(1-{[3-(2,4-Dichloro-6- methylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 117					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278597	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307333	378160191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530009	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(C)cc(C)cc2C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C28H27FN2O4/c1-15-12-16(2)22(17(3)13-15)25-24(26(35-30-25)28(5,6)29)27(34)31-14-18(4)23-19(10-11-21(32)33)8-7-9-20(23)31/h7-14H,1-6H3,(H,32,33)/b11-10+	FCFMKLBKEDFTME-ZHACJKMWSA-N	278598	(2E)-3-(1-{[5-(2-Fluoropropan- 2-yl)-3-(2,4,6-trimethylphenyl)- 1,2-oxazol-4-yl]carbonyl}-3- methyl-1H-indol-4-yl)prop-2- enoic acid ::US10040791, Example 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 116					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306993	378160192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530011	Cc1cn(C(=O)c2c(noc2C(F)(F)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C23H12Cl3F3N2O4/c1-10-9-31(15-4-2-3-11(17(10)15)5-6-16(32)33)22(34)19-20(30-35-21(19)23(27,28)29)18-13(25)7-12(24)8-14(18)26/h2-9H,1H3,(H,32,33)/b6-5+	FPKKACLXGYDUPX-AATRIKPKSA-N	278599	(2E)-3-(3-Methyl-1-{[3-(2,4,6- trichlorophenyl)-5- (trifluoromethyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 300					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307334	378160193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530013	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2ccc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H19Cl2FN2O4/c1-13-12-30(18-6-4-5-14(20(13)18)7-10-19(31)32)24(33)21-22(29-34-23(21)25(2,3)28)16-9-8-15(26)11-17(16)27/h4-12H,1-3H3,(H,31,32)/b10-7+	MMJOWRUYBHASCG-JXMROGBWSA-N	278600	(2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 155					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307068	378160194							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530015	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2cc(F)c(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(18-6-4-5-13(20(12)18)7-8-19(32)33)24(34)21-22(30-35-23(21)25(2,3)29)14-9-17(28)16(27)10-15(14)26/h4-11H,1-3H3,(H,32,33)/b8-7+	WBPDQOJZARDPEL-BQYQJAHWSA-N	278601	(2E)-3-(1-{[3-(2,4-Dichloro-5- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 145					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307253	378160195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530017	CC(=O)c1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H18Cl3FN2O5/c1-12(33)15-11-32(18-6-4-5-13(20(15)18)7-8-19(34)35)25(36)22-23(31-37-24(22)26(2,3)30)21-16(28)9-14(27)10-17(21)29/h4-11H,1-3H3,(H,34,35)/b8-7+	QGAVUUHKYZSBQO-BQYQJAHWSA-N	278602	(2E)-3-(3-Acetyl-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 888					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306992	378160196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530019	CCc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H20Cl3FN2O4/c1-4-13-12-32(18-7-5-6-14(20(13)18)8-9-19(33)34)25(35)22-23(31-36-24(22)26(2,3)30)21-16(28)10-15(27)11-17(21)29/h5-12H,4H2,1-3H3,(H,33,34)/b9-8+	IQILTNDZZWHOEV-CMDGGOBGSA-N	278603	(2E)-3-(3-Ethyl-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 198					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306991	378160197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530021	CC(C)(F)c1onc(c1C(=O)n1cc(Cl)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H15Cl4FN2O4/c1-24(2,29)22-20(21(30-35-22)19-13(26)8-12(25)9-14(19)27)23(34)31-10-15(28)18-11(6-7-17(32)33)4-3-5-16(18)31/h3-10H,1-2H3,(H,32,33)/b7-6+	GTUFCGZBEHYIGM-VOTSOKGWSA-N	278604	(2E)-3-(3-Chloro-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 122					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307139	378160198							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530023	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3c(F)ccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H17Cl3F2N2O4/c1-26(2,31)24-22(23(32-37-24)21-14(28)8-13(27)9-15(21)29)25(36)33-10-12-4-3-11(7-18(34)35)19-16(30)5-6-17(33)20(12)19/h5-10H,3-4H2,1-2H3,(H,34,35)/b11-7+	HOJSBNIOXHFHBI-YRNVUSSQSA-N	278605	(2E)-[6-Fluoro-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 154					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307159	378160199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530025	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Br)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18BrCl2FN2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	QKRPPLFDALWFIQ-BQYQJAHWSA-N	278606	(2E)-3-(1-{[3-(4-Bromo-2,6- dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 125					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306994	378160200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530027	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1ccc(Cl)cc1Cl	InChI=1S/C26H19Cl2FN2O4/c1-26(2,29)24-22(23(30-35-24)17-9-8-15(27)11-18(17)28)25(34)31-12-14-7-6-13(10-20(32)33)16-4-3-5-19(31)21(14)16/h3-5,8-12H,6-7H2,1-2H3,(H,32,33)/b13-10+	PMMGFBOYSSKUGN-JLHYYAGUSA-N	278607	(2E)-[1-{[3-(2,4- Dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 168					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307070	378160201							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530029	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(cc2Cl)C2CC2)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C28H23Cl2FN2O4/c1-14-13-33(20-6-4-5-16(22(14)20)9-10-21(34)35)27(36)24-25(32-37-26(24)28(2,3)31)23-18(29)11-17(12-19(23)30)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,34,35)/b10-9+	ZYBSPNFPDQBLMM-MDZDMXLPSA-N	278608	(2E)-3-(1-{[3-(2,6-Dichloro-4- cyclopropylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 153					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306995	378160202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530031	CC(C)(F)c1onc(c1C(=O)n1cc(C2CC2)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H20Cl3FN2O4/c1-27(2,31)25-23(24(32-37-25)22-17(29)10-15(28)11-18(22)30)26(36)33-12-16(13-6-7-13)21-14(8-9-20(34)35)4-3-5-19(21)33/h3-5,8-13H,6-7H2,1-2H3,(H,34,35)/b9-8+	QFGHNJIRWWIBFH-CMDGGOBGSA-N	278609	(2E)-3-(3-Cyclopropyl-1-{[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 646					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307167	378160203							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530033	CC(C)(C)c1onc(c1C(=O)n1cc(C(F)F)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3F2N2O4/c1-26(2,3)23-21(22(32-37-23)20-15(28)9-13(27)10-16(20)29)25(36)33-11-14(24(30)31)19-12(7-8-18(34)35)5-4-6-17(19)33/h4-11,24H,1-3H3,(H,34,35)/b8-7+	JUAQLUCSKVIFPL-BQYQJAHWSA-N	278610	(2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-(difluoromethyl)-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 201					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307000	378160204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530035	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1-c1ccc(C=C)nc1)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H16Cl3N3O4/c1-2-18-8-6-16(14-32-18)27-25(26(33-38-27)24-20(30)12-17(29)13-21(24)31)28(37)34-11-10-19-15(7-9-23(35)36)4-3-5-22(19)34/h2-14H,1H2,(H,35,36)/b9-7+	FXAOGOGERGMUHQ-VQHVLOKHSA-N	278611	(2E)-3-(1-{[5-(6-Ethenylpyridin-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 208					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278611&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307147	378160205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530037	COC1(CCC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3N2O5/c1-35-26(9-3-10-26)24-22(23(30-36-24)21-17(28)12-15(27)13-18(21)29)25(34)31-11-8-16-14(6-7-20(32)33)4-2-5-19(16)31/h2,4-8,11-13H,3,9-10H2,1H3,(H,32,33)/b7-6+	ASVPWKNLTARYMM-VOTSOKGWSA-N	278612	(2E)-3-(1-{[5-(1-Methoxycyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 175					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307337	378160206							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530039	CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H18Cl2N2O5/c1-25(12-33-13-25)23-21(22(28-34-23)20-16(26)5-3-6-17(20)27)24(32)29-11-10-15-14(8-9-19(30)31)4-2-7-18(15)29/h2-11H,12-13H2,1H3,(H,30,31)/b9-8+	JNJIAVNFRMJGQU-CMDGGOBGSA-N	278613	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methyloxetan-3-yl)-1,2-oxazol- 4-yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 118					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307005	378160207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530041	COC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H18Cl2N2O6/c1-33-25(12-34-13-25)23-21(22(28-35-23)20-16(26)5-3-6-17(20)27)24(32)29-11-10-15-14(8-9-19(30)31)4-2-7-18(15)29/h2-11H,12-13H2,1H3,(H,30,31)/b9-8+	ICGQVDDAIBQZER-CMDGGOBGSA-N	278614	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methoxyoxetan-3-yl)-1,2- oxazol-4-yl]carbonyl}-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 94					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307144	378160208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530043	CC1(CCO1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H18Cl2N2O5/c1-25(11-13-33-25)23-21(22(28-34-23)20-16(26)5-3-6-17(20)27)24(32)29-12-10-15-14(8-9-19(30)31)4-2-7-18(15)29/h2-10,12H,11,13H2,1H3,(H,30,31)/b9-8+	ICORGZBJRVKPJH-CMDGGOBGSA-N	278615	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- methyloxetan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 94					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307170	378160209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530045	Cc1cn(C(=O)c2c(noc2C2(C)COC2)-c2ccc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H20Cl2N2O5/c1-14-11-30(19-5-3-4-15(21(14)19)6-9-20(31)32)25(33)22-23(17-8-7-16(27)10-18(17)28)29-35-24(22)26(2)12-34-13-26/h3-11H,12-13H2,1-2H3,(H,31,32)/b9-6+	QKDGUBMFMNBEAM-RMKNXTFCSA-N	278616	(2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(3- methyloxetan-3-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 192					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278616	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130306999	378160210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530047	COC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H21Cl3N2O5/c1-14-13-32(19-6-3-5-15(21(14)19)7-8-20(33)34)26(35)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(36-2)9-4-10-27/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,33,34)/b8-7+	HOVOVARKDAICLH-BQYQJAHWSA-N	278617	(2E)-3-(1-{[5-(1- Methoxycyclobutyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 161					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307003	378160211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530049	COCC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H23Cl3N2O5/c1-15-13-33(20-6-3-5-16(22(15)20)7-8-21(34)35)27(36)24-25(23-18(30)11-17(29)12-19(23)31)32-38-26(24)28(14-37-2)9-4-10-28/h3,5-8,11-13H,4,9-10,14H2,1-2H3,(H,34,35)/b8-7+	RQBVWIAGIKITQA-BQYQJAHWSA-N	278618	(2E)-3-(1-{[5-[1- (Methoxymethyl)cyclobutyl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-3- methyl-1H-indol-4-yl)prop-2- enoic acid ::US10040791, Example 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 335					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278618	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307336	378160212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530051	CN(C)C1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H24Cl3N3O4/c1-15-14-34(20-7-4-6-16(22(15)20)8-9-21(35)36)27(37)24-25(23-18(30)12-17(29)13-19(23)31)32-38-26(24)28(33(2)3)10-5-11-28/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,35,36)/b9-8+	HWUIGZVLXYUEMK-CMDGGOBGSA-N	278619	(2E)-3-(1-{[5-[1-(Dimethylamino)cyclobutyl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 163					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278619	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307173	378160213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530053	CN(C)C1(CC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H22Cl3N3O4/c1-14-13-33(19-6-4-5-15(21(14)19)7-8-20(34)35)26(36)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(9-10-27)32(2)3/h4-8,11-13H,9-10H2,1-3H3,(H,34,35)/b8-7+	ADKCWUPCLIWNNO-BQYQJAHWSA-N	278620	(2E)-3-(1-{[5-[1- (Dimethylamino)cyclopropyl]- 3-(2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-3- methyl-1H-indol-4-yl)prop-2- enoic acid ::US10040791, Example 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 96					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278620	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307148	378160214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530055	CNC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H22Cl3N3O4/c1-14-13-33(19-6-3-5-15(21(14)19)7-8-20(34)35)26(36)23-24(22-17(29)11-16(28)12-18(22)30)32-37-25(23)27(31-2)9-4-10-27/h3,5-8,11-13,31H,4,9-10H2,1-2H3,(H,34,35)/b8-7+	UVTWTYURHDRISP-BQYQJAHWSA-N	278621	(2E)-3-(3-Methyl-1-{[5-[1-(methylamino)cyclobutyl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 87					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307008	378160215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530057	CNC(C)(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H22Cl3N3O4/c1-13-12-32(18-7-5-6-14(20(13)18)8-9-19(33)34)25(35)22-23(31-36-24(22)26(2,3)30-4)21-16(28)10-15(27)11-17(21)29/h5-12,30H,1-4H3,(H,33,34)/b9-8+	JGTKFHUTIOMNMG-CMDGGOBGSA-N	278622	(2E)-3-[3-Methyl-1-({5-[2- (methylamino)propan-2-yl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 80					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307150	378160216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530059	CNC(C)(C)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H22Cl3N3O4/c1-27(2,31-3)25-23(24(32-37-25)22-17(29)10-15(28)11-18(22)30)26(36)33-12-14-8-7-13(9-20(34)35)16-5-4-6-19(33)21(14)16/h4-6,9-12,31H,7-8H2,1-3H3,(H,34,35)/b13-9+	DNMLSJMVECKSQZ-UKTHLTGXSA-N	278623	(2E)-[1-({5-[2- (Methylamino)propan-2-yl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl}carbonyl)-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 99					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307153	378160217							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530061	CNC1(CC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H20Cl3N3O4/c1-31-27(7-8-27)25-23(24(32-37-25)22-17(29)10-15(28)11-18(22)30)26(36)33-12-14-6-5-13(9-20(34)35)16-3-2-4-19(33)21(14)16/h2-4,9-12,31H,5-8H2,1H3,(H,34,35)/b13-9+	VOQZIABIIAPGMT-UKTHLTGXSA-N	278624	(2E)-[1-({5-[1- (Methylamino)cyclopropyl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl}carbonyl)-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 79					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278624	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307011	378160218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530063	CN(C(=O)C=C)C1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C30H24Cl3N3O5/c1-4-22(37)35(3)30(11-6-12-30)28-26(27(34-41-28)25-19(32)13-18(31)14-20(25)33)29(40)36-15-16(2)24-17(9-10-23(38)39)7-5-8-21(24)36/h4-5,7-10,13-15H,1,6,11-12H2,2-3H3,(H,38,39)/b10-9+	YXBCQUICNXIUIG-MDZDMXLPSA-N	278625	(2E)-3-(1-{[5-{1-[Acryloyl(methyl)amino]cyclobutyl}-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 145					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307072	378160219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530065	CN(C)CC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C29H26Cl3N3O4/c1-16-14-35(21-7-4-6-17(23(16)21)8-9-22(36)37)28(38)25-26(24-19(31)12-18(30)13-20(24)32)33-39-27(25)29(10-5-11-29)15-34(2)3/h4,6-9,12-14H,5,10-11,15H2,1-3H3,(H,36,37)/b9-8+	ZCYNRQVUCJXHSY-CMDGGOBGSA-N	278626	(2E)-3-(1-{[5-{1-[(Dimethylamino)methyl]cyclobutyl}-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 158					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307158	378160220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530067	CN(C)C(=O)C1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C29H24Cl3N3O5/c1-15-14-35(20-7-4-6-16(22(15)20)8-9-21(36)37)27(38)24-25(23-18(31)12-17(30)13-19(23)32)33-40-26(24)29(10-5-11-29)28(39)34(2)3/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,36,37)/b9-8+	LWWAJJNQDWRXSD-CMDGGOBGSA-N	278627	(2E)-3-(1-{[5-[1-(Dimethylcarbamoyl)cyclobutyl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 185					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307340	378160221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530069	Cc1cn(C(=O)c2c(noc2C2(N)CCC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H20Cl3N3O4/c1-13-12-32(18-5-2-4-14(20(13)18)6-7-19(33)34)25(35)22-23(21-16(28)10-15(27)11-17(21)29)31-36-24(22)26(30)8-3-9-26/h2,4-7,10-12H,3,8-9,30H2,1H3,(H,33,34)/b7-6+	MDACIPHPUNNIDF-VOTSOKGWSA-N	278628	(2E)-3-(1-{[5-(1-Aminocyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 59					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307162	378160222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530071	CN(C)C(C)(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H24Cl3N3O4/c1-14-13-33(19-8-6-7-15(21(14)19)9-10-20(34)35)26(36)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(2,3)32(4)5/h6-13H,1-5H3,(H,34,35)/b10-9+	XKYNZOJQGKVERP-MDZDMXLPSA-N	278629	(2E)-3-[1-({5-[2-(Dimethylamino)propan-2-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-3-methyl-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 120					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278629	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307179	378160223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530073	CN(C)C1(CC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H22Cl3N3O4/c1-33(2)28(8-9-28)26-24(25(32-38-26)23-18(30)11-16(29)12-19(23)31)27(37)34-13-15-7-6-14(10-21(35)36)17-4-3-5-20(34)22(15)17/h3-5,10-13H,6-9H2,1-2H3,(H,35,36)/b14-10+	PLRVVEGDTXSPNU-GXDHUFHOSA-N	278630	US10040791, Example 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 80					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278630	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307017	378160224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530075	Cc1cn(C(=O)c2c(noc2C2(CCC2)C#N)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C27H18Cl3N3O4/c1-14-12-33(19-5-2-4-15(21(14)19)6-7-20(34)35)26(36)23-24(22-17(29)10-16(28)11-18(22)30)32-37-25(23)27(13-31)8-3-9-27/h2,4-7,10-12H,3,8-9H2,1H3,(H,34,35)/b7-6+	LPZYXALZTFWCGH-VOTSOKGWSA-N	278631	(2E)-3-(1-{[5-(1-Cyanocyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 85					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278631	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307258	378160225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530077	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3c(Cl)cc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl3N3O5/c1-2-24(38)36-10-8-16(9-11-36)30-28(29(35-42-30)27-21(33)13-19(32)14-22(27)34)31(41)37-15-18-7-6-17(12-25(39)40)20-4-3-5-23(37)26(18)20/h2-5,12-16H,1,6-11H2,(H,39,40)/b17-12+	CMZJOEOPYWOXKF-SFQUDFHCSA-N	278632	(2E)-[1-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid::US10040791, Example 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 159					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307186	378160226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530079	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CN(C1)C(=O)C=C	InChI=1S/C27H18Cl3N3O5/c1-2-21(34)32-12-15(13-32)26-24(25(31-38-26)23-18(29)10-16(28)11-19(23)30)27(37)33-9-8-17-14(6-7-22(35)36)4-3-5-20(17)33/h2-11,15H,1,12-13H2,(H,35,36)/b7-6+	LSNVNZWGLMRMOA-VOTSOKGWSA-N	278633	US10040791, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 67					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278633	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307165	378160227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530081	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCCN(C1)C(=O)C=C	InChI=1S/C29H22Cl3N3O5/c1-2-23(36)34-11-4-6-17(15-34)28-26(27(33-40-28)25-20(31)13-18(30)14-21(25)32)29(39)35-12-10-19-16(8-9-24(37)38)5-3-7-22(19)35/h2-3,5,7-10,12-14,17H,1,4,6,11,15H2,(H,37,38)/b9-8+	IATXSYSSKVHZIR-CMDGGOBGSA-N	278634	US10040791, Example 96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 422					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278634	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307344	378160228							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530083	COC1(CN(C1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H20Cl3N3O6/c1-3-21(35)33-13-28(14-33,39-2)26-24(25(32-40-26)23-18(30)11-16(29)12-19(23)31)27(38)34-10-9-17-15(7-8-22(36)37)5-4-6-20(17)34/h3-12H,1,13-14H2,2H3,(H,36,37)/b8-7+	ZEABNMJGQXPLEO-BQYQJAHWSA-N	278635	US10040791, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 164					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278635	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307166	378160229							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530085	CC1(CN(C1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H20Cl3N3O5/c1-3-21(35)33-13-28(2,14-33)26-24(25(32-39-26)23-18(30)11-16(29)12-19(23)31)27(38)34-10-9-17-15(7-8-22(36)37)5-4-6-20(17)34/h3-12H,1,13-14H2,2H3,(H,36,37)/b8-7+	KVSHZPGHVSROLM-BQYQJAHWSA-N	278636	US10040791, Example 98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 116					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278636	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307190	378160230							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530087	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H22Cl3N3O5/c1-2-23(36)34-11-8-17(9-12-34)28-26(27(33-40-28)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,37,38)/b7-6+	QNXKXQBXQDNUQO-VOTSOKGWSA-N	278637	US10040791, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 272					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278637	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307174	378160231							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530089	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C#C	InChI=1S/C29H20Cl3N3O5/c1-2-23(36)34-11-8-17(9-12-34)28-26(27(33-40-28)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h1,3-7,10,13-15,17H,8-9,11-12H2,(H,37,38)/b7-6+	CHNAINSHCUVKLS-VOTSOKGWSA-N	278638	US10040791, Example 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 189					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278638	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307175	378160232							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530091	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CN(C1)C(=O)C#C	InChI=1S/C27H16Cl3N3O5/c1-2-21(34)32-12-15(13-32)26-24(25(31-38-26)23-18(29)10-16(28)11-19(23)30)27(37)33-9-8-17-14(6-7-22(35)36)4-3-5-20(17)33/h1,3-11,15H,12-13H2,(H,35,36)/b7-6+	VIMRJHVJAVWFKT-VOTSOKGWSA-N	278639	US10040791, Example 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 189					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278639	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307346	378160233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530093	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H23Cl2N3O5/c1-2-23(35)33-14-11-18(12-15-33)28-26(27(32-39-28)25-20(30)6-4-7-21(25)31)29(38)34-16-13-19-17(9-10-24(36)37)5-3-8-22(19)34/h2-10,13,16,18H,1,11-12,14-15H2,(H,36,37)/b10-9+	WRWLWJJKRVPXGR-MDZDMXLPSA-N	278640	US10040791, Example 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 117					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278640	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307262	378160234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530095	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)S(=O)(=O)C=C	InChI=1S/C28H22Cl3N3O6S/c1-2-41(38,39)33-11-8-17(9-12-33)27-25(26(32-40-27)24-20(30)14-18(29)15-21(24)31)28(37)34-13-10-19-16(6-7-23(35)36)4-3-5-22(19)34/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,35,36)/b7-6+	HSWZYJKXKLAJHP-VOTSOKGWSA-N	278641	US10040791, Example 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 114					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278641	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307176	378160235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530097	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl3N3O5/c1-3-23(37)35-11-9-18(10-12-35)29-27(28(34-41-29)26-20(32)13-19(31)14-21(26)33)30(40)36-15-16(2)25-17(7-8-24(38)39)5-4-6-22(25)36/h3-8,13-15,18H,1,9-12H2,2H3,(H,38,39)/b8-7+	OQCSPKPCFMSGAE-BQYQJAHWSA-N	278642	US10040791, Example 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 93					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278642	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307073	378160236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530099	OC(=O)C1CC1c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C30H24Cl3N3O5/c1-2-24(37)35-9-6-15(7-10-35)28-26(27(34-41-28)25-21(32)12-16(31)13-22(25)33)29(38)36-11-8-18-17(4-3-5-23(18)36)19-14-20(19)30(39)40/h2-5,8,11-13,15,19-20H,1,6-7,9-10,14H2,(H,39,40)	GCHDNDCHWIOMRR-UHFFFAOYSA-N	278643	US10040791, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 567					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307019	378160237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530101	Cc1cn(C(=O)c2c(onc2-c2ccc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H25Cl2N3O5/c1-3-24(36)34-13-11-19(12-14-34)29-27(28(33-40-29)21-9-8-20(31)15-22(21)32)30(39)35-16-17(2)26-18(7-10-25(37)38)5-4-6-23(26)35/h3-10,15-16,19H,1,11-14H2,2H3,(H,37,38)/b10-7+	RDZBITAYWJWVBX-JXMROGBWSA-N	278644	US10040791, Example 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 149					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278644	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307345	378160238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530103	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(F)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H22Cl2FN3O5/c1-2-23(36)34-11-8-17(9-12-34)28-26(27(33-40-28)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,37,38)/b7-6+	CYIIMTPWLIOMSY-VOTSOKGWSA-N	278645	US10040791, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 169					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278645	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307075	378160239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530105	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cccc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H25Cl2N3O5/c1-3-23(36)34-14-12-19(13-15-34)29-27(28(33-40-29)26-20(31)7-5-8-21(26)32)30(39)35-16-17(2)25-18(10-11-24(37)38)6-4-9-22(25)35/h3-11,16,19H,1,12-15H2,2H3,(H,37,38)/b11-10+	KRAUYSVFLVTJMW-ZHACJKMWSA-N	278646	US10040791, Example 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 149					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278646	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307189	378160240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530107	Cc1cc(C)c(-c2noc(C3CCN(CC3)C(=O)C=C)c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)c(C)c1	InChI=1S/C32H31N3O5/c1-5-26(36)34-14-11-23(12-15-34)31-29(30(33-40-31)28-20(3)17-19(2)18-21(28)4)32(39)35-16-13-24-22(9-10-27(37)38)7-6-8-25(24)35/h5-10,13,16-18,23H,1,11-12,14-15H2,2-4H3,(H,37,38)/b10-9+	IFKSWVJENTVUAV-MDZDMXLPSA-N	278647	US10040791, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 243					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278647	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307026	378160241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530109	Cc1cc(Cl)cc(C)c1-c1noc(C2CCN(CC2)C(=O)C=C)c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12	InChI=1S/C31H28ClN3O5/c1-4-25(36)34-13-10-21(11-14-34)30-28(29(33-40-30)27-18(2)16-22(32)17-19(27)3)31(39)35-15-12-23-20(8-9-26(37)38)6-5-7-24(23)35/h4-9,12,15-17,21H,1,10-11,13-14H2,2-3H3,(H,37,38)/b9-8+	NKXDOIDVZXEBPS-CMDGGOBGSA-N	278648	US10040791, Example 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 316					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278648	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307177	378160242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530111	CC1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C30H24Cl3N3O5/c1-3-23(37)35-13-10-30(2,11-14-35)28-26(27(34-41-28)25-20(32)15-18(31)16-21(25)33)29(40)36-12-9-19-17(7-8-24(38)39)5-4-6-22(19)36/h3-9,12,15-16H,1,10-11,13-14H2,2H3,(H,38,39)/b8-7+	QHIWXOFVPUWFCD-BQYQJAHWSA-N	278649	US10040791, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 188					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278649	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307027	378160243							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530113	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(F)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl2FN3O5/c1-3-23(37)35-11-9-18(10-12-35)29-27(28(34-41-29)26-20(31)13-19(33)14-21(26)32)30(40)36-15-16(2)25-17(7-8-24(38)39)5-4-6-22(25)36/h3-8,13-15,18H,1,9-12H2,2H3,(H,38,39)/b8-7+	OLSZYSVLPKIWFU-BQYQJAHWSA-N	278650	US10040791, Example 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 115					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278650	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307076	378160244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530115	Cc1cn(C(=O)c2c(noc2C2(C)CCN(CC2)C(=O)C=C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C31H26Cl3N3O5/c1-4-23(38)36-12-10-31(3,11-13-36)29-27(28(35-42-29)26-20(33)14-19(32)15-21(26)34)30(41)37-16-17(2)25-18(8-9-24(39)40)6-5-7-22(25)37/h4-9,14-16H,1,10-13H2,2-3H3,(H,39,40)/b9-8+	NRZOBPKLVYBMMQ-CMDGGOBGSA-N	278651	US10040791, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 104					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278651	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307348	378160245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530117	Cc1cn(C(=O)c2c(onc2-c2c(C)cc(C)cc2C)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C33H33N3O5/c1-6-26(37)35-14-12-24(13-15-35)32-30(31(34-41-32)28-20(3)16-19(2)17-21(28)4)33(40)36-18-22(5)29-23(10-11-27(38)39)8-7-9-25(29)36/h6-11,16-18,24H,1,12-15H2,2-5H3,(H,38,39)/b11-10+	ASRIWAMVNPKEQY-ZHACJKMWSA-N	278652	US10040791, Example 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 81					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278652	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307263	378160246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530119	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(CCC(O)=O)c12	InChI=1S/C30H26Cl3N3O5/c1-3-23(37)35-11-9-18(10-12-35)29-27(28(34-41-29)26-20(32)13-19(31)14-21(26)33)30(40)36-15-16(2)25-17(7-8-24(38)39)5-4-6-22(25)36/h3-6,13-15,18H,1,7-12H2,2H3,(H,38,39)	APFWWCWTBSANOT-UHFFFAOYSA-N	278653	US10040791, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 301					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278653	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307350	378160247							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530121	C\C(=C/c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C)C(O)=O	InChI=1S/C30H24Cl3N3O5/c1-3-24(37)35-10-7-17(8-11-35)28-26(27(34-41-28)25-21(32)14-19(31)15-22(25)33)29(38)36-12-9-20-18(5-4-6-23(20)36)13-16(2)30(39)40/h3-6,9,12-15,17H,1,7-8,10-11H2,2H3,(H,39,40)/b16-13+	DVCSJUAIOWDAIW-DTQAZKPQSA-N	278654	US10040791, Example 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 471					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278654	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307191	378160248							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530123	COC1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C31H26Cl3N3O6/c1-4-23(38)36-12-10-31(42-3,11-13-36)29-27(28(35-43-29)26-20(33)14-19(32)15-21(26)34)30(41)37-16-17(2)25-18(8-9-24(39)40)6-5-7-22(25)37/h4-9,14-16H,1,10-13H2,2-3H3,(H,39,40)/b9-8+	IQVLOSQGBGAFAU-CMDGGOBGSA-N	278655	US10040791, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 117					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278655	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307031	378160249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530125	OC(=O)\C=C\c1cccc2n(ncc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C28H21Cl3N4O5/c1-2-22(36)34-10-8-16(9-11-34)27-25(26(33-40-27)24-19(30)12-17(29)13-20(24)31)28(39)35-21-5-3-4-15(6-7-23(37)38)18(21)14-32-35/h2-7,12-14,16H,1,8-11H2,(H,37,38)/b7-6+	SWURKQYRUCMQLT-VOTSOKGWSA-N	278656	US10040791, Example 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 625					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278656	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307184	378160250							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530127	C\C=C\C(=O)N1CCC(CC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C31H26Cl3N3O5/c1-3-5-24(38)36-12-10-19(11-13-36)30-28(29(35-42-30)27-21(33)14-20(32)15-22(27)34)31(41)37-16-17(2)26-18(8-9-25(39)40)6-4-7-23(26)37/h3-9,14-16,19H,10-13H2,1-2H3,(H,39,40)/b5-3+,9-8+	JQOLVOZQJFCFCB-YEQUJYSKSA-N	278657	US10040791, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 190					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307351	378160251							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530129	COCC1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C31H26Cl3N3O6/c1-3-24(38)36-13-10-31(11-14-36,17-42-2)29-27(28(35-43-29)26-21(33)15-19(32)16-22(26)34)30(41)37-12-9-20-18(7-8-25(39)40)5-4-6-23(20)37/h3-9,12,15-16H,1,10-11,13-14,17H2,2H3,(H,39,40)/b8-7+	PRKOTSIWJLRFJM-BQYQJAHWSA-N	278658	US10040791, Example 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 357					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278658	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307353	378160252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530131	Cc1cn(C(=O)c2c(onc2-c2cc(F)c(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl2FN3O5/c1-3-24(37)35-11-9-18(10-12-35)29-27(28(34-41-29)19-13-22(33)21(32)14-20(19)31)30(40)36-15-16(2)26-17(7-8-25(38)39)5-4-6-23(26)36/h3-8,13-15,18H,1,9-12H2,2H3,(H,38,39)/b8-7+	OCEWIPPXOQOQQP-BQYQJAHWSA-N	278659	US10040791, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 110					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307077	378160253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530133	Cc1cn(C(=O)c2c(onc2-c2c(C)cc(Cl)cc2C)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C32H30ClN3O5/c1-5-25(37)35-13-11-22(12-14-35)31-29(30(34-41-31)27-18(2)15-23(33)16-19(27)3)32(40)36-17-20(4)28-21(9-10-26(38)39)7-6-8-24(28)36/h5-10,15-17,22H,1,11-14H2,2-4H3,(H,38,39)/b10-9+	MVRYLDWWLXDTFY-MDZDMXLPSA-N	278660	US10040791, Example 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 94					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307032	378160254							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530135	Cc1cn(C(=O)c2c(noc2C2(O)CCN(CC2)C(=O)C=C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl3N3O6/c1-3-22(37)35-11-9-30(41,10-12-35)28-26(27(34-42-28)25-19(32)13-18(31)14-20(25)33)29(40)36-15-16(2)24-17(7-8-23(38)39)5-4-6-21(24)36/h3-8,13-15,41H,1,9-12H2,2H3,(H,38,39)/b8-7+	WCYDRAWVHFFUSE-BQYQJAHWSA-N	278661	US10040791, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 149					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307200	378160255							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530137	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2C3CN(CC23)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H22Cl3N3O5/c1-3-22(37)35-12-17-18(13-35)25(17)29-27(28(34-41-29)26-19(32)9-16(31)10-20(26)33)30(40)36-11-14(2)24-15(7-8-23(38)39)5-4-6-21(24)36/h3-11,17-18,25H,1,12-13H2,2H3,(H,38,39)/b8-7+	VDYUEXGDLAHKLA-BQYQJAHWSA-N	278662	US10040791, Example 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 125					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307078	378160256							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530139	OC(=O)CC1CCc2cn(C(=O)c3c(onc3-c3c(Cl)cc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H26Cl3N3O5/c1-2-24(38)36-10-8-16(9-11-36)30-28(29(35-42-30)27-21(33)13-19(32)14-22(27)34)31(41)37-15-18-7-6-17(12-25(39)40)20-4-3-5-23(37)26(18)20/h2-5,13-17H,1,6-12H2,(H,39,40)	MCBXERFWRRATGD-UHFFFAOYSA-N	278663	US10040791, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 454					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278663	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307264	378160257							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530141	CN(C)C1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C32H29Cl3N4O5/c1-5-24(40)38-13-11-32(12-14-38,37(3)4)30-28(29(36-44-30)27-21(34)15-20(33)16-22(27)35)31(43)39-17-18(2)26-19(9-10-25(41)42)7-6-8-23(26)39/h5-10,15-17H,1,11-14H2,2-4H3,(H,41,42)/b10-9+	YHMDYZDSIMKOGF-MDZDMXLPSA-N	278664	US10040791, Example 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 149					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278664	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307185	378160258							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530143	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3c(Cl)cc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl3N3O5/c1-2-24(38)36-10-8-16(9-11-36)30-28(29(35-42-30)27-21(33)13-19(32)14-22(27)34)31(41)37-15-18-7-6-17(12-25(39)40)20-4-3-5-23(37)26(18)20/h2-5,12-16H,1,6-11H2,(H,39,40)/b17-12+	CMZJOEOPYWOXKF-SFQUDFHCSA-N	278665	US10040791, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 139					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278665	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307186	378160259							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530145	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3cc(F)c(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl2FN3O5/c1-2-25(38)36-10-8-16(9-11-36)30-28(29(35-42-30)20-13-23(34)22(33)14-21(20)32)31(41)37-15-18-7-6-17(12-26(39)40)19-4-3-5-24(37)27(18)19/h2-5,12-16H,1,6-11H2,(H,39,40)/b17-12+	QNNPJOOJDDDDNY-SFQUDFHCSA-N	278666	US10040791, Example 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 91					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278666	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307036	378160260							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530147	Cc1cn(C(=O)c2c(onc2-c2ccc(Cl)c(F)c2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl2FN3O5/c1-3-22(37)35-13-11-18(12-14-35)29-25(28(34-41-29)19-8-9-20(31)27(33)26(19)32)30(40)36-15-16(2)24-17(7-10-23(38)39)5-4-6-21(24)36/h3-10,15,18H,1,11-14H2,2H3,(H,38,39)/b10-7+	ICCSHMQZNRTNRV-JXMROGBWSA-N	278667	US10040791, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 182					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278667	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307201	378160261							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530149	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3ccc(Cl)c(F)c3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl2FN3O5/c1-2-23(38)36-12-10-16(11-13-36)30-26(29(35-42-30)20-8-9-21(32)28(34)27(20)33)31(41)37-15-18-7-6-17(14-24(39)40)19-4-3-5-22(37)25(18)19/h2-5,8-9,14-16H,1,6-7,10-13H2,(H,39,40)/b17-14+	QKYJFALUFVDGFL-SAPNQHFASA-N	278668	 (2E)-[1-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4-dichloro-3-fluorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid::US10040791, Example 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 143					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278668	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307192	378160262							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530151	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3ccc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H25Cl2N3O5/c1-2-25(37)35-12-10-17(11-13-35)30-28(29(34-41-30)22-9-8-20(32)15-23(22)33)31(40)36-16-19-7-6-18(14-26(38)39)21-4-3-5-24(36)27(19)21/h2-5,8-9,14-17H,1,6-7,10-13H2,(H,38,39)/b18-14+	TXEIQQMABKQWLJ-NBVRZTHBSA-N	278669	 (2E)-[1-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid::US10040791, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 133					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307352	378160263							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530153	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H22Cl3N3O5/c1-2-23(36)34-11-8-17(9-12-34)27-26(28(40-33-27)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,37,38)/b7-6+	HPILQFSRJMCTKF-VOTSOKGWSA-N	278670	(2E)-3-(1-{[3-(1-Acryloylpiperidin-4-yl)-5-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 279					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278670	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307266	378160264							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530155	CN(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C23H17Cl2N3O4/c1-27(2)23-20(21(26-32-23)19-15(24)6-4-7-16(19)25)22(31)28-12-11-14-13(9-10-18(29)30)5-3-8-17(14)28/h3-12H,1-2H3,(H,29,30)/b10-9+	MMFAVRRGTJHELG-MDZDMXLPSA-N	278671	(2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(dimethylamino)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 93					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278671	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307354	378160265							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530157	CCN(CC)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H21Cl2N3O4/c1-3-29(4-2)25-22(23(28-34-25)21-17(26)8-6-9-18(21)27)24(33)30-14-13-16-15(11-12-20(31)32)7-5-10-19(16)30/h5-14H,3-4H2,1-2H3,(H,31,32)/b12-11+	JFFOTDLLWGLPHG-VAWYXSNFSA-N	278672	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(diethylamino)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 143					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278672	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307368	378160266							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530159	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCCC1	InChI=1S/C25H19Cl2N3O4/c26-17-6-4-7-18(27)21(17)23-22(25(34-28-23)29-12-1-2-13-29)24(33)30-14-11-16-15(9-10-20(31)32)5-3-8-19(16)30/h3-11,14H,1-2,12-13H2,(H,31,32)/b10-9+	PNEPUQSOUVIVBT-MDZDMXLPSA-N	278673	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(pyrrolidin-1-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 122					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307361	378160267							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530161	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCOCC1)-c1c(Cl)cccc1Cl	InChI=1S/C25H19Cl2N3O5/c26-17-4-2-5-18(27)21(17)23-22(25(35-28-23)29-11-13-34-14-12-29)24(33)30-10-9-16-15(7-8-20(31)32)3-1-6-19(16)30/h1-10H,11-14H2,(H,31,32)/b8-7+	GTCIZPWDOPSRCT-BQYQJAHWSA-N	278674	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(morpholin-4-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 140					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307037	378160268							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530163	C[C@H]1CCC[C@@H](C)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C28H25Cl2N3O4/c1-16-6-3-7-17(2)33(16)28-25(26(31-37-28)24-20(29)9-5-10-21(24)30)27(36)32-15-14-19-18(12-13-23(34)35)8-4-11-22(19)32/h4-5,8-17H,3,6-7H2,1-2H3,(H,34,35)/b13-12+/t16-,17+	XZNPFKYVGHWAEQ-JZDNNTCESA-N	278675	(2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(cis-2,6-dimethylpiperidin-1-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 189					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278675	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307359	378160269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530165	CN(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C23H16Cl3N3O4/c1-28(2)23-20(21(27-33-23)19-15(25)10-13(24)11-16(19)26)22(32)29-9-8-14-12(6-7-18(30)31)4-3-5-17(14)29/h3-11H,1-2H3,(H,30,31)/b7-6+	GTIQFOVRFAIMPD-VOTSOKGWSA-N	278676	 (2E)-3-(1-{[5-(Dimethylamino)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 88					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278676	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278676&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307196	378160270							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530167	NC[C@H]1CCN(C1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C26H22Cl2N4O4/c27-18-4-2-5-19(28)22(18)24-23(26(36-30-24)31-11-9-15(13-29)14-31)25(35)32-12-10-17-16(7-8-21(33)34)3-1-6-20(17)32/h1-8,10,12,15H,9,11,13-14,29H2,(H,33,34)/b8-7+/t15-/m1/s1	NUMWHIFQZLUUBP-MVGZEHJDSA-N	278677	(2E)-3-[1-({5-[(3R)-3-(Aminomethyl)pyrrolidin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 373					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307371	378160271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530169	NC[C@@H]1CCN(C1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C26H22Cl2N4O4/c27-18-4-2-5-19(28)22(18)24-23(26(36-30-24)31-11-9-15(13-29)14-31)25(35)32-12-10-17-16(7-8-21(33)34)3-1-6-20(17)32/h1-8,10,12,15H,9,11,13-14,29H2,(H,33,34)/b8-7+/t15-/m0/s1	NUMWHIFQZLUUBP-KIUWMYQTSA-N	278678	 (2E)-3[1-({5-[(3S)-3-(Aminomethyl)pyrrolidin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 1038					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278678	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307038	378160272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530171	C[C@@H]1CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C29H24Cl2N4O5/c1-3-23(36)33-14-15-34(17(2)16-33)29-26(27(32-40-29)25-20(30)7-5-8-21(25)31)28(39)35-13-12-19-18(10-11-24(37)38)6-4-9-22(19)35/h3-13,17H,1,14-16H2,2H3,(H,37,38)/b11-10+/t17-/m1/s1	QZOLGWIJLOKKGY-SXSDINLZSA-N	278679	(2E)-3-[1-({5-[(2R)-4-Acryloyl-2-methylpiperazin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 137					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307048	378160273							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530173	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCN(CC1)C(=O)C=C)-c1c(Cl)cccc1Cl	InChI=1S/C28H22Cl2N4O5/c1-2-22(35)32-13-15-33(16-14-32)28-25(26(31-39-28)24-19(29)6-4-7-20(24)30)27(38)34-12-11-18-17(9-10-23(36)37)5-3-8-21(18)34/h2-12H,1,13-16H2,(H,36,37)/b10-9+	JRZUMJQOESHEED-MDZDMXLPSA-N	278680	 (2E)-3-(1-{[5-(4-Acryloylpiperazin-1-yl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 123					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278680	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307197	378160274							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530175	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCN(CC1)C(=O)C=C)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H21Cl3N4O5/c1-2-22(36)33-10-12-34(13-11-33)28-25(26(32-40-28)24-19(30)14-17(29)15-20(24)31)27(39)35-9-8-18-16(6-7-23(37)38)4-3-5-21(18)35/h2-9,14-15H,1,10-13H2,(H,37,38)/b7-6+	KKHDGMIUMMNJGD-VOTSOKGWSA-N	278681	 (2E)-3-(1-{[5-(4-Acryloylpiperazin-1-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 150					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278681	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307081	378160275							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530177	C[C@H]1CN(C[C@@H](C)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C30H26Cl2N4O5/c1-4-24(37)34-15-17(2)36(18(3)16-34)30-27(28(33-41-30)26-21(31)8-6-9-22(26)32)29(40)35-14-13-20-19(11-12-25(38)39)7-5-10-23(20)35/h4-14,17-18H,1,15-16H2,2-3H3,(H,38,39)/b12-11+/t17-,18+	IUPMKLXZXSGEEK-JZYAGYNQSA-N	278682	 (2E)-3-(1-{[5-(4-Acryloyl-cis-2,6-dimethylpiperazin-1-yl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 151					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307079	378160276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530179	C[C@H]1CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C29H24Cl2N4O5/c1-3-23(36)33-14-15-34(17(2)16-33)29-26(27(32-40-29)25-20(30)7-5-8-21(25)31)28(39)35-13-12-19-18(10-11-24(37)38)6-4-9-22(19)35/h3-13,17H,1,14-16H2,2H3,(H,37,38)/b11-10+/t17-/m0/s1	QZOLGWIJLOKKGY-DVQDXYAYSA-N	278683	 (2E)-3-[1-({5-[(2S)-4-Acryloyl-2-methylpiperazin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 214					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278683	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307080	378160277							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530181	C[C@H]1CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl)C(=O)C=C	InChI=1S/C29H23Cl3N4O5/c1-3-23(37)34-11-12-35(16(2)15-34)29-26(27(33-41-29)25-20(31)13-18(30)14-21(25)32)28(40)36-10-9-19-17(7-8-24(38)39)5-4-6-22(19)36/h3-10,13-14,16H,1,11-12,15H2,2H3,(H,38,39)/b8-7+/t16-/m0/s1	HGTWIFFSNDPQBH-WAVCKPEOSA-N	278684	 (2E)-3-[1-({5-[(2R)-4-Acryloyl-2-methylpiperazin-1-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 144					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278684	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			132070950	378160278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530183	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCN(CC11CC1)C(=O)C=C	InChI=1S/C30H24Cl2N4O5/c1-2-23(37)34-15-16-36(30(17-34)12-13-30)29-26(27(33-41-29)25-20(31)6-4-7-21(25)32)28(40)35-14-11-19-18(9-10-24(38)39)5-3-8-22(19)35/h2-11,14H,1,12-13,15-17H2,(H,38,39)/b10-9+	KADALMMGLFJRDG-MDZDMXLPSA-N	278685	 (2E)-3-(1-{[5-[7-Acryloyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 78					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278685	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307056	378160279							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530185	C[C@@H]1CN(CCN1C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C29H23Cl3N4O5/c1-3-23(37)35-12-11-34(15-16(35)2)29-26(27(33-41-29)25-20(31)13-18(30)14-21(25)32)28(40)36-10-9-19-17(7-8-24(38)39)5-4-6-22(19)36/h3-10,13-14,16H,1,11-12,15H2,2H3,(H,38,39)/b8-7+/t16-/m1/s1	SIWWMHDNRFCNDE-KXPUMZMLSA-N	278686	 (2E)-3-[1-({5-[(3R)-4-Acryloyl-3-methylpiperazin-1-yl]3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 225					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278686	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130311619	378160280							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530187	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCN(CC1)S(=O)(=O)C=C)-c1c(Cl)cccc1Cl	InChI=1S/C27H22Cl2N4O6S/c1-2-40(37,38)32-15-13-31(14-16-32)27-24(25(30-39-27)23-19(28)6-4-7-20(23)29)26(36)33-12-11-18-17(9-10-22(34)35)5-3-8-21(18)33/h2-12H,1,13-16H2,(H,34,35)/b10-9+	DBJFRGCDXOKEGT-MDZDMXLPSA-N	278687	 (2E)-3-[1-({3-(2,6-Dichlorophenyl)-5-[4-(ethenylsulfonyl)piperazin-1-yl]-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 132					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278687	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307366	378160281							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530189	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)N1CCN(CC11CC1)C(=O)C=C	InChI=1S/C30H23Cl3N4O5/c1-2-23(38)35-12-13-37(30(16-35)9-10-30)29-26(27(34-42-29)25-20(32)14-18(31)15-21(25)33)28(41)36-11-8-19-17(6-7-24(39)40)4-3-5-22(19)36/h2-8,11,14-15H,1,9-10,12-13,16H2,(H,39,40)/b7-6+	FOLZMPFXCMRKTM-VOTSOKGWSA-N	278688	 (2E)-3-(1-{[5-[7-Acryloyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 98					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278688	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307215	378160282							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530191	C[C@H]1CN(C[C@@H](C)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl)C(=O)C=C	InChI=1S/C30H25Cl3N4O5/c1-4-24(38)35-14-16(2)37(17(3)15-35)30-27(28(34-42-30)26-21(32)12-19(31)13-22(26)33)29(41)36-11-10-20-18(8-9-25(39)40)6-5-7-23(20)36/h4-13,16-17H,1,14-15H2,2-3H3,(H,39,40)/b9-8+/t16-,17+	YCTWCFULURHWLP-CWNHSUMWSA-N	278689	 (2E)-3-(1-{[5-(4-Acryloyl-cis-2,6-dimethylpiperazin-1-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 168					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278689	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278689&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307199	378160283							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530193	C[C@@H]1CN([C@H](C)CN1C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C30H25Cl3N4O5/c1-4-24(38)36-14-17(3)37(15-16(36)2)30-27(28(34-42-30)26-21(32)12-19(31)13-22(26)33)29(41)35-11-10-20-18(8-9-25(39)40)6-5-7-23(20)35/h4-13,16-17H,1,14-15H2,2-3H3,(H,39,40)/b9-8+/t16-,17-/m1/s1	ZTABWOUHCSEFHZ-PIIXRYACSA-N	278690	 (2E)-3-[1-({5-[(2R,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl} carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 222					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278690&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307268	378160284							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530195	CC1(C)CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C30H26Cl2N4O5/c1-4-23(37)34-15-16-36(30(2,3)17-34)29-26(27(33-41-29)25-20(31)8-6-9-21(25)32)28(40)35-14-13-19-18(11-12-24(38)39)7-5-10-22(19)35/h4-14H,1,15-17H2,2-3H3,(H,38,39)/b12-11+	AGNMUVJZIKIIGO-VAWYXSNFSA-N	278691	 (2E)-3-(1-{[5-(4-Acryloyl-2,2-dimethylpiperazin-1-yl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 130					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278691	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278691&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307219	378160285							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530197	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCN(C[C@H]1C1CC1)C(=O)C=C	InChI=1S/C31H26Cl2N4O5/c1-2-25(38)35-15-16-37(24(17-35)19-9-10-19)31-28(29(34-42-31)27-21(32)6-4-7-22(27)33)30(41)36-14-13-20-18(11-12-26(39)40)5-3-8-23(20)36/h2-8,11-14,19,24H,1,9-10,15-17H2,(H,39,40)/b12-11+/t24-/m0/s1	IVRTWLTWACZOFF-LCJITAHGSA-N	278692	 (2E)-3-[1-({5-[(2R)-4-Acryloyl-2-cyclopropylpiperazin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 235					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307221	378160286							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530199	C[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(Cl)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C31H26Cl2N4O5/c1-3-24(38)36-17-31(13-14-31)37(16-18(36)2)30-27(28(34-42-30)26-21(32)7-5-8-22(26)33)29(41)35-15-12-20-19(10-11-25(39)40)6-4-9-23(20)35/h3-12,15,18H,1,13-14,16-17H2,2H3,(H,39,40)/b11-10+/t18-/m1/s1	YNMYTTWXBCEWBD-DOJUMQAQSA-N	278693	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 122					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278693	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278693&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307224	378160287							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530201	C[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(F)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C31H26ClFN4O5/c1-3-24(38)36-17-31(13-14-31)37(16-18(36)2)30-27(28(34-42-30)26-21(32)7-5-8-22(26)33)29(41)35-15-12-20-19(10-11-25(39)40)6-4-9-23(20)35/h3-12,15,18H,1,13-14,16-17H2,2H3,(H,39,40)/b11-10+/t18-/m1/s1	HNRBYJFAXWNXLU-DOJUMQAQSA-N	278694	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 167					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278694	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307207	378160288							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530203	CC1(C)CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(F)cccc1Cl)C(=O)C=C	InChI=1S/C30H26ClFN4O5/c1-4-23(37)34-15-16-36(30(2,3)17-34)29-26(27(33-41-29)25-20(31)8-6-9-21(25)32)28(40)35-14-13-19-18(11-12-24(38)39)7-5-10-22(19)35/h4-14H,1,15-17H2,2-3H3,(H,38,39)/b12-11+	QBTZFZVPUDMQES-VAWYXSNFSA-N	278695	 (2E)-3-(1-{[5-(4-Acryloyl-2,2-dimethylpiperazin-1-yl)-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 256					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278695	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278695&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307209	378160289							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530205	COc1cccc(Cl)c1-c1noc(N2C[C@@H](C)N(CC22CC2)C(=O)C=C)c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12	InChI=1S/C32H29ClN4O6/c1-4-25(38)36-18-32(14-15-32)37(17-19(36)2)31-28(29(34-43-31)27-22(33)8-6-10-24(27)42-3)30(41)35-16-13-21-20(11-12-26(39)40)7-5-9-23(21)35/h4-13,16,19H,1,14-15,17-18H2,2-3H3,(H,39,40)/b12-11+/t19-/m1/s1	FZEVZYHOOKBFAQ-TZZQJPOUSA-N	278696	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-methoxyphenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 179					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278696	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278696&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307269	378160290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530207	C[C@@H]1CN(CC2(CC2)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C31H26Cl2N4O5/c1-3-24(38)35-16-18(2)37(31(17-35)13-14-31)30-27(28(34-42-30)26-21(32)7-5-8-22(26)33)29(41)36-15-12-20-19(10-11-25(39)40)6-4-9-23(20)36/h3-12,15,18H,1,13-14,16-17H2,2H3,(H,39,40)/b11-10+/t18-/m1/s1	WTRJIQMMQXVJTR-DOJUMQAQSA-N	278697	 (2E)-3-[1-({5-[(5R)7-Acryloyl-5-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 84					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278697&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307058	378160291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530209	CC[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(F)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C32H28ClFN4O5/c1-3-20-17-38(32(14-15-32)18-37(20)25(39)4-2)31-28(29(35-43-31)27-22(33)8-6-9-23(27)34)30(42)36-16-13-21-19(11-12-26(40)41)7-5-10-24(21)36/h4-13,16,20H,2-3,14-15,17-18H2,1H3,(H,40,41)/b12-11+/t20-/m1/s1	XKYRKDXEEDGAFF-YVNCXZRQSA-N	278698	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-ethyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 81					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278698	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307061	378160292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530211	CC[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(Cl)cccc2OC)C2(CC2)CN1C(=O)C=C	InChI=1S/C33H31ClN4O6/c1-4-21-18-38(33(15-16-33)19-37(21)26(39)5-2)32-29(30(35-44-32)28-23(34)9-7-11-25(28)43-3)31(42)36-17-14-22-20(12-13-27(40)41)8-6-10-24(22)36/h5-14,17,21H,2,4,15-16,18-19H2,1,3H3,(H,40,41)/b13-12+/t21-/m1/s1	MTTSULIETFPACO-JNCYCUAHSA-N	278699	 (2E)-3-[1-({5-{(6R)7-Acryloyl-6-ethyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-methoxyphenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 98					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278699	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307367	378160293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530213	C[C@@H]1CN(c2onc(c2C(=O)n2cc(C)c3c(\C=C\C(O)=O)cccc23)-c2c(F)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C32H28ClFN4O5/c1-4-24(39)37-17-32(13-14-32)38(16-19(37)3)31-28(29(35-43-31)27-21(33)8-6-9-22(27)34)30(42)36-15-18(2)26-20(11-12-25(40)41)7-5-10-23(26)36/h4-12,15,19H,1,13-14,16-17H2,2-3H3,(H,40,41)/b12-11+/t19-/m1/s1	IQCLBTXWISQULI-TZZQJPOUSA-N	278700	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl}carbonyl)-3-methyl-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 95					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278700	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278700&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307084	378160294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530215	CC[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(Cl)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C32H28Cl2N4O5/c1-3-20-17-38(32(14-15-32)18-37(20)25(39)4-2)31-28(29(35-43-31)27-22(33)8-6-9-23(27)34)30(42)36-16-13-21-19(11-12-26(40)41)7-5-10-24(21)36/h4-13,16,20H,2-3,14-15,17-18H2,1H3,(H,40,41)/b12-11+/t20-/m1/s1	RUYCHNOTZLQFMC-YVNCXZRQSA-N	278701	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-ethyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 98					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278701	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307374	378160295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530217	Cn1cc(C(=O)c2c(noc2C(C)(C)C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl3N2O4/c1-26(2,3)25-21(22(30-35-25)20-17(28)10-14(27)11-18(20)29)24(34)16-12-31(4)23-13(8-9-19(32)33)6-5-7-15(16)23/h5-12H,1-4H3,(H,32,33)/b9-8+	KMKQLYWDTOLCEJ-CMDGGOBGSA-N	278702	(2E)-3-(3-[5-tert-Butyl-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1-methyl-1H-indol-7-yl)prop-2-enoic acid::US10040791, Example 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 95					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278702	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278702&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307238	378160296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530219	Cn1cc(C(=O)c2c(noc2C2(C)CC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H19Cl3N2O4/c1-26(8-9-26)25-21(22(30-35-25)20-17(28)10-14(27)11-18(20)29)24(34)16-12-31(2)23-13(6-7-19(32)33)4-3-5-15(16)23/h3-7,10-12H,8-9H2,1-2H3,(H,32,33)/b7-6+	KDZZPEPBMYAXLB-VOTSOKGWSA-N	278703	 (2E)-3-(1-Methyl-3-{[5-(1-methylcyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-7-yl)prop-2-enoic acid::US10040791, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 81					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278703	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307085	378160297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530221	Cn1cc(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl3N3O5/c1-3-23(37)36-11-9-17(10-12-36)30-26(27(34-41-30)25-21(32)13-18(31)14-22(25)33)29(40)20-15-35(2)28-16(7-8-24(38)39)5-4-6-19(20)28/h3-8,13-15,17H,1,9-12H2,2H3,(H,38,39)/b8-7+	VHTMFXILPVFQDZ-BQYQJAHWSA-N	278704	(2E)-3-(3-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1-methyl-1H-indol-7-yl)prop-2-enoic acid::US10040791, Example 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 141					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278704	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278704&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307211	378160298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530223	Cn1cc(C(=O)c2c(noc2C(C)(C)C)-c2c(Cl)cc(Cl)cc2Cl)c2ccc3ccc(cc3c12)C(O)=O	InChI=1S/C28H21Cl3N2O4/c1-28(2,3)26-22(23(32-37-26)21-19(30)10-15(29)11-20(21)31)25(34)18-12-33(4)24-16(18)8-7-13-5-6-14(27(35)36)9-17(13)24/h5-12H,1-4H3,(H,35,36)	PSGMVWXGZRFBCU-UHFFFAOYSA-N	278705	3-{[5-tert-Butyl-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1-methyl-1H-benzo[g]indole-8-carboxylic acid::US10040791, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 196					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278705	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278705&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			130307271	378160299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532362	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)nc(NCC2CC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-3-1-2-12(23-13)14-24-15(21-8-10-4-5-10)26-16(25-14)22-9-11-6-7-11/h1-3,10-11H,4-9H2,(H2,21,22,24,25,26)	KNDBYTOOVAJFRN-UHFFFAOYSA-N	279854	US10028961, Compound 1::US10172864, Compound 1::US10946023, Compound 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817069	378161425							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532367	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)/t10-,11-/m1/s1	KRSKURCJOGAEOS-GHMZBOCLSA-N	279855	US10028961, Compound 2::US10172864, Compound 2::US10946023, Compound 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	QWM	6VG0	117817076	378161426							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532371	CC(C)Nc1nc(NC(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6/c1-8(2)19-13-22-12(23-14(24-13)20-9(3)4)10-6-5-7-11(21-10)15(16,17)18/h5-9H,1-4H3,(H2,19,20,22,23,24)	WDSFOQJWJKBMPM-UHFFFAOYSA-N	279856	US10028961, Compound 3::US10172864, Compound 3::US10946023, Compound 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817527	378161427							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532374	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	BDBM279926::US10028961, Compound 4::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532378	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	SBWSJSCKQBEYEK-VXGBXAGGSA-N	279859	US10028961, Compound 6::US10028961, Compound 77::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532380	FC(F)(F)c1cccc(n1)-c1nc(NCC2CCC2)nc(NCC2CCC2)n1	InChI=1S/C19H23F3N6/c20-19(21,22)15-9-3-8-14(25-15)16-26-17(23-10-12-4-1-5-12)28-18(27-16)24-11-13-6-2-7-13/h3,8-9,12-13H,1-2,4-7,10-11H2,(H2,23,24,26,27,28)	VPNNRJRDRDIMTN-UHFFFAOYSA-N	279860	US10028961, Compound 7::US10172864, Compound 7::US10946023, Compound 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466271	378161431							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532382	COc1ccc(F)c(c1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1	InChI=1S/C20H26FN5O/c1-11(13-4-5-13)22-19-24-18(16-10-15(27-3)8-9-17(16)21)25-20(26-19)23-12(2)14-6-7-14/h8-14H,4-7H2,1-3H3,(H2,22,23,24,25,26)/t11-,12-/m1/s1	WWRAJFZRAVDBHX-VXGBXAGGSA-N	279861	US10028961, Compound 78::US10028961, Compound 8::US10172864, Compound 78::US10946023, Compound 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817112	378161432							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532385	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC2)nc(NC2CCC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-9-3-8-12(23-13)14-24-15(21-10-4-1-5-10)26-16(25-14)22-11-6-2-7-11/h3,8-11H,1-2,4-7H2,(H2,21,22,24,25,26)	PVIJXHIYMYVGOF-UHFFFAOYSA-N	279862	US10028961, Compound 9::US10172864, Compound 9::US10946023, Compound 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466412	378161433							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532388	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)/t10-/m1/s1	BMMLVEOASUDOHV-SNVBAGLBSA-N	279863	US10028961, Compound 10::US10028961, Compound 79::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532392	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	JCZPGZCYKZMOEK-VXGBXAGGSA-N	279864	US10028961, Compound 11::US10028961, Compound 80::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532395	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t9?,10-/m1/s1	YADRVMCMMMHOSZ-QVDQXJPCSA-N	279865	US10028961, Compound 12::US10028961, Compound 81::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532399	CC(C)C(C)Nc1nc(NC(C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279866	US10028961, Compound 13::US10172864, Compound 13::US10946023, Compound 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466273	378161437							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532401	CC(O)CNc1nc(NCC(C)O)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6O2/c1-8(25)6-19-13-22-12(23-14(24-13)20-7-9(2)26)10-4-3-5-11(21-10)15(16,17)18/h3-5,8-9,25-26H,6-7H2,1-2H3,(H2,19,20,22,23,24)	QYMUDBQWLSGBAS-UHFFFAOYSA-N	279867	US10028961, Compound 14::US10172864, Compound 14::US10946023, Compound 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817085	378161438							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532404	C[C@@H](Nc1nc(NCC(C)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H19F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,10-11H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t10-/m1/s1	GZYMCQBNCUYDKE-SNVBAGLBSA-N	279868	US10028961, Compound 15::US10172864, Compound 15::US10946023, Compound 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817099	378161439							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532406	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)/t12-,13-/m1/s1	DXDMRKXHWQBBBA-CHWSQXEVSA-N	279869	US10028961, Compound 16::US10028961, Compound 82::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532410	CC(C)[C@H](C)Nc1nc(N[C@@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)/t12-,13-/m0/s1	OLELDTDOYATLQM-STQMWFEESA-N	279870	US10028961, Compound 17::US10172864, Compound 17::US10946023, Compound 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817087	378161441							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532413	CC(C)[C@@H](C)Nc1nc(N[C@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)/t12-,13-/m1/s1	OLELDTDOYATLQM-CHWSQXEVSA-N	279871	US10028961, Compound 18::US10172864, Compound 18::US10946023, Compound 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817080	378161442							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532416	C[C@@H](Nc1nc(N[C@H](C)C2CCC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CCC1	InChI=1S/C21H27F3N6/c1-12(14-6-3-7-14)25-19-28-18(16-10-5-11-17(27-16)21(22,23)24)29-20(30-19)26-13(2)15-8-4-9-15/h5,10-15H,3-4,6-9H2,1-2H3,(H2,25,26,28,29,30)/t12-,13-/m1/s1	HTFFUPGDRXDEIP-CHWSQXEVSA-N	279872	US10028961, Compound 19::US10172864, Compound 19::US10946023, Compound 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817233	378161443							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532419	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)/t13-,14+/m0/s1	YJZZCQZAKQBAMU-UONOGXRCSA-N	279873	US10028961, Compound 20::US10172864, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817082	378161444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532422	C[C@@H](Nc1nc(NCc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H21F3N6/c1-13(15-10-11-15)26-20-29-18(16-8-5-9-17(27-16)21(22,23)24)28-19(30-20)25-12-14-6-3-2-4-7-14/h2-9,13,15H,10-12H2,1H3,(H2,25,26,28,29,30)/t13-/m1/s1	IUYXTIDKXVUWDD-CYBMUJFWSA-N	279874	US10028961, Compound 21::US10172864, Compound 21::US10946023, Compound 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817101	378161445							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532425	C[C@@H](Nc1nc(N[C@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)/t13-,14-/m1/s1	YJZZCQZAKQBAMU-ZIAGYGMSSA-N	279875	US10028961, Compound 22::US10172864, Compound 22::US10946023, Compound 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817118	378161446							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532428	C[C@@H](Nc1nc(N[C@@H]2C[C@H]2c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-13(14-10-11-14)27-21-30-20(17-8-5-9-19(28-17)23(24,25)26)31-22(32-21)29-18-12-16(18)15-6-3-2-4-7-15/h2-9,13-14,16,18H,10-12H2,1H3,(H2,27,29,30,31,32)/t13-,16+,18-/m1/s1	MPVKJRGUFDYPQR-RPVQJOFSSA-N	279876	US10028961, Compound 23::US10172864, Compound 23::US10946023, Compound 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817033	378161447							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532430	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)/t12-/m1/s1	YMKOTGDUPIYQMS-GFCCVEGCSA-N	279877	US10028961, Compound 24::US10028961, Compound 83::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532432	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)/t12-,13?/m1/s1	PVBOMIYGGWSXIY-PZORYLMUSA-N	279878	US10028961, Compound 25::US10028961, Compound 84::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532434	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)c1ccccc1	InChI=1S/C25H23F3N6/c1-16(18-10-5-3-6-11-18)29-23-32-22(20-14-9-15-21(31-20)25(26,27)28)33-24(34-23)30-17(2)19-12-7-4-8-13-19/h3-17H,1-2H3,(H2,29,30,32,33,34)/t16-,17+	LBAZIFOJZOIFON-CALCHBBNSA-N	279879	US10028961, Compound 26::US10172864, Compound 26::US10946023, Compound 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817147	378161450							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532437	C[C@@H](Nc1nc(NC(C)c2cccc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H22F6N6/c1-12(14-9-10-14)30-20-33-19(17-7-4-8-18(32-17)23(27,28)29)34-21(35-20)31-13(2)15-5-3-6-16(11-15)22(24,25)26/h3-8,11-14H,9-10H2,1-2H3,(H2,30,31,33,34,35)/t12-,13?/m1/s1	OUNUKDITMWXSMU-PZORYLMUSA-N	279880	US10028961, Compound 27::US10172864, Compound 27::US10946023, Compound 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817140	378161451							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532441	C[C@@H](Nc1nc(NC(C)c2cccc(F)c2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H22F4N6/c1-12(14-9-10-14)27-20-30-19(17-7-4-8-18(29-17)22(24,25)26)31-21(32-20)28-13(2)15-5-3-6-16(23)11-15/h3-8,11-14H,9-10H2,1-2H3,(H2,27,28,30,31,32)/t12-,13?/m1/s1	JYVZJECTMOHVFX-PZORYLMUSA-N	279881	US10028961, Compound 28::US10172864, Compound 28::US10946023, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817145	378161452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532443	C[C@@H](Nc1nc(NC(=O)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H19F3N6O/c1-12(13-10-11-13)25-19-27-17(15-8-5-9-16(26-15)21(22,23)24)28-20(30-19)29-18(31)14-6-3-2-4-7-14/h2-9,12-13H,10-11H2,1H3,(H2,25,27,28,29,30,31)/t12-/m1/s1	IQRLKQDCDTZTJN-GFCCVEGCSA-N	279882	US10028961, Compound 29::US10172864, Compound 29::US10946023, Compound 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817153	378161453							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532445	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)/t14-/m1/s1	MMQKYUIBTNHALE-CQSZACIVSA-N	279883	US10028961, Compound 30::US10028961, Compound 85::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532449	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279884	US10028961, Compound 31::US10172864, Compound 31::US10946023, Compound 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86580656	378161455							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532452	COc1ccc(F)c(c1)-c1nc(NC(C)C)nc(NC(C)(C)C#N)n1	InChI=1S/C17H21FN6O/c1-10(2)20-15-21-14(12-8-11(25-5)6-7-13(12)18)22-16(23-15)24-17(3,4)9-19/h6-8,10H,1-5H3,(H2,20,21,22,23,24)	JTBPNQFDWIZOKU-UHFFFAOYSA-N	279885	US10028961, Compound 32::US10172864, Compound 32::US10946023, Compound 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799404	378161456							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532455	C[C@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)/t10-,11-/m0/s1	KRSKURCJOGAEOS-QWRGUYRKSA-N	279886	US10028961, Compound 33::US10172864, Compound 33::US10946023, Compound 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817234	378161457							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532458	C[C@@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)/t10-,11+	KRSKURCJOGAEOS-PHIMTYICSA-N	279887	US10028961, Compound 34::US10172864, Compound 34::US10946023, Compound 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817526	378161458							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532460	CC(C)Nc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C16H19FN6O/c1-9(2)19-14-20-13(11-7-10(24)5-6-12(11)17)21-15(22-14)23-16(3,4)8-18/h5-7,9,24H,1-4H3,(H2,19,20,21,22,23)	ZKCSHTWHAVTEDI-UHFFFAOYSA-N	279888	US10028961, Compound 35::US10172864, Compound 35::US10946023, Compound 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817394	378161459							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532463	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3CC3C2)nc(NC2CC3CC3C2)n1	InChI=1S/C21H23F3N6/c22-21(23,24)17-3-1-2-16(27-17)18-28-19(25-14-6-10-4-11(10)7-14)30-20(29-18)26-15-8-12-5-13(12)9-15/h1-3,10-15H,4-9H2,(H2,25,26,28,29,30)	DLSICRMIGDILCI-UHFFFAOYSA-N	279889	US10028961, Compound 36::US10172864, Compound 36::US10946023, Compound 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466413	378161460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532465	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)/t10-/m1/s1	QDXATNXZLOTYRV-SNVBAGLBSA-N	279890	US10028961, Compound 37::US10028961, Compound 87::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532467	C[C@@H](Nc1nc(NC2CCOC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H21F3N6O/c1-10(11-5-6-11)22-16-25-15(13-3-2-4-14(24-13)18(19,20)21)26-17(27-16)23-12-7-8-28-9-12/h2-4,10-12H,5-9H2,1H3,(H2,22,23,25,26,27)/t10-,12?/m1/s1	RWSYXAQFFAQAEC-RWANSRKNSA-N	279891	US10028961, Compound 38::US10172864, Compound 38::US10946023, Compound 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817537	378161462							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532470	CCCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H25F3N6/c1-4-6-11(2)23-17-26-16(14-7-5-8-15(25-14)19(20,21)22)27-18(28-17)24-12(3)13-9-10-13/h5,7-8,11-13H,4,6,9-10H2,1-3H3,(H2,23,24,26,27,28)/t11?,12-/m1/s1	PETSAMLQOBIHSS-PIJUOVFKSA-N	279892	US10028961, Compound 39::US10172864, Compound 39::US10946023, Compound 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799007	378161463							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532472	CC(Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C17H18F3N7/c1-9(8-21)22-15-25-14(12-4-3-5-13(24-12)17(18,19)20)26-16(27-15)23-10(2)11-6-7-11/h3-5,9-11H,6-7H2,1-2H3,(H2,22,23,25,26,27)/t9?,10-/m1/s1	YBMLCUNTUFVOKD-QVDQXJPCSA-N	279893	US10028961, Compound 40::US10172864, Compound 40::US10946023, Compound 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817588	378161464							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532474	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	LYMZYGUSADHRMY-UHFFFAOYSA-N	279894	US10028961, Compound 41::US10172864, Compound 41::US10946023, Compound 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466415	378161465							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532476	C[C@@H](Nc1nc(N[C@H]2CCCC[C@@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H25F3N6O/c1-11(12-9-10-12)24-18-27-17(14-6-4-8-16(25-14)20(21,22)23)28-19(29-18)26-13-5-2-3-7-15(13)30/h4,6,8,11-13,15,30H,2-3,5,7,9-10H2,1H3,(H2,24,26,27,28,29)/t11-,13+,15+/m1/s1	DNYYBCNJEMMGNA-ZLDLUXBVSA-N	279895	US10028961, Compound 42::US10172864, Compound 42::US10946023, Compound 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817502	378161466							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532478	C[C@@H](Nc1nc(N[C@H]2CCC[C@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6O/c1-10(11-8-9-11)23-17-26-16(13-5-3-7-15(24-13)19(20,21)22)27-18(28-17)25-12-4-2-6-14(12)29/h3,5,7,10-12,14,29H,2,4,6,8-9H2,1H3,(H2,23,25,26,27,28)/t10-,12+,14-/m1/s1	UHUHOBBXPQIHRY-SCDSUCTJSA-N	279896	US10028961, Compound 43::US10172864, Compound 43::US10946023, Compound 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			122440835	378161467							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532480	COCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H23F3N6O/c1-10(9-28-3)22-16-25-15(13-5-4-6-14(24-13)18(19,20)21)26-17(27-16)23-11(2)12-7-8-12/h4-6,10-12H,7-9H2,1-3H3,(H2,22,23,25,26,27)/t10?,11-/m1/s1	LUBVUPNBKHPQTK-RRKGBCIJSA-N	279897	US10028961, Compound 44::US10172864, Compound 44::US10946023, Compound 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817089	378161468							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532482	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C18H23ClN6/c1-10(12-6-7-12)20-17-23-16(14-4-3-5-15(19)22-14)24-18(25-17)21-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,20,21,23,24,25)/t10-,11-/m1/s1	GTMXNXATSGQGCH-GHMZBOCLSA-N	279898	US10028961, Compound 45::US10172864, Compound 45::US10946023, Compound 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799064	378161469							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532484	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)/t11-/m1/s1	XYQKRMAHYVIZRA-LLVKDONJSA-N	279899	US10028961, Compound 46::US10028961, Compound 88::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532488	CC(C)(CO)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H20F5N7O/c1-18(2,10-33)32-17-30-15(12-5-4-6-13(28-12)20(23,24)25)29-16(31-17)27-11-7-8-26-14(9-11)19(3,21)22/h4-9,33H,10H2,1-3H3,(H2,26,27,29,30,31,32)	VPNOHMBISYXVRN-UHFFFAOYSA-N	279902	US10028961, Compound 49::US10172864, Compound 49::US10946023, Compound 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279902&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817105	378161473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532491	C[C@@H](Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H23F5N6/c1-11(12-5-6-12)26-17-29-16(14-3-2-4-15(28-14)20(23,24)25)30-18(31-17)27-13-7-9-19(21,22)10-8-13/h2-4,11-13H,5-10H2,1H3,(H2,26,27,29,30,31)/t11-/m1/s1	VHWMBKQPXXLOFJ-LLVKDONJSA-N	279903	US10028961, Compound 50::US10172864, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817596	378161474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532493	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)/t13-,14-/m1/s1	HSMKSLUXGRHQJU-ZIAGYGMSSA-N	279904	US10028961, Compound 51::US10028961, Compound 89::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532495	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F5N6O/c19-17(20)6-4-10(8-17)24-15-27-14(12-2-1-3-13(26-12)18(21,22)23)28-16(29-15)25-11-5-7-30-9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	HBTPVNIAECEEFE-UHFFFAOYSA-N	279905	US10028961, Compound 52::US10172864, Compound 52::US10946023, Compound 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279905&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466560	378161476							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532497	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 53::US10028961, Compound 90::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532499	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 54::US10028961, Compound 91::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532501	CC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H22F5N7O/c1-11(33)32-8-6-13(10-32)27-18-30-16(14-3-2-4-15(28-14)20(23,24)25)29-17(31-18)26-12-5-7-19(21,22)9-12/h2-4,12-13H,5-10H2,1H3,(H2,26,27,29,30,31)	YVNPRQSYAIXEEB-UHFFFAOYSA-N	279908	US10028961, Compound 55::US10172864, Compound 55::US10946023, Compound 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279908&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817503	378161479							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532503	CS(=O)(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7O2S/c1-34(32,33)31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	CCAAECSCQISUPX-UHFFFAOYSA-N	279909	US10028961, Compound 56::US10172864, Compound 56::US10946023, Compound 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279909&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817533	378161480							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532505	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	GWYWLYIKFLDUMQ-VXGBXAGGSA-N	279910	US10028961, Compound 57::US10028961, Compound 92::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532507	C[C@@H](Nc1nc(NC2CC3(C2)CC(F)(F)C3)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H23F5N6/c1-11(12-5-6-12)27-17-30-16(14-3-2-4-15(29-14)21(24,25)26)31-18(32-17)28-13-7-19(8-13)9-20(22,23)10-19/h2-4,11-13H,5-10H2,1H3,(H2,27,28,30,31,32)/t11-/m1/s1	RMLKOVRFURMNDJ-LLVKDONJSA-N	279911	US10028961, Compound 58::US10172864, Compound 58::US10946023, Compound 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279911&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817535	378161482							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532529	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	BDBM279926::US10028961, Compound 4::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532532	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	SBWSJSCKQBEYEK-VXGBXAGGSA-N	279859	US10028961, Compound 6::US10028961, Compound 77::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532533	COc1ccc(F)c(c1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1	InChI=1S/C20H26FN5O/c1-11(13-4-5-13)22-19-24-18(16-10-15(27-3)8-9-17(16)21)25-20(26-19)23-12(2)14-6-7-14/h8-14H,4-7H2,1-3H3,(H2,22,23,24,25,26)/t11-,12-/m1/s1	WWRAJFZRAVDBHX-VXGBXAGGSA-N	279861	US10028961, Compound 78::US10028961, Compound 8::US10172864, Compound 78::US10946023, Compound 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817112	378161432							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532536	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)/t10-/m1/s1	BMMLVEOASUDOHV-SNVBAGLBSA-N	279863	US10028961, Compound 10::US10028961, Compound 79::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532540	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	JCZPGZCYKZMOEK-VXGBXAGGSA-N	279864	US10028961, Compound 11::US10028961, Compound 80::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532543	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t9?,10-/m1/s1	YADRVMCMMMHOSZ-QVDQXJPCSA-N	279865	US10028961, Compound 12::US10028961, Compound 81::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532546	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)/t12-,13-/m1/s1	DXDMRKXHWQBBBA-CHWSQXEVSA-N	279869	US10028961, Compound 16::US10028961, Compound 82::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532549	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)/t12-/m1/s1	YMKOTGDUPIYQMS-GFCCVEGCSA-N	279877	US10028961, Compound 24::US10028961, Compound 83::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532551	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)/t12-,13?/m1/s1	PVBOMIYGGWSXIY-PZORYLMUSA-N	279878	US10028961, Compound 25::US10028961, Compound 84::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532553	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)/t14-/m1/s1	MMQKYUIBTNHALE-CQSZACIVSA-N	279883	US10028961, Compound 30::US10028961, Compound 85::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532557	CC(C)CNc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C17H21FN6O/c1-10(2)8-20-15-21-14(12-7-11(25)5-6-13(12)18)22-16(23-15)24-17(3,4)9-19/h5-7,10,25H,8H2,1-4H3,(H2,20,21,22,23,24)	SXDPYZOSOGORMF-UHFFFAOYSA-N	279936	US10028961, Compound 86::US10172864, Compound 86::US10946023, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279936&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817467	378161495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532559	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)/t10-/m1/s1	QDXATNXZLOTYRV-SNVBAGLBSA-N	279890	US10028961, Compound 37::US10028961, Compound 87::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532561	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)/t11-/m1/s1	XYQKRMAHYVIZRA-LLVKDONJSA-N	279899	US10028961, Compound 46::US10028961, Compound 88::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532563	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)/t13-,14-/m1/s1	HSMKSLUXGRHQJU-ZIAGYGMSSA-N	279904	US10028961, Compound 51::US10028961, Compound 89::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532565	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 53::US10028961, Compound 90::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532567	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 54::US10028961, Compound 91::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532569	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	GWYWLYIKFLDUMQ-VXGBXAGGSA-N	279910	US10028961, Compound 57::US10028961, Compound 92::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532578	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1	QCZAWDGAVJMPTA-RNFRBKRXSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532595	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C20H22F6N6/c1-18(21,22)14-4-2-3-13(29-14)15-30-16(27-11-5-7-19(23,24)9-11)32-17(31-15)28-12-6-8-20(25,26)10-12/h2-4,11-12H,5-10H2,1H3,(H2,27,28,30,31,32)	RZUPVAWGQZNFEZ-UHFFFAOYSA-N	279952	US10028961, Compound 105::US10172864, Compound 105::US10946023, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279952&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817521	378161502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532615	CCC(Nc1nc(NC(CC)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C20H27ClN6/c1-3-14(12-8-9-12)23-19-25-18(16-6-5-7-17(21)22-16)26-20(27-19)24-15(4-2)13-10-11-13/h5-7,12-15H,3-4,8-11H2,1-2H3,(H2,23,24,25,26,27)	SDVGLHHVYYZRJZ-UHFFFAOYSA-N	279957	US10028961, Compound 110::US10172864, Compound 110::US10946023, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279957&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817125	378161507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532628	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-3-1-2-12(26-13)14-27-15(24-10-4-6-17(20,21)8-10)29-16(28-14)25-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	WFTCEDYVKXKHBE-UHFFFAOYSA-N	279960	US10028961, Compound 113::US10172864, Compound 113::US10946023, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279960&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817141	378161510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532637	FC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C19H15ClF5N7/c20-14-3-1-2-12(29-14)15-30-16(27-10-5-7-26-13(8-10)19(23,24)25)32-17(31-15)28-11-4-6-18(21,22)9-11/h1-3,5,7-8,11H,4,6,9H2,(H2,26,27,28,30,31,32)	GCDKECOSGNFZAP-UHFFFAOYSA-N	279962	US10028961, Compound 115::US10172864, Compound 115::US10946023, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279962&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117798735	378161512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532646	CC(C)(C)Nc1nc(Nc2cccc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H18F3N7/c1-19(2,3)30-18-28-16(14-8-5-9-15(26-14)20(21,22)23)27-17(29-18)25-13-7-4-6-12(10-13)11-24/h4-10H,1-3H3,(H2,25,27,28,29,30)	CZMWMJOWERHTGF-UHFFFAOYSA-N	279964	US10028961, Compound 117::US10172864, Compound 117::US10946023, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279964&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799236	378161514							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532662	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1ccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H22F3N7/c1-9(11-3-4-11)21-14-23-15(22-10(2)12-5-6-12)25-16(24-14)27-8-7-13(26-27)17(18,19)20/h7-12H,3-6H2,1-2H3,(H2,21,22,23,24,25)/t9-,10-/m1/s1	ZFCNVKABVPLJJM-NXEZZACHSA-N	279968	US10028961, Compound 121::US10172864, Compound 121::US10946023, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279968&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817536	378161518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532671	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F7N6/c21-10-6-11(22)8-13(7-10)29-18-32-16(14-2-1-3-15(30-14)20(25,26)27)31-17(33-18)28-12-4-5-19(23,24)9-12/h1-3,6-8,12H,4-5,9H2,(H2,28,29,31,32,33)	DTFRDAWQNHNMEU-UHFFFAOYSA-N	279970	US10028961, Compound 123::US10172864, Compound 123::US10946023, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279970&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117798777	378161520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532676	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C21H15F6N7/c22-12-6-11(10-28)7-14(8-12)30-19-33-17(15-2-1-3-16(31-15)21(25,26)27)32-18(34-19)29-13-4-5-20(23,24)9-13/h1-3,6-8,13H,4-5,9H2,(H2,29,30,32,33,34)	NTKHRYLRDAXKRH-UHFFFAOYSA-N	279971	US10028961, Compound 124::US10172864, Compound 124::US10946023, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279971&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799282	378161521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532680	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C21H17F7N6/c22-11-8-12(23)10-14(9-11)30-19-33-17(15-2-1-3-16(31-15)21(26,27)28)32-18(34-19)29-13-4-6-20(24,25)7-5-13/h1-3,8-10,13H,4-7H2,(H2,29,30,32,33,34)	PEKCODXRCQZWOA-UHFFFAOYSA-N	279972	US10028961, Compound 125::US10172864, Compound 125::US10946023, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279972&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817565	378161522							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532684	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F7N7/c16-13(17)3-7(4-13)23-10-25-11(24-8-5-14(18,19)6-8)27-12(26-10)29-2-1-9(28-29)15(20,21)22/h1-2,7-8H,3-6H2,(H2,23,24,25,26,27)	NYHCCPXGTKQDAW-UHFFFAOYSA-N	279973	US10028961, Compound 126::US10172864, Compound 126::US10946023, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279973&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817544	378161523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532688	FC1(F)CCC(C1)Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1	InChI=1S/C22H19ClF2N8/c23-17-3-1-2-15(30-17)18-31-19(33-20(32-18)29-14-4-6-22(24,25)11-14)28-13-5-9-27-16(10-13)21(12-26)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,27,28,29,31,32,33)	ZENVCUIOSQAXHI-UHFFFAOYSA-N	279974	US10028961, Compound 127::US10172864, Compound 127::US10946023, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279974&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799128	378161524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532693	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(10-25-8(5-29-10)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	DSJXHLDOLTTWGN-UHFFFAOYSA-N	279975	US10028961, Compound 128::US10172864, Compound 128::US10946023, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279975&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817465	378161525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532701	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279977	US10028961, Compound 130::US10172864, Compound 130::US10946023, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279977&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817435	378161527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532706	Clc1cccc(n1)-c1nc(NC(C2CC2)C2CC2)nc(NC(C2CC2)C2CC2)n1	InChI=1S/C22H27ClN6/c23-17-3-1-2-16(24-17)20-27-21(25-18(12-4-5-12)13-6-7-13)29-22(28-20)26-19(14-8-9-14)15-10-11-15/h1-3,12-15,18-19H,4-11H2,(H2,25,26,27,28,29)	UYZPRJVBJGBQLI-UHFFFAOYSA-N	279978	US10028961, Compound 131::US10172864, Compound 131::US10946023, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279978&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817455	378161528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532718	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C20H16ClF3N8/c1-11(20(22,23)24)27-17-30-16(13-3-2-4-15(21)29-13)31-18(32-17)28-12-5-8-26-14(9-12)19(10-25)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,26,27,28,30,31,32)	CFSIYYWIWLPLNQ-UHFFFAOYSA-N	279981	US10028961, Compound 134::US10172864, Compound 134::US10946023, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279981&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817443	378161531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532724	C[C@@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7+	QCZAWDGAVJMPTA-KNVOCYPGSA-N	279983	US10028961, Compound 136::US10172864, Compound 136::US10946023, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279983&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817448	378161533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532748	C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m0/s1	QCZAWDGAVJMPTA-BQBZGAKWSA-N	279989	US10028961, Compound 142::US10172864, Compound 142::US10946023, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279989&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817339	378161539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532761	FC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H16F6N6/c18-12(19)10-2-1-3-11(26-10)13-27-14(24-8-4-16(20,21)5-8)29-15(28-13)25-9-6-17(22,23)7-9/h1-3,8-9,12H,4-7H2,(H2,24,25,27,28,29)	CMDVCIGBLUTSCG-UHFFFAOYSA-N	279992	US10028961, Compound 145::US10172864, Compound 145::US10946023, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279992&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466129	378161542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532766	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F7N7/c18-15(19)4-1-9(7-15)25-12-27-13(26-10-2-5-16(20,21)8-10)29-14(28-12)31-6-3-11(30-31)17(22,23)24/h3,6,9-10H,1-2,4-5,7-8H2,(H2,25,26,27,28,29)	MLJRZPLHOBYNMG-UHFFFAOYSA-N	279993	US10028961, Compound 146::US10172864, Compound 146::US10946023, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817473	378161543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532770	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C19H22ClF4N7/c20-14-10-25-9-13(28-14)15-29-16(26-11-1-5-18(21,22)6-2-11)31-17(30-15)27-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,26,27,29,30,31)	MEWHAARPVJKYDP-UHFFFAOYSA-N	279994	US10028961, Compound 147::US10172864, Compound 147::US10946023, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817495	378161544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532778	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	GJNPRCBREKXFRM-UHFFFAOYSA-N	279996	US10028961, Compound 149::US10172864, Compound 149::US10946023, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817132	378161546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532786	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H19F5N8/c1-29-21(8-9-21)17-11-13(6-10-30-17)31-19-34-18(15-3-2-4-16(33-15)23(26,27)28)35-20(36-19)32-14-5-7-22(24,25)12-14/h2-4,6,10-11,14H,5,7-9,12H2,(H2,30,31,32,34,35,36)	LVLCYRFGYKSVJF-UHFFFAOYSA-N	279998	US10028961, Compound 151::US10172864, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123318205	378161548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532791	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccccc3C2)n1	InChI=1S/C23H21F5N6/c24-22(25)9-8-15(12-22)29-20-32-19(17-6-3-7-18(31-17)23(26,27)28)33-21(34-20)30-16-10-13-4-1-2-5-14(13)11-16/h1-7,15-16H,8-12H2,(H2,29,30,32,33,34)	WFJGUJXRROVRQM-UHFFFAOYSA-N	279999	US10028961, Compound 152::US10172864, Compound 152::US10946023, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817119	378161549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532831	CC(C)(C)Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8/c1-18(2,3)30-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)25-11-7-8-24-12(9-11)10-23/h4-9H,1-3H3,(H2,24,25,27,28,29,30)	AJDWHCKBPZAYQS-UHFFFAOYSA-N	280009	US10028961, Compound 162::US10172864, Compound 162::US10946023, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799392	378161559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532839	Fc1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C22H17F6N7/c23-13-8-12(11-29)9-15(10-13)31-20-34-18(16-2-1-3-17(32-16)22(26,27)28)33-19(35-20)30-14-4-6-21(24,25)7-5-14/h1-3,8-10,14H,4-7H2,(H2,30,31,33,34,35)	RAQUPWWEGSOPEV-UHFFFAOYSA-N	280011	US10028961, Compound 164::US10172864, Compound 164::US10946023, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817554	378161561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532849	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C22H21ClN8/c1-13(14-5-6-14)26-20-29-19(16-3-2-4-18(23)28-16)30-21(31-20)27-15-7-10-25-17(11-15)22(12-24)8-9-22/h2-4,7,10-11,13-14H,5-6,8-9H2,1H3,(H2,25,26,27,29,30,31)/t13-/m1/s1	YPMMASFCPXGGFB-CYBMUJFWSA-N	280014	US10028961, Compound 167::US10172864, Compound 167::US10946023, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799158	378161564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532861	FC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(8-5-29-10(25-8)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	PFVOIDGYPOBGID-UHFFFAOYSA-N	280017	US10028961, Compound 170::US10172864, Compound 170::US10946023, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817334	378161567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532885	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)6-1-11(2-7-17)27-14-29-15(28-12-3-8-18(22,23)9-4-12)31-16(30-14)33-10-5-13(32-33)19(24,25)26/h5,10-12H,1-4,6-9H2,(H2,27,28,29,30,31)	SLPLEYMIEBFOSW-UHFFFAOYSA-N	280023	US10028961, Compound 176::US10172864, Compound 176::US10946023, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817355	378161573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532894	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280025	US10028961, Compound 178::US10172864, Compound 178::US10946023, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117798985	378161575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532907	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C20H15F5N8/c21-19(22)6-4-12(9-19)29-18-32-16(14-2-1-3-15(30-14)20(23,24)25)31-17(33-18)28-11-5-7-27-13(8-11)10-26/h1-3,5,7-8,12H,4,6,9H2,(H2,27,28,29,31,32,33)	CPONOLJSMXHPCO-UHFFFAOYSA-N	280028	US10028961, Compound 181::US10172864, Compound 181::US10946023, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799213	378161578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532912	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Cl)cc3C2)n1	InChI=1S/C23H20ClF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	XWCYRXFAEIUJMO-UHFFFAOYSA-N	280029	US10028961, Compound 182::US10172864, Compound 182::US10946023, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817114	378161579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532931	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C18H18F6N6/c1-16(19,20)12-4-2-3-11(27-12)13-28-14(25-9-5-17(21,22)6-9)30-15(29-13)26-10-7-18(23,24)8-10/h2-4,9-10H,5-8H2,1H3,(H2,25,26,28,29,30)	YRSZQQILDIHZRT-UHFFFAOYSA-N	280034	US10028961, Compound 187::US10172864, Compound 187::US10946023, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817115	378161584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532937	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532946	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C21H21F7N6/c22-19(23)5-4-11(8-19)29-16-32-15(13-2-1-3-14(31-13)21(26,27)28)33-17(34-16)30-12-6-18(7-12)9-20(24,25)10-18/h1-3,11-12H,4-10H2,(H2,29,30,32,33,34)	RHCDZLRZYCRNDX-UHFFFAOYSA-N	280038	US10028961, Compound 191::US10172864, Compound 191::US10946023, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817431	378161588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532951	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H17F8N7/c22-19(23)7-4-11(5-8-19)31-17-34-16(13-2-1-3-14(33-13)20(24,25)26)35-18(36-17)32-12-6-9-30-15(10-12)21(27,28)29/h1-3,6,9-11H,4-5,7-8H2,(H2,30,31,32,34,35,36)	ODBLPFGHFKRKHG-UHFFFAOYSA-N	280039	US10028961, Compound 192::US10172864, Compound 192::US10946023, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117798913	378161589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532956	C[C@@H](Nc1nc(NC(C2CC2)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H25F3N6/c1-11(12-5-6-12)25-19-28-18(15-3-2-4-16(26-15)21(22,23)24)29-20(30-19)27-17(13-7-8-13)14-9-10-14/h2-4,11-14,17H,5-10H2,1H3,(H2,25,27,28,29,30)/t11-/m1/s1	IEWNKIUGPADRRO-LLVKDONJSA-N	280040	US10028961, Compound 193::US10172864, Compound 193::US10946023, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817507	378161590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532979	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)/t14-,16?,17+	MVZVTAYGMMCXIJ-FHQBBSRKSA-N	280046	US10028961, Compound 199::US10172864, Compound 199::US10946023, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280046&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532995	C[C@@H](Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H18F6N6/c1-8(10-6-7-10)24-14-27-13(11-4-3-5-12(26-11)17(21,22)23)28-15(29-14)25-9(2)16(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H2,24,25,27,28,29)/t8-,9?/m1/s1	AFJDSJYOWKPURG-VEDVMXKPSA-N	280050	US10028961, Compound 203::US10172864, Compound 203::US10946023, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280050&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817231	378161600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533029	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C19H13F5N8/c20-18(21)7-12(8-18)28-17-31-15(13-2-1-3-14(29-13)19(22,23)24)30-16(32-17)27-10-4-5-26-11(6-10)9-25/h1-6,12H,7-8H2,(H2,26,27,28,30,31,32)	RQRJJSVAJSUINU-UHFFFAOYSA-N	280060	US10028961, Compound 213::US10172864, Compound 213::US10946023, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280060&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817155	378161610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533033	CC(CC#N)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H20F3N7/c1-10(8-9-22)23-16-26-15(13-4-3-5-14(25-13)18(19,20)21)27-17(28-16)24-11(2)12-6-7-12/h3-5,10-12H,6-8H2,1-2H3,(H2,23,24,26,27,28)/t10?,11-/m1/s1	IFMDZJNJPFFCSK-RRKGBCIJSA-N	280061	US10028961, Compound 214::US10172864, Compound 214::US10946023, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280061&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799309	378161611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533062	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C23H23F5N8/c24-22(25)9-7-14(12-22)30-20-33-19(16-4-3-5-17(32-16)23(26,27)28)34-21(35-20)31-15-8-11-36(13-15)18-6-1-2-10-29-18/h1-6,10,14-15H,7-9,11-13H2,(H2,30,31,33,34,35)	TYLCUGJKUXBFOZ-UHFFFAOYSA-N	280069	US10028961, Compound 222::US10172864, Compound 222::US10946023, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280069&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817038	378161619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533066	FC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(12-9-33-14(29-12)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	PFTFOLWIPCINKJ-UHFFFAOYSA-N	280070	US10028961, Compound 223::US10172864, Compound 223::US10946023, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280070&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817026	378161620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533070	FC(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H24F6N6/c22-16(23)14-2-1-3-15(30-14)17-31-18(28-12-4-8-20(24,25)9-5-12)33-19(32-17)29-13-6-10-21(26,27)11-7-13/h1-3,12-13,16H,4-11H2,(H2,28,29,31,32,33)	VPZNRBLRTQODKB-UHFFFAOYSA-N	280071	US10028961, Compound 224::US10172864, Compound 224::US10946023, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280071&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817029	378161621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533076	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H14F6N8/c1-27-18(6-7-18)14-9-11(5-8-28-14)30-17-33-15(32-16(34-17)29-10-19(21,22)23)12-3-2-4-13(31-12)20(24,25)26/h2-5,8-9H,6-7,10H2,(H2,28,29,30,32,33,34)	PFZLERVPZNDZDD-UHFFFAOYSA-N	280073	US10028961, Compound 226::US10172864, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280073&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123942898	378161623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533080	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ncccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H22F5N9/c23-21(24)7-5-13(11-21)30-18-33-17(15-3-1-4-16(32-15)22(25,26)27)34-19(35-18)31-14-6-10-36(12-14)20-28-8-2-9-29-20/h1-4,8-9,13-14H,5-7,10-12H2,(H2,30,31,33,34,35)	YPXQHURHYKDPKF-UHFFFAOYSA-N	280074	US10028961, Compound 227::US10172864, Compound 227::US10946023, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280074&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817030	378161624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533087	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C25H21F5N8/c1-31-23(6-7-23)18-9-14(5-8-32-18)33-20-36-19(16-3-2-4-17(35-16)25(28,29)30)37-21(38-20)34-15-10-22(11-15)12-24(26,27)13-22/h2-5,8-9,15H,6-7,10-13H2,(H2,32,33,34,36,37,38)	QOYBVQHDVXHECC-UHFFFAOYSA-N	280076	US10028961, Compound 229::US10172864, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123245946	378161626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533095	CC(C)(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H19F5N8/c1-19(2,8-9-27)34-18-32-16(13-5-4-6-14(30-13)21(24,25)26)31-17(33-18)29-12-7-10-28-15(11-12)20(3,22)23/h4-7,10-11H,8H2,1-3H3,(H2,28,29,31,32,33,34)	BFTBMPMZGISYIU-UHFFFAOYSA-N	280078	US10028961, Compound 231::US10172864, Compound 231::US10946023, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117800590	378161628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533114	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-13(12-26-6-3-11(29-12)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	KWUXKJRKEMYSCZ-UHFFFAOYSA-N	280084	US10028961, Compound 237::US10172864, Compound 237::US10946023, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817165	378161634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533124	CC(C)OCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H27F3N6O/c1-11(2)30-10-12(3)24-18-27-17(15-6-5-7-16(26-15)20(21,22)23)28-19(29-18)25-13(4)14-8-9-14/h5-7,11-14H,8-10H2,1-4H3,(H2,24,25,27,28,29)/t12?,13-/m1/s1	HNZFJEZPGBZOCO-ZGTCLIOFSA-N	280088	US10028961, Compound 241::US10172864, Compound 241::US10946023, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280088&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817568	378161638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533126	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(cc3C2)C#N)n1	InChI=1S/C24H20F5N7/c25-23(26)7-6-16(11-23)31-21-34-20(18-2-1-3-19(33-18)24(27,28)29)35-22(36-21)32-17-9-14-5-4-13(12-30)8-15(14)10-17/h1-5,8,16-17H,6-7,9-11H2,(H2,31,32,34,35,36)	TXAOJZZVXLZXJJ-UHFFFAOYSA-N	280089	US10028961, Compound 242::US10172864, Compound 242::US10946023, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817436	378161639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533130	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F4N7O/c1-19(2,32)10-26-17-29-16(14-4-3-5-15(28-14)20(22,23)24)30-18(31-17)27-13-7-11(9-25)6-12(21)8-13/h3-8,32H,10H2,1-2H3,(H2,26,27,29,30,31)	MVCBBRZTMZDXPK-UHFFFAOYSA-N	280091	US10028961, Compound 244::US10172864, Compound 244::US10946023, Compound 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117798806	378161641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533135	CC(C)(C)Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H16F4N8/c1-18(2,3)31-17-29-15(14-25-5-4-13(27-14)19(21,22)23)28-16(30-17)26-12-7-10(9-24)6-11(20)8-12/h4-8H,1-3H3,(H2,26,28,29,30,31)	TWTMGQUEQUWIKR-UHFFFAOYSA-N	280092	US10028961, Compound 245::US10172864, Compound 245::US10946023, Compound 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280092&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817542	378161642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533139	C[C@@H](Nc1nc(NCCOc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6O/c1-14(15-10-11-15)27-21-30-19(17-8-5-9-18(28-17)22(23,24)25)29-20(31-21)26-12-13-32-16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,26,27,29,30,31)/t14-/m1/s1	YVNVAIVKELSNHE-CQSZACIVSA-N	280093	US10028961, Compound 246::US10172864, Compound 246::US10946023, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817294	378161643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533143	CC(C)(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C20H17F5N8/c1-18(2,10-26)33-17-31-15(12-5-4-6-13(29-12)20(23,24)25)30-16(32-17)28-11-7-8-27-14(9-11)19(3,21)22/h4-9H,1-3H3,(H2,27,28,30,31,32,33)	BDJHMJRZDMMMSY-UHFFFAOYSA-N	280094	US10028961, Compound 247::US10172864, Compound 247::US10946023, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799111	378161644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533147	CC(C)(O)CNc1nc(Nc2cccc(Cl)c2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H18ClF3N6O/c1-18(2,30)10-24-16-27-15(13-7-4-8-14(26-13)19(21,22)23)28-17(29-16)25-12-6-3-5-11(20)9-12/h3-9,30H,10H2,1-2H3,(H2,24,25,27,28,29)	NRKSVSMTVTZXKR-UHFFFAOYSA-N	280095	US10028961, Compound 248::US10172864, Compound 248::US10946023, Compound 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280095&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817492	378161645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533155	CC(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F5N8/c1-11(6-8-26)28-17-31-16(13-4-3-5-14(30-13)20(23,24)25)32-18(33-17)29-12-7-9-27-15(10-12)19(2,21)22/h3-5,7,9-11H,6H2,1-2H3,(H2,27,28,29,31,32,33)	KFKFZAMDAKZTOH-UHFFFAOYSA-N	280097	US10028961, Compound 250::US10172864, Compound 250::US10946023, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117800753	378161647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533163	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6O/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)33-19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	MQELCCGCZSQGHW-UHFFFAOYSA-N	280099	US10028961, Compound 252::US10172864, Compound 252::US10946023, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817037	378161649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533167	CC(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C19H15F5N8/c1-10(9-25)27-16-30-15(12-4-3-5-13(29-12)19(22,23)24)31-17(32-16)28-11-6-7-26-14(8-11)18(2,20)21/h3-8,10H,1-2H3,(H2,26,27,28,30,31,32)	DOYNKYWVGHFSIP-UHFFFAOYSA-N	280100	US10028961, Compound 253::US10172864, Compound 253::US10946023, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280100&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799196	378161650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533172	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOCC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-19(22)8-4-12(5-9-19)26-17-29-16(14-2-1-3-15(28-14)20(23,24)25)30-18(31-17)27-13-6-10-32-11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	XOGJBAWBFBEDJT-UHFFFAOYSA-N	280102	US10028961, Compound 255::US10172864, Compound 255::US10946023, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817036	378161652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533175	FC(F)(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-11(10-24-2-1-9(27-10)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	FPHDGFLOXFTVGJ-UHFFFAOYSA-N	280103	US10028961, Compound 256::US10172864, Compound 256::US10946023, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817034	378161653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533179	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)	BTPLBROFKCBOEI-UHFFFAOYSA-N	280104	US10028961, Compound 257::US10172864, Compound 257::US10946023, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799484	378161654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533189	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C20H16F6N6/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(24)29-16)30-18(32-19)27-12-3-5-20(25,26)6-4-12/h1-2,7-9,12H,3-6H2,(H2,27,28,30,31,32)	KQPYGTOTVLIIEB-UHFFFAOYSA-N	280107	US10028961, Compound 260::US10172864, Compound 260::US10946023, Compound 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280107&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817161	378161657							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533194	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280108	US10028961, Compound 261::US10172864, Compound 261::US10946023, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799322	378161658							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533198	C[C@@H](Nc1nc(NCC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H22F3N7/c1-11(12-7-8-12)25-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)24-10-18(2,3)9-23/h4-6,11-12H,7-8,10H2,1-3H3,(H2,24,25,27,28,29)/t11-/m1/s1	YMYMOIAVHSSRHV-LLVKDONJSA-N	280109	US10028961, Compound 262::US10172864, Compound 262::US10946023, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817189	378161659							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533200	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)C(=O)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H24F5N7O/c26-24(27)11-9-16(13-24)31-22-34-20(18-7-4-8-19(33-18)25(28,29)30)35-23(36-22)32-17-10-12-37(14-17)21(38)15-5-2-1-3-6-15/h1-8,16-17H,9-14H2,(H2,31,32,34,35,36)	IGICKZPCOKPPMZ-UHFFFAOYSA-N	280110	US10028961, Compound 263::US10172864, Compound 263::US10946023, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817170	378161660							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533205	FC1(F)CC2(CC(C2)Nc2nc(NC3CC4(C3)CC(F)(F)C4)nc(n2)-c2cccc(Cl)n2)C1	InChI=1S/C22H23ClF4N6/c23-15-3-1-2-14(30-15)16-31-17(28-12-4-19(5-12)8-21(24,25)9-19)33-18(32-16)29-13-6-20(7-13)10-22(26,27)11-20/h1-3,12-13H,4-11H2,(H2,28,29,31,32,33)	PBFHHOMGSNGWEC-UHFFFAOYSA-N	280112	US10028961, Compound 265::US10172864, Compound 265::US10946023, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817162	378161662							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533207	CS(=O)(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H26F5N7O2S/c1-36(34,35)33-11-7-14(8-12-33)28-19-31-17(15-3-2-4-16(29-15)21(24,25)26)30-18(32-19)27-13-5-9-20(22,23)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,27,28,30,31,32)	XMCNRFYMKPJZQG-UHFFFAOYSA-N	280113	US10028961, Compound 266::US10172864, Compound 266::US10946023, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817164	378161663							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533210	CC(C)(CNc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C21H19F5N8/c1-19(2,10-27)11-29-17-32-16(13-5-4-6-14(31-13)21(24,25)26)33-18(34-17)30-12-7-8-28-15(9-12)20(3,22)23/h4-9H,11H2,1-3H3,(H2,28,29,30,32,33,34)	LWUOICMGVABMMB-UHFFFAOYSA-N	280114	US10028961, Compound 267::US10172864, Compound 267::US10946023, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280114&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117800203	378161664							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533214	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1nccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H22F3N7/c1-9(11-3-4-11)23-16-26-15(14-22-8-7-13(25-14)18(19,20)21)27-17(28-16)24-10(2)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,23,24,26,27,28)/t9-,10-/m1/s1	DDVPWDBXRXZEBC-NXEZZACHSA-N	280115	US10028961, Compound 268::US10172864, Compound 268::US10946023, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817172	378161665							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533220	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-14(13-5-10-28-15(31-13)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	VFDBHGHEXPAMBP-UHFFFAOYSA-N	280117	US10028961, Compound 270::US10172864, Compound 270::US10946023, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817589	378161667							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533224	CC(CC#N)Nc1nc(NC(C)C[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C16H17ClN8/c1-10(7-8-18)20-15-23-14(12-5-4-6-13(17)22-12)24-16(25-15)21-11(2)9-19-3/h4-6,10-11H,7,9H2,1-2H3,(H2,20,21,23,24,25)	DPKMJIDGQOHGGQ-UHFFFAOYSA-N	280118	US10028961, Compound 271::US10172864, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			124023000	378161668							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533226	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)/t18-,19-,22+,23+	NMLSZZYWTRQLTB-MBEIMAIZSA-N	280119	US10028961, Compound 272::US10172864, Compound 272::US10946023, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161669							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533231	CC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H26F5N7O/c1-13(35)34-11-7-15(8-12-34)29-20-32-18(16-3-2-4-17(30-16)22(25,26)27)31-19(33-20)28-14-5-9-21(23,24)10-6-14/h2-4,14-15H,5-12H2,1H3,(H2,28,29,31,32,33)	PVZIUYNREPTYEJ-UHFFFAOYSA-N	280120	US10028961, Compound 273::US10172864, Compound 273::US10946023, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817549	378161670							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533234	CC(C)(C)OC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C25H32F5N7O2/c1-23(2,3)39-22(38)37-13-9-16(10-14-37)32-21-35-19(17-5-4-6-18(33-17)25(28,29)30)34-20(36-21)31-15-7-11-24(26,27)12-8-15/h4-6,15-16H,7-14H2,1-3H3,(H2,31,32,34,35,36)	MMAPFCIIBGUZQG-UHFFFAOYSA-N	280121	US10028961, Compound 274::US10172864, Compound 274::US10946023, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817557	378161671							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533237	Fc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F6N6/c21-13-1-2-14(22)29-15(13)16-30-17(27-11-3-7-19(23,24)8-4-11)32-18(31-16)28-12-5-9-20(25,26)10-6-12/h1-2,11-12H,3-10H2,(H2,27,28,30,31,32)	PKVKJUWOHXPGCE-UHFFFAOYSA-N	280123	US10028961, Compound 276::US10172864, Compound 276::US10946023, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799150	378161673							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533245	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(I)cn1)C1CC1	InChI=1S/C16H22IN7/c1-9(11-3-4-11)19-14-21-15(20-10(2)12-5-6-12)23-16(22-14)24-8-13(17)7-18-24/h7-12H,3-6H2,1-2H3,(H2,19,20,21,22,23)/t9-,10-/m1/s1	XKHRDUPMIXLGTD-NXEZZACHSA-N	280126	US10028961, Compound 279::US10172864, Compound 279::US10946023, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817477	378161676							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533249	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(Cc3ccccc3)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H26F5N7/c26-24(27)11-9-17(13-24)31-22-34-21(19-7-4-8-20(33-19)25(28,29)30)35-23(36-22)32-18-10-12-37(15-18)14-16-5-2-1-3-6-16/h1-8,17-18H,9-15H2,(H2,31,32,34,35,36)	UWVLIFBOSBPFON-UHFFFAOYSA-N	280127	US10028961, Compound 280::US10172864, Compound 280::US10946023, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817414	378161677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533269	CC(C)(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H19F5N8/c1-17(2,3)32-16-30-14(13-26-8-6-11(28-13)19(22,23)24)29-15(31-16)27-10-5-7-25-12(9-10)18(4,20)21/h5-9H,1-4H3,(H2,25,27,29,30,31,32)	VVDJVXUCSQFDNF-UHFFFAOYSA-N	280136	US10028961, Compound 289::US10172864, Compound 289::US10946023, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280136&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817459	378161686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533277	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-15(14-28-10-5-13(31-14)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	MDCZNBIZILVZSF-UHFFFAOYSA-N	280140	US10028961, Compound 293::US10172864, Compound 293::US10946023, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280140&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817463	378161690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533283	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6O/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)35-21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	HSAOXCHGPDCXKT-UHFFFAOYSA-N	280143	US10028961, Compound 296::US10172864, Compound 296::US10946023, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817462	378161693							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533285	FC(F)(F)c1n[nH]cc1-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)5-1-10(2-6-17)28-15-30-14(12-9-27-33-13(12)19(24,25)26)31-16(32-15)29-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H,27,33)(H2,28,29,30,31,32)	WYHVNJNVMROQBY-UHFFFAOYSA-N	280144	US10028961, Compound 297::US10172864, Compound 297::US10946023, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817464	378161694							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533287	CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)	MNWAUMZTPYXVGO-UHFFFAOYSA-N	280145	US10028961, Compound 298::US10172864, Compound 298::US10946023, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117798710	378161695							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533293	Cc1nc(co1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-20-10(6-26-7)11-23-12(21-8-2-14(16,17)3-8)25-13(24-11)22-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H2,21,22,23,24,25)	YBHPSBQYBQRDEV-UHFFFAOYSA-N	280148	US10028961, Compound 301::US10172864, Compound 301::US10946023, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817319	378161698							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533295	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-n1cc(Cl)cn1	InChI=1S/C18H22ClF4N7/c19-11-9-24-30(10-11)16-28-14(25-12-1-5-17(20,21)6-2-12)27-15(29-16)26-13-3-7-18(22,23)8-4-13/h9-10,12-13H,1-8H2,(H2,25,26,27,28,29)	QSWMJNNVEMLNDB-UHFFFAOYSA-N	280149	US10028961, Compound 302::US10172864, Compound 302::US10946023, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817332	378161699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533309	Cc1cc(no1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-2-10(25-26-7)11-22-12(20-8-3-14(16,17)4-8)24-13(23-11)21-9-5-15(18,19)6-9/h2,8-9H,3-6H2,1H3,(H2,20,21,22,23,24)	JWLFPLOMUNYBLN-UHFFFAOYSA-N	280158	US10028961, Compound 311::US10172864, Compound 311::US10946023, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817411	378161708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533320	COc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F5N6O/c1-33-15-3-2-14(22)16(29-15)17-30-18(27-12-4-8-20(23,24)9-5-12)32-19(31-17)28-13-6-10-21(25,26)11-7-13/h2-3,12-13H,4-11H2,1H3,(H2,27,28,30,31,32)	PUYRUGBORWDDDV-UHFFFAOYSA-N	280168	US10028961, Compound 321::US10172864, Compound 321::US10946023, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817329	378161718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533325	CC(C)(O)CNc1nc(Nc2cc(F)cc(F)c2)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H16F5N7O/c1-17(2,31)8-25-15-28-14(13-24-4-3-12(27-13)18(21,22)23)29-16(30-15)26-11-6-9(19)5-10(20)7-11/h3-7,31H,8H2,1-2H3,(H2,25,26,28,29,30)	MDLNQVWWUAJKJT-UHFFFAOYSA-N	280172	US10028961, Compound 325::US10172864, Compound 325::US10946023, Compound 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799047	378161722							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533517	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m1/s1	MEKMADZCSPFPMP-VXGBXAGGSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533519	C[C@@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12+	MEKMADZCSPFPMP-TXEJJXNPSA-N	280256	US10028961, Compound 415::US10172864, Compound 415::US10946023, Compound 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817171	378161805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533522	C[C@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m0/s1	MEKMADZCSPFPMP-RYUDHWBXSA-N	280257	US10028961, Compound 416::US10172864, Compound 416::US10946023, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817194	378161806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533524	C[C@@H](Nc1cc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H24F3N5/c1-11(12-8-9-12)23-15-10-16(27-18(2,3)4)26-17(25-15)13-6-5-7-14(24-13)19(20,21)22/h5-7,10-12H,8-9H2,1-4H3,(H2,23,25,26,27)/t11-/m1/s1	SICOBUZBFFTRIB-LLVKDONJSA-N	280258	US10028961, Compound 417::US10172864, Compound 417::US10946023, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817175	378161807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533537	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1	QCZAWDGAVJMPTA-RNFRBKRXSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533547	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C17H12F7N7/c18-8-3-9(19)5-10(4-8)25-13-27-14(26-11-6-16(20,21)7-11)29-15(28-13)31-2-1-12(30-31)17(22,23)24/h1-5,11H,6-7H2,(H2,25,26,27,28,29)	XSFFZJKIWXEYIL-UHFFFAOYSA-N	279953	US10028961, Compound 106::US10172864, Compound 106::US10946023, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279953&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799077	378161503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533600	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)/t14-/m0/s1	FQOVWGJWJAOWBO-AWEZNQCLSA-N	279980	US10028961, Compound 133::US10172864, Compound 133::US10946023, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279980&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817510	378161530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533608	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)/t14-/m1/s1	FQOVWGJWJAOWBO-CQSZACIVSA-N	279984	US10028961, Compound 137::US10172864, Compound 137::US10946023, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279984&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799135	378161534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533647	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)/t11-/m0/s1	PDXMOPYZKDLAPA-NSHDSACASA-N	280005	US10028961, Compound 158::US10172864, Compound 158::US10946023, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799020	378161555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533652	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)5-1-11(2-6-18)29-16-32-15(13-9-28-10-14(31-13)20(25,26)27)33-17(34-16)30-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,29,30,32,33,34)	SUGBJFIPDULVRS-UHFFFAOYSA-N	280007	US10028961, Compound 160::US10172864, Compound 160::US10946023, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817538	378161557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533655	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)1-7(2-14)25-12-28-11(9-5-24-6-10(27-9)16(21,22)23)29-13(30-12)26-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,25,26,28,29,30)	BJUUMSAHTGGBTK-UHFFFAOYSA-N	280008	US10028961, Compound 161::US10172864, Compound 161::US10946023, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817567	378161558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533670	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-12(5-8-29-16)30-18-33-17(14-3-2-4-15(32-14)22(25,26)27)34-19(35-18)31-13-10-21(23,24)11-13/h2-5,8-9,13H,6-7,10-11H2,(H2,29,30,31,33,34,35)	MNROPBMECNHKDS-UHFFFAOYSA-N	280015	US10028961, Compound 168::US10172864, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123886256	378161565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533683	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)/t13-/m0/s1	ZSYUHTUAGISLHX-ZDUSSCGKSA-N	280021	US10028961, Compound 174::US10172864, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123271414	378161571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533713	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533716	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-10(8-17)30-16-33-14(11-2-1-3-12(31-11)18(22,23)24)32-15(34-16)29-9-4-5-28-13(6-9)19(25,26)27/h1-6,10H,7-8H2,(H2,28,29,30,32,33,34)	VURZKJCJGOOOFL-UHFFFAOYSA-N	280037	US10028961, Compound 190::US10172864, Compound 190::US10946023, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817505	378161587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533924	FC(F)(F)c1ccn(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)/t13-/m1/s1	WFGLMCWPQJGAJJ-CYBMUJFWSA-N	280192	US10028961, Compound 350::US10946023, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799289	378161741							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534004	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H16F8N8/c21-18(22)4-1-10(2-5-18)31-16-34-15(12-8-29-9-14(33-12)20(26,27)28)35-17(36-16)32-11-3-6-30-13(7-11)19(23,24)25/h3,6-10H,1-2,4-5H2,(H2,30,31,32,34,35,36)	DZAOGXHFTBFLFH-UHFFFAOYSA-N	280231	US10028961, Compound 389::US10172864, Compound 389::US10946023, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817166	378161780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534010	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)/t10-/m0/s1	ONCVYPCVWHYEJW-JTQLQIEISA-N	280233	US10028961, Compound 391::US10172864, Compound 391::US10946023, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799014	378161782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534016	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)/t10-/m0/s1	RACFSMUYWZWUMF-JTQLQIEISA-N	280235	US10028961, Compound 393::US10172864, Compound 393::US10946023, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799021	378161784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534029	C[C@@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)/t7-/m1/s1	ORPDRKJAHZEOLR-SSDOTTSWSA-N	280241	US10028961, Compound 400::US10172864, Compound 400::US10946023, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817128	378161790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534033	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H16F5N9/c22-20(23)6-12(7-20)31-18-34-16(13-8-28-9-15(32-13)21(24,25)26)33-17(35-18)30-11-1-4-29-14(5-11)19(10-27)2-3-19/h1,4-5,8-9,12H,2-3,6-7H2,(H2,29,30,31,33,34,35)	POVDFECNFQEJSG-UHFFFAOYSA-N	280242	US10028961, Compound 401::US10946023, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280242&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799510	378161791							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534053	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)/t9-,10-/m1/s1	YWUBJNPVIIBDPD-NXEZZACHSA-N	280251	US10028961, Compound 410::US10172864, Compound 410::US10946023, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817192	378161800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534061	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m1/s1	MEKMADZCSPFPMP-VXGBXAGGSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	5K10,5K11,6IO0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617047	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)nc(NCC2CC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-3-1-2-12(23-13)14-24-15(21-8-10-4-5-10)26-16(25-14)22-9-11-6-7-11/h1-3,10-11H,4-9H2,(H2,21,22,24,25,26)	KNDBYTOOVAJFRN-UHFFFAOYSA-N	279854	US10028961, Compound 1::US10172864, Compound 1::US10946023, Compound 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817069	378161425							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617050	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)	KRSKURCJOGAEOS-UHFFFAOYSA-N	279855	US10028961, Compound 2::US10172864, Compound 2::US10946023, Compound 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817076	378161426							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617053	CC(C)Nc1nc(NC(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6/c1-8(2)19-13-22-12(23-14(24-13)20-9(3)4)10-6-5-7-11(21-10)15(16,17)18/h5-9H,1-4H3,(H2,19,20,22,23,24)	WDSFOQJWJKBMPM-UHFFFAOYSA-N	279856	US10028961, Compound 3::US10172864, Compound 3::US10946023, Compound 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817527	378161427							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617055	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	US10028961, Compound 4::BDBM279926::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617059	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1 |r|	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)	SBWSJSCKQBEYEK-UHFFFAOYSA-N	279859	US10028961, Compound 77::US10028961, Compound 6::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617061	FC(F)(F)c1cccc(n1)-c1nc(NCC2CCC2)nc(NCC2CCC2)n1	InChI=1S/C19H23F3N6/c20-19(21,22)15-9-3-8-14(25-15)16-26-17(23-10-12-4-1-5-12)28-18(27-16)24-11-13-6-2-7-13/h3,8-9,12-13H,1-2,4-7,10-11H2,(H2,23,24,26,27,28)	VPNNRJRDRDIMTN-UHFFFAOYSA-N	279860	US10028961, Compound 7::US10172864, Compound 7::US10946023, Compound 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466271	378161431							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617063	COc1ccc(F)c(c1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1 |r|	InChI=1S/C20H26FN5O/c1-11(13-4-5-13)22-19-24-18(16-10-15(27-3)8-9-17(16)21)25-20(26-19)23-12(2)14-6-7-14/h8-14H,4-7H2,1-3H3,(H2,22,23,24,25,26)	WWRAJFZRAVDBHX-UHFFFAOYSA-N	279861	US10028961, Compound 78::US10028961, Compound 8::US10172864, Compound 78::US10946023, Compound 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817112	378161432							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617066	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC2)nc(NC2CCC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-9-3-8-12(23-13)14-24-15(21-10-4-1-5-10)26-16(25-14)22-11-6-2-7-11/h3,8-11H,1-2,4-7H2,(H2,21,22,24,25,26)	PVIJXHIYMYVGOF-UHFFFAOYSA-N	279862	US10028961, Compound 9::US10172864, Compound 9::US10946023, Compound 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466412	378161433							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617069	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)	BMMLVEOASUDOHV-UHFFFAOYSA-N	279863	US10028961, Compound 79::US10028961, Compound 10::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617072	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1 |r|	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)	JCZPGZCYKZMOEK-UHFFFAOYSA-N	279864	US10028961, Compound 80::US10028961, Compound 11::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617075	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)	YADRVMCMMMHOSZ-UHFFFAOYSA-N	279865	US10028961, Compound 81::US10028961, Compound 12::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617078	CC(C)C(C)Nc1nc(NC(C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279866	US10028961, Compound 13::US10172864, Compound 13::US10946023, Compound 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466273	378161437							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617080	CC(O)CNc1nc(NCC(C)O)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6O2/c1-8(25)6-19-13-22-12(23-14(24-13)20-7-9(2)26)10-4-3-5-11(21-10)15(16,17)18/h3-5,8-9,25-26H,6-7H2,1-2H3,(H2,19,20,22,23,24)	QYMUDBQWLSGBAS-UHFFFAOYSA-N	279867	US10028961, Compound 14::US10172864, Compound 14::US10946023, Compound 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817085	378161438							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617083	C[C@@H](Nc1nc(NCC(C)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H19F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,10-11H,6-8H2,1-2H3,(H2,21,22,24,25,26)	GZYMCQBNCUYDKE-UHFFFAOYSA-N	279868	US10028961, Compound 15::US10172864, Compound 15::US10946023, Compound 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817099	378161439							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617085	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1 |r|	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)	DXDMRKXHWQBBBA-UHFFFAOYSA-N	279869	US10028961, Compound 82::US10028961, Compound 16::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617088	CC(C)[C@H](C)Nc1nc(N[C@@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279870	US10028961, Compound 17::US10172864, Compound 17::US10946023, Compound 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817087	378161441							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617090	CC(C)[C@@H](C)Nc1nc(N[C@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279871	US10028961, Compound 18::US10172864, Compound 18::US10946023, Compound 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817080	378161442							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617092	C[C@@H](Nc1nc(N[C@H](C)C2CCC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CCC1 |r|	InChI=1S/C21H27F3N6/c1-12(14-6-3-7-14)25-19-28-18(16-10-5-11-17(27-16)21(22,23)24)29-20(30-19)26-13(2)15-8-4-9-15/h5,10-15H,3-4,6-9H2,1-2H3,(H2,25,26,28,29,30)	HTFFUPGDRXDEIP-UHFFFAOYSA-N	279872	US10028961, Compound 19::US10172864, Compound 19::US10946023, Compound 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817233	378161443							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617095	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)	YJZZCQZAKQBAMU-UHFFFAOYSA-N	279873	US10028961, Compound 20::US10172864, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817082	378161444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617098	C[C@@H](Nc1nc(NCc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H21F3N6/c1-13(15-10-11-15)26-20-29-18(16-8-5-9-17(27-16)21(22,23)24)28-19(30-20)25-12-14-6-3-2-4-7-14/h2-9,13,15H,10-12H2,1H3,(H2,25,26,28,29,30)	IUYXTIDKXVUWDD-UHFFFAOYSA-N	279874	US10028961, Compound 21::US10172864, Compound 21::US10946023, Compound 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817101	378161445							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617101	C[C@@H](Nc1nc(N[C@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)	YJZZCQZAKQBAMU-UHFFFAOYSA-N	279875	US10028961, Compound 22::US10172864, Compound 22::US10946023, Compound 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817118	378161446							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617104	C[C@@H](Nc1nc(N[C@@H]2C[C@H]2c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-13(14-10-11-14)27-21-30-20(17-8-5-9-19(28-17)23(24,25)26)31-22(32-21)29-18-12-16(18)15-6-3-2-4-7-15/h2-9,13-14,16,18H,10-12H2,1H3,(H2,27,29,30,31,32)	MPVKJRGUFDYPQR-UHFFFAOYSA-N	279876	US10028961, Compound 23::US10172864, Compound 23::US10946023, Compound 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817033	378161447							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617106	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)	YMKOTGDUPIYQMS-UHFFFAOYSA-N	279877	US10028961, Compound 83::US10028961, Compound 24::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617108	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)	PVBOMIYGGWSXIY-UHFFFAOYSA-N	279878	US10028961, Compound 84::US10028961, Compound 25::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617110	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)c1ccccc1 |r|	InChI=1S/C25H23F3N6/c1-16(18-10-5-3-6-11-18)29-23-32-22(20-14-9-15-21(31-20)25(26,27)28)33-24(34-23)30-17(2)19-12-7-4-8-13-19/h3-17H,1-2H3,(H2,29,30,32,33,34)	LBAZIFOJZOIFON-UHFFFAOYSA-N	279879	US10028961, Compound 26::US10172864, Compound 26::US10946023, Compound 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817147	378161450							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617113	C[C@@H](Nc1nc(NC(C)c2cccc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H22F6N6/c1-12(14-9-10-14)30-20-33-19(17-7-4-8-18(32-17)23(27,28)29)34-21(35-20)31-13(2)15-5-3-6-16(11-15)22(24,25)26/h3-8,11-14H,9-10H2,1-2H3,(H2,30,31,33,34,35)	OUNUKDITMWXSMU-UHFFFAOYSA-N	279880	US10028961, Compound 27::US10172864, Compound 27::US10946023, Compound 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817140	378161451							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617116	C[C@@H](Nc1nc(NC(C)c2cccc(F)c2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H22F4N6/c1-12(14-9-10-14)27-20-30-19(17-7-4-8-18(29-17)22(24,25)26)31-21(32-20)28-13(2)15-5-3-6-16(23)11-15/h3-8,11-14H,9-10H2,1-2H3,(H2,27,28,30,31,32)	JYVZJECTMOHVFX-UHFFFAOYSA-N	279881	US10028961, Compound 28::US10172864, Compound 28::US10946023, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817145	378161452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617118	C[C@@H](Nc1nc(NC(=O)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H19F3N6O/c1-12(13-10-11-13)25-19-27-17(15-8-5-9-16(26-15)21(22,23)24)28-20(30-19)29-18(31)14-6-3-2-4-7-14/h2-9,12-13H,10-11H2,1H3,(H2,25,27,28,29,30,31)	IQRLKQDCDTZTJN-UHFFFAOYSA-N	279882	US10028961, Compound 29::US10172864, Compound 29::US10946023, Compound 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817153	378161453							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617120	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)	MMQKYUIBTNHALE-UHFFFAOYSA-N	279883	US10028961, Compound 85::US10028961, Compound 30::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617123	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279884	US10028961, Compound 31::US10172864, Compound 31::US10946023, Compound 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86580656	378161455							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617126	COc1ccc(F)c(c1)-c1nc(NC(C)C)nc(NC(C)(C)C#N)n1	InChI=1S/C17H21FN6O/c1-10(2)20-15-21-14(12-8-11(25-5)6-7-13(12)18)22-16(23-15)24-17(3,4)9-19/h6-8,10H,1-5H3,(H2,20,21,22,23,24)	JTBPNQFDWIZOKU-UHFFFAOYSA-N	279885	US10028961, Compound 32::US10172864, Compound 32::US10946023, Compound 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799404	378161456							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617128	C[C@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)	KRSKURCJOGAEOS-UHFFFAOYSA-N	279886	US10028961, Compound 33::US10172864, Compound 33::US10946023, Compound 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817234	378161457							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617130	C[C@@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)	KRSKURCJOGAEOS-UHFFFAOYSA-N	279887	US10028961, Compound 34::US10172864, Compound 34::US10946023, Compound 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817526	378161458							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617132	CC(C)Nc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C16H19FN6O/c1-9(2)19-14-20-13(11-7-10(24)5-6-12(11)17)21-15(22-14)23-16(3,4)8-18/h5-7,9,24H,1-4H3,(H2,19,20,21,22,23)	ZKCSHTWHAVTEDI-UHFFFAOYSA-N	279888	US10028961, Compound 35::US10172864, Compound 35::US10946023, Compound 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817394	378161459							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617135	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3CC3C2)nc(NC2CC3CC3C2)n1	InChI=1S/C21H23F3N6/c22-21(23,24)17-3-1-2-16(27-17)18-28-19(25-14-6-10-4-11(10)7-14)30-20(29-18)26-15-8-12-5-13(12)9-15/h1-3,10-15H,4-9H2,(H2,25,26,28,29,30)	DLSICRMIGDILCI-UHFFFAOYSA-N	279889	US10028961, Compound 36::US10172864, Compound 36::US10946023, Compound 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466413	378161460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617137	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)	QDXATNXZLOTYRV-UHFFFAOYSA-N	279890	US10028961, Compound 87::US10028961, Compound 37::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617139	C[C@@H](Nc1nc(NC2CCOC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H21F3N6O/c1-10(11-5-6-11)22-16-25-15(13-3-2-4-14(24-13)18(19,20)21)26-17(27-16)23-12-7-8-28-9-12/h2-4,10-12H,5-9H2,1H3,(H2,22,23,25,26,27)	RWSYXAQFFAQAEC-UHFFFAOYSA-N	279891	US10028961, Compound 38::US10172864, Compound 38::US10946023, Compound 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817537	378161462							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617141	CCCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H25F3N6/c1-4-6-11(2)23-17-26-16(14-7-5-8-15(25-14)19(20,21)22)27-18(28-17)24-12(3)13-9-10-13/h5,7-8,11-13H,4,6,9-10H2,1-3H3,(H2,23,24,26,27,28)	PETSAMLQOBIHSS-UHFFFAOYSA-N	279892	US10028961, Compound 39::US10172864, Compound 39::US10946023, Compound 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799007	378161463							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617143	CC(Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C#N |r|	InChI=1S/C17H18F3N7/c1-9(8-21)22-15-25-14(12-4-3-5-13(24-12)17(18,19)20)26-16(27-15)23-10(2)11-6-7-11/h3-5,9-11H,6-7H2,1-2H3,(H2,22,23,25,26,27)	YBMLCUNTUFVOKD-UHFFFAOYSA-N	279893	US10028961, Compound 40::US10172864, Compound 40::US10946023, Compound 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817588	378161464							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617145	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	LYMZYGUSADHRMY-UHFFFAOYSA-N	279894	US10028961, Compound 41::US10172864, Compound 41::US10946023, Compound 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466415	378161465							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617147	C[C@@H](Nc1nc(N[C@H]2CCCC[C@@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H25F3N6O/c1-11(12-9-10-12)24-18-27-17(14-6-4-8-16(25-14)20(21,22)23)28-19(29-18)26-13-5-2-3-7-15(13)30/h4,6,8,11-13,15,30H,2-3,5,7,9-10H2,1H3,(H2,24,26,27,28,29)	DNYYBCNJEMMGNA-UHFFFAOYSA-N	279895	US10028961, Compound 42::US10172864, Compound 42::US10946023, Compound 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817502	378161466							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617149	C[C@@H](Nc1nc(N[C@H]2CCC[C@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6O/c1-10(11-8-9-11)23-17-26-16(13-5-3-7-15(24-13)19(20,21)22)27-18(28-17)25-12-4-2-6-14(12)29/h3,5,7,10-12,14,29H,2,4,6,8-9H2,1H3,(H2,23,25,26,27,28)	UHUHOBBXPQIHRY-UHFFFAOYSA-N	279896	US10028961, Compound 43::US10172864, Compound 43::US10946023, Compound 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			122440835	378161467							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617151	COCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C18H23F3N6O/c1-10(9-28-3)22-16-25-15(13-5-4-6-14(24-13)18(19,20)21)26-17(27-16)23-11(2)12-7-8-12/h4-6,10-12H,7-9H2,1-3H3,(H2,22,23,25,26,27)	LUBVUPNBKHPQTK-UHFFFAOYSA-N	279897	US10028961, Compound 44::US10172864, Compound 44::US10946023, Compound 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817089	378161468							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617153	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1 |r|	InChI=1S/C18H23ClN6/c1-10(12-6-7-12)20-17-23-16(14-4-3-5-15(19)22-14)24-18(25-17)21-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,20,21,23,24,25)	GTMXNXATSGQGCH-UHFFFAOYSA-N	279898	US10028961, Compound 45::US10172864, Compound 45::US10946023, Compound 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799064	378161469							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617155	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1 |r|	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)	XYQKRMAHYVIZRA-UHFFFAOYSA-N	279899	US10028961, Compound 88::US10028961, Compound 46::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617159	CC(C)(CO)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H20F5N7O/c1-18(2,10-33)32-17-30-15(12-5-4-6-13(28-12)20(23,24)25)29-16(31-17)27-11-7-8-26-14(9-11)19(3,21)22/h4-9,33H,10H2,1-3H3,(H2,26,27,29,30,31,32)	VPNOHMBISYXVRN-UHFFFAOYSA-N	279902	US10028961, Compound 49::US10172864, Compound 49::US10946023, Compound 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279902&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817105	378161473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617162	C[C@@H](Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H23F5N6/c1-11(12-5-6-12)26-17-29-16(14-3-2-4-15(28-14)20(23,24)25)30-18(31-17)27-13-7-9-19(21,22)10-8-13/h2-4,11-13H,5-10H2,1H3,(H2,26,27,29,30,31)	VHWMBKQPXXLOFJ-UHFFFAOYSA-N	279903	US10028961, Compound 50::US10172864, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817596	378161474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617164	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1 |r|	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)	HSMKSLUXGRHQJU-UHFFFAOYSA-N	279904	US10028961, Compound 89::US10028961, Compound 51::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617192	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	US10028961, Compound 4::BDBM279926::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617195	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1 |r|	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)	SBWSJSCKQBEYEK-UHFFFAOYSA-N	279859	US10028961, Compound 77::US10028961, Compound 6::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617196	COc1ccc(F)c(c1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1 |r|	InChI=1S/C20H26FN5O/c1-11(13-4-5-13)22-19-24-18(16-10-15(27-3)8-9-17(16)21)25-20(26-19)23-12(2)14-6-7-14/h8-14H,4-7H2,1-3H3,(H2,22,23,24,25,26)	WWRAJFZRAVDBHX-UHFFFAOYSA-N	279861	US10028961, Compound 78::US10028961, Compound 8::US10172864, Compound 78::US10946023, Compound 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817112	378161432							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617199	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)	BMMLVEOASUDOHV-UHFFFAOYSA-N	279863	US10028961, Compound 79::US10028961, Compound 10::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617202	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1 |r|	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)	JCZPGZCYKZMOEK-UHFFFAOYSA-N	279864	US10028961, Compound 80::US10028961, Compound 11::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617205	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)	YADRVMCMMMHOSZ-UHFFFAOYSA-N	279865	US10028961, Compound 81::US10028961, Compound 12::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617208	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1 |r|	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)	DXDMRKXHWQBBBA-UHFFFAOYSA-N	279869	US10028961, Compound 82::US10028961, Compound 16::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617211	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)	YMKOTGDUPIYQMS-UHFFFAOYSA-N	279877	US10028961, Compound 83::US10028961, Compound 24::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617213	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)	PVBOMIYGGWSXIY-UHFFFAOYSA-N	279878	US10028961, Compound 84::US10028961, Compound 25::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617215	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)	MMQKYUIBTNHALE-UHFFFAOYSA-N	279883	US10028961, Compound 85::US10028961, Compound 30::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617219	CC(C)CNc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C17H21FN6O/c1-10(2)8-20-15-21-14(12-7-11(25)5-6-13(12)18)22-16(23-15)24-17(3,4)9-19/h5-7,10,25H,8H2,1-4H3,(H2,20,21,22,23,24)	SXDPYZOSOGORMF-UHFFFAOYSA-N	279936	US10028961, Compound 86::US10172864, Compound 86::US10946023, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279936&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817467	378161495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617221	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)	QDXATNXZLOTYRV-UHFFFAOYSA-N	279890	US10028961, Compound 87::US10028961, Compound 37::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617223	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1 |r|	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)	XYQKRMAHYVIZRA-UHFFFAOYSA-N	279899	US10028961, Compound 88::US10028961, Compound 46::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617225	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1 |r|	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)	HSMKSLUXGRHQJU-UHFFFAOYSA-N	279904	US10028961, Compound 89::US10028961, Compound 51::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617795	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617797	C[C@@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280256	US10028961, Compound 415::US10172864, Compound 415::US10946023, Compound 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817171	378161805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617800	C[C@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280257	US10028961, Compound 416::US10172864, Compound 416::US10946023, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817194	378161806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617802	C[C@@H](Nc1cc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H24F3N5/c1-11(12-8-9-12)23-15-10-16(27-18(2,3)4)26-17(25-15)13-6-5-7-14(24-13)19(20,21)22/h5-7,10-12H,8-9H2,1-4H3,(H2,23,25,26,27)	SICOBUZBFFTRIB-UHFFFAOYSA-N	280258	US10028961, Compound 417::US10172864, Compound 417::US10946023, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817175	378161807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617810	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617816	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C17H12F7N7/c18-8-3-9(19)5-10(4-8)25-13-27-14(26-11-6-16(20,21)7-11)29-15(28-13)31-2-1-12(30-31)17(22,23)24/h1-5,11H,6-7H2,(H2,25,26,27,28,29)	XSFFZJKIWXEYIL-UHFFFAOYSA-N	279953	US10028961, Compound 106::US10172864, Compound 106::US10946023, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279953&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799077	378161503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617844	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)	FQOVWGJWJAOWBO-UHFFFAOYSA-N	279980	US10028961, Compound 133::US10172864, Compound 133::US10946023, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279980&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817510	378161530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617848	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)	FQOVWGJWJAOWBO-UHFFFAOYSA-N	279984	US10028961, Compound 137::US10172864, Compound 137::US10946023, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279984&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799135	378161534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617867	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280005	US10028961, Compound 158::US10172864, Compound 158::US10946023, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799020	378161555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617870	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)5-1-11(2-6-18)29-16-32-15(13-9-28-10-14(31-13)20(25,26)27)33-17(34-16)30-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,29,30,32,33,34)	SUGBJFIPDULVRS-UHFFFAOYSA-N	280007	US10028961, Compound 160::US10172864, Compound 160::US10946023, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817538	378161557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617872	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)1-7(2-14)25-12-28-11(9-5-24-6-10(27-9)16(21,22)23)29-13(30-12)26-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,25,26,28,29,30)	BJUUMSAHTGGBTK-UHFFFAOYSA-N	280008	US10028961, Compound 161::US10172864, Compound 161::US10946023, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817567	378161558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617880	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-12(5-8-29-16)30-18-33-17(14-3-2-4-15(32-14)22(25,26)27)34-19(35-18)31-13-10-21(23,24)11-13/h2-5,8-9,13H,6-7,10-11H2,(H2,29,30,31,33,34,35)	MNROPBMECNHKDS-UHFFFAOYSA-N	280015	US10028961, Compound 168::US10172864, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123886256	378161565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617887	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)	ZSYUHTUAGISLHX-UHFFFAOYSA-N	280021	US10028961, Compound 174::US10172864, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123271414	378161571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617902	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617904	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-10(8-17)30-16-33-14(11-2-1-3-12(31-11)18(22,23)24)32-15(34-16)29-9-4-5-28-13(6-9)19(25,26)27/h1-6,10H,7-8H2,(H2,28,29,30,32,33,34)	VURZKJCJGOOOFL-UHFFFAOYSA-N	280037	US10028961, Compound 190::US10172864, Compound 190::US10946023, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817505	378161587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618032	FC(F)(F)c1ccn(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)	ZSYUHTUAGISLHX-UHFFFAOYSA-N	316393	US10172864, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316393&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123907163	383542680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618075	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H16F8N8/c21-18(22)4-1-10(2-5-18)31-16-34-15(12-8-29-9-14(33-12)20(26,27)28)35-17(36-16)32-11-3-6-30-13(7-11)19(23,24)25/h3,6-10H,1-2,4-5H2,(H2,30,31,32,34,35,36)	DZAOGXHFTBFLFH-UHFFFAOYSA-N	280231	US10028961, Compound 389::US10172864, Compound 389::US10946023, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817166	378161780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618079	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)	ONCVYPCVWHYEJW-UHFFFAOYSA-N	280233	US10028961, Compound 391::US10172864, Compound 391::US10946023, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799014	378161782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618083	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280235	US10028961, Compound 393::US10172864, Compound 393::US10946023, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117799021	378161784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618092	C[C@@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280241	US10028961, Compound 400::US10172864, Compound 400::US10946023, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817128	378161790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618095	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C21H16F5N9/c1-27-19(3-4-19)14-6-11(2-5-29-14)30-17-33-16(13-9-28-10-15(32-13)21(24,25)26)34-18(35-17)31-12-7-20(22,23)8-12/h2,5-6,9-10,12H,3-4,7-8H2,(H2,29,30,31,33,34,35)	JQPXXLMNBIGQIB-UHFFFAOYSA-N	316443	US10172864, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316443&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			123753384	383542686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618106	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	280251	US10028961, Compound 410::US10172864, Compound 410::US10946023, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817192	378161800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618112	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719728	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H23ClF3N5O3/c28-20-8-2-1-7-19(20)23(24(38)34-17-14-27(30,31)15-17)35(18-6-3-5-16(29)13-18)25(39)21-9-10-22(37)36(21)26-32-11-4-12-33-26/h1-8,11-13,17,21,23H,9-10,14-15H2,(H,34,38)	XEHAZACRPFRAJJ-UHFFFAOYSA-N	363504	US9850277, Compound 1::US10689414, Compound 1::US10640534, Compound 1::US10717764, Compound 1::US11021515, Compound 1::US11667673, Compound 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71620855	401958958							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719730	CN1[C@@H](CCC1=O)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C24H23ClF3N3O3/c1-30-19(9-10-20(30)32)23(34)31(16-6-4-5-14(26)11-16)21(17-7-2-3-8-18(17)25)22(33)29-15-12-24(27,28)13-15/h2-8,11,15,19,21H,9-10,12-13H2,1H3,(H,29,33)	WTODWBLYOUDTID-UHFFFAOYSA-N	363509	US9850277, Compound 2::US10689414, Compound 2::US10640534, Compound 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707825	401958962							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719732	Fc1cccc(c1)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)C1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-8-2-1-7-21(22)25(26(40)36-19-11-13-29(32,33)14-12-19)37(20-6-3-5-18(31)17-20)27(41)23-9-10-24(39)38(23)28-34-15-4-16-35-28/h1-8,15-17,19,23,25H,9-14H2,(H,36,40)	NTMQXDPSVIDVCI-UHFFFAOYSA-N	363510	US9850277, Compound 3::US10689414, Compound 3::US10640534, Compound 3::US10717764, Compound 3::US11021515, Compound 3::US11667673, Compound 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699661	401958963							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719734	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)C1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-8-2-1-7-21(22)25(26(40)36-19-11-13-29(32,33)14-12-19)37(20-6-3-5-18(31)17-20)27(41)23-9-10-24(39)38(23)28-34-15-4-16-35-28/h1-8,15-17,19,23,25H,9-14H2,(H,36,40)	NTMQXDPSVIDVCI-UHFFFAOYSA-N	363511	US9850277, Compound 4::US10689414, Compound 4::US10640534, Compound 4::US10717764, Compound 4::US11021515, Compound 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699550	401958964							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719736	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccccn1 |r|	InChI=1S/C28H24ClF3N4O3/c29-21-9-2-1-8-20(21)25(26(38)34-18-15-28(31,32)16-18)35(19-7-5-6-17(30)14-19)27(39)22-11-12-24(37)36(22)23-10-3-4-13-33-23/h1-10,13-14,18,22,25H,11-12,15-16H2,(H,34,38)	BNMZIPHBCZHHSG-UHFFFAOYSA-N	363512	US9850277, Compound 5::US10689414, Compound 5::US10640534, Compound 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707827	401958965							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719738	Fc1cccc(c1)N([C@@H](C(=O)NC1CCCCC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H29ClFN5O3/c30-23-13-5-4-12-22(23)26(27(38)34-20-9-2-1-3-10-20)35(21-11-6-8-19(31)18-21)28(39)24-14-15-25(37)36(24)29-32-16-7-17-33-29/h4-8,11-13,16-18,20,24,26H,1-3,9-10,14-15H2,(H,34,38)	WDEWUONHJCNHPC-UHFFFAOYSA-N	363513	US9850277, Compound 6::US10689414, Compound 6::US10640534, Compound 6::US11021515, Compound 6::US11667673, Compound 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707826	401958966							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719740	Fc1cccc(c1)N([C@H](C(=O)NC1CCCCC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H29ClFN5O3/c30-23-13-5-4-12-22(23)26(27(38)34-20-9-2-1-3-10-20)35(21-11-6-8-19(31)18-21)28(39)24-14-15-25(37)36(24)29-32-16-7-17-33-29/h4-8,11-13,16-18,20,24,26H,1-3,9-10,14-15H2,(H,34,38)	WDEWUONHJCNHPC-UHFFFAOYSA-N	363514	US9850277, Compound 7::US10689414, Compound 7::US10640534, Compound 7::US10717764, Compound 7::US11021515, Compound 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707828	401958967							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719742	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1ncccn1 |r|	InChI=1S/C26H21ClF3N5O4/c27-19-8-2-1-7-18(19)21(22(36)33-16-12-26(29,30)13-16)34(17-6-3-5-15(28)11-17)23(37)20-14-39-25(38)35(20)24-31-9-4-10-32-24/h1-11,16,20-21H,12-14H2,(H,33,36)	DGNVKHSKMRTWAV-UHFFFAOYSA-N	363515	US9850277, Compound 8::US10689414, Compound 8::US10640534, Compound 8::US10717764, Compound 8::US11021515, Compound 8::US11667673, Compound 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690596	401958968							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719744	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1ncccn1 |r|	InChI=1S/C26H21ClF3N5O4/c27-19-8-2-1-7-18(19)21(22(36)33-16-12-26(29,30)13-16)34(17-6-3-5-15(28)11-17)23(37)20-14-39-25(38)35(20)24-31-9-4-10-32-24/h1-11,16,20-21H,12-14H2,(H,33,36)	DGNVKHSKMRTWAV-UHFFFAOYSA-N	363516	US9850277, Compound 9::US10689414, Compound 9::US10640534, Compound 9::US10717764, Compound 9::US11021515, Compound 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699850	401958969							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719746	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccnc1 |r|	InChI=1S/C28H24ClF3N4O3/c29-22-9-2-1-8-21(22)25(26(38)34-18-14-28(31,32)15-18)36(19-6-3-5-17(30)13-19)27(39)23-10-11-24(37)35(23)20-7-4-12-33-16-20/h1-9,12-13,16,18,23,25H,10-11,14-15H2,(H,34,38)	UMLWDDXKOCBRGN-UHFFFAOYSA-N	363518	US9850277, Compound 10::US10689414, Compound 10::US10640534, Compound 10::US10717764, Compound 10::US11021515, Compound 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707829	401958971							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719748	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(F)n1 |r|	InChI=1S/C28H23ClF4N4O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(32,33)15-17)36(18-6-3-5-16(30)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(31)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H,34,39)	VOKYMLJKRXOWSX-UHFFFAOYSA-N	363519	US9850277, Compound 11::US10689414, Compound 11::US10640534, Compound 11::US10717764, Compound 11::US11021515, Compound 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707830	401958972							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719750	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccc1F |r|	InChI=1S/C28H23ClF4N4O3/c29-20-8-2-1-7-19(20)24(26(39)35-17-14-28(32,33)15-17)36(18-6-3-5-16(30)13-18)27(40)22-10-11-23(38)37(22)25-21(31)9-4-12-34-25/h1-9,12-13,17,22,24H,10-11,14-15H2,(H,35,39)	GHHXPAIKTCHCIO-UHFFFAOYSA-N	363520	US9850277, Compound 12::US10689414, Compound 12::US10640534, Compound 12::US10717764, Compound 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707832	401958973							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719752	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccs1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)22(23(36)32-16-13-26(29,30)14-16)33(17-5-3-4-15(28)12-17)24(37)20-8-9-21(35)34(20)25-31-10-11-38-25/h1-7,10-12,16,20,22H,8-9,13-14H2,(H,32,36)	HAHDJLUASRMCOO-UHFFFAOYSA-N	363521	US9850277, Compound 13::US10689414, Compound 13::US10640534, Compound 13::US10717764, Compound 13::US11021515, Compound 13::US11667673, Compound 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707831	401958974							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719754	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccs1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)22(23(36)32-16-13-26(29,30)14-16)33(17-5-3-4-15(28)12-17)24(37)20-8-9-21(35)34(20)25-31-10-11-38-25/h1-7,10-12,16,20,22H,8-9,13-14H2,(H,32,36)	HAHDJLUASRMCOO-UHFFFAOYSA-N	363522	US9850277, Compound 14::US10689414, Compound 14::US10640534, Compound 14::US10717764, Compound 14::US11021515, Compound 14::US11667673, Compound 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707834	401958975							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719756	Cc1cccnc1N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-6-5-13-34-26(17)37-23(11-12-24(37)38)28(40)36(20-8-4-7-18(31)14-20)25(21-9-2-3-10-22(21)30)27(39)35-19-15-29(32,33)16-19/h2-10,13-14,19,23,25H,11-12,15-16H2,1H3,(H,35,39)	SITQEJPACKGZEU-UHFFFAOYSA-N	363523	US9850277, Compound 15::US10689414, Compound 15::US10640534, Compound 15::US10717764, Compound 15::US11021515, Compound 15::US11667673, Compound 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707833	401958976							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719758	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc2ccccc12 |r|	InChI=1S/C32H26ClF3N4O3/c33-25-11-4-3-10-24(25)28(30(42)38-21-17-32(35,36)18-21)39(22-8-5-7-20(34)16-22)31(43)26-12-13-27(41)40(26)29-23-9-2-1-6-19(23)14-15-37-29/h1-11,14-16,21,26,28H,12-13,17-18H2,(H,38,42)	UTMYJGCWNXATLI-UHFFFAOYSA-N	363524	US9850277, Compound 16::US10689414, Compound 16::US10640534, Compound 16::US10717764, Compound 16::US11021515, Compound 16::US11667673, Compound 16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707836	401958977							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719760	COc1cccnc1N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O4/c1-41-23-10-5-13-34-26(23)37-22(11-12-24(37)38)28(40)36(19-7-4-6-17(31)14-19)25(20-8-2-3-9-21(20)30)27(39)35-18-15-29(32,33)16-18/h2-10,13-14,18,22,25H,11-12,15-16H2,1H3,(H,35,39)	ZFVSKCAAVXOSBL-UHFFFAOYSA-N	363525	US9850277, Compound 17::US10689414, Compound 17::US10640534, Compound 17::US10717764, Compound 17::US11021515, Compound 17::US11667673, Compound 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707835	401958978							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719762	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cnccn1 |r|	InChI=1S/C27H23ClF3N5O3/c28-20-7-2-1-6-19(20)24(25(38)34-17-13-27(30,31)14-17)35(18-5-3-4-16(29)12-18)26(39)21-8-9-23(37)36(21)22-15-32-10-11-33-22/h1-7,10-12,15,17,21,24H,8-9,13-14H2,(H,34,38)	XRYKKBGVCNAGKT-UHFFFAOYSA-N	363526	US9850277, Compound 18::US10689414, Compound 18::US10717764, Compound 18::US11667673, Compound 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707837	401958979							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719764	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-9-2-1-8-20(21)24(25(39)35-18-15-28(31,32)16-18)36(19-7-3-6-17(30)14-19)26(40)22-10-4-11-23(38)37(22)27-33-12-5-13-34-27/h1-3,5-9,12-14,18,22,24H,4,10-11,15-16H2,(H,35,39)	SBKILLKIGMRENY-UHFFFAOYSA-N	363527	US9850277, Compound 19::US10689414, Compound 19::US10640534, Compound 19::US10717764, Compound 19::US11021515, Compound 19::US11667673, Compound 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699539	401958980							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719766	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-9-2-1-8-20(21)24(25(39)35-18-15-28(31,32)16-18)36(19-7-3-6-17(30)14-19)26(40)22-10-4-11-23(38)37(22)27-33-12-5-13-34-27/h1-3,5-9,12-14,18,22,24H,4,10-11,15-16H2,(H,35,39)	SBKILLKIGMRENY-UHFFFAOYSA-N	363528	US9850277, Compound 20::US10689414, Compound 20::US10640534, Compound 20::US10717764, Compound 20::US11021515, Compound 20::US11667673, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699424	401958981							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719768	Cc1ccc(nc1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-9-11-24(34-16-17)37-23(10-12-25(37)38)28(40)36(20-6-4-5-18(31)13-20)26(21-7-2-3-8-22(21)30)27(39)35-19-14-29(32,33)15-19/h2-9,11,13,16,19,23,26H,10,12,14-15H2,1H3,(H,35,39)	CYFBHINCADEEHB-UHFFFAOYSA-N	363529	US9850277, Compound 21::US10689414, Compound 21::US10640534, Compound 21::US10717764, Compound 21::US11021515, Compound 21::US11667673, Compound 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707839	401958982							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719770	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccncn1 |r|	InChI=1S/C27H23ClF3N5O3/c28-20-7-2-1-6-19(20)24(25(38)34-17-13-27(30,31)14-17)35(18-5-3-4-16(29)12-18)26(39)21-8-9-23(37)36(21)22-10-11-32-15-33-22/h1-7,10-12,15,17,21,24H,8-9,13-14H2,(H,34,38)	PIGGPXXOZCYULW-UHFFFAOYSA-N	363530	US9850277, Compound 22::US10689414, Compound 22::US10640534, Compound 22::US10717764, Compound 22::US11021515, Compound 22::US11667673, Compound 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707840	401958983							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719772	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccccc1 |r|	InChI=1S/C29H25ClF3N3O3/c30-23-12-5-4-11-22(23)26(27(38)34-19-16-29(32,33)17-19)36(21-10-6-7-18(31)15-21)28(39)24-13-14-25(37)35(24)20-8-2-1-3-9-20/h1-12,15,19,24,26H,13-14,16-17H2,(H,34,38)	ZGAOYVSEPPLYRQ-UHFFFAOYSA-N	363531	US9850277, Compound 23::US10689414, Compound 23::US10640534, Compound 23::US10717764, Compound 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707841	401958984							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719774	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(n1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-20-8-2-1-7-19(20)25(26(42)37-17-14-28(32,33)15-17)39(18-6-3-5-16(31)13-18)27(43)21-11-12-24(41)40(21)23-10-4-9-22(38-23)29(34,35)36/h1-10,13,17,21,25H,11-12,14-15H2,(H,37,42)	PWTYTETZLNPWSK-UHFFFAOYSA-N	363532	US9850277, Compound 24::US10689414, Compound 24::US10640534, Compound 24::US10717764, Compound 24::US11021515, Compound 24::US11667673, Compound 24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707842	401958985							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719776	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(n1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-20-8-2-1-7-19(20)25(26(42)37-17-14-28(32,33)15-17)39(18-6-3-5-16(31)13-18)27(43)21-11-12-24(41)40(21)23-10-4-9-22(38-23)29(34,35)36/h1-10,13,17,21,25H,11-12,14-15H2,(H,37,42)	PWTYTETZLNPWSK-UHFFFAOYSA-N	363533	US9850277, Compound 25::US10689414, Compound 25::US10640534, Compound 25::US10717764, Compound 25::US11021515, Compound 25::US11667673, Compound 25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707843	401958986							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719778	COc1ccc(nc1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O4/c1-41-20-9-11-24(34-16-20)37-23(10-12-25(37)38)28(40)36(19-6-4-5-17(31)13-19)26(21-7-2-3-8-22(21)30)27(39)35-18-14-29(32,33)15-18/h2-9,11,13,16,18,23,26H,10,12,14-15H2,1H3,(H,35,39)	XZOZVXRAZQWLDW-UHFFFAOYSA-N	363534	US9850277, Compound 26::US10689414, Compound 26::US10640534, Compound 26::US10717764, Compound 26::US11021515, Compound 26::US11667673, Compound 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707844	401958987							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719780	Cc1ccnc(c1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-11-12-34-24(13-17)37-23(9-10-25(37)38)28(40)36(20-6-4-5-18(31)14-20)26(21-7-2-3-8-22(21)30)27(39)35-19-15-29(32,33)16-19/h2-8,11-14,19,23,26H,9-10,15-16H2,1H3,(H,35,39)	AROXJRALBXVLMA-UHFFFAOYSA-N	363535	US9850277, Compound 27::US10689414, Compound 27::US10640534, Compound 27::US10717764, Compound 27::US11021515, Compound 27::US11667673, Compound 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707845	401958988							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719782	Cc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-6-4-11-24(34-17)37-23(12-13-25(37)38)28(40)36(20-8-5-7-18(31)14-20)26(21-9-2-3-10-22(21)30)27(39)35-19-15-29(32,33)16-19/h2-11,14,19,23,26H,12-13,15-16H2,1H3,(H,35,39)	CGJBPVMJDOSEKZ-UHFFFAOYSA-N	363536	US9850277, Compound 28::US10689414, Compound 28::US10640534, Compound 28::US10717764, Compound 28::US11021515, Compound 28::US11667673, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707846	401958989							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719784	Fc1ccc(nc1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H23ClF4N4O3/c29-21-7-2-1-6-20(21)25(26(39)35-18-13-28(32,33)14-18)36(19-5-3-4-16(30)12-19)27(40)22-9-11-24(38)37(22)23-10-8-17(31)15-34-23/h1-8,10,12,15,18,22,25H,9,11,13-14H2,(H,35,39)	SOWPYWCTKWCMFB-UHFFFAOYSA-N	363537	US9850277, Compound 29::US10689414, Compound 29::US10640534, Compound 29::US10717764, Compound 29::US11021515, Compound 29::US11667673, Compound 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707847	401958990							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719786	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H23ClF3N5O4/c28-20-8-2-1-7-19(20)23(24(38)34-17-12-27(30,31)13-17)35(18-6-3-5-16(29)11-18)25(39)21-14-40-15-22(37)36(21)26-32-9-4-10-33-26/h1-11,17,21,23H,12-15H2,(H,34,38)	WHTZBGLMWBVRDT-UHFFFAOYSA-N	363538	US9850277, Compound 30::US10689414, Compound 30::US10640534, Compound 30::US10717764, Compound 30::US11021515, Compound 30::US11667673, Compound 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707849	401958991							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719788	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(cn1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-21-7-2-1-6-20(21)25(26(42)38-18-13-28(32,33)14-18)39(19-5-3-4-17(31)12-19)27(43)22-9-11-24(41)40(22)23-10-8-16(15-37-23)29(34,35)36/h1-8,10,12,15,18,22,25H,9,11,13-14H2,(H,38,42)	NDUOCLRZDKMNMX-UHFFFAOYSA-N	363539	US9850277, Compound 31::US10689414, Compound 31::US10640534, Compound 31::US10717764, Compound 31::US11021515, Compound 31::US11667673, Compound 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707850	401958992							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719790	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(Cl)ccn1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-16-10-11-34-23(12-16)37-22(8-9-24(37)38)27(40)36(19-5-3-4-17(31)13-19)25(20-6-1-2-7-21(20)30)26(39)35-18-14-28(32,33)15-18/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,35,39)	GRRXZSNAFJEVHD-UHFFFAOYSA-N	363540	US9850277, Compound 32::US10689414, Compound 32::US10640534, Compound 32::US10717764, Compound 32::US11021515, Compound 32::US11667673, Compound 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707851	401958993							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719792	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(Cl)ccn1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-16-10-11-34-23(12-16)37-22(8-9-24(37)38)27(40)36(19-5-3-4-17(31)13-19)25(20-6-1-2-7-21(20)30)26(39)35-18-14-28(32,33)15-18/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,35,39)	GRRXZSNAFJEVHD-UHFFFAOYSA-N	363541	US9850277, Compound 33::US10689414, Compound 33::US10640534, Compound 33::US10717764, Compound 33::US11021515, Compound 33::US11667673, Compound 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707852	401958994							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719794	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(Cl)n1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(32,33)15-17)36(18-6-3-5-16(31)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(30)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H,34,39)	KGVKTOYOZORCGW-UHFFFAOYSA-N	363542	US9850277, Compound 34::US10689414, Compound 34::US10640534, Compound 34::US10717764, Compound 34::US11021515, Compound 34::US11667673, Compound 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707853	401958995							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719796	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(Cl)n1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(32,33)15-17)36(18-6-3-5-16(31)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(30)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H,34,39)	KGVKTOYOZORCGW-UHFFFAOYSA-N	363543	US9850277, Compound 35::US10689414, Compound 35::US10640534, Compound 35::US10717764, Compound 35::US11021515, Compound 35::US11667673, Compound 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707854	401958996							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719798	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	LVTAMMPAQQMIPZ-UHFFFAOYSA-N	363544	US9850277, Compound 36::US10689414, Compound 36::US10640534, Compound 54::US10717764, Compound 36::US11021515, Compound 36::US11667673, Compound 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89708744	401958997							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719800	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	LVTAMMPAQQMIPZ-UHFFFAOYSA-N	363545	US9850277, Compound 37::US9850277, Compound 64::US10689414, Compound 64::US10640534, Compound 64::US10717764, Compound 64::US11021515, Compound 64::US11667673, Compound 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700075	401958998							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719802	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(n1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-9-2-1-8-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-7-3-5-17(31)13-20)28(41)23-11-12-25(39)38(23)24-10-4-6-18(16-34)35-24/h1-10,13,19,23,26H,11-12,14-15H2,(H,36,40)	NVRVZFIFEQNQRO-UHFFFAOYSA-N	363546	US9850277, Compound 38::US10689414, Compound 38::US10640534, Compound 38::US10717764, Compound 38::US11021515, Compound 38::US11667673, Compound 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89708745	401958999							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719804	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-21-7-2-1-6-20(21)25(26(42)38-18-14-28(32,33)15-18)39(19-5-3-4-17(31)13-19)27(43)22-8-9-24(41)40(22)23-12-16(10-11-37-23)29(34,35)36/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,38,42)	ZPVRDYRLRGZBHU-UHFFFAOYSA-N	363547	US9850277, Compound 39::US10689414, Compound 39::US10640534, Compound 39::US10717764, Compound 39::US11021515, Compound 39::US11667673, Compound 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89708748	401959000							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719806	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-21-7-2-1-6-20(21)25(26(42)38-18-14-28(32,33)15-18)39(19-5-3-4-17(31)13-19)27(43)22-8-9-24(41)40(22)23-12-16(10-11-37-23)29(34,35)36/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,38,42)	ZPVRDYRLRGZBHU-UHFFFAOYSA-N	363548	US9850277, Compound 40::US10689414, Compound 40::US10640534, Compound 40::US10717764, Compound 40::US11021515, Compound 40::US11667673, Compound 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89708772	401959001							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719808	COc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O4/c1-41-24-11-5-10-23(35-24)37-22(12-13-25(37)38)28(40)36(19-7-4-6-17(31)14-19)26(20-8-2-3-9-21(20)30)27(39)34-18-15-29(32,33)16-18/h2-11,14,18,22,26H,12-13,15-16H2,1H3,(H,34,39)	PWADGCFTVYFXKI-UHFFFAOYSA-N	363549	US9850277, Compound 41::US10689414, Compound 41::US10640534, Compound 41::US10717764, Compound 41::US11021515, Compound 41::US11667673, Compound 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707856	401959002							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719810	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cscn1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)23(24(36)32-16-11-26(29,30)12-16)33(17-5-3-4-15(28)10-17)25(37)20-8-9-22(35)34(20)21-13-38-14-31-21/h1-7,10,13-14,16,20,23H,8-9,11-12H2,(H,32,36)	BVSZFZYUBWWULE-UHFFFAOYSA-N	363550	US9850277, Compound 42::US10689414, Compound 42::US10640534, Compound 42::US10717764, Compound 42::US11021515, Compound 42::US11667673, Compound 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699849	401959003							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719812	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cscn1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)23(24(36)32-16-11-26(29,30)12-16)33(17-5-3-4-15(28)10-17)25(37)20-8-9-22(35)34(20)21-13-38-14-31-21/h1-7,10,13-14,16,20,23H,8-9,11-12H2,(H,32,36)	BVSZFZYUBWWULE-UHFFFAOYSA-N	363551	US9850277, Compound 43::US10689414, Compound 43::US10640534, Compound 43::US10717764, Compound 43::US11021515, Compound 43::US11667673, Compound 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699734	401959004							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719814	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1Cc1ccccn1 |r|	InChI=1S/C29H26ClF3N4O3/c30-23-10-2-1-9-22(23)26(27(39)35-20-15-29(32,33)16-20)37(21-8-5-6-18(31)14-21)28(40)24-11-12-25(38)36(24)17-19-7-3-4-13-34-19/h1-10,13-14,20,24,26H,11-12,15-17H2,(H,35,39)	DQVODDVYWWAOQC-UHFFFAOYSA-N	363552	US9850277, Compound 44::US10689414, Compound 44::US10640534, Compound 44::US10717764, Compound 44::US11021515, Compound 44::US11667673, Compound 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699953	401959005							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719816	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H23ClF3N5O4/c28-20-8-2-1-7-19(20)23(24(38)34-17-12-27(30,31)13-17)35(18-6-3-5-16(29)11-18)25(39)21-14-40-15-22(37)36(21)26-32-9-4-10-33-26/h1-11,17,21,23H,12-15H2,(H,34,38)	WHTZBGLMWBVRDT-UHFFFAOYSA-N	363553	US9850277, Compound 45::US10689414, Compound 45::US10640534, Compound 45::US10717764, Compound 45::US11021515, Compound 45::US11667673, Compound 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690600	401959006							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719818	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(cn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-13-29(32,33)14-19)37(20-5-3-4-18(31)12-20)28(41)23-9-11-25(39)38(23)24-10-8-17(15-34)16-35-24/h1-8,10,12,16,19,23,26H,9,11,13-14H2,(H,36,40)	COACOKWKMBXXGC-UHFFFAOYSA-N	363555	US9850277, Compound 46::US10689414, Compound 46::US10640534, Compound 46::US10717764, Compound 46::US11021515, Compound 46::US11667673, Compound 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707859	401959008							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719820	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(cn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-13-29(32,33)14-19)37(20-5-3-4-18(31)12-20)28(41)23-9-11-25(39)38(23)24-10-8-17(15-34)16-35-24/h1-8,10,12,16,19,23,26H,9,11,13-14H2,(H,36,40)	COACOKWKMBXXGC-UHFFFAOYSA-N	363556	US9850277, Compound 47::US10689414, Compound 47::US10640534, Compound 47::US10717764, Compound 47::US11021515, Compound 47::US11667673, Compound 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707860	401959009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719822	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(Cl)cn1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-16-8-10-23(34-15-16)37-22(9-11-24(37)38)27(40)36(19-5-3-4-17(31)12-19)25(20-6-1-2-7-21(20)30)26(39)35-18-13-28(32,33)14-18/h1-8,10,12,15,18,22,25H,9,11,13-14H2,(H,35,39)	IGKPNPLXJJOZHS-UHFFFAOYSA-N	363557	US9850277, Compound 48::US10689414, Compound 48::US10640534, Compound 48::US10717764, Compound 48::US11021515, Compound 48::US11667673, Compound 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707862	401959010							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719824	FC1CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1ncccn1)c1cccc(F)c1)c1ccccc1Cl |r,wU:8.9,wD:12.12,(-7.54,2.24,;-6.21,1.47,;-4.72,1.87,;-4.32,.38,;-5.81,-.01,;-2.99,-.38,;-1.65,.38,;-1.65,1.93,;-.32,-.38,;1.01,.38,;2.35,-.38,;2.35,-1.93,;3.68,.38,;3.68,1.93,;5.15,2.4,;6.05,1.15,;7.54,.76,;5.15,-.09,;5.55,-1.58,;4.46,-2.67,;4.86,-4.15,;6.34,-4.55,;7.43,-3.46,;7.03,-1.98,;1.01,1.93,;-.32,2.69,;-.32,4.23,;1.01,5,;2.35,4.23,;3.68,5,;2.35,2.69,;-.32,-1.93,;1.01,-2.69,;1.01,-4.23,;-.32,-5,;-1.65,-4.23,;-1.65,-2.69,;-3.19,-2.69,)|	InChI=1S/C27H24ClF2N5O3/c28-21-8-2-1-7-20(21)24(25(37)33-18-13-17(30)14-18)34(19-6-3-5-16(29)15-19)26(38)22-9-10-23(36)35(22)27-31-11-4-12-32-27/h1-8,11-12,15,17-18,22,24H,9-10,13-14H2,(H,33,37)	IBTFPSAOWVAVLH-UHFFFAOYSA-N	363558	US9850277, Compound 49::US10689414, Compound 49::US10640534, Compound 49::US10717764, Compound 49::US11021515, Compound 49::US11667673, Compound 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707861	401959011							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719826	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccnn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-8-2-1-7-21(22)26(27(40)35-19-12-14-29(32,33)15-13-19)37(20-6-3-5-18(31)17-20)28(41)23-10-11-25(39)38(23)24-9-4-16-34-36-24/h1-9,16-17,19,23,26H,10-15H2,(H,35,40)	PZQIJIWUOPSNLV-UHFFFAOYSA-N	363559	US9850277, Compound 50::US10689414, Compound 50::US10640534, Compound 50::US10717764, Compound 50::US11021515, Compound 50::US11667673, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707863	401959012							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719828	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1c(Cl)cccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H22Cl2F3N5O3/c28-18-6-2-7-19(29)22(18)23(24(39)35-16-13-27(31,32)14-16)36(17-5-1-4-15(30)12-17)25(40)20-8-9-21(38)37(20)26-33-10-3-11-34-26/h1-7,10-12,16,20,23H,8-9,13-14H2,(H,35,39)	KGIDCLBKTUVDTP-UHFFFAOYSA-N	363560	US9850277, Compound 51::US10689414, Compound 51::US10640534, Compound 51::US10717764, Compound 51::US11021515, Compound 51::US11667673, Compound 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707864	401959013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719830	Fc1cccc(c1)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H27ClF3N5O3/c32-24-7-2-1-6-23(24)28(29(42)38-21-10-13-31(34,35)14-11-21)39(22-5-3-4-20(33)17-22)30(43)25-8-9-27(41)40(25)26-16-19(18-36)12-15-37-26/h1-7,12,15-17,21,25,28H,8-11,13-14H2,(H,38,42)	JLCXBOXRVPRHLC-UHFFFAOYSA-N	363561	US9850277, Compound 52::US10689414, Compound 52::US10640534, Compound 52::US10717764, Compound 52::US11021515, Compound 52::US11667673, Compound 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707865	401959014							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719832	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H27ClF3N5O3/c32-24-7-2-1-6-23(24)28(29(42)38-21-10-13-31(34,35)14-11-21)39(22-5-3-4-20(33)17-22)30(43)25-8-9-27(41)40(25)26-16-19(18-36)12-15-37-26/h1-7,12,15-17,21,25,28H,8-11,13-14H2,(H,38,42)	JLCXBOXRVPRHLC-UHFFFAOYSA-N	363563	US9850277, Compound 53::US10689414, Compound 53::US10640534, Compound 53::US10717764, Compound 53::US11021515, Compound 53::US11667673, Compound 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657134	401959016							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719834	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O3/c31-23-8-2-1-7-22(23)27(28(41)37-20-15-30(33,34)16-20)38(21-6-3-5-19(32)14-21)29(42)24-9-4-10-26(40)39(24)25-13-18(17-35)11-12-36-25/h1-3,5-8,11-14,20,24,27H,4,9-10,15-16H2,(H,37,41)	HVUAKFIZNPTSGN-UHFFFAOYSA-N	363564	US9850277, Compound 54::US10689414, Compound 54::US10717764, Compound 54::US11021515, Compound 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89708749	401959017							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719836	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O3/c31-23-8-2-1-7-22(23)27(28(41)37-20-15-30(33,34)16-20)38(21-6-3-5-19(32)14-21)29(42)24-9-4-10-26(40)39(24)25-13-18(17-35)11-12-36-25/h1-3,5-8,11-14,20,24,27H,4,9-10,15-16H2,(H,37,41)	HVUAKFIZNPTSGN-UHFFFAOYSA-N	363565	US9850277, Compound 55::US10689414, Compound 55::US10640534, Compound 55::US10717764, Compound 55::US11021515, Compound 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699580	401959018							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719838	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccc1F |r|	InChI=1S/C30H27ClF4N4O3/c31-22-8-2-1-7-21(22)26(28(41)37-19-12-14-30(34,35)15-13-19)38(20-6-3-5-18(32)17-20)29(42)24-10-11-25(40)39(24)27-23(33)9-4-16-36-27/h1-9,16-17,19,24,26H,10-15H2,(H,37,41)	WYMSLDXYSGVDTN-UHFFFAOYSA-N	363566	US9850277, Compound 56::US10689414, Compound 56::US10640534, Compound 56::US10717764, Compound 56::US11021515, Compound 56::US11667673, Compound 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707866	401959019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719840	Fc1cccc(c1)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cnccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-10-12-29(32,33)13-11-19)37(20-5-3-4-18(31)16-20)28(41)23-8-9-25(39)38(23)24-17-34-14-15-35-24/h1-7,14-17,19,23,26H,8-13H2,(H,36,40)	LZIRTPPXKUUODZ-UHFFFAOYSA-N	363567	US9850277, Compound 57::US10689414, Compound 57::US10640534, Compound 57::US10717764, Compound 57::US11021515, Compound 57::US11667673, Compound 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707867	401959020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719842	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cnccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-10-12-29(32,33)13-11-19)37(20-5-3-4-18(31)16-20)28(41)23-8-9-25(39)38(23)24-17-34-14-15-35-24/h1-7,14-17,19,23,26H,8-13H2,(H,36,40)	LZIRTPPXKUUODZ-UHFFFAOYSA-N	363568	US9850277, Compound 58::US10689414, Compound 58::US10640534, Compound 58::US10717764, Compound 58::US11021515, Compound 58::US11667673, Compound 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700095	401959021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719844	Nc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H25ClF3N5O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(31,32)15-17)36(18-6-3-5-16(30)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(33)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H2,33,35)(H,34,39)	LILZITSTXWZWOD-UHFFFAOYSA-N	363569	US9850277, Compound 59::US10689414, Compound 59::US10640534, Compound 59::US10717764, Compound 59::US11021515, Compound 59::US11667673, Compound 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707868	401959022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719846	Nc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H25ClF3N5O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(31,32)15-17)36(18-6-3-5-16(30)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(33)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H2,33,35)(H,34,39)	LILZITSTXWZWOD-UHFFFAOYSA-N	363571	US9850277, Compound 60::US10689414, Compound 60::US10640534, Compound 60::US10717764, Compound 60::US11021515, Compound 60::US11667673, Compound 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707869	401959024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719848	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cncs1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)23(24(36)32-16-11-26(29,30)12-16)33(17-5-3-4-15(28)10-17)25(37)20-8-9-21(35)34(20)22-13-31-14-38-22/h1-7,10,13-14,16,20,23H,8-9,11-12H2,(H,32,36)	YQYGQGYNCDVXME-UHFFFAOYSA-N	363572	US9850277, Compound 61::US10689414, Compound 61::US10640534, Compound 61::US10717764, Compound 61::US11021515, Compound 61::US11667673, Compound 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707870	401959025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719850	Nc1ccnc(c1)N1[C@@H](CCC1=O)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-7-2-1-6-20(21)25(26(39)35-18-14-28(31,32)15-18)36(19-5-3-4-16(30)12-19)27(40)22-8-9-24(38)37(22)23-13-17(33)10-11-34-23/h1-7,10-13,18,22,25H,8-9,14-15H2,(H2,33,34)(H,35,39)	AYAJVGUBUPODPY-UHFFFAOYSA-N	363573	US9850277, Compound 62::US10689414, Compound 62::US10640534, Compound 62::US10717764, Compound 62::US11667673, Compound 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707871	401959026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719852	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1c(Cl)cccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22Cl2F3N5O3/c30-20-5-2-6-21(31)25(20)26(27(41)37-18-13-29(33,34)14-18)38(19-4-1-3-17(32)12-19)28(42)22-7-8-24(40)39(22)23-11-16(15-35)9-10-36-23/h1-6,9-12,18,22,26H,7-8,13-14H2,(H,37,41)	VBWGIZOBLNWNSL-UHFFFAOYSA-N	363574	US9850277, Compound 63::US10689414, Compound 63::US10640534, Compound 63::US10717764, Compound 63::US11021515, Compound 63::US11667673, Compound 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89708773	401959027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719854	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	LVTAMMPAQQMIPZ-UHFFFAOYSA-N	363545	US9850277, Compound 37::US9850277, Compound 64::US10689414, Compound 64::US10640534, Compound 64::US10717764, Compound 64::US11021515, Compound 64::US11667673, Compound 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700075	401958998							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719856	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H22ClF3N6O3/c29-21-7-2-1-6-20(21)24(25(40)35-18-13-28(31,32)14-18)37(19-5-3-4-16(30)12-19)26(41)22-8-9-23(39)38(22)27-34-11-10-17(15-33)36-27/h1-7,10-12,18,22,24H,8-9,13-14H2,(H,35,40)	WCSZYVFQFJRLEV-UHFFFAOYSA-N	363576	US9850277, Compound 68::US10689414, Compound 68::US10640534, Compound 68::US10717764, Compound 68::US11021515, Compound 68::US11667673, Compound 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700010	401959028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719858	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccc1C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-9-2-1-8-21(22)25(27(40)36-19-14-29(32,33)15-19)37(20-7-3-6-18(31)13-20)28(41)23-10-11-24(39)38(23)26-17(16-34)5-4-12-35-26/h1-9,12-13,19,23,25H,10-11,14-15H2,(H,36,40)	HOXIQRRXXBEOBO-UHFFFAOYSA-N	363577	US9850277, Compound 69::US10689414, Compound 69::US10640534, Compound 69::US10717764, Compound 69::US11021515, Compound 69::US11667673, Compound 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699743	401959029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719860	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H22ClF4N5O3/c28-20-5-2-1-4-19(20)23(24(39)35-17-13-27(31,32)14-17)36(18-11-15(29)10-16(30)12-18)25(40)21-6-7-22(38)37(21)26-33-8-3-9-34-26/h1-5,8-12,17,21,23H,6-7,13-14H2,(H,35,39)	BUVIOXMCRDPGRC-UHFFFAOYSA-N	363578	US9850277, Compound 70::US10689414, Compound 70::US10640534, Compound 70::US10717764, Compound 70::US11021515, Compound 70::US11667673, Compound 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699866	401959030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719862	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O3/c30-22-4-2-1-3-21(22)26(27(41)37-19-13-29(33,34)14-19)38(20-11-17(31)10-18(32)12-20)28(42)23-5-6-25(40)39(23)24-9-16(15-35)7-8-36-24/h1-4,7-12,19,23,26H,5-6,13-14H2,(H,37,41)	KICQCOSIQLKQBA-UHFFFAOYSA-N	363579	US9850277, Compound 71::US9850277, Compound 163::US10689414, Compound 163::US10640534, Compound 163::US10717764, Compound 163::US11021515, Compound 163::US11667673, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699884	401959031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719864	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cscn1 |r|	InChI=1S/C25H20ClF3N4O4S/c26-18-7-2-1-6-17(18)21(22(34)31-15-9-25(28,29)10-15)32(16-5-3-4-14(27)8-16)23(35)19-11-37-24(36)33(19)20-12-38-13-30-20/h1-8,12-13,15,19,21H,9-11H2,(H,31,34)	VIOYFAYJHYKQQA-UHFFFAOYSA-N	363580	US9850277, Compound 72::US10689414, Compound 72::US10640534, Compound 72::US10717764, Compound 72::US11021515, Compound 72::US11667673, Compound 72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700209	401959032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719866	Fc1cccc(c1)N([C@H](C(=O)N[C@H]1CCC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-8-2-1-7-20(21)24(25(39)35-18-11-12-28(31,32)16-18)36(19-6-3-5-17(30)15-19)26(40)22-9-10-23(38)37(22)27-33-13-4-14-34-27/h1-8,13-15,18,22,24H,9-12,16H2,(H,35,39)	ZLYUNZVZRUVFAX-UHFFFAOYSA-N	363581	US9850277, Compound 73::US10689414, Compound 73::US10717764, Compound 73::US11021515, Compound 73::US11667673, Compound 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89711355	401959033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719868	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cscn1 |r|	InChI=1S/C28H26ClF3N4O3S/c29-21-7-2-1-6-20(21)25(26(38)34-18-10-12-28(31,32)13-11-18)35(19-5-3-4-17(30)14-19)27(39)22-8-9-24(37)36(22)23-15-40-16-33-23/h1-7,14-16,18,22,25H,8-13H2,(H,34,38)	NNLLCCIBLADXHQ-UHFFFAOYSA-N	363582	US9850277, Compound 74::US10689414, Compound 74::US10640534, Compound 74::US10717764, Compound 74::US11021515, Compound 74::US11667673, Compound 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707874	401959034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719870	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H29ClF3N5O3/c33-25-8-2-1-7-24(25)29(30(43)39-22-11-14-32(35,36)15-12-22)40(23-6-3-5-21(34)18-23)31(44)26-9-4-10-28(42)41(26)27-17-20(19-37)13-16-38-27/h1-3,5-8,13,16-18,22,26,29H,4,9-12,14-15H2,(H,39,43)	PYJCQKGRYZJDGK-UHFFFAOYSA-N	363583	US9850277, Compound 75::US10689414, Compound 75::US10640534, Compound 75::US10717764, Compound 75::US11021515, Compound 75::US11667673, Compound 75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699545	401959035							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719872	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O4/c29-21-8-2-1-7-20(21)23(24(38)35-18-9-11-28(31,32)12-10-18)36(19-6-3-5-17(30)15-19)25(39)22-16-41-27(40)37(22)26-33-13-4-14-34-26/h1-8,13-15,18,22-23H,9-12,16H2,(H,35,38)	CRGXKSLJFWSBMI-UHFFFAOYSA-N	363584	US9850277, Compound 76::US10689414, Compound 78::US10640534, Compound 76::US10717764, Compound 76::US11021515, Compound 76::US11667673, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699725	401959036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719874	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H21ClF3N5O4/c29-21-7-2-1-6-20(21)24(25(38)35-18-12-28(31,32)13-18)36(19-5-3-4-17(30)11-19)26(39)22-15-41-27(40)37(22)23-10-16(14-33)8-9-34-23/h1-11,18,22,24H,12-13,15H2,(H,35,38)	HTRBLQKFOCUZKD-UHFFFAOYSA-N	363585	US9850277, Compound 77::US10689414, Compound 77::US10640534, Compound 77::US10717764, Compound 77::US11021515, Compound 77::US11667673, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699781	401959037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719876	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O4/c31-23-7-2-1-6-22(23)26(27(40)37-20-8-11-30(33,34)12-9-20)38(21-5-3-4-19(32)15-21)28(41)24-17-43-29(42)39(24)25-14-18(16-35)10-13-36-25/h1-7,10,13-15,20,24,26H,8-9,11-12,17H2,(H,37,40)	XCPHAKYOINLUBX-UHFFFAOYSA-N	363586	US9850277, Compound 78::US10640534, Compound 78::US10717764, Compound 78::US11021515, Compound 78::US11667673, Compound 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699471	401959038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719878	CN1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H24ClF3N6O3/c1-37-16-23(39(28(37)42)24-11-17(15-34)9-10-35-24)27(41)38(20-6-4-5-18(31)12-20)25(21-7-2-3-8-22(21)30)26(40)36-19-13-29(32,33)14-19/h2-12,19,23,25H,13-14,16H2,1H3,(H,36,40)	AHQAKBHZGHUNQX-UHFFFAOYSA-N	363587	US9850277, Compound 79::US10689414, Compound 79::US10640534, Compound 79::US10717764, Compound 79::US11021515, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700007	401959039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719880	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CNC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22ClF3N6O3/c29-21-7-2-1-6-20(21)24(25(39)36-18-12-28(31,32)13-18)37(19-5-3-4-17(30)11-19)26(40)22-15-35-27(41)38(22)23-10-16(14-33)8-9-34-23/h1-11,18,22,24H,12-13,15H2,(H,35,41)(H,36,39)	MELMGGWIAVKJQO-UHFFFAOYSA-N	363588	US9850277, Compound 80::US10689414, Compound 80::US10640534, Compound 80::US10717764, Compound 80::US11021515, Compound 80::US11667673, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699600	401959040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719882	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H26ClF4N5O3/c32-24-4-2-1-3-23(24)28(29(43)39-21-7-10-31(35,36)11-8-21)40(22-15-19(33)14-20(34)16-22)30(44)25-5-6-27(42)41(25)26-13-18(17-37)9-12-38-26/h1-4,9,12-16,21,25,28H,5-8,10-11H2,(H,39,43)	SPJCWFFCGIYMTC-UHFFFAOYSA-N	363589	US9850277, Compound 81::US10689414, Compound 81::US10640534, Compound 81::US10717764, Compound 81::US11021515, Compound 81::US11667673, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707878	401959041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719884	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(C#N)c1F |r|	InChI=1S/C29H22ClF4N5O3/c30-21-7-2-1-6-20(21)25(27(41)37-18-13-29(33,34)14-18)38(19-5-3-4-17(31)12-19)28(42)22-8-9-23(40)39(22)26-24(32)16(15-35)10-11-36-26/h1-7,10-12,18,22,25H,8-9,13-14H2,(H,37,41)	MRCPGLJHHAYGDB-UHFFFAOYSA-N	363590	US9850277, Compound 82::US10689414, Compound 82::US10640534, Compound 82::US10717764, Compound 82::US11021515, Compound 82::US11667673, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699682	401959042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719886	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(C#N)c1F |r|	InChI=1S/C31H26ClF4N5O3/c32-23-7-2-1-6-22(23)27(29(43)39-20-10-13-31(35,36)14-11-20)40(21-5-3-4-19(33)16-21)30(44)24-8-9-25(42)41(24)28-26(34)18(17-37)12-15-38-28/h1-7,12,15-16,20,24,27H,8-11,13-14H2,(H,39,43)	RLMQRNHTTAAEPT-UHFFFAOYSA-N	363591	US9850277, Compound 83::US10689414, Compound 83::US10640534, Compound 83::US10717764, Compound 83::US11021515, Compound 83::US11667673, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700121	401959043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719888	NS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H25ClF2N6O5S/c30-22-7-2-1-6-21(22)26(27(40)36-18-14-29(31,32)15-18)37(19-4-3-5-20(13-19)44(34,42)43)28(41)23-8-9-25(39)38(23)24-12-17(16-33)10-11-35-24/h1-7,10-13,18,23,26H,8-9,14-15H2,(H,36,40)(H2,34,42,43)	IXGSJIHNRYNQIX-UHFFFAOYSA-N	363592	US9850277, Compound 84::US10689414, Compound 84::US10640534, Compound 84::US10717764, Compound 84::US11021515, Compound 84::US11667673, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699559	401959044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719890	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C30H26ClF3N6O3/c31-23-7-2-1-6-22(23)26(27(42)37-19-10-13-30(33,34)14-11-19)39(21-5-3-4-18(32)16-21)28(43)24-8-9-25(41)40(24)29-36-15-12-20(17-35)38-29/h1-7,12,15-16,19,24,26H,8-11,13-14H2,(H,37,42)	VNFCBYHEBLFKDJ-UHFFFAOYSA-N	363594	US9850277, Compound 85::US10689414, Compound 85::US10640534, Compound 85::US10717764, Compound 85::US11021515, Compound 85::US11667673, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699473	401959046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719892	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H21ClF4N6O3/c29-21-4-2-1-3-20(21)24(25(41)36-18-12-28(32,33)13-18)38(19-10-15(30)9-16(31)11-19)26(42)22-5-6-23(40)39(22)27-35-8-7-17(14-34)37-27/h1-4,7-11,18,22,24H,5-6,12-13H2,(H,36,41)	BHXJMLXDEUJSGK-UHFFFAOYSA-N	363595	US9850277, Compound 86::US10689414, Compound 86::US10640534, Compound 86::US10717764, Compound 86::US11021515, Compound 86::US11667673, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699777	401959047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719894	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C30H25ClF4N6O3/c31-23-4-2-1-3-22(23)26(27(43)38-19-7-10-30(34,35)11-8-19)40(21-14-17(32)13-18(33)15-21)28(44)24-5-6-25(42)41(24)29-37-12-9-20(16-36)39-29/h1-4,9,12-15,19,24,26H,5-8,10-11H2,(H,38,43)	FACIRSQMPRSNGP-UHFFFAOYSA-N	363596	US9850277, Compound 87::US10689414, Compound 87::US10640534, Compound 87::US10717764, Compound 87::US11021515, Compound 87::US11667673, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699528	401959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719896	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(C#N)c1F |r|	InChI=1S/C29H21ClF5N5O3/c30-21-4-2-1-3-20(21)25(27(42)38-18-12-29(34,35)13-18)39(19-10-16(31)9-17(32)11-19)28(43)22-5-6-23(41)40(22)26-24(33)15(14-36)7-8-37-26/h1-4,7-11,18,22,25H,5-6,12-13H2,(H,38,42)	FSFQFBBIBVXCAK-UHFFFAOYSA-N	363597	US9850277, Compound 88::US10689414, Compound 88::US10640534, Compound 88::US10717764, Compound 88::US11021515, Compound 88::US11667673, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699992	401959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719898	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C34H32ClF3N6O5/c1-33(2,3)49-32(48)42-18-26(44(28(45)19-42)27-13-20(17-39)11-12-40-27)31(47)43(23-8-6-7-21(36)14-23)29(24-9-4-5-10-25(24)35)30(46)41-22-15-34(37,38)16-22/h4-14,22,26,29H,15-16,18-19H2,1-3H3,(H,41,46)	BANLQGVIUZDTJG-UHFFFAOYSA-N	363598	US9850277, Compound 89::US10689414, Compound 89::US10640534, Compound 89::US10717764, Compound 89::US11021515, Compound 89::US11667673, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707966	401959050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719900	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O4/c30-22-7-2-1-6-21(22)25(26(39)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)27(40)23-9-11-42-28(41)38(23)24-12-17(16-34)8-10-35-24/h1-8,10,12-13,19,23,25H,9,11,14-15H2,(H,36,39)	WRKXERBFBRLAEJ-UHFFFAOYSA-N	363599	US9850277, Compound 90::US10640534, Compound 90::US10717764, Compound 90::US11667673, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700094	401959051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719902	Fc1cncc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)	WIJZXSAJMHAVGX-UHFFFAOYSA-N	363600	US9850277, Compound 91::US10689414, Compound 91::US10640534, Compound 91::US10717764, Compound 91::US11667673, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699486	401959052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719904	CC(=O)N1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H26ClF3N6O4/c1-18(42)39-16-25(41(27(43)17-39)26-11-19(15-36)9-10-37-26)30(45)40(22-6-4-5-20(33)12-22)28(23-7-2-3-8-24(23)32)29(44)38-21-13-31(34,35)14-21/h2-12,21,25,28H,13-14,16-17H2,1H3,(H,38,44)	OUQWDHLTDLNHJN-UHFFFAOYSA-N	363601	US9850277, Compound 92::US10689414, Compound 92::US10640534, Compound 92::US10717764, Compound 92::US11021515, Compound 92::US11667673, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690606	401959053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719906	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C35H34ClF4N7O5/c1-34(2,3)52-33(51)45-18-27(47(28(48)19-45)32-42-13-10-23(17-41)44-32)31(50)46(24-15-20(37)14-21(38)16-24)29(25-6-4-5-7-26(25)36)30(49)43-22-8-11-35(39,40)12-9-22/h4-7,10,13-16,22,27,29H,8-9,11-12,18-19H2,1-3H3,(H,43,49)	OOKMYLRSAKAGGR-UHFFFAOYSA-N	363602	US9850277, Compound 93::US10689414, Compound 93::US10640534, Compound 93::US10717764, Compound 93::US11021515, Compound 93::US11667673, Compound 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707887	401959054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719908	CCOC(=O)CN1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C32H28ClF3N6O5/c1-2-47-27(43)18-40-17-25(42(31(40)46)26-12-19(16-37)10-11-38-26)30(45)41(22-7-5-6-20(34)13-22)28(23-8-3-4-9-24(23)33)29(44)39-21-14-32(35,36)15-21/h3-13,21,25,28H,2,14-15,17-18H2,1H3,(H,39,44)	XKUYMOBPJINALI-UHFFFAOYSA-N	363605	US9850277, Compound 94::US10689414, Compound 94::US10640534, Compound 94::US10717764, Compound 94::US11667673, Compound 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690633	401959056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719910	CS(=O)(=O)c1cccc(c1)N(C(C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H30ClF2N5O5S/c1-46(44,45)23-6-4-5-22(18-23)39(31(43)26-9-10-28(41)40(26)27-17-20(19-36)13-16-37-27)29(24-7-2-3-8-25(24)33)30(42)38-21-11-14-32(34,35)15-12-21/h2-8,13,16-18,21,26,29H,9-12,14-15H2,1H3,(H,38,42)	DALSLUXHMCXKOX-UHFFFAOYSA-N	363606	US9850277, Compound 95::US10689414, Compound 95::US10640534, Compound 95::US10717764, Compound 95::US11021515, Compound 95::US11667673, Compound 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699723	401959057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719912	CS(=O)(=O)c1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF2N5O5S/c1-44(42,43)21-6-4-5-20(14-21)37(29(41)24-9-10-26(39)38(24)25-13-18(17-34)11-12-35-25)27(22-7-2-3-8-23(22)31)28(40)36-19-15-30(32,33)16-19/h2-8,11-14,19,24,27H,9-10,15-16H2,1H3,(H,36,40)	WKNABTPTCYOUFK-UHFFFAOYSA-N	363607	US9850277, Compound 96::US10689414, Compound 96::US10640534, Compound 96::US10717764, Compound 96::US11021515, Compound 96::US11667673, Compound 96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699944	401959058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719914	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C34H31ClF4N6O5/c1-33(2,3)50-32(49)43-17-26(45(28(46)18-43)27-10-19(16-40)8-9-41-27)31(48)44(23-12-20(36)11-21(37)13-23)29(24-6-4-5-7-25(24)35)30(47)42-22-14-34(38,39)15-22/h4-13,22,26,29H,14-15,17-18H2,1-3H3,(H,42,47)	NBBOZZYCTJIARB-UHFFFAOYSA-N	363608	US9850277, Compound 97::US10689414, Compound 97::US10640534, Compound 97::US10717764, Compound 97::US11021515, Compound 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707967	401959059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719916	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C33H30ClF4N7O5/c1-32(2,3)50-31(49)43-16-25(45(26(46)17-43)30-40-9-8-20(15-39)42-30)29(48)44(22-11-18(35)10-19(36)12-22)27(23-6-4-5-7-24(23)34)28(47)41-21-13-33(37,38)14-21/h4-12,21,25,27H,13-14,16-17H2,1-3H3,(H,41,47)	IUNCTNMRVWJOSU-UHFFFAOYSA-N	363609	US9850277, Compound 98::US10689414, Compound 98::US10640534, Compound 98::US10717764, Compound 98::US11021515, Compound 98::US11667673, Compound 98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707965	401959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719918	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CNCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H22ClF4N7O3/c29-21-4-2-1-3-20(21)24(25(42)37-18-10-28(32,33)11-18)39(19-8-15(30)7-16(31)9-19)26(43)22-13-35-14-23(41)40(22)27-36-6-5-17(12-34)38-27/h1-9,18,22,24,35H,10-11,13-14H2,(H,37,42)	XXXSWJFXEYXJFL-UHFFFAOYSA-N	363610	US9850277, Compound 99::US10689414, Compound 99::US10640534, Compound 99::US10717764, Compound 99::US11021515, Compound 99::US11667673, Compound 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657247	401959061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719920	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CNCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF4N6O3/c30-22-4-2-1-3-21(22)26(27(42)38-19-11-29(33,34)12-19)39(20-9-17(31)8-18(32)10-20)28(43)23-14-36-15-25(41)40(23)24-7-16(13-35)5-6-37-24/h1-10,19,23,26,36H,11-12,14-15H2,(H,38,42)	LQBYWGAJHMTLHT-UHFFFAOYSA-N	363611	US9850277, Compound 100::US10689414, Compound 100::US10640534, Compound 100::US10717764, Compound 100::US11021515, Compound 100::US11667673, Compound 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363611&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657353	401959062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719922	CN1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C30H25ClF4N6O3/c1-39-15-24(41(26(42)16-39)25-8-17(14-36)6-7-37-25)29(44)40(21-10-18(32)9-19(33)11-21)27(22-4-2-3-5-23(22)31)28(43)38-20-12-30(34,35)13-20/h2-11,20,24,27H,12-13,15-16H2,1H3,(H,38,43)	QJEBLQACNOGKQO-UHFFFAOYSA-N	363612	US9850277, Compound 101::US10689414, Compound 101::US10640534, Compound 101::US10717764, Compound 101::US11021515, Compound 101::US11667673, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657354	401959063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719924	CS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H25ClF2N6O5S/c1-44(42,43)20-6-4-5-19(13-20)37(27(41)23-9-10-24(39)38(23)28-34-12-11-17(16-33)36-28)25(21-7-2-3-8-22(21)30)26(40)35-18-14-29(31,32)15-18/h2-8,11-13,18,23,25H,9-10,14-15H2,1H3,(H,35,40)	BHVLUTCWSVLIGI-UHFFFAOYSA-N	363613	US9850277, Compound 102::US10689414, Compound 102::US10640534, Compound 102::US10717764, Compound 102::US11021515, Compound 102::US11667673, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657355	401959064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719926	CS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C31H29ClF2N6O5S/c1-46(44,45)22-6-4-5-21(17-22)39(29(43)25-9-10-26(41)40(25)30-36-16-13-20(18-35)38-30)27(23-7-2-3-8-24(23)32)28(42)37-19-11-14-31(33,34)15-12-19/h2-8,13,16-17,19,25,27H,9-12,14-15H2,1H3,(H,37,42)	CHSBBVUPZCWOII-UHFFFAOYSA-N	363614	US9850277, Compound 103::US10689414, Compound 103::US10640534, Compound 103::US10717764, Compound 103::US11021515, Compound 103::US11667673, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657565	401959065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719928	CCOC(=O)CN1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C33H29ClF4N6O5/c1-2-49-29(46)18-42-16-26(44(28(45)17-42)27-9-19(15-39)7-8-40-27)32(48)43(23-11-20(35)10-21(36)12-23)30(24-5-3-4-6-25(24)34)31(47)41-22-13-33(37,38)14-22/h3-12,22,26,30H,2,13-14,16-18H2,1H3,(H,41,47)	DMAIXYDWQGBGSF-UHFFFAOYSA-N	363615	US9850277, Compound 104::US10689414, Compound 104::US10640534, Compound 104::US10717764, Compound 104::US11021515, Compound 104::US11667673, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707969	401959066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719930	CS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H29ClF3N5O5S/c1-47(45,46)23-16-20(34)15-22(17-23)40(31(44)26-6-7-28(42)41(26)27-14-19(18-37)10-13-38-27)29(24-4-2-3-5-25(24)33)30(43)39-21-8-11-32(35,36)12-9-21/h2-5,10,13-17,21,26,29H,6-9,11-12H2,1H3,(H,39,43)	AQXHTRJAGRYZRT-UHFFFAOYSA-N	363616	US9850277, Compound 105::US11021515, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657678	401959067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719932	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CN(CC(=O)N1c1cc(ccn1)C#N)C1CC1 |r|	InChI=1S/C32H27ClF4N6O3/c33-25-4-2-1-3-24(25)29(30(45)40-21-13-32(36,37)14-21)42(23-11-19(34)10-20(35)12-23)31(46)26-16-41(22-5-6-22)17-28(44)43(26)27-9-18(15-38)7-8-39-27/h1-4,7-12,21-22,26,29H,5-6,13-14,16-17H2,(H,40,45)	WZJIOHMGOOFJQE-UHFFFAOYSA-N	363617	US9850277, Compound 106::US10689414, Compound 106::US10640534, Compound 106::US10717764, Compound 106::US11021515, Compound 106::US11667673, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690608	401959068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719934	OCCN1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H27ClF4N6O4/c32-24-4-2-1-3-23(24)28(29(45)39-21-13-31(35,36)14-21)41(22-11-19(33)10-20(34)12-22)30(46)25-16-40(7-8-43)17-27(44)42(25)26-9-18(15-37)5-6-38-26/h1-6,9-12,21,25,28,43H,7-8,13-14,16-17H2,(H,39,45)	ZCMHCAKOIRNDDK-UHFFFAOYSA-N	363618	US9850277, Compound 107::US10689414, Compound 107::US10640534, Compound 107::US10717764, Compound 107::US11021515, Compound 107::US11667673, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89705456	401959069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719936	CS(=O)(=O)c1cc(F)cc(c1)N(C(C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C31H28ClF3N6O5S/c1-47(45,46)22-15-18(33)14-21(16-22)40(29(44)25-6-7-26(42)41(25)30-37-13-10-20(17-36)39-30)27(23-4-2-3-5-24(23)32)28(43)38-19-8-11-31(34,35)12-9-19/h2-5,10,13-16,19,25,27H,6-9,11-12H2,1H3,(H,38,43)	RQQJQPCYZQWNLO-UHFFFAOYSA-N	363619	US9850277, Compound 108::US10689414, Compound 108::US10640534, Compound 108::US10717764, Compound 108::US11667673, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699677	401959070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719938	CS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H24ClF3N6O5S/c1-45(43,44)20-11-16(31)10-19(12-20)38(27(42)23-6-7-24(40)39(23)28-35-9-8-17(15-34)37-28)25(21-4-2-3-5-22(21)30)26(41)36-18-13-29(32,33)14-18/h2-5,8-12,18,23,25H,6-7,13-14H2,1H3,(H,36,41)	QSKCJDJWUNSQEQ-UHFFFAOYSA-N	363620	US9850277, Compound 109::US10640534, Compound 109::US10717764, Compound 109::US11021515, Compound 109::US11667673, Compound 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657139	401959071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719940	CS(=O)(=O)c1cc(F)cc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O5S/c1-45(43,44)21-12-18(32)11-20(13-21)38(29(42)24-6-7-26(40)39(24)25-10-17(16-35)8-9-36-25)27(22-4-2-3-5-23(22)31)28(41)37-19-14-30(33,34)15-19/h2-5,8-13,19,24,27H,6-7,14-15H2,1H3,(H,37,41)	SCCPCYNFZXXVLQ-UHFFFAOYSA-N	363621	US9850277, Compound 110::US10717764, Compound 110::US11667673, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699741	401959072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719942	CCOC(=O)CN1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H27ClF3N7O5/c1-2-47-25(43)17-40-16-24(42(30(40)46)29-37-11-10-19(15-36)39-29)28(45)41(21-7-5-6-18(33)12-21)26(22-8-3-4-9-23(22)32)27(44)38-20-13-31(34,35)14-20/h3-12,20,24,26H,2,13-14,16-17H2,1H3,(H,38,44)	KOFDSMNVMVYQLB-UHFFFAOYSA-N	363622	US9850277, Compound 111::US10689414, Compound 111::US10640534, Compound 111::US10717764, Compound 111::US11021515, Compound 111::US11667673, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699500	401959073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719944	OCCN1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-23-7-2-1-6-22(23)26(27(42)37-20-14-30(33,34)15-20)39(21-5-3-4-19(32)13-21)28(43)24-17-38(10-11-41)29(44)40(24)25-12-18(16-35)8-9-36-25/h1-9,12-13,20,24,26,41H,10-11,14-15,17H2,(H,37,42)	VUOSCTWKQJJYNF-UHFFFAOYSA-N	363623	US9850277, Compound 112::US10689414, Compound 112::US10640534, Compound 112::US10717764, Compound 112::US11021515, Compound 112::US11667673, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699484	401959074							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719946	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H23ClF3N5O4/c30-21-7-2-1-6-20(21)25(26(40)36-18-13-29(32,33)14-18)37(19-5-3-4-17(31)11-19)27(41)22-12-23(39)28(42)38(22)24-10-16(15-34)8-9-35-24/h1-11,18,22-23,25,39H,12-14H2,(H,36,40)	HITFKTSXSYNXEY-UHFFFAOYSA-N	363624	US9850277, Compound 113::US10689414, Compound 113::US10640534, Compound 113::US10717764, Compound 113::US11021515, Compound 113::US11667673, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657245	401959075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719948	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C29H22ClF4N5O4/c30-21-4-2-1-3-20(21)25(26(41)37-18-12-29(33,34)13-18)38(19-9-16(31)8-17(32)10-19)27(42)22-11-23(40)28(43)39(22)24-7-15(14-35)5-6-36-24/h1-10,18,22-23,25,40H,11-13H2,(H,37,41)	CEYKEKGDKNZKJE-UHFFFAOYSA-N	363625	US9850277, Compound 114::US10689414, Compound 114::US10640534, Compound 114::US10717764, Compound 114::US11021515, Compound 114::US11667673, Compound 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657246	401959076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719950	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C29H22ClF4N5O4/c30-21-4-2-1-3-20(21)25(26(41)37-18-12-29(33,34)13-18)38(19-9-16(31)8-17(32)10-19)27(42)22-11-23(40)28(43)39(22)24-7-15(14-35)5-6-36-24/h1-10,18,22-23,25,40H,11-13H2,(H,37,41)	CEYKEKGDKNZKJE-UHFFFAOYSA-N	363626	US9850277, Compound 115::US10689414, Compound 115::US10640534, Compound 115::US10717764, Compound 115::US11021515, Compound 115::US11667673, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656858	401959077							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719952	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C28H21ClF4N6O4/c29-20-4-2-1-3-19(20)23(24(41)36-17-11-28(32,33)12-17)38(18-8-14(30)7-15(31)9-18)25(42)21-10-22(40)26(43)39(21)27-35-6-5-16(13-34)37-27/h1-9,17,21-23,40H,10-12H2,(H,36,41)	GYKVHPWYXLIJFP-UHFFFAOYSA-N	363627	US9850277, Compound 116::US10689414, Compound 116::US10640534, Compound 116::US10717764, Compound 116::US11021515, Compound 116::US11667673, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656951	401959078							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719954	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C28H21ClF4N6O4/c29-20-4-2-1-3-19(20)23(24(41)36-17-11-28(32,33)12-17)38(18-8-14(30)7-15(31)9-18)25(42)21-10-22(40)26(43)39(21)27-35-6-5-16(13-34)37-27/h1-9,17,21-23,40H,10-12H2,(H,36,41)	GYKVHPWYXLIJFP-UHFFFAOYSA-N	363628	US9850277, Compound 117::US10689414, Compound 117::US10640534, Compound 117::US10717764, Compound 117::US11021515, Compound 117::US11667673, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656952	401959079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719956	O[C@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H23ClF3N5O4/c30-21-7-2-1-6-20(21)25(26(40)36-18-13-29(32,33)14-18)37(19-5-3-4-17(31)11-19)27(41)22-12-23(39)28(42)38(22)24-10-16(15-34)8-9-35-24/h1-11,18,22-23,25,39H,12-14H2,(H,36,40)	HITFKTSXSYNXEY-UHFFFAOYSA-N	363630	US9850277, Compound 118::US10689414, Compound 118::US10640534, Compound 118::US10717764, Compound 118::US11021515, Compound 118::US11667673, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656953	401959081							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719958	O[C@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H22ClF3N6O4/c29-20-7-2-1-6-19(20)23(24(40)35-17-12-28(31,32)13-17)37(18-5-3-4-15(30)10-18)25(41)21-11-22(39)26(42)38(21)27-34-9-8-16(14-33)36-27/h1-10,17,21-23,39H,11-13H2,(H,35,40)	GLKNGSWMTABBHU-UHFFFAOYSA-N	363631	US9850277, Compound 119::US10689414, Compound 119::US10640534, Compound 119::US10717764, Compound 119::US11021515, Compound 119::US11667673, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657137	401959082							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719960	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H22ClF3N6O4/c29-20-7-2-1-6-19(20)23(24(40)35-17-12-28(31,32)13-17)37(18-5-3-4-15(30)10-18)25(41)21-11-22(39)26(42)38(21)27-34-9-8-16(14-33)36-27/h1-10,17,21-23,39H,11-13H2,(H,35,40)	GLKNGSWMTABBHU-UHFFFAOYSA-N	363632	US9850277, Compound 120::US10640534, Compound 120::US10717764, Compound 120::US11021515, Compound 120::US11667673, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657043	401959083							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719962	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H27ClF3N5O4/c32-23-7-2-1-6-22(23)27(28(42)38-20-8-11-31(34,35)12-9-20)39(21-5-3-4-19(33)15-21)29(43)24-16-25(41)30(44)40(24)26-14-18(17-36)10-13-37-26/h1-7,10,13-15,20,24-25,27,41H,8-9,11-12,16H2,(H,38,42)	ZMWJRAJUGBQNSR-UHFFFAOYSA-N	363633	US9850277, Compound 121::US10689414, Compound 121::US10640534, Compound 121::US10717764, Compound 121::US11021515, Compound 121::US11667673, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657044	401959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719964	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-22-7-2-1-6-21(22)25(26(42)37-18-8-11-30(33,34)12-9-18)39(20-5-3-4-17(32)14-20)27(43)23-15-24(41)28(44)40(23)29-36-13-10-19(16-35)38-29/h1-7,10,13-14,18,23-25,41H,8-9,11-12,15H2,(H,37,42)	LHIJKVKSIGTZTB-UHFFFAOYSA-N	363634	US9850277, Compound 122::US10689414, Compound 122::US10640534, Compound 122::US10717764, Compound 122::US11021515, Compound 122::US11667673, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657045	401959085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719966	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-22-7-2-1-6-21(22)25(26(42)37-18-8-11-30(33,34)12-9-18)39(20-5-3-4-17(32)14-20)27(43)23-15-24(41)28(44)40(23)29-36-13-10-19(16-35)38-29/h1-7,10,13-14,18,23-25,41H,8-9,11-12,15H2,(H,37,42)	LHIJKVKSIGTZTB-UHFFFAOYSA-N	363635	US9850277, Compound 123::US10689414, Compound 123::US10640534, Compound 123::US10717764, Compound 123::US11021515, Compound 123::US11667673, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656765	401959086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719968	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H26ClF4N5O4/c32-23-4-2-1-3-22(23)27(28(43)39-20-5-8-31(35,36)9-6-20)40(21-13-18(33)12-19(34)14-21)29(44)24-15-25(42)30(45)41(24)26-11-17(16-37)7-10-38-26/h1-4,7,10-14,20,24-25,27,42H,5-6,8-9,15H2,(H,39,43)	IMOFWCACDGLXAQ-UHFFFAOYSA-N	363637	US9850277, Compound 124::US10689414, Compound 124::US10640534, Compound 124::US10717764, Compound 124::US11021515, Compound 124::US11667673, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699901	401959088							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719970	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H26ClF4N5O4/c32-23-4-2-1-3-22(23)27(28(43)39-20-5-8-31(35,36)9-6-20)40(21-13-18(33)12-19(34)14-21)29(44)24-15-25(42)30(45)41(24)26-11-17(16-37)7-10-38-26/h1-4,7,10-14,20,24-25,27,42H,5-6,8-9,15H2,(H,39,43)	IMOFWCACDGLXAQ-UHFFFAOYSA-N	363638	US9850277, Compound 125::US10689414, Compound 125::US10640534, Compound 125::US10717764, Compound 125::US11021515, Compound 125::US11667673, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656767	401959089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719972	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C30H25ClF4N6O4/c31-22-4-2-1-3-21(22)25(26(43)38-18-5-8-30(34,35)9-6-18)40(20-12-16(32)11-17(33)13-20)27(44)23-14-24(42)28(45)41(23)29-37-10-7-19(15-36)39-29/h1-4,7,10-13,18,23-25,42H,5-6,8-9,14H2,(H,38,43)	UEZUXIBTQPCFJK-UHFFFAOYSA-N	363639	US9850277, Compound 126::US10689414, Compound 126::US10640534, Compound 126::US10717764, Compound 126::US11021515, Compound 126::US11667673, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656766	401959090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719974	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C30H25ClF4N6O4/c31-22-4-2-1-3-21(22)25(26(43)38-18-5-8-30(34,35)9-6-18)40(20-12-16(32)11-17(33)13-20)27(44)23-14-24(42)28(45)41(23)29-37-10-7-19(15-36)39-29/h1-4,7,10-13,18,23-25,42H,5-6,8-9,14H2,(H,38,43)	UEZUXIBTQPCFJK-UHFFFAOYSA-N	363640	US9850277, Compound 127::US10689414, Compound 127::US10640534, Compound 127::US10717764, Compound 127::US11021515, Compound 127::US11667673, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656950	401959091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719976	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C30H23ClF2N6O3/c31-23-7-2-1-6-22(23)27(28(41)37-20-14-30(32,33)15-20)38(21-5-3-4-18(12-21)16-34)29(42)24-8-9-26(40)39(24)25-13-19(17-35)10-11-36-25/h1-7,10-13,20,24,27H,8-9,14-15H2,(H,37,41)	MOZQKVSZMSFZFY-UHFFFAOYSA-N	363641	US9850277, Compound 128::US10689414, Compound 128::US10640534, Compound 128::US10717764, Compound 128::US11021515, Compound 128::US11667673, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656855	401959092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719978	COc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF2N5O4/c1-42-21-6-4-5-20(14-21)37(29(41)24-9-10-26(39)38(24)25-13-18(17-34)11-12-35-25)27(22-7-2-3-8-23(22)31)28(40)36-19-15-30(32,33)16-19/h2-8,11-14,19,24,27H,9-10,15-16H2,1H3,(H,36,40)	LVKKYPKVAKECNR-UHFFFAOYSA-N	363642	US9850277, Compound 129::US10689414, Compound 129::US10640534, Compound 129::US10717764, Compound 129::US11021515, Compound 129::US11667673, Compound 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656856	401959093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719980	OCCOc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H28ClF2N5O5/c32-24-7-2-1-6-23(24)28(29(42)37-20-16-31(33,34)17-20)38(21-4-3-5-22(15-21)44-13-12-40)30(43)25-8-9-27(41)39(25)26-14-19(18-35)10-11-36-26/h1-7,10-11,14-15,20,25,28,40H,8-9,12-13,16-17H2,(H,37,42)	LIPHIEXIZBAWHI-UHFFFAOYSA-N	363643	US9850277, Compound 130::US10689414, Compound 130::US10640534, Compound 130::US10717764, Compound 130::US11021515, Compound 130::US11667673, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656857	401959094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719982	OCc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF2N5O4/c31-23-7-2-1-6-22(23)27(28(41)36-20-14-30(32,33)15-20)37(21-5-3-4-19(12-21)17-39)29(42)24-8-9-26(40)38(24)25-13-18(16-34)10-11-35-25/h1-7,10-13,20,24,27,39H,8-9,14-15,17H2,(H,36,41)	XLBMVGQAYDFMHL-UHFFFAOYSA-N	363644	US9850277, Compound 131::US10689414, Compound 131::US10640534, Compound 131::US10717764, Compound 131::US11021515, Compound 131::US11667673, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699511	401959095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719984	Fc1cncc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H24ClF3N6O4/c30-22-4-2-1-3-21(22)25(26(40)37-19-5-8-29(32,33)9-6-19)38(20-12-18(31)14-35-15-20)27(41)23-16-43-28(42)39(23)24-11-17(13-34)7-10-36-24/h1-4,7,10-12,14-15,19,23,25H,5-6,8-9,16H2,(H,37,40)	YQGRTCGDQCWOMA-UHFFFAOYSA-N	363645	US9850277, Compound 132::US10689414, Compound 132::US10640534, Compound 132::US10717764, Compound 132::US11021515, Compound 132::US11667673, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656584	401959096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719986	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O4/c30-22-4-2-1-3-21(22)25(26(40)37-19-13-29(33,34)14-19)38(20-11-17(31)10-18(32)12-20)27(41)23-6-8-43-28(42)39(23)24-9-16(15-35)5-7-36-24/h1-5,7,9-12,19,23,25H,6,8,13-14H2,(H,37,40)	IVQTUCSKJSKDRA-UHFFFAOYSA-N	363646	US9850277, Compound 133::US10689414, Compound 133::US10640534, Compound 133::US10717764, Compound 133::US11021515, Compound 133::US11667673, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656585	401959097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719988	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C29H20ClF3N6O4/c30-22-4-2-1-3-21(22)25(26(40)37-19-11-29(32,33)12-19)38(20-8-17(14-35)7-18(31)10-20)27(41)23-15-43-28(42)39(23)24-9-16(13-34)5-6-36-24/h1-10,19,23,25H,11-12,15H2,(H,37,40)	HDXKKWIPXADQOT-UHFFFAOYSA-N	363647	US9850277, Compound 134::US10689414, Compound 134::US10640534, Compound 134::US10717764, Compound 134::US11021515, Compound 134::US11667673, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656764	401959098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719990	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C27H20ClF3N6O4/c28-20-4-2-1-3-19(20)23(24(38)35-17-9-27(30,31)10-17)36(18-8-16(29)12-33-13-18)25(39)21-14-41-26(40)37(21)22-7-15(11-32)5-6-34-22/h1-8,12-13,17,21,23H,9-10,14H2,(H,35,38)	SCHVCLWDSRCNTE-UHFFFAOYSA-N	363648	US9850277, Compound 135::US10689414, Compound 135::US10640534, Compound 135::US10717764, Compound 135::US11021515, Compound 135::US11667673, Compound 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656676	401959099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719992	Fc1cc(cc2cn[nH]c12)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H27ClF3N7O3/c33-23-4-2-1-3-22(23)29(30(45)40-20-7-10-32(35,36)11-8-20)42(21-14-19-17-39-41-28(19)24(34)15-21)31(46)25-5-6-27(44)43(25)26-13-18(16-37)9-12-38-26/h1-4,9,12-15,17,20,25,29H,5-8,10-11H2,(H,39,41)(H,40,45)	BBRDYZKSFLDBPC-UHFFFAOYSA-N	363649	US9850277, Compound 136::US10640534, Compound 136::US10717764, Compound 136::US11021515, Compound 136::US11667673, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656677	401959100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719994	Fc1cncc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF3N6O4/c31-23-4-2-1-3-22(23)26(27(41)38-20-5-9-30(33,34)10-6-20)39(21-14-19(32)16-36-17-21)28(42)24-8-12-44-29(43)40(24)25-13-18(15-35)7-11-37-25/h1-4,7,11,13-14,16-17,20,24,26H,5-6,8-10,12H2,(H,38,41)	XTVGVCVRBJUKSW-UHFFFAOYSA-N	363650	US9850277, Compound 137::US10689414, Compound 137::US10640534, Compound 137::US10717764, Compound 137::US11021515, Compound 137::US11667673, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656678	401959101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719996	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H24F3N5O3/c30-20-7-4-8-22(14-20)36(26(19-5-2-1-3-6-19)27(39)35-21-15-29(31,32)16-21)28(40)23-9-10-25(38)37(23)24-13-18(17-33)11-12-34-24/h1-8,11-14,21,23,26H,9-10,15-16H2,(H,35,39)	RLORRIOOVFASIB-UHFFFAOYSA-N	363651	US9850277, Compound 138::US10689414, Compound 138::US10640534, Compound 138::US10717764, Compound 138::US11021515, Compound 138::US11667673, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656679	401959102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719998	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H26ClF4N5O4/c32-24-4-2-1-3-23(24)27(28(42)39-21-5-9-31(35,36)10-6-21)40(22-15-19(33)14-20(34)16-22)29(43)25-8-12-45-30(44)41(25)26-13-18(17-37)7-11-38-26/h1-4,7,11,13-16,21,25,27H,5-6,8-10,12H2,(H,39,42)	MXUZEFGBLPRNCF-UHFFFAOYSA-N	363652	US9850277, Compound 139::US10689414, Compound 139::US10640534, Compound 139::US10717764, Compound 139::US11021515, Compound 139::US11667673, Compound 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656582	401959103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720000	OC1(CC1)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H28ClF2N5O4/c33-24-7-2-1-6-23(24)28(29(42)38-21-16-32(34,35)17-21)39(22-5-3-4-20(15-22)31(44)11-12-31)30(43)25-8-9-27(41)40(25)26-14-19(18-36)10-13-37-26/h1-7,10,13-15,21,25,28,44H,8-9,11-12,16-17H2,(H,38,42)	MQUWSLVEIHMPEF-UHFFFAOYSA-N	363653	US9850277, Compound 140::US10640534, Compound 140::US10717764, Compound 140::US11021515, Compound 140::US11667673, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656374	401959104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720002	FC1(F)CCC(CC1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2[nH]cnc12)c1ccccc1Cl |r|	InChI=1S/C32H28ClF2N7O3/c33-22-5-2-1-4-21(22)29(30(44)40-20-10-13-32(34,35)14-11-20)42(24-7-3-6-23-28(24)39-18-38-23)31(45)25-8-9-27(43)41(25)26-16-19(17-36)12-15-37-26/h1-7,12,15-16,18,20,25,29H,8-11,13-14H2,(H,38,39)(H,40,44)	AOKUPZGWXWHPJH-UHFFFAOYSA-N	363654	US9850277, Compound 141::US10689414, Compound 141::US10640534, Compound 141::US10717764, Compound 141::US11021515, Compound 141::US11667673, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690624	401959105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720004	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2cn[nH]c12)c1ccccc1Cl |r|	InChI=1S/C32H28ClF2N7O3/c33-23-6-2-1-5-22(23)29(30(44)39-21-10-13-32(34,35)14-11-21)42(24-7-3-4-20-18-38-40-28(20)24)31(45)25-8-9-27(43)41(25)26-16-19(17-36)12-15-37-26/h1-7,12,15-16,18,21,25,29H,8-11,13-14H2,(H,38,40)(H,39,44)	XNWUIVIZPHKIDU-UHFFFAOYSA-N	363655	US9850277, Compound 142::US10689414, Compound 142::US10640534, Compound 142::US10717764, Compound 142::US11021515, Compound 142::US11667673, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145452958	401959106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720006	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22ClF3N6O4/c29-21-4-2-1-3-20(21)24(25(39)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)26(40)22-6-8-42-27(41)38(22)23-9-16(13-33)5-7-35-23/h1-5,7,9-10,14-15,18,22,24H,6,8,11-12H2,(H,36,39)	OZPXDAJSVCYNNF-UHFFFAOYSA-N	363656	US9850277, Compound 143::US10689414, Compound 143::US10640534, Compound 143::US10717764, Compound 143::US11021515, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656375	401959107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720008	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C30H25ClF4N6O4/c31-23-4-2-1-3-22(23)25(26(42)38-19-5-9-30(34,35)10-6-19)40(21-14-17(32)13-18(33)15-21)27(43)24-8-12-45-29(44)41(24)28-37-11-7-20(16-36)39-28/h1-4,7,11,13-15,19,24-25H,5-6,8-10,12H2,(H,38,42)	VQJHOXGWXBTTPK-UHFFFAOYSA-N	363657	US9850277, Compound 144::US10689414, Compound 144::US10640534, Compound 144::US10717764, Compound 144::US11021515, Compound 144::US11667673, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699564	401959108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720010	CC(C)(O)c1cc(F)cc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H27ClF3N5O5/c1-30(2,44)18-10-19(33)12-21(11-18)39(28(42)24-16-45-29(43)40(24)25-9-17(15-36)7-8-37-25)26(22-5-3-4-6-23(22)32)27(41)38-20-13-31(34,35)14-20/h3-12,20,24,26,44H,13-14,16H2,1-2H3,(H,38,41)	TZXIEFFSQLYJQJ-UHFFFAOYSA-N	363658	US9850277, Compound 145::US10640534, Compound 145::US10717764, Compound 145::US11021515, Compound 145::US11667673, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699619	401959109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720012	CC(C)(O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H29ClF3N5O5/c1-31(2,45)19-12-20(34)14-22(13-19)40(27(23-5-3-4-6-24(23)33)28(42)39-21-15-32(35,36)16-21)29(43)25-8-10-46-30(44)41(25)26-11-18(17-37)7-9-38-26/h3-7,9,11-14,21,25,27,45H,8,10,15-16H2,1-2H3,(H,39,42)	POIIFFFQSQIQHA-UHFFFAOYSA-N	363659	US9850277, Compound 146::US10689414, Compound 146::US10640534, Compound 146::US10717764, Compound 146::US11021515, Compound 146::US11667673, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656479	401959110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720014	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H23F3N6O3/c29-19-11-21(16-33-15-19)36(25(18-4-2-1-3-5-18)26(39)35-20-12-28(30,31)13-20)27(40)22-6-7-24(38)37(22)23-10-17(14-32)8-9-34-23/h1-5,8-11,15-16,20,22,25H,6-7,12-13H2,(H,35,39)	BKWVETAXXJILAU-UHFFFAOYSA-N	363660	US9850277, Compound 147::US10689414, Compound 147::US10640534, Compound 147::US10717764, Compound 147::US11021515, Compound 147::US11667673, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699526	401959111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720016	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22F4N6O3/c29-17-10-19(15-34-14-17)37(27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23)25(20-3-1-2-4-21(20)30)26(40)36-18-11-28(31,32)12-18/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)	SUANQEARPHOGRR-UHFFFAOYSA-N	363661	US9850277, Compound 148::US10689414, Compound 148::US10640534, Compound 148::US10717764, Compound 148::US11021515, Compound 148::US11667673, Compound 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699518	401959112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720018	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23F4N5O3/c30-18-4-3-5-20(13-18)37(28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24)26(21-6-1-2-7-22(21)31)27(40)36-19-14-29(32,33)15-19/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	AGDOJAFSZKVDGU-UHFFFAOYSA-N	363662	US9850277, Compound 149::US10689414, Compound 149::US10640534, Compound 149::US10717764, Compound 149::US11021515, Compound 149::US11667673, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656274	401959113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720020	CC(C)(O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#C |r|	InChI=1S/C33H30ClF3N4O4/c1-4-19-11-12-38-27(13-19)41-26(9-10-28(41)42)31(44)40(23-15-20(32(2,3)45)14-21(35)16-23)29(24-7-5-6-8-25(24)34)30(43)39-22-17-33(36,37)18-22/h1,5-8,11-16,22,26,29,45H,9-10,17-18H2,2-3H3,(H,39,43)	JDWMNYUNELKFRO-UHFFFAOYSA-N	363663	US9850277, Compound 150::US11667673, Compound 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			124193798	401959114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720022	F[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H26ClF4N5O3/c32-23-7-2-1-6-22(23)27(28(42)39-20-8-11-31(35,36)12-9-20)40(21-5-3-4-19(33)15-21)30(44)25-16-24(34)29(43)41(25)26-14-18(17-37)10-13-38-26/h1-7,10,13-15,20,24-25,27H,8-9,11-12,16H2,(H,39,42)	JMDFVJCPOQZKCU-UHFFFAOYSA-N	363664	US9850277, Compound 151::US10689414, Compound 151::US10640534, Compound 151::US10717764, Compound 151::US11021515, Compound 151::US11667673, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656373	401959115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720024	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2[nH]ncc12)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-21-5-2-1-4-19(21)27(28(42)37-18-13-30(32,33)14-18)40(23-7-3-6-22-20(23)16-36-38-22)29(43)24-8-9-26(41)39(24)25-12-17(15-34)10-11-35-25/h1-7,10-12,16,18,24,27H,8-9,13-14H2,(H,36,38)(H,37,42)	MBVBELUTRVZREP-UHFFFAOYSA-N	363665	US9850277, Compound 152::US10689414, Compound 152::US10640534, Compound 152::US10717764, Compound 152::US11021515, Compound 152::US11667673, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145452959	401959116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720026	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cc(cc(c1)C#N)C#N)c1ccccc1Cl |r|	InChI=1S/C31H22ClF2N7O3/c32-24-4-2-1-3-23(24)28(29(43)39-21-13-31(33,34)14-21)40(22-10-19(16-36)9-20(11-22)17-37)30(44)25-5-6-27(42)41(25)26-12-18(15-35)7-8-38-26/h1-4,7-12,21,25,28H,5-6,13-14H2,(H,39,43)	JVZLOTLFFCFWBA-UHFFFAOYSA-N	363666	US9850277, Compound 153::US10689414, Compound 153::US10640534, Compound 153::US10717764, Compound 153::US11021515, Compound 153::US11667673, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657133	401959117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720028	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H21ClF4N6O4/c29-21-4-2-1-3-20(21)23(24(40)36-18-12-28(32,33)13-18)38(19-10-15(30)9-16(31)11-19)25(41)22-6-8-43-27(42)39(22)26-35-7-5-17(14-34)37-26/h1-5,7,9-11,18,22-23H,6,8,12-13H2,(H,36,40)	BEWMGBTVYNQDOG-UHFFFAOYSA-N	363667	US9850277, Compound 154::US10689414, Compound 154::US10640534, Compound 154::US10717764, Compound 154::US11021515, Compound 154::US11667673, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699642	401959118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720030	CC(C)(O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H30F3N5O4/c1-31(2,44)21-13-22(33)15-24(14-21)39(28(20-6-4-3-5-7-20)29(42)38-23-16-32(34,35)17-23)30(43)25-8-9-27(41)40(25)26-12-19(18-36)10-11-37-26/h3-7,10-15,23,25,28,44H,8-9,16-17H2,1-2H3,(H,38,42)	CWFLCBXOMIENMO-UHFFFAOYSA-N	363668	US9850277, Compound 155::US10689414, Compound 155::US10640534, Compound 155::US10717764, Compound 155::US11021515, Compound 155::US11667673, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707925	401959119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720032	CN(C)S(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H29ClF2N6O5S/c1-38(2)46(44,45)22-7-5-6-21(15-22)39(30(43)25-10-11-27(41)40(25)26-14-19(18-35)12-13-36-26)28(23-8-3-4-9-24(23)32)29(42)37-20-16-31(33,34)17-20/h3-9,12-15,20,25,28H,10-11,16-17H2,1-2H3,(H,37,42)	ZXVYIJWNIVZMJM-UHFFFAOYSA-N	363669	US9850277, Compound 156::US10689414, Compound 156::US10640534, Compound 156::US10717764, Compound 156::US11021515, Compound 156::US11667673, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657791	401959120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720034	CNS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H27ClF2N6O5S/c1-35-45(43,44)21-6-4-5-20(14-21)38(29(42)24-9-10-26(40)39(24)25-13-18(17-34)11-12-36-25)27(22-7-2-3-8-23(22)31)28(41)37-19-15-30(32,33)16-19/h2-8,11-14,19,24,27,35H,9-10,15-16H2,1H3,(H,37,41)	VTJAXLZURITKHL-UHFFFAOYSA-N	363670	US9850277, Compound 157::US10689414, Compound 157::US10640534, Compound 157::US10717764, Compound 157::US11021515, Compound 157::US11667673, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657792	401959121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720036	NS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H24ClF3N6O5S/c30-22-4-2-1-3-21(22)26(27(41)37-18-13-29(32,33)14-18)38(19-10-17(31)11-20(12-19)45(35,43)44)28(42)23-5-6-25(40)39(23)24-9-16(15-34)7-8-36-24/h1-4,7-12,18,23,26H,5-6,13-14H2,(H,37,41)(H2,35,43,44)	PFIJJYHIKFHICJ-UHFFFAOYSA-N	363671	US9850277, Compound 158::US10689414, Compound 158::US10640534, Compound 158::US10717764, Compound 158::US11021515, Compound 158::US11667673, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657793	401959122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720038	CS(=O)(=O)Nc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H27ClF2N6O5S/c1-45(43,44)37-19-5-4-6-21(14-19)38(29(42)24-9-10-26(40)39(24)25-13-18(17-34)11-12-35-25)27(22-7-2-3-8-23(22)31)28(41)36-20-15-30(32,33)16-20/h2-8,11-14,20,24,27,37H,9-10,15-16H2,1H3,(H,36,41)	PDXIYNMEIVGTEM-UHFFFAOYSA-N	363672	US9850277, Compound 159::US10689414, Compound 159::US10640534, Compound 159::US10717764, Compound 159::US11021515, Compound 159::US11667673, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656372	401959123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720040	OCCc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H28ClF2N5O4/c32-24-7-2-1-6-23(24)28(29(42)37-21-16-31(33,34)17-21)38(22-5-3-4-19(14-22)11-13-40)30(43)25-8-9-27(41)39(25)26-15-20(18-35)10-12-36-26/h1-7,10,12,14-15,21,25,28,40H,8-9,11,13,16-17H2,(H,37,42)	HNSJWOTXMJVNME-UHFFFAOYSA-N	363673	US9850277, Compound 160::US10689414, Compound 160::US10640534, Compound 160::US10717764, Compound 160::US11021515, Compound 160::US11667673, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656271	401959124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720042	CN(C)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H29ClF2N6O3/c1-38(2)21-6-5-7-22(15-21)39(30(43)25-10-11-27(41)40(25)26-14-19(18-35)12-13-36-26)28(23-8-3-4-9-24(23)32)29(42)37-20-16-31(33,34)17-20/h3-9,12-15,20,25,28H,10-11,16-17H2,1-2H3,(H,37,42)	DZVPQUYLMIIRMO-UHFFFAOYSA-N	363674	US9850277, Compound 161::US10689414, Compound 161::US10640534, Compound 161::US10717764, Compound 161::US11021515, Compound 161::US11667673, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656272	401959125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720044	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncc(o1)C#N |r|	InChI=1S/C27H20ClF4N5O4/c28-20-4-2-1-3-19(20)23(24(39)35-16-10-27(31,32)11-16)36(17-8-14(29)7-15(30)9-17)25(40)21-5-6-22(38)37(21)26-34-13-18(12-33)41-26/h1-4,7-9,13,16,21,23H,5-6,10-11H2,(H,35,39)	DVWRXABLNUGTNX-UHFFFAOYSA-N	363675	US9850277, Compound 162::US10689414, Compound 162::US10640534, Compound 162::US10717764, Compound 162::US11021515, Compound 162::US11667673, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656273	401959126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720046	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O3/c30-22-4-2-1-3-21(22)26(27(41)37-19-13-29(33,34)14-19)38(20-11-17(31)10-18(32)12-20)28(42)23-5-6-25(40)39(23)24-9-16(15-35)7-8-36-24/h1-4,7-12,19,23,26H,5-6,13-14H2,(H,37,41)	KICQCOSIQLKQBA-UHFFFAOYSA-N	363579	US9850277, Compound 71::US9850277, Compound 163::US10689414, Compound 163::US10640534, Compound 163::US10717764, Compound 163::US11021515, Compound 163::US11667673, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699884	401959031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720048	COc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H25ClF2N6O4/c1-42-20-6-4-5-19(13-20)37(27(41)23-9-10-24(39)38(23)28-34-12-11-17(16-33)36-28)25(21-7-2-3-8-22(21)30)26(40)35-18-14-29(31,32)15-18/h2-8,11-13,18,23,25H,9-10,14-15H2,1H3,(H,35,40)	RTTFSFYIVVXTLC-UHFFFAOYSA-N	363677	US9850277, Compound 164::US10689414, Compound 164::US10640534, Compound 164::US10717764, Compound 164::US11021515, Compound 164::US11667673, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657562	401959127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720051	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C32H27ClF2N6O3/c33-25-7-2-1-6-24(25)29(30(43)39-22-10-13-32(34,35)14-11-22)40(23-5-3-4-20(16-23)18-36)31(44)26-8-9-28(42)41(26)27-17-21(19-37)12-15-38-27/h1-7,12,15-17,22,26,29H,8-11,13-14H2,(H,39,43)	NWTJGIZNJQWQNT-UHFFFAOYSA-N	363679	US9850277, Compound 166::US10689414, Compound 166::US10640534, Compound 166::US10717764, Compound 166::US11021515, Compound 166::US11667673, Compound 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657564	401959129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720054	CS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C31H28ClF3N6O5S/c1-47(45,46)22-15-18(33)14-21(16-22)40(29(44)25-6-7-26(42)41(25)30-37-13-10-20(17-36)39-30)27(23-4-2-3-5-24(23)32)28(43)38-19-8-11-31(34,35)12-9-19/h2-5,10,13-16,19,25,27H,6-9,11-12H2,1H3,(H,38,43)	RQQJQPCYZQWNLO-UHFFFAOYSA-N	363681	US9850277, Compound 168::US10689414, Compound 168::US10640534, Compound 168::US10717764, Compound 168::US11021515, Compound 168::US11667673, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657138	401959131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720061	O[C@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H26ClF4N5O4/c32-23-4-2-1-3-22(23)27(28(43)39-20-5-8-31(35,36)9-6-20)40(21-13-18(33)12-19(34)14-21)29(44)24-15-25(42)30(45)41(24)26-11-17(16-37)7-10-38-26/h1-4,7,10-14,20,24-25,27,42H,5-6,8-9,15H2,(H,39,43)	IMOFWCACDGLXAQ-UHFFFAOYSA-N	363687	US9850277, Compound 174::US10689414, Compound 174::US10640534, Compound 174::US10717764, Compound 174::US11021515, Compound 174::US11667673, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657452	401959137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720063	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1ccc2[nH]ncc2c1)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-22-4-2-1-3-21(22)27(28(42)37-19-13-30(32,33)14-19)39(20-5-6-23-18(12-20)16-36-38-23)29(43)24-7-8-26(41)40(24)25-11-17(15-34)9-10-35-25/h1-6,9-12,16,19,24,27H,7-8,13-14H2,(H,36,38)(H,37,42)	MMGNTQLURSXJMR-UHFFFAOYSA-N	363688	US9850277, Compound 175::US10689414, Compound 175::US10640534, Compound 175::US10717764, Compound 175::US11021515, Compound 175::US11667673, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657453	401959138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720065	c1ccc(c(c1)[C@@H](C(=O)NC2CC(C2)(F)F)N(c3cc(cnc3)F)C(=O)[C@@H]4CCC(=O)N4c5cc(ccn5)C#N)Cl	InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)	WIJZXSAJMHAVGX-UHFFFAOYSA-N	363689	US9850277, Compound 176::US10682352, Compound AG120::US10640534, Compound 176::US10717764, Compound 176::US11021515, Compound 176::US11376246, Cpd ID AG-120::US11576906, Compound AG-120::US11311527, Cpd ID AG-120::US11667673, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363689&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	IV3	8T7O	71657455	401959139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720067	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C30H22ClF3N6O3/c31-23-4-2-1-3-22(23)27(28(42)38-20-13-30(33,34)14-20)39(21-10-18(16-36)9-19(32)12-21)29(43)24-5-6-26(41)40(24)25-11-17(15-35)7-8-37-25/h1-4,7-12,20,24,27H,5-6,13-14H2,(H,38,42)	OUOPAIJHGSDRMV-UHFFFAOYSA-N	363690	US9850277, Compound 177::US10689414, Compound 177::US10640534, Compound 177::US10717764, Compound 177::US11021515, Compound 177::US11667673, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363690&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657454	401959140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720069	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C31H26ClF2N7O3/c32-24-7-2-1-6-23(24)27(28(43)38-20-10-13-31(33,34)14-11-20)40(22-5-3-4-19(16-22)17-35)29(44)25-8-9-26(42)41(25)30-37-15-12-21(18-36)39-30/h1-7,12,15-16,20,25,27H,8-11,13-14H2,(H,38,43)	IFPDRGUZVMVZSF-UHFFFAOYSA-N	363691	US9850277, Compound 178::US10689414, Compound 178::US10640534, Compound 178::US10717764, Compound 178::US11021515, Compound 178::US11667673, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363691&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699704	401959141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720071	CC(C)(O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H30ClF2N5O4/c1-31(2,44)20-6-5-7-22(15-20)39(30(43)25-10-11-27(41)40(25)26-14-19(18-36)12-13-37-26)28(23-8-3-4-9-24(23)33)29(42)38-21-16-32(34,35)17-21/h3-9,12-15,21,25,28,44H,10-11,16-17H2,1-2H3,(H,38,42)	HHGYXOPFMWBBIL-UHFFFAOYSA-N	363692	US9850277, Compound 179::US10689414, Compound 179::US10640534, Compound 179::US10717764, Compound 179::US11021515, Compound 179::US11667673, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657136	401959142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720073	FC(F)(F)Oc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H22ClF5N6O4/c30-21-7-2-1-6-20(21)24(25(43)38-17-13-28(31,32)14-17)40(18-4-3-5-19(12-18)45-29(33,34)35)26(44)22-8-9-23(42)41(22)27-37-11-10-16(15-36)39-27/h1-7,10-12,17,22,24H,8-9,13-14H2,(H,38,43)	TWMOXSSMBQPSKI-UHFFFAOYSA-N	363693	US9850277, Compound 180::US10689414, Compound 180::US10640534, Compound 180::US10717764, Compound 180::US11021515, Compound 180::US11667673, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363693&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89700031	401959143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720075	FC(F)Oc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H24ClF4N5O4/c31-22-7-2-1-6-21(22)26(27(42)38-18-14-30(34,35)15-18)39(19-4-3-5-20(13-19)44-29(32)33)28(43)23-8-9-25(41)40(23)24-12-17(16-36)10-11-37-24/h1-7,10-13,18,23,26,29H,8-9,14-15H2,(H,38,42)	IQBNCPMUMOBIBD-UHFFFAOYSA-N	363694	US9850277, Compound 181::US10689414, Compound 181::US10717764, Compound 181::US11021515, Compound 181::US11667673, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699515	401959144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720077	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)c1cccc(c1)C1CC1)c1ccccc1Cl |r|	InChI=1S/C31H27ClF2N6O3/c32-24-7-2-1-6-23(24)27(28(42)37-21-15-31(33,34)16-21)39(22-5-3-4-19(14-22)18-8-9-18)29(43)25-10-11-26(41)40(25)30-36-13-12-20(17-35)38-30/h1-7,12-14,18,21,25,27H,8-11,15-16H2,(H,37,42)	NEEFZHLDHWRLNC-UHFFFAOYSA-N	363695	US9850277, Compound 182::US10689414, Compound 182::US10640534, Compound 182::US10717764, Compound 182::US11021515, Compound 182::US11667673, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363695&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699532	401959145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720080	Fc1cc(cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C32H26ClF3N6O3/c33-25-4-2-1-3-24(25)29(30(44)40-22-7-10-32(35,36)11-8-22)41(23-14-20(18-38)13-21(34)16-23)31(45)26-5-6-28(43)42(26)27-15-19(17-37)9-12-39-27/h1-4,9,12-16,22,26,29H,5-8,10-11H2,(H,40,44)	LNGNGQRPGYSXLQ-UHFFFAOYSA-N	363697	US9850277, Compound 184::US10689414, Compound 184::US10640534, Compound 184::US10717764, Compound 184::US11021515, Compound 184::US11667673, Compound 184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363697&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657243	401959147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720082	Fc1cc(cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)C#N |r|	InChI=1S/C31H25ClF3N7O3/c32-24-4-2-1-3-23(24)27(28(44)39-20-7-10-31(34,35)11-8-20)41(22-14-18(16-36)13-19(33)15-22)29(45)25-5-6-26(43)42(25)30-38-12-9-21(17-37)40-30/h1-4,9,12-15,20,25,27H,5-8,10-11H2,(H,39,44)	YFPRYFOHOGEFQY-UHFFFAOYSA-N	363698	US9850277, Compound 185::US10689414, Compound 185::US10640534, Compound 185::US10717764, Compound 185::US11021515, Compound 185::US11667673, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657348	401959148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720084	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2cn[nH]c12)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-21-6-2-1-5-20(21)27(28(42)37-19-13-30(32,33)14-19)40(22-7-3-4-18-16-36-38-26(18)22)29(43)23-8-9-25(41)39(23)24-12-17(15-34)10-11-35-24/h1-7,10-12,16,19,23,27H,8-9,13-14H2,(H,36,38)(H,37,42)	JVKSHAPFLQYINL-UHFFFAOYSA-N	363699	US9850277, Compound 186::US10689414, Compound 186::US11021515, Compound 186::US11667673, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657349	401959149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720086	Fc1ccccc1N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-20-6-2-1-5-19(20)26(27(40)36-18-14-29(32,33)15-18)38(22-8-4-3-7-21(22)31)28(41)23-9-10-25(39)37(23)24-13-17(16-34)11-12-35-24/h1-8,11-13,18,23,26H,9-10,14-15H2,(H,36,40)	WZQDKINHBLUCPG-UHFFFAOYSA-N	363700	US9850277, Compound 187::US10689414, Compound 187::US10640534, Compound 187::US10717764, Compound 187::US11021515, Compound 187::US11667673, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363700&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657039	401959150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720088	Fc1cccc(N([C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)C(=O)[C@@H]2CCC(=O)N2c2cc(ccn2)C#N)c1F |r|	InChI=1S/C29H22ClF4N5O3/c30-19-5-2-1-4-18(19)26(27(41)37-17-13-29(33,34)14-17)39(21-7-3-6-20(31)25(21)32)28(42)22-8-9-24(40)38(22)23-12-16(15-35)10-11-36-23/h1-7,10-12,17,22,26H,8-9,13-14H2,(H,37,41)	AFVGQWQJMPQEFQ-UHFFFAOYSA-N	363701	US9850277, Compound 188::US10689414, Compound 188::US10640534, Compound 188::US10717764, Compound 188::US11021515, Compound 188::US11667673, Compound 188	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657040	401959151							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720091	C[S@](=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O4S/c1-44(43)21-12-18(32)11-20(13-21)38(29(42)24-6-7-26(40)39(24)25-10-17(16-35)8-9-36-25)27(22-4-2-3-5-23(22)31)28(41)37-19-14-30(33,34)15-19/h2-5,8-13,19,24,27H,6-7,14-15H2,1H3,(H,37,41)	HAJLXEGWTKLTAE-UHFFFAOYSA-N	363703	US9850277, Compound 190::US10689414, Compound 190::US10640534, Compound 190::US10717764, Compound 190::US11021515, Compound 190::US11667673, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71657042	401959153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720093	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cc(cc(c1)C#N)C#N)c1ccccc1Cl |r|	InChI=1S/C31H22ClF2N7O3/c32-24-4-2-1-3-23(24)28(29(43)39-21-13-31(33,34)14-21)40(22-10-19(16-36)9-20(11-22)17-37)30(44)25-5-6-27(42)41(25)26-12-18(15-35)7-8-38-26/h1-4,7-12,21,25,28H,5-6,13-14H2,(H,39,43)	JVZLOTLFFCFWBA-UHFFFAOYSA-N	363704	US9850277, Compound 191::US10689414, Compound 191::US10640534, Compound 191::US10717764, Compound 191::US11021515, Compound 191::US11667673, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363704&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			86690602	401959154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720096	Fc1cncc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF3N6O3/c31-23-4-2-1-3-22(23)27(28(42)38-20-7-10-30(33,34)11-8-20)39(21-14-19(32)16-36-17-21)29(43)24-5-6-26(41)40(24)25-13-18(15-35)9-12-37-25/h1-4,9,12-14,16-17,20,24,27H,5-8,10-11H2,(H,38,42)	LPPNMHGIZPKQMV-UHFFFAOYSA-N	363706	US9850277, Compound 193::US10689414, Compound 193::US10640534, Compound 193::US10717764, Compound 193::US11021515, Compound 193::US11667673, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363706&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699756	401959156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720101	Fc1ccc(F)c(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O3/c30-20-4-2-1-3-19(20)26(27(41)37-18-13-29(33,34)14-18)39(23-12-17(31)5-6-21(23)32)28(42)22-7-8-25(40)38(22)24-11-16(15-35)9-10-36-24/h1-6,9-12,18,22,26H,7-8,13-14H2,(H,37,41)	QRPVHYKENSGVGR-UHFFFAOYSA-N	363710	US9850277, Compound 197::US10689414, Compound 197::US10640534, Compound 197::US10717764, Compound 197::US11021515, Compound 197::US11667673, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363710&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699680	401959160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720103	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ncccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H21ClF4N6O3/c29-20-2-1-6-36-24(20)25(26(41)37-18-12-28(32,33)13-18)38(19-10-16(30)9-17(31)11-19)27(42)21-3-4-23(40)39(21)22-8-15(14-34)5-7-35-22/h1-2,5-11,18,21,25H,3-4,12-13H2,(H,37,41)	NXJFKNDGZLGJNN-UHFFFAOYSA-N	363711	US9850277, Compound 198::US10689414, Compound 198::US10640534, Compound 198::US10717764, Compound 198::US11021515, Compound 198::US11667673, Compound 198	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363711&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656674	401959161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720105	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1c(Cl)cccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H21Cl2F4N5O3/c30-20-2-1-3-21(31)25(20)26(27(42)38-18-12-29(34,35)13-18)39(19-10-16(32)9-17(33)11-19)28(43)22-4-5-24(41)40(22)23-8-15(14-36)6-7-37-23/h1-3,6-11,18,22,26H,4-5,12-13H2,(H,38,42)	TZAMEDXGVYYPDI-UHFFFAOYSA-N	363712	US9850277, Compound 199::US10689414, Compound 199::US10640534, Compound 199::US10717764, Compound 199::US11021515, Compound 199::US11667673, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363712&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699450	401959162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720107	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)-c1cn[nH]c1)c1ccccc1Cl |r|	InChI=1S/C32H26ClF2N7O3/c33-25-7-2-1-6-24(25)29(30(44)40-22-14-32(34,35)15-22)41(23-5-3-4-20(13-23)21-17-38-39-18-21)31(45)26-8-9-28(43)42(26)27-12-19(16-36)10-11-37-27/h1-7,10-13,17-18,22,26,29H,8-9,14-15H2,(H,38,39)(H,40,44)	FTHDRVINJMQWNE-UHFFFAOYSA-N	363713	US9850277, Compound 200::US10689414, Compound 200::US10640534, Compound 200::US10717764, Compound 200::US11021515, Compound 200::US11667673, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363713&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656947	401959163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720109	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1cc(Cl)ccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H21Cl2F4N5O3/c30-16-1-2-22(31)21(8-16)26(27(42)38-19-12-29(34,35)13-19)39(20-10-17(32)9-18(33)11-20)28(43)23-3-4-25(41)40(23)24-7-15(14-36)5-6-37-24/h1-2,5-11,19,23,26H,3-4,12-13H2,(H,38,42)	ZIMWCPCYVIIWAW-UHFFFAOYSA-N	363714	US9850277, Compound 201::US10689414, Compound 201::US10640534, Compound 201::US10717764, Compound 201::US11021515, Compound 201::US11667673, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363714&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699755	401959164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720113	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C1CC1 |r|	InChI=1S/C32H27ClF3N5O3/c33-25-4-2-1-3-24(25)29(30(43)39-22-15-32(35,36)16-22)40(23-13-20(19-5-6-19)12-21(34)14-23)31(44)26-7-8-28(42)41(26)27-11-18(17-37)9-10-38-27/h1-4,9-14,19,22,26,29H,5-8,15-16H2,(H,39,43)	MNGWSCAYBGMVFJ-UHFFFAOYSA-N	363717	US9850277, Compound 204::US10689414, Compound 204::US10640534, Compound 204::US10717764, Compound 204::US11021515, Compound 204::US11667673, Compound 204	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363717&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699487	401959167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720115	Fc1cc(cc2cn[nH]c12)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H23ClF3N7O3/c31-21-4-2-1-3-20(21)27(28(43)38-18-12-30(33,34)13-18)40(19-10-17-15-37-39-26(17)22(32)11-19)29(44)23-5-6-25(42)41(23)24-9-16(14-35)7-8-36-24/h1-4,7-11,15,18,23,27H,5-6,12-13H2,(H,37,39)(H,38,43)	YNIOAKDCKQDEIA-UHFFFAOYSA-N	363718	US9850277, Compound 205::US10689414, Compound 205::US10640534, Compound 205::US10717764, Compound 205::US11021515, Compound 205::US11667673, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363718&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707942	401959168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720118	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C30H22F4N6O3/c31-19-9-18(16-36)10-21(12-19)39(29(43)24-5-6-26(41)40(24)25-11-17(15-35)7-8-37-25)27(22-3-1-2-4-23(22)32)28(42)38-20-13-30(33,34)14-20/h1-4,7-12,20,24,27H,5-6,13-14H2,(H,38,42)	DRVUZEMPTKEPSZ-UHFFFAOYSA-N	363720	US9850277, Compound 207::US10689414, Compound 207::US10640534, Compound 208::US10717764, Compound 207::US11021515, Compound 207::US11667673, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699853	401959170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720120	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22F5N5O3/c30-17-10-18(31)12-20(11-17)38(28(42)23-5-6-25(40)39(23)24-9-16(15-35)7-8-36-24)26(21-3-1-2-4-22(21)32)27(41)37-19-13-29(33,34)14-19/h1-4,7-12,19,23,26H,5-6,13-14H2,(H,37,41)	CSUCANDZUTVXIB-UHFFFAOYSA-N	363721	US9850277, Compound 208::US10689414, Compound 208::US10717764, Compound 208::US11021515, Compound 208::US11667673, Compound 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699570	401959171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720122	Cn1ccc2cc(ccc12)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H27ClF2N6O3/c1-39-13-11-20-15-22(6-7-25(20)39)40(31(44)26-8-9-28(42)41(26)27-14-19(18-36)10-12-37-27)29(23-4-2-3-5-24(23)33)30(43)38-21-16-32(34,35)17-21/h2-7,10-15,21,26,29H,8-9,16-17H2,1H3,(H,38,43)	YDLXHMNHTCETPG-UHFFFAOYSA-N	363722	US9850277, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			124193799	401959172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720124	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23F4N5O3/c30-19-11-20(31)13-22(12-19)37(26(18-4-2-1-3-5-18)27(40)36-21-14-29(32,33)15-21)28(41)23-6-7-25(39)38(23)24-10-17(16-34)8-9-35-24/h1-5,8-13,21,23,26H,6-7,14-15H2,(H,36,40)	GSVHDCFGWNYGKB-UHFFFAOYSA-N	363723	US9850277, Compound 210::US10689414, Compound 210::US10640534, Compound 210::US10717764, Compound 210::US11021515, Compound 210::US11667673, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363723&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			71656948	401959173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720126	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C30H23F3N6O3/c31-21-10-19(17-35)11-23(13-21)38(27(20-4-2-1-3-5-20)28(41)37-22-14-30(32,33)15-22)29(42)24-6-7-26(40)39(24)25-12-18(16-34)8-9-36-25/h1-5,8-13,22,24,27H,6-7,14-15H2,(H,37,41)	YWBPCKHECALHTK-UHFFFAOYSA-N	363724	US9850277, Compound 211::US10689414, Compound 211::US10640534, Compound 211::US10717764, Compound 211::US11021515, Compound 211::US11667673, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89699948	401959174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720128	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cncc(c1)C#N)c1ccccc1 |r|	InChI=1S/C29H23F2N7O3/c30-29(31)12-21(13-29)36-27(40)26(20-4-2-1-3-5-20)37(22-10-19(15-33)16-34-17-22)28(41)23-6-7-25(39)38(23)24-11-18(14-32)8-9-35-24/h1-5,8-11,16-17,21,23,26H,6-7,12-13H2,(H,36,40)	HVVOBLPWJZTTAM-UHFFFAOYSA-N	363725	US9850277, Compound 212::US10689414, Compound 212::US10640534, Compound 212::US10717764, Compound 212::US11021515, Compound 212::US11667673, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363725&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			89707963	401959175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746429	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(22-17-7-16(25-2)12(8-20)9-21-17)14-6-11-5-13(19)3-4-15(11)23-18(14)24/h3-7,9-10H,1-2H3,(H,21,22)(H,23,24)	ATBYPAVFMVZPHR-UHFFFAOYSA-N	375141	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375141&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866101	404344187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746431	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(22-17-7-16(25-2)12(8-20)9-21-17)14-6-11-5-13(19)3-4-15(11)23-18(14)24/h3-7,9-10H,1-2H3,(H,21,22)(H,23,24)	ATBYPAVFMVZPHR-UHFFFAOYSA-N	375141	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375141&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866101	404344187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746433	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)ncc1C#N |r|	InChI=1S/C19H17ClN4O2/c1-11(23-18-8-17(26-3)13(9-21)10-22-18)15-7-12-6-14(20)4-5-16(12)24(2)19(15)25/h4-8,10-11H,1-3H3,(H,22,23)	RXDHNCUXTNJIDV-UHFFFAOYSA-N	375142	6-{[(1S)-1-(6-chloro-1-::US10253015, Compound I-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375142&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			118956165	404344188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746435	COc1cc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(22-17-7-16(25-2)12(8-20)9-21-17)14-6-11-5-13(19)3-4-15(11)23-18(14)24/h3-7,9-10H,1-2H3,(H,21,22)(H,23,24)	ATBYPAVFMVZPHR-UHFFFAOYSA-N	375143	6-{[(1R)-1-(6-chloro-2-::US10253015, Compound I-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866102	404344189							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746437	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375144	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866103	404344190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746439	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375144	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866103	404344190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746441	C[C@H](Nc1cc(C)c(cn1)C#N)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-5-17(21-9-13(10)8-20)22-11(2)15-7-12-6-14(19)3-4-16(12)23-18(15)24/h3-7,9,11H,1-2H3,(H,21,22)(H,23,24)	APLSHCOQIQKKJA-UHFFFAOYSA-N	375145	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866104	404344191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746443	C[C@H](Nc1cc(C)c(cn1)C#N)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-5-17(21-9-13(10)8-20)22-11(2)15-7-12-6-14(19)3-4-16(12)23-18(15)24/h3-7,9,11H,1-2H3,(H,21,22)(H,23,24)	APLSHCOQIQKKJA-UHFFFAOYSA-N	375145	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866104	404344191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746445	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-3-11(9-20)18(23-16)25-2)14-8-12-7-13(19)4-5-15(12)22-17(14)24/h3-8,10H,1-2H3,(H,21,23)(H,22,24)	GODRNGSVIZIHOY-UHFFFAOYSA-N	375146	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375146&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866105	404344192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746447	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-3-11(9-20)18(23-16)25-2)14-8-12-7-13(19)4-5-15(12)22-17(14)24/h3-8,10H,1-2H3,(H,21,23)(H,22,24)	GODRNGSVIZIHOY-UHFFFAOYSA-N	375146	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375146&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866105	404344192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746449	COc1nc(ccc1N[C@@H](C)c1cc2cc(Cl)ccc2[nH]c1=O)C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)22-18(16)25-2)14-8-11-7-12(19)3-5-15(11)23-17(14)24/h3-8,10,21H,1-2H3,(H,23,24)	LXAVQRJBWNUBTP-UHFFFAOYSA-N	375147	5-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375147&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866106	404344193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746451	COc1nc(ccc1N[C@@H](C)c1cc2cc(Cl)ccc2[nH]c1=O)C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)22-18(16)25-2)14-8-11-7-12(19)3-5-15(11)23-17(14)24/h3-8,10,21H,1-2H3,(H,23,24)	LXAVQRJBWNUBTP-UHFFFAOYSA-N	375147	5-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375147&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866106	404344193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746454	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375149	6-{[1-(6-chloro-2-oxo-::US10253015, Compound I-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866108	404344195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746456	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375149	6-{[1-(6-chloro-2-oxo-::US10253015, Compound I-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866108	404344195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746458	C[C@H](Nc1cc(ccn1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN4O3/c1-11(15-9-12-8-13(20)2-3-16(12)23-18(15)25)22-17-10-14(4-5-21-17)24-6-7-27-19(24)26/h2-5,8-11H,6-7H2,1H3,(H,21,22)(H,23,25)	BOLKOIMIOCFWLZ-UHFFFAOYSA-N	375150	6-chloro-3-[(1S)-1-{[4-(2-::US10253015, Compound I-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375150&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866109	404344196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746460	C[C@H](Nc1cccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN4O3/c1-11(14-10-12-9-13(20)5-6-15(12)22-18(14)25)21-16-3-2-4-17(23-16)24-7-8-27-19(24)26/h2-6,9-11H,7-8H2,1H3,(H,21,23)(H,22,25)	RNAUWLUZXNUTMK-UHFFFAOYSA-N	375151	6-chloro-3-[(1S)-1-{[6-(2-::US10253015, Compound I-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375151&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866110	404344197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746462	C[C@H](Nc1cccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN4O3/c1-11(14-10-12-9-13(20)5-6-15(12)22-18(14)25)21-16-3-2-4-17(23-16)24-7-8-27-19(24)26/h2-6,9-11H,7-8H2,1H3,(H,21,23)(H,22,25)	RNAUWLUZXNUTMK-UHFFFAOYSA-N	375151	6-chloro-3-[(1S)-1-{[6-(2-::US10253015, Compound I-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375151&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866110	404344197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746465	C[C@H](Nc1cc(ccn1)N1C(=O)OCC1(C)C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H21ClN4O3/c1-12(16-9-13-8-14(22)4-5-17(13)25-19(16)27)24-18-10-15(6-7-23-18)26-20(28)29-11-21(26,2)3/h4-10,12H,11H2,1-3H3,(H,23,24)(H,25,27)	AJYIONBIQGQQEY-UHFFFAOYSA-N	375153	6-chloro-3-[(1S)-1-{[4-(4,4-::US10253015, Compound I-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375153&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866112	404344199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746467	C[C@H](Nc1nccc(N2CCOC2=O)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClFN4O3/c1-10(13-9-11-8-12(20)2-3-14(11)24-18(13)26)23-17-16(21)15(4-5-22-17)25-6-7-28-19(25)27/h2-5,8-10H,6-7H2,1H3,(H,22,23)(H,24,26)	SOOZHBULFSDQIK-UHFFFAOYSA-N	375154	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375154&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866113	404344200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746469	C[C@H](Nc1nccc(N2CCOC2=O)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClFN4O3/c1-10(13-9-11-8-12(20)2-3-14(11)24-18(13)26)23-17-16(21)15(4-5-22-17)25-6-7-28-19(25)27/h2-5,8-10H,6-7H2,1H3,(H,22,23)(H,24,26)	SOOZHBULFSDQIK-UHFFFAOYSA-N	375154	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375154&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866113	404344200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746474	CC(C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)c1 |r|	InChI=1S/C22H23ClN4O3/c1-12(2)19-11-30-22(29)27(19)16-6-7-24-20(10-16)25-13(3)17-9-14-8-15(23)4-5-18(14)26-21(17)28/h4-10,12-13,19H,11H2,1-3H3,(H,24,25)(H,26,28)	MEMPGRIFXZBEDA-UHFFFAOYSA-N	375158	6-chloro-3-[1-({4-[(4S)-2-::US10253015, Compound I-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866117	404344204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746476	CC(C)[C@H]1COC(=O)N1c1cccc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN4O3/c1-12(2)18-11-30-22(29)27(18)20-6-4-5-19(26-20)24-13(3)16-10-14-9-15(23)7-8-17(14)25-21(16)28/h4-10,12-13,18H,11H2,1-3H3,(H,24,26)(H,25,28)	IAEUARYYOPFFRD-UHFFFAOYSA-N	375159	6-chloro-3-[(1S)-1-({6-::US10253015, Compound I-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375159&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866118	404344205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746479	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375161	6-{[1-(6-chloro-7-fluoro-2-::US10253015, Compound I-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375161&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866120	404344207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746481	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375161	6-{[1-(6-chloro-7-fluoro-2-::US10253015, Compound I-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375161&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866120	404344207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746483	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375162	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866121	404344208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746485	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375162	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866121	404344208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746487	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(C)n1 |r|	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375163	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375163&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866122	404344209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746489	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(C)n1 |r|	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375163	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375163&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866122	404344209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746491	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ccc(C#N)c(C)n1	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375164	6-{[1-(6-chloro-7-methoxy-::US10253015, Compound I-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866123	404344210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746493	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ccc(C#N)c(C)n1	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375164	6-{[1-(6-chloro-7-methoxy-::US10253015, Compound I-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866123	404344210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746495	COc1cc(N[C@@H](C)c2cc3cc(Cl)c(OC)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C19H17ClN4O3/c1-10(23-18-7-16(26-2)12(8-21)9-22-18)13-4-11-5-14(20)17(27-3)6-15(11)24-19(13)25/h4-7,9-10H,1-3H3,(H,22,23)(H,24,25)	OMSUZXKASANRMP-UHFFFAOYSA-N	375165	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866124	404344211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746497	COc1cc(N[C@@H](C)c2cc3cc(Cl)c(OC)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C19H17ClN4O3/c1-10(23-18-7-16(26-2)12(8-21)9-22-18)13-4-11-5-14(20)17(27-3)6-15(11)24-19(13)25/h4-7,9-10H,1-3H3,(H,22,23)(H,24,25)	OMSUZXKASANRMP-UHFFFAOYSA-N	375165	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866124	404344211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746499	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(OC)n1 |r|	InChI=1S/C19H17ClN4O3/c1-10(22-17-5-4-11(9-21)19(24-17)27-3)13-6-12-7-14(20)16(26-2)8-15(12)23-18(13)25/h4-8,10H,1-3H3,(H,22,24)(H,23,25)	XHEZMIFLPAHWJT-UHFFFAOYSA-N	375166	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866125	404344212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746501	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(OC)n1 |r|	InChI=1S/C19H17ClN4O3/c1-10(22-17-5-4-11(9-21)19(24-17)27-3)13-6-12-7-14(20)16(26-2)8-15(12)23-18(13)25/h4-8,10H,1-3H3,(H,22,24)(H,23,25)	XHEZMIFLPAHWJT-UHFFFAOYSA-N	375166	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866125	404344212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746503	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1cc(C)c(cn1)C#N |r|	InChI=1S/C19H17ClN4O2/c1-10-4-18(22-9-13(10)8-21)23-11(2)14-5-12-6-15(20)17(26-3)7-16(12)24-19(14)25/h4-7,9,11H,1-3H3,(H,22,23)(H,24,25)	UTUVGPIHWMVGKK-UHFFFAOYSA-N	375167	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866126	404344213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746505	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1cc(C)c(cn1)C#N |r|	InChI=1S/C19H17ClN4O2/c1-10-4-18(22-9-13(10)8-21)23-11(2)14-5-12-6-15(20)17(26-3)7-16(12)24-19(14)25/h4-7,9,11H,1-3H3,(H,22,23)(H,24,25)	UTUVGPIHWMVGKK-UHFFFAOYSA-N	375167	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866126	404344213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746507	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375168	6-{[(1S)-1-[6-chloro-2-oxo-::US10253015, Compound I-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866127	404344214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746509	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375168	6-{[(1S)-1-[6-chloro-2-oxo-::US10253015, Compound I-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866127	404344214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746512	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375169	6-({1-[6-chloro-2-oxo-7-::US10253015, Compound I-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375169&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866128	404344215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746514	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCC3CC(F)(F)C3)cc2[nH]c1=O	InChI=1S/C23H21ClF2N4O2/c1-12-15(10-27)3-4-21(28-12)29-13(2)17-5-16-6-18(24)20(7-19(16)30-22(17)31)32-11-14-8-23(25,26)9-14/h3-7,13-14H,8-9,11H2,1-2H3,(H,28,29)(H,30,31)	KOQJXYKJVNZSIH-UHFFFAOYSA-N	375170	6-[(1-{6-chloro-7-[(3,3-::US10253015, Compound I-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866129	404344216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746516	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCC3CC(F)(F)C3)cc2[nH]c1=O	InChI=1S/C23H21ClF2N4O2/c1-12-15(10-27)3-4-21(28-12)29-13(2)17-5-16-6-18(24)20(7-19(16)30-22(17)31)32-11-14-8-23(25,26)9-14/h3-7,13-14H,8-9,11H2,1-2H3,(H,28,29)(H,30,31)	KOQJXYKJVNZSIH-UHFFFAOYSA-N	375170	6-[(1-{6-chloro-7-[(3,3-::US10253015, Compound I-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866129	404344216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746521	C[C@H](Nc1nccc(NC(C)=O)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClFN4O2/c1-9(22-17-16(20)15(5-6-21-17)23-10(2)25)13-8-11-7-12(19)3-4-14(11)24-18(13)26/h3-9H,1-2H3,(H,24,26)(H2,21,22,23,25)	JILJRTQNPBPZLZ-UHFFFAOYSA-N	375174	N-(2-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375174&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866133	404344220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746524	C[C@H](Nc1nccc(NCCO)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H18ClFN4O2/c1-10(23-17-16(20)15(4-5-22-17)21-6-7-25)13-9-11-8-12(19)2-3-14(11)24-18(13)26/h2-5,8-10,25H,6-7H2,1H3,(H,24,26)(H2,21,22,23)	PREVMHPABPEPEQ-UHFFFAOYSA-N	375176	6-chloro-3-[(1S)-1-({3-::US10253015, Compound I-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866135	404344222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746528	C[C@H](Nc1cc(ccn1)-c1cc(C)nn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12-8-19(27(3)26-12)14-6-7-23-20(11-14)24-13(2)17-10-15-9-16(22)4-5-18(15)25-21(17)28/h4-11,13H,1-3H3,(H,23,24)(H,25,28)	UVJTWKGPNRAHNW-UHFFFAOYSA-N	375179	6-chloro-3-[(1S)-1-{[4-(1,3-dimethyl-1H-::US10253015, Compound I-39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866138	404344225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746530	C[C@H](Nc1cc(ccn1)-c1cnn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12(17-9-15-8-16(22)4-5-19(15)26-21(17)28)25-20-10-14(6-7-23-20)18-11-24-27(3)13(18)2/h4-12H,1-3H3,(H,23,25)(H,26,28)	SPUFCDSCJOZNBH-UHFFFAOYSA-N	375180	6-chloro-3-[(1S)-1-{[4-(1,5-dimethyl-1H-::US10253015, Compound I-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866139	404344226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746532	C[C@H](Nc1cc(ccn1)-c1cnn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12(17-9-15-8-16(22)4-5-19(15)26-21(17)28)25-20-10-14(6-7-23-20)18-11-24-27(3)13(18)2/h4-12H,1-3H3,(H,23,25)(H,26,28)	SPUFCDSCJOZNBH-UHFFFAOYSA-N	375180	6-chloro-3-[(1S)-1-{[4-(1,5-dimethyl-1H-::US10253015, Compound I-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866139	404344226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746534	C[C@H](Nc1cc(ccn1)-c1ccn[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClN5O/c1-11(15-9-13-8-14(20)2-3-16(13)24-19(15)26)23-18-10-12(4-6-21-18)17-5-7-22-25-17/h2-11H,1H3,(H,21,23)(H,22,25)(H,24,26)	ILLYIVJHFCMEDX-UHFFFAOYSA-N	375181	6-chloro-3-[(1S)-1-{[4-(1H-pyrazol-5-yl)pyridin-::US10253015, Compound I-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375181&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866140	404344227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746537	CC(C)Cn1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1 |r|	InChI=1S/C23H24ClN5O/c1-14(2)13-29-21(7-9-26-29)16-6-8-25-22(12-16)27-15(3)19-11-17-10-18(24)4-5-20(17)28-23(19)30/h4-12,14-15H,13H2,1-3H3,(H,25,27)(H,28,30)	WWWFRQPTFRLINL-UHFFFAOYSA-N	375183	6-chloro-3-[(1S)-1-({4-[1-(2-methylpropyl)-1H-::US10253015, Compound I-43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375183&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866142	404344229							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746539	CC(C)n1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1 |r|	InChI=1S/C22H22ClN5O/c1-13(2)28-20(7-9-25-28)15-6-8-24-21(12-15)26-14(3)18-11-16-10-17(23)4-5-19(16)27-22(18)29/h4-14H,1-3H3,(H,24,26)(H,27,29)	ORSPJAPRETYQAL-UHFFFAOYSA-N	375184	6-chloro-3-[(1S)-1-({4-[1-(propan-2-yl)-1H-::US10253015, Compound I-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375184&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866143	404344230							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746543	C[C@H](Nc1cc(ccn1)-c1ccnn1C1CCCCO1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C24H24ClN5O2/c1-15(19-13-17-12-18(25)5-6-20(17)29-24(19)31)28-22-14-16(7-9-26-22)21-8-10-27-30(21)23-4-2-3-11-32-23/h5-10,12-15,23H,2-4,11H2,1H3,(H,26,28)(H,29,31)	ROBMPVUHFWUUAF-UHFFFAOYSA-N	375187	6-chloro-3-[(1S)-1-({4-[1-(oxan-2-yl)-1H-::US10253015, Compound I-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375187&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866146	404344233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746545	C[C@H](Nc1cc(ccn1)-c1cscc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClN3OS/c1-12-10-27-11-18(12)14-5-6-23-20(9-14)24-13(2)17-8-15-7-16(22)3-4-19(15)25-21(17)26/h3-11,13H,1-2H3,(H,23,24)(H,25,26)	IPMCQKIUANVIHL-UHFFFAOYSA-N	375188	6-chloro-3-[(1S)-1-{[4-(4-methylthiophen-3-::US10253015, Compound I-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375188&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866147	404344234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746547	C[C@H](Nc1cc(ccn1)-c1ccnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5O/c1-12(16-10-14-9-15(21)3-4-17(14)25-20(16)27)24-19-11-13(5-7-22-19)18-6-8-23-26(18)2/h3-12H,1-2H3,(H,22,24)(H,25,27)	TVBIEZPKQZLNHR-UHFFFAOYSA-N	375189	6-chloro-3-[(1S)-1-{[4-(1-methyl-1H-pyrazol-5-::US10253015, Compound I-49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375189&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866148	404344235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746549	C[C@H](Nc1cc(ccn1)-c1c[nH]nc1C(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H15ClF3N5O/c1-10(14-7-12-6-13(21)2-3-16(12)28-19(14)30)27-17-8-11(4-5-25-17)15-9-26-29-18(15)20(22,23)24/h2-10H,1H3,(H,25,27)(H,26,29)(H,28,30)	JQJSWPLSMHFOCE-UHFFFAOYSA-N	375190	6-chloro-3-[(1S)-1-({4-[3-(trifluoromethyl)-1H-::US10253015, Compound I-50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375190&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866149	404344236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746552	C[C@H](Nc1nccc(-c2cc(C)nn2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H19ClFN5O/c1-11-8-18(28(3)27-11)15-6-7-24-20(19(15)23)25-12(2)16-10-13-9-14(22)4-5-17(13)26-21(16)29/h4-10,12H,1-3H3,(H,24,25)(H,26,29)	VNYLNCVIABLMDR-UHFFFAOYSA-N	375192	6-chloro-3-[(1S)-1-{[4-(1,3-dimethyl-1H-::US10253015, Compound I-52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866151	404344238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746554	C[C@H](Nc1nccc(-c2ccnn2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H17ClFN5O/c1-11(15-10-12-9-13(21)3-4-16(12)26-20(15)28)25-19-18(22)14(5-7-23-19)17-6-8-24-27(17)2/h3-11H,1-2H3,(H,23,25)(H,26,28)	UYGTXGQZGGESCZ-UHFFFAOYSA-N	375193	6-chloro-3-[(1S)-1-{[3-fluoro-4-(1-methyl-1H-::US10253015, Compound I-53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375193&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866152	404344239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746558	CC(C)Cn1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1F |r|	InChI=1S/C23H23ClFN5O/c1-13(2)12-30-20(7-9-27-30)17-6-8-26-22(21(17)25)28-14(3)18-11-15-10-16(24)4-5-19(15)29-23(18)31/h4-11,13-14H,12H2,1-3H3,(H,26,28)(H,29,31)	SUBHERSBVVYQIF-UHFFFAOYSA-N	375196	6-chloro-3-[(1S)-1-({3-fluoro-4-[1-(2-::US10253015, Compound I-56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375196&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866155	404344242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746561	Cc1c(ccc(n1)NCC2=Cc3cc(ccc3NC2=O)Cl)C#N	InChI=1S/C17H13ClN4O/c1-10-11(8-19)2-5-16(21-10)20-9-13-6-12-7-14(18)3-4-15(12)22-17(13)23/h2-7H,9H2,1H3,(H,20,21)(H,22,23)	BPIFALCAPCGTGS-UHFFFAOYSA-N	375198	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	LJV	6O2Z	145866157	404344244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746563	Cc1c(ccc(n1)NCC2=Cc3cc(ccc3NC2=O)Cl)C#N	InChI=1S/C17H13ClN4O/c1-10-11(8-19)2-5-16(21-10)20-9-13-6-12-7-14(18)3-4-15(12)22-17(13)23/h2-7H,9H2,1H3,(H,20,21)(H,22,23)	BPIFALCAPCGTGS-UHFFFAOYSA-N	375198	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	LJV	6O2Z	145866157	404344244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746565	Cc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N	InChI=1S/C17H13ClN4O/c1-10-4-16(21-9-13(10)7-19)20-8-12-5-11-6-14(18)2-3-15(11)22-17(12)23/h2-6,9H,8H2,1H3,(H,20,21)(H,22,23)	LXMKACJDWYHEEG-UHFFFAOYSA-N	375199	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375199&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866158	404344245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746574	Clc1ccc2[nH]c(=O)c(CNc3ccc(cn3)C#N)cc2c1	InChI=1S/C16H11ClN4O/c17-13-2-3-14-11(6-13)5-12(16(22)21-14)9-20-15-4-1-10(7-18)8-19-15/h1-6,8H,9H2,(H,19,20)(H,21,22)	GWBZGQRLLUJXRH-UHFFFAOYSA-N	375207	6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375207&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866166	404344253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746591	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(C)n3)cc2cc1Cl	InChI=1S/C18H15ClN4O2/c1-10-11(8-20)3-4-17(22-10)21-9-13-5-12-6-14(19)16(25-2)7-15(12)23-18(13)24/h3-7H,9H2,1-2H3,(H,21,22)(H,23,24)	JKVBPFJAMHQRCZ-UHFFFAOYSA-N	375223	6-{[(6-chloro-7-methoxy-2-oxo-1,2-::US10253015, Compound I-83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866182	404344269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746593	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(C)n3)cc2cc1Cl	InChI=1S/C18H15ClN4O2/c1-10-11(8-20)3-4-17(22-10)21-9-13-5-12-6-14(19)16(25-2)7-15(12)23-18(13)24/h3-7H,9H2,1-2H3,(H,21,22)(H,23,24)	JKVBPFJAMHQRCZ-UHFFFAOYSA-N	375223	6-{[(6-chloro-7-methoxy-2-oxo-1,2-::US10253015, Compound I-83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866182	404344269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746596	Cc1nc(NCc2cc3cc(Cl)c(OCCN4CCN(CC4)S(C)(=O)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H27ClN6O4S/c1-16-17(14-26)3-4-23(28-16)27-15-19-11-18-12-20(25)22(13-21(18)29-24(19)32)35-10-9-30-5-7-31(8-6-30)36(2,33)34/h3-4,11-13H,5-10,15H2,1-2H3,(H,27,28)(H,29,32)	PKIRZPJXKJUCFZ-UHFFFAOYSA-N	375225	6-[({6-chloro-7-[2-(4-::US10253015, Compound I-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375225&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866184	404344271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755297	COc1cc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O2/c1-11(22-15-5-3-12(10-21)18(9-15)25-2)16-8-13-7-14(20)4-6-17(13)23-19(16)24/h3-9,11,22H,1-2H3,(H,23,24)	POQQQCAOZAXQHW-UHFFFAOYSA-N	377521	US10266495, Compound I-1::4-{[1-(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866737	404346489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755299	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C19H16ClN3O2/c1-11(22-15-5-3-12(10-21)18(9-15)25-2)16-8-13-7-14(20)4-6-17(13)23-19(16)24/h3-9,11,22H,1-2H3,(H,23,24)	POQQQCAOZAXQHW-UHFFFAOYSA-N	377574	US10266495, Compound I-2::4-{[(1S)-1-(6-chloro-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866738	404346541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755303	COc1cc(NC(C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-15(29-18-7-6-16(13-27)23(11-18)32-2)20-9-17-10-21(26)24(12-22(17)30-25(20)31)33-14-19-5-3-4-8-28-19/h3-12,15,29H,14H2,1-2H3,(H,30,31)	ORMQJKSZDSYQNK-UHFFFAOYSA-N	377593	US10266495, Compound I-5::4-({1-[6-chloro-2-oxo-7-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866741	404346560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755306	COc1cc(ccc1C#N)NCC2=Cc3cc(ccc3NC2=O)Cl	InChI=1S/C18H14ClN3O2/c1-24-17-8-15(4-2-11(17)9-20)21-10-13-6-12-7-14(19)3-5-16(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	DHTDEOJRSYUVPD-UHFFFAOYSA-N	377595	US10266495, Compound I-7::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	LJY	6O2Y	145866743	404346562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755308	Oc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C17H12ClN3O2/c18-13-2-4-15-11(6-13)5-12(17(23)21-15)9-20-14-3-1-10(8-19)16(22)7-14/h1-7,20,22H,9H2,(H,21,23)	VDYPXURCTYLBFX-UHFFFAOYSA-N	377596	US10266495, Compound I-8::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866744	404346563							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755310	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)cc(OC)c1C#N	InChI=1S/C19H16ClN3O3/c1-25-17-7-14(8-18(26-2)15(17)9-21)22-10-12-5-11-6-13(20)3-4-16(11)23-19(12)24/h3-8,22H,10H2,1-2H3,(H,23,24)	QMMJQMZFINBAFK-UHFFFAOYSA-N	377597	US10266495, Compound I-9::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866745	404346564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755312	FC(F)(F)Oc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H11ClF3N3O2/c19-13-2-4-15-11(6-13)5-12(17(26)25-15)9-24-14-3-1-10(8-23)16(7-14)27-18(20,21)22/h1-7,24H,9H2,(H,25,26)	AGNDYSBKXMQKIB-UHFFFAOYSA-N	377598	US10266495, Compound I-10::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866746	404346565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755319	COc1cc(NCc2cc3cc(C)ccc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C19H18N6O2/c1-12-3-5-16-13(7-12)8-14(19(26)22-16)10-20-15-4-6-17(18(9-15)27-2)25-11-21-23-24-25/h3-9,11,20H,10H2,1-2H3,(H,22,26)	GGLPMVYVIFIYHC-UHFFFAOYSA-N	377604	US10266495, Compound I-16::3-({[3-methoxy-4-(1H-1,2,3,4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			75260688	404346571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755325	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2cc1Cl	InChI=1S/C19H16ClN3O3/c1-25-17-7-14(4-3-11(17)9-21)22-10-13-5-12-6-15(20)18(26-2)8-16(12)23-19(13)24/h3-8,22H,10H2,1-2H3,(H,23,24)	LTDKQKQDKAKNGO-UHFFFAOYSA-N	377609	US10266495, Compound I-21::4-{[(6-chloro-7-methoxy-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866755	404346576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755327	COc1cc(NCc2cc3ccc(C)cc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C19H18N6O2/c1-12-3-4-13-8-14(19(26)22-16(13)7-12)10-20-15-5-6-17(18(9-15)27-2)25-11-21-23-24-25/h3-9,11,20H,10H2,1-2H3,(H,22,26)	BPKREDZWJFPBSA-UHFFFAOYSA-N	377610	US10266495, Compound I-22::3-({[3-methoxy-4-(1H-1,2,3,4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866756	404346577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755330	COc1cc(NCc2cc3cc(ccc3[nH]c2=O)C(C)(C)C)ccc1C#N	InChI=1S/C22H23N3O2/c1-22(2,3)17-6-8-19-15(10-17)9-16(21(26)25-19)13-24-18-7-5-14(12-23)20(11-18)27-4/h5-11,24H,13H2,1-4H3,(H,25,26)	OEDVWCKFJJKSQV-UHFFFAOYSA-N	377612	US10266495, Compound I-24::4-{[(6-tert-butyl-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866758	404346579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755332	COc1cc(NCc2cc3cc(ccc3[nH]c2=O)C(F)(F)F)ccc1C#N	InChI=1S/C19H14F3N3O2/c1-27-17-8-15(4-2-11(17)9-23)24-10-13-6-12-7-14(19(20,21)22)3-5-16(12)25-18(13)26/h2-8,24H,10H2,1H3,(H,25,26)	FJTQXYUFLWOBDV-UHFFFAOYSA-N	377613	US10266495, Compound I-25::2-methoxy-4-({[2-oxo-6-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866759	404346580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755334	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2cc1F	InChI=1S/C19H16FN3O3/c1-25-17-7-14(4-3-11(17)9-21)22-10-13-5-12-6-15(20)18(26-2)8-16(12)23-19(13)24/h3-8,22H,10H2,1-2H3,(H,23,24)	GPCTVBQLFMBFGO-UHFFFAOYSA-N	377614	US10266495, Compound I-26::4-{[(6-fluoro-7-methoxy-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866760	404346581							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755336	COc1cc(NCc2cc3cc(F)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14FN3O2/c1-24-17-8-15(4-2-11(17)9-20)21-10-13-6-12-7-14(19)3-5-16(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	NKLSBGPINAONGO-UHFFFAOYSA-N	377615	US10266495, Compound I-27::4-{[(6-fluoro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866761	404346582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755340	COc1cc(NCc2cc3ccc(O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C18H15N3O3/c1-24-17-7-14(4-2-12(17)9-19)20-10-13-6-11-3-5-15(22)8-16(11)21-18(13)23/h2-8,20,22H,10H2,1H3,(H,21,23)	GXCVGRIFRRAEIM-UHFFFAOYSA-N	377618	US10266495, Compound I-30::4-{[(7-hydroxy-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866764	404346585							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755343	Clc1ccc2cc(CNc3ccc(cc3)C#N)c(=O)[nH]c2c1	InChI=1S/C17H12ClN3O/c18-14-4-3-12-7-13(17(22)21-16(12)8-14)10-20-15-5-1-11(9-19)2-6-15/h1-8,20H,10H2,(H,21,22)	RQNLUJKZCLTLHU-UHFFFAOYSA-N	377620	US10266495, Compound I-32::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866766	404346587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755345	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C18H15ClN6O2/c1-27-17-8-14(3-5-16(17)25-10-21-23-24-25)20-9-12-6-11-7-13(19)2-4-15(11)22-18(12)26/h2-8,10,20H,9H2,1H3,(H,22,26)	NITCQMNPAJNNEX-UHFFFAOYSA-N	377621	US10266495, Compound I-33::6-chloro-3-({[3-methoxy-4-(1H-1,2,3,4-tetrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866767	404346588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755349	Cc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14ClN3O/c1-11-6-16(4-2-12(11)9-20)21-10-14-7-13-8-15(19)3-5-17(13)22-18(14)23/h2-8,21H,10H2,1H3,(H,22,23)	PEMDUUPRWVAMBW-UHFFFAOYSA-N	377624	US10266495, Compound I-36::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866770	404346591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755352	Cc1nnnn1-c1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)cc1	InChI=1S/C18H15ClN6O/c1-11-22-23-24-25(11)16-5-3-15(4-6-16)20-10-13-8-12-9-14(19)2-7-17(12)21-18(13)26/h2-9,20H,10H2,1H3,(H,21,26)	YTNJBJHNTIQCJD-UHFFFAOYSA-N	377626	US10266495, Compound I-38::6-chloro-3-({[4-(5-methyl-1H-1,2,3,4-tetrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866772	404346593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755362	COc1cc(NCc2cc3ccccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H15N3O2/c1-23-17-9-15(7-6-13(17)10-19)20-11-14-8-12-4-2-3-5-16(12)21-18(14)22/h2-9,20H,11H2,1H3,(H,21,22)	LPHVOAHPNPOSNP-UHFFFAOYSA-N	377635	US10266495, Compound I-47::2-methoxy-4-{[(2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866781	404346602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755374	COc1cc(NCc2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-22-10-18(6-5-15(22)12-26)28-13-17-8-16-9-20(25)23(11-21(16)29-24(17)30)32-14-19-4-2-3-7-27-19/h2-11,28H,13-14H2,1H3,(H,29,30)	NRASQWAHCMHZAP-UHFFFAOYSA-N	377646	US10266495, Compound I-58::4-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866791	404346613							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755376	COc1cc(NCc2cc3cc(Cl)c(OCC(O)CN4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O5/c1-33-23-10-19(3-2-16(23)12-27)28-13-18-8-17-9-21(26)24(11-22(17)29-25(18)32)35-15-20(31)14-30-4-6-34-7-5-30/h2-3,8-11,20,28,31H,4-7,13-15H2,1H3,(H,29,32)	PWEFSJMBJSQTBI-UHFFFAOYSA-N	377647	US10266495, Compound I-59::4-[({6-chloro-7-[2-hydroxy-3-(morpholin-4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866792	404346614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755378	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O4/c1-31-22-12-19(3-2-16(22)14-26)27-15-18-10-17-11-20(25)23(13-21(17)28-24(18)30)33-9-6-29-4-7-32-8-5-29/h2-3,10-13,27H,4-9,15H2,1H3,(H,28,30)	CWJLOFYZEOVYFQ-UHFFFAOYSA-N	377648	US10266495, Compound I-60::4-[({6-chloro-7-[2-(morpholin-4-yl)ethoxy]-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866793	404346615							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755380	COc1cc(NCc2cc3cc(Cl)c(OCCN(C)C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C22H23ClN4O3/c1-27(2)6-7-30-21-11-19-15(9-18(21)23)8-16(22(28)26-19)13-25-17-5-4-14(12-24)20(10-17)29-3/h4-5,8-11,25H,6-7,13H2,1-3H3,(H,26,28)	VSNNNQAXGFVANM-UHFFFAOYSA-N	377649	US10266495, Compound I-61::4-[({6-chloro-7-[2-(dimethylamino)ethoxy]-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866794	404346616							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755382	COc1cc(NCc2cc3cc(Cl)c(OCc4cccnc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-22-9-19(5-4-16(22)11-26)28-13-18-7-17-8-20(25)23(10-21(17)29-24(18)30)32-14-15-3-2-6-27-12-15/h2-10,12,28H,13-14H2,1H3,(H,29,30)	PZFURKFSHLGJCY-UHFFFAOYSA-N	377650	US10266495, Compound I-62::4-({[6-chloro-2-oxo-7-(pyridin-3-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866795	404346617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755384	COc1cc(NCc2cc3cc(Cl)c(OCC4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H24ClN3O4/c1-30-22-10-19(3-2-16(22)12-26)27-13-18-8-17-9-20(25)23(11-21(17)28-24(18)29)32-14-15-4-6-31-7-5-15/h2-3,8-11,15,27H,4-7,13-14H2,1H3,(H,28,29)	NYSSOJQKFSDYTD-UHFFFAOYSA-N	377651	US10266495, Compound I-63::4-({[6-chloro-7-(oxan-4-ylmethoxy)-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866796	404346618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755386	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCN(CC4)S(C)(=O)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H28ClN5O5S/c1-35-23-13-20(4-3-17(23)15-27)28-16-19-11-18-12-21(26)24(14-22(18)29-25(19)32)36-10-9-30-5-7-31(8-6-30)37(2,33)34/h3-4,11-14,28H,5-10,16H2,1-2H3,(H,29,32)	CUKDDYYYWUICSQ-UHFFFAOYSA-N	377652	US10266495, Compound I-64::4-[({6-chloro-7-[2-(4-methanesulfonylpiperazin-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866797	404346619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755388	COc1cc(NCc2cc3cc(Cl)c(OC[C@H]4CCOC4)cc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C23H22ClN3O4/c1-29-21-8-18(3-2-15(21)10-25)26-11-17-6-16-7-19(24)22(9-20(16)27-23(17)28)31-13-14-4-5-30-12-14/h2-3,6-9,14,26H,4-5,11-13H2,1H3,(H,27,28)	GBASNBSJKNSNDD-UHFFFAOYSA-N	377653	US10266495, Compound I-65::4-[({6-chloro-2-oxo-7-[(3S)-oxolan-3-ylmethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866798	404346620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755390	COc1cc(NCc2cc3cc(Cl)c(OC4CCN(C)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O3/c1-29-7-5-19(6-8-29)32-23-12-21-16(10-20(23)25)9-17(24(30)28-21)14-27-18-4-3-15(13-26)22(11-18)31-2/h3-4,9-12,19,27H,5-8,14H2,1-2H3,(H,28,30)	WXTNBBYABWLYTK-UHFFFAOYSA-N	377654	US10266495, Compound I-66::4-[({6-chloro-7-[(1-methylpiperidin-4-yl)oxy]-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866799	404346621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755392	COc1cc(NCc2cc3cc(Cl)c(OCC(=O)N(C)C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C22H21ClN4O4/c1-27(2)21(28)12-31-20-9-18-14(7-17(20)23)6-15(22(29)26-18)11-25-16-5-4-13(10-24)19(8-16)30-3/h4-9,25H,11-12H2,1-3H3,(H,26,29)	FAQBAUNUPUIYJU-UHFFFAOYSA-N	377655	US10266495, Compound I-67::2-[(6-chloro-3-{[(4-cyano-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866800	404346622							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755394	COc1cc(NCc2cc3cc(Cl)c(OCC(N)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C20H17ClN4O4/c1-28-17-6-14(3-2-11(17)8-22)24-9-13-4-12-5-15(21)18(29-10-19(23)26)7-16(12)25-20(13)27/h2-7,24H,9-10H2,1H3,(H2,23,26)(H,25,27)	BHOQCOWIIIQYHF-UHFFFAOYSA-N	377656	US10266495, Compound I-68::2-[(6-chloro-3-{[(4-cyano-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866801	404346623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755396	COc1cc(NCc2cc3cc(Cl)c(OCC(=O)N4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H23ClN4O5/c1-32-21-10-18(3-2-15(21)12-26)27-13-17-8-16-9-19(25)22(11-20(16)28-24(17)31)34-14-23(30)29-4-6-33-7-5-29/h2-3,8-11,27H,4-7,13-14H2,1H3,(H,28,31)	YOLJPYAFGCDCOX-UHFFFAOYSA-N	377657	US10266495, Compound I-69::4-[({6-chloro-7-[2-(morpholin-4-yl)-2-oxoethoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866802	404346624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755398	COc1cc(NCc2cc3cc(Cl)c(OCc4cc(C)n(C)n4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H22ClN5O3/c1-14-6-19(29-30(14)2)13-33-23-10-21-16(8-20(23)25)7-17(24(31)28-21)12-27-18-5-4-15(11-26)22(9-18)32-3/h4-10,27H,12-13H2,1-3H3,(H,28,31)	XHFLRLFPWAYZQN-UHFFFAOYSA-N	377658	US10266495, Compound I-70::4-[({6-chloro-7-[(1,5-dimethyl-1H-pyrazol-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866803	404346625							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755400	COc1cc(NCc2cc3cc(Cl)c(OCc4ccccc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H20ClN3O3/c1-31-23-11-20(8-7-17(23)13-27)28-14-19-9-18-10-21(26)24(12-22(18)29-25(19)30)32-15-16-5-3-2-4-6-16/h2-12,28H,14-15H2,1H3,(H,29,30)	VJOKHRHCQQMVSN-UHFFFAOYSA-N	377659	US10266495, Compound I-71::4-({[7-(benzyloxy)-6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866804	404346626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755402	COc1cc(NCc2cc3cc(Cl)c(OCC4CCCCN4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O3/c1-30-8-4-3-5-20(30)15-33-24-12-22-17(10-21(24)26)9-18(25(31)29-22)14-28-19-7-6-16(13-27)23(11-19)32-2/h6-7,9-12,20,28H,3-5,8,14-15H2,1-2H3,(H,29,31)	SNBIPUDRMOXTPE-UHFFFAOYSA-N	377660	US10266495, Compound I-72::4-[({6-chloro-7-[(1-methylpiperidin-2-yl)methoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866805	404346627							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755405	COc1cc(NCc2cc3cc(Cl)c(OCc4ccncc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-22-10-19(3-2-16(22)12-26)28-13-18-8-17-9-20(25)23(11-21(17)29-24(18)30)32-14-15-4-6-27-7-5-15/h2-11,28H,13-14H2,1H3,(H,29,30)	LUMAMFZEXNQSKB-UHFFFAOYSA-N	377662	US10266495, Compound I-74::4-({[6-chloro-2-oxo-7-(pyridin-4-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866807	404346629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755407	COc1cc(NCc2cc3cc(Cl)c(OCC4CCS(=O)(=O)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H24ClN3O5S/c1-32-22-10-19(3-2-16(22)12-26)27-13-18-8-17-9-20(25)23(11-21(17)28-24(18)29)33-14-15-4-6-34(30,31)7-5-15/h2-3,8-11,15,27H,4-7,13-14H2,1H3,(H,28,29)	BYTHIWYWHFZDAG-UHFFFAOYSA-N	377663	US10266495, Compound I-75::4-[({6-chloro-7-[(1,1-dioxo-1lambda6-thian-4-yl)methoxy]-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866808	404346630							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755409	COc1cc(NCc2cc3cc(Cl)c(OCc4cnccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H18ClN5O3/c1-31-21-8-17(3-2-14(21)10-25)28-11-16-6-15-7-19(24)22(9-20(15)29-23(16)30)32-13-18-12-26-4-5-27-18/h2-9,12,28H,11,13H2,1H3,(H,29,30)	MAMKQZAUYSSTJE-UHFFFAOYSA-N	377664	US10266495, Compound I-76::4-({[6-chloro-2-oxo-7-(pyrazin-2-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866809	404346631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755411	COc1cc(NCc2cc3cc(Cl)c(OCc4cncn4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H20ClN5O3/c1-29-13-26-11-18(29)12-32-22-8-20-15(6-19(22)24)5-16(23(30)28-20)10-27-17-4-3-14(9-25)21(7-17)31-2/h3-8,11,13,27H,10,12H2,1-2H3,(H,28,30)	XBRVTKHNQJZBOM-UHFFFAOYSA-N	377665	US10266495, Compound I-77::4-[({6-chloro-7-[(1-methyl-1H-imidazol-5-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866810	404346632							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755413	COc1cc(NCc2cc3cc(Cl)c(OCc4nccn4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H20ClN5O3/c1-29-6-5-26-22(29)13-32-21-10-19-15(8-18(21)24)7-16(23(30)28-19)12-27-17-4-3-14(11-25)20(9-17)31-2/h3-10,27H,12-13H2,1-2H3,(H,28,30)	ZNNYIZWXQHUQAE-UHFFFAOYSA-N	377666	US10266495, Compound I-78::4-[({6-chloro-7-[(1-methyl-1H-imidazol-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866811	404346633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755415	COc1cc(NCc2cc3cc(Cl)c(OCc4nc(no4)C(N)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C22H17ClN6O5/c1-32-17-6-14(3-2-11(17)8-24)26-9-13-4-12-5-15(23)18(7-16(12)27-22(13)31)33-10-19-28-21(20(25)30)29-34-19/h2-7,26H,9-10H2,1H3,(H2,25,30)(H,27,31)	MXJDLEVWMIQVAZ-UHFFFAOYSA-N	377667	US10266495, Compound I-79::5-{[(6-chloro-3-{[(4-cyano-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866812	404346634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755417	COc1cc(NCc2cc3cc(Cl)c(OCCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-32-23-12-20(6-5-16(23)14-27)29-15-18-10-17-11-21(26)24(13-22(17)30-25(18)31)33-9-7-19-4-2-3-8-28-19/h2-6,8,10-13,29H,7,9,15H2,1H3,(H,30,31)	ZKPLTVZRYJMSDR-UHFFFAOYSA-N	377668	US10266495, Compound I-80::4-[({6-chloro-2-oxo-7-[2-(pyridin-2-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866813	404346635							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755419	COc1cc(NCc2cc3cc(Cl)c(OCCc4ccncc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-32-23-12-20(3-2-17(23)14-27)29-15-19-10-18-11-21(26)24(13-22(18)30-25(19)31)33-9-6-16-4-7-28-8-5-16/h2-5,7-8,10-13,29H,6,9,15H2,1H3,(H,30,31)	QDVONHZHLDMQJV-UHFFFAOYSA-N	377669	US10266495, Compound I-81::4-[({6-chloro-2-oxo-7-[2-(pyridin-4-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866814	404346636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755421	COc1cc(NCc2cc3cc(Cl)c(OCCCN(C)C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H25ClN4O3/c1-28(2)7-4-8-31-22-12-20-16(10-19(22)24)9-17(23(29)27-20)14-26-18-6-5-15(13-25)21(11-18)30-3/h5-6,9-12,26H,4,7-8,14H2,1-3H3,(H,27,29)	JDBMLADWDOHSJS-UHFFFAOYSA-N	377670	US10266495, Compound I-82::4-[({6-chloro-7-[3-(dimethylamino)propoxy]-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866815	404346637							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755423	COc1cc(NCc2cc3cc(Cl)c(OCCCN4CCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O3/c1-32-23-13-20(6-5-17(23)15-27)28-16-19-11-18-12-21(26)24(14-22(18)29-25(19)31)33-10-4-9-30-7-2-3-8-30/h5-6,11-14,28H,2-4,7-10,16H2,1H3,(H,29,31)	CUGQFMLSKRUENL-UHFFFAOYSA-N	377671	US10266495, Compound I-83::4-[({6-chloro-2-oxo-7-[3-(pyrrolidin-1-yl)propoxy]-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866816	404346638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755425	COc1cc(NCc2cc3cc(Cl)c(OCCCN4CCCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C26H29ClN4O3/c1-33-24-14-21(7-6-18(24)16-28)29-17-20-12-19-13-22(27)25(15-23(19)30-26(20)32)34-11-5-10-31-8-3-2-4-9-31/h6-7,12-15,29H,2-5,8-11,17H2,1H3,(H,30,32)	PIAOIQPQNWUOFI-UHFFFAOYSA-N	377672	US10266495, Compound I-84::4-[({6-chloro-2-oxo-7-[3-(piperidin-1-yl)propoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866817	404346639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755427	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O3/c1-31-22-12-19(5-4-16(22)14-26)27-15-18-10-17-11-20(25)23(13-21(17)28-24(18)30)32-9-8-29-6-2-3-7-29/h4-5,10-13,27H,2-3,6-9,15H2,1H3,(H,28,30)	MSZKIFCUJHHGFO-UHFFFAOYSA-N	377673	US10266495, Compound I-85::4-[({6-chloro-2-oxo-7-[2-(pyrrolidin-1-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866818	404346640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755429	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCCC4=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H23ClN4O4/c1-32-21-11-18(5-4-15(21)13-26)27-14-17-9-16-10-19(25)22(12-20(16)28-24(17)31)33-8-7-29-6-2-3-23(29)30/h4-5,9-12,27H,2-3,6-8,14H2,1H3,(H,28,31)	OUSJMTATPGEBST-UHFFFAOYSA-N	377674	US10266495, Compound I-86::4-[({6-chloro-2-oxo-7-[2-(2-oxopyrrolidin-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866819	404346641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755431	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O3/c1-32-23-13-20(6-5-17(23)15-27)28-16-19-11-18-12-21(26)24(14-22(18)29-25(19)31)33-10-9-30-7-3-2-4-8-30/h5-6,11-14,28H,2-4,7-10,16H2,1H3,(H,29,31)	CTMYLAQMJOILMA-UHFFFAOYSA-N	377675	US10266495, Compound I-87::4-[({6-chloro-2-oxo-7-[2-(piperidin-1-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866820	404346642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755433	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCN(C)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H28ClN5O3/c1-30-5-7-31(8-6-30)9-10-34-24-14-22-18(12-21(24)26)11-19(25(32)29-22)16-28-20-4-3-17(15-27)23(13-20)33-2/h3-4,11-14,28H,5-10,16H2,1-2H3,(H,29,32)	XRGWIHWIKBCYHZ-UHFFFAOYSA-N	377676	US10266495, Compound I-88::4-[({6-chloro-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377676&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866821	404346643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755435	COc1cc(NCc2cc3cc(Cl)c(OCCn4ccnc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H20ClN5O3/c1-31-21-10-18(3-2-15(21)12-25)27-13-17-8-16-9-19(24)22(11-20(16)28-23(17)30)32-7-6-29-5-4-26-14-29/h2-5,8-11,14,27H,6-7,13H2,1H3,(H,28,30)	JVVZGQLJZNKJNR-UHFFFAOYSA-N	377677	US10266495, Compound I-89::4-[({6-chloro-7-[2-(1H-imidazol-1-yl)ethoxy]-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866822	404346644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755437	COc1cc(NCc2cc3cc(Cl)c(OCCn4ccnc4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H22ClN5O3/c1-15-27-5-6-30(15)7-8-33-23-12-21-17(10-20(23)25)9-18(24(31)29-21)14-28-19-4-3-16(13-26)22(11-19)32-2/h3-6,9-12,28H,7-8,14H2,1-2H3,(H,29,31)	LWWFYUMGJBBWIN-UHFFFAOYSA-N	377678	US10266495, Compound I-90::4-[({6-chloro-7-[2-(2-methyl-1H-imidazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866823	404346645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755439	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCS(=O)(=O)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O5S/c1-33-22-12-19(3-2-16(22)14-26)27-15-18-10-17-11-20(25)23(13-21(17)28-24(18)30)34-7-4-29-5-8-35(31,32)9-6-29/h2-3,10-13,27H,4-9,15H2,1H3,(H,28,30)	CKUQYUUOKYQJPI-UHFFFAOYSA-N	377679	US10266495, Compound I-91::4-[({6-chloro-7-[2-(1,1-dioxo-1lambda6,4-thiomorpholin-4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866824	404346646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755441	COc1cc(NCc2cc3cc(Cl)c(OCCn4nc(C)cc4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H24ClN5O3/c1-15-8-16(2)31(30-15)6-7-34-24-12-22-18(10-21(24)26)9-19(25(32)29-22)14-28-20-5-4-17(13-27)23(11-20)33-3/h4-5,8-12,28H,6-7,14H2,1-3H3,(H,29,32)	ZANYSXIWJIXTEB-UHFFFAOYSA-N	377680	US10266495, Compound I-92::4-[({6-chloro-7-[2-(3,5-dimethyl-1H-pyrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866825	404346647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755444	COc1cc(NCc2cc3cc(Cl)c(OC[C@@H]4CCCN4C)cc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C24H25ClN4O3/c1-29-7-3-4-19(29)14-32-23-11-21-16(9-20(23)25)8-17(24(30)28-21)13-27-18-6-5-15(12-26)22(10-18)31-2/h5-6,8-11,19,27H,3-4,7,13-14H2,1-2H3,(H,28,30)	AUSQEMWCDVUKEF-UHFFFAOYSA-N	377682	US10266495, Compound I-94::4-{[(6-chloro-7-{[(2S)-1-methylpyrrolidin-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866827	404346649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755446	COc1cc(NCc2cc3cc(Cl)cc(C)c3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O2/c1-11-5-15(20)7-13-6-14(19(24)23-18(11)13)10-22-16-4-3-12(9-21)17(8-16)25-2/h3-8,22H,10H2,1-2H3,(H,23,24)	VXQVZYJIBKUGQX-UHFFFAOYSA-N	377683	US10266495, Compound I-95::4-{[(6-chloro-8-methyl-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866828	404346650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755449	COc1cc(NCc2cc3cc(Cl)cc(OC)c3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O3/c1-25-16-8-15(4-3-11(16)9-21)22-10-13-5-12-6-14(20)7-17(26-2)18(12)23-19(13)24/h3-8,22H,10H2,1-2H3,(H,23,24)	CQVRJZBBBURMFP-UHFFFAOYSA-N	377685	US10266495, Compound I-97::4-{[(6-chloro-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866830	404346652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755451	COc1cc(NCc2cc3cc(Cl)cc(OCc4ccccn4)c3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-21-11-19(6-5-15(21)12-26)28-13-17-8-16-9-18(25)10-22(23(16)29-24(17)30)32-14-20-4-2-3-7-27-20/h2-11,28H,13-14H2,1H3,(H,29,30)	ARZTYPQTGCGOHE-UHFFFAOYSA-N	377686	US10266495, Compound I-98::4-({[6-chloro-2-oxo-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866831	404346653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755453	COc1cc(NCc2cc3cc(Cl)cc(OCCN4CCOCC4)c3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O4/c1-31-21-13-20(3-2-16(21)14-26)27-15-18-10-17-11-19(25)12-22(23(17)28-24(18)30)33-9-6-29-4-7-32-8-5-29/h2-3,10-13,27H,4-9,15H2,1H3,(H,28,30)	BDNAALPRTZXITM-UHFFFAOYSA-N	377687	US10266495, Compound I-99::4-[({6-chloro-8-[2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866832	404346654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755455	COc1cc(NCc2cc3cc(Cl)cc(OCCN4CCCC4)c3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O3/c1-31-21-13-20(5-4-16(21)14-26)27-15-18-10-17-11-19(25)12-22(23(17)28-24(18)30)32-9-8-29-6-2-3-7-29/h4-5,10-13,27H,2-3,6-9,15H2,1H3,(H,28,30)	KLQXWNJVVYZFDQ-UHFFFAOYSA-N	377688	US10266495, Compound I-100::4-[({6-chloro-2-oxo-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145866833	404346655							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766486	C[C@H](Nc1nccc(n1)N(CC1CC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H22ClN5O3S/c1-12(16-10-14-9-15(21)5-6-17(14)24-19(16)27)23-20-22-8-7-18(25-20)26(30(2,28)29)11-13-3-4-13/h5-10,12-13H,3-4,11H2,1-2H3,(H,24,27)(H,22,23,25)	IIWIVYXMZOQFHZ-UHFFFAOYSA-N	383719	US10280150, Cmpd No I-2::US10550099, Compound I-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995695	404853007							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766488	C[C@H](Nc1nccc(n1)N(C1CCCOC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H24ClN5O4S/c1-13(17-11-14-10-15(22)5-6-18(14)25-20(17)28)24-21-23-8-7-19(26-21)27(32(2,29)30)16-4-3-9-31-12-16/h5-8,10-11,13,16H,3-4,9,12H2,1-2H3,(H,25,28)(H,23,24,26)	OADNTPKRAPIVSV-UHFFFAOYSA-N	383720	US10280150, Cmpd No I-3::US10550099, Compound I-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995696	404853008							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766490	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)c1cccnc1 |r|	InChI=1S/C23H23ClN6O3S/c1-14(2)30(34(32,33)18-5-4-9-25-13-18)21-8-10-26-23(29-21)27-15(3)19-12-16-11-17(24)6-7-20(16)28-22(19)31/h4-15H,1-3H3,(H,28,31)(H,26,27,29)	ZGVRNACKYKKXCX-UHFFFAOYSA-N	383721	US10280150, Cmpd No I-4::US10550099, Compound I-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995697	404853009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766492	CC(C)CS(=O)(=O)N(C(C)C)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H28ClN5O3S/c1-13(2)12-32(30,31)28(14(3)4)20-8-9-24-22(27-20)25-15(5)18-11-16-10-17(23)6-7-19(16)26-21(18)29/h6-11,13-15H,12H2,1-5H3,(H,26,29)(H,24,25,27)	BNDBBKCRPAPOCQ-UHFFFAOYSA-N	383722	US10280150, Cmpd No I-5::US10550099, Compound I-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995698	404853010							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766495	C[C@H](Nc1nccc(NC(C)(C)C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H22ClN5O/c1-11(22-18-21-8-7-16(24-18)25-19(2,3)4)14-10-12-9-13(20)5-6-15(12)23-17(14)26/h5-11H,1-4H3,(H,23,26)(H2,21,22,24,25)	WYGVSXRMOFLNOZ-UHFFFAOYSA-N	383724	US10280150, Cmpd No I-7::US10550099, Compound I-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995700	404853012							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766497	CC(C)CN(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C20H24ClN5O3S/c1-12(2)11-26(30(4,28)29)18-7-8-22-20(25-18)23-13(3)16-10-14-9-15(21)5-6-17(14)24-19(16)27/h5-10,12-13H,11H2,1-4H3,(H,24,27)(H,22,23,25)	NOTMFFJQECVSJE-UHFFFAOYSA-N	383725	US10280150, Cmpd No I-8::US10550099, Compound I-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383725&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995701	404853013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766500	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C19H22ClN5O3S/c1-11(2)25(29(4,27)28)17-7-8-21-19(24-17)22-12(3)15-10-13-9-14(20)5-6-16(13)23-18(15)26/h5-12H,1-4H3,(H,23,26)(H,21,22,24)	FJGJXQOALOTHEU-UHFFFAOYSA-N	383727	US10280150, Cmpd No I-10::US10550099, Compound I-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383727&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995703	404853015							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766502	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)CC1CC1 |r|	InChI=1S/C22H26ClN5O3S/c1-13(2)28(32(30,31)12-15-4-5-15)20-8-9-24-22(27-20)25-14(3)18-11-16-10-17(23)6-7-19(16)26-21(18)29/h6-11,13-15H,4-5,12H2,1-3H3,(H,26,29)(H,24,25,27)	MQBZFIAATYLIPQ-UHFFFAOYSA-N	383728	US10280150, Cmpd No I-11::US10550099, Compound I-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383728&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995704	404853016							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766504	C[C@H](Nc1nccc(n1)N1CCCS1(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H18ClN5O3S/c1-11(14-10-12-9-13(19)3-4-15(12)22-17(14)25)21-18-20-6-5-16(23-18)24-7-2-8-28(24,26)27/h3-6,9-11H,2,7-8H2,1H3,(H,22,25)(H,20,21,23)	YZFVEWXCTMVFEM-UHFFFAOYSA-N	383729	US10280150, Cmpd No I-12::US10550099, Compound I-12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383729&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995705	404853017							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766507	C[C@H](Nc1nccc(n1)N(C1CC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H20ClN5O3S/c1-11(15-10-12-9-13(20)3-6-16(12)23-18(15)26)22-19-21-8-7-17(24-19)25(14-4-5-14)29(2,27)28/h3,6-11,14H,4-5H2,1-2H3,(H,23,26)(H,21,22,24)	OXUYSIFHQVERHS-UHFFFAOYSA-N	383731	US10280150, Cmpd No I-14::US10550099, Compound I-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383731&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995707	404853019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766509	CC(C)CS(=O)(=O)N(C)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H24ClN5O3S/c1-12(2)11-30(28,29)26(4)18-7-8-22-20(25-18)23-13(3)16-10-14-9-15(21)5-6-17(14)24-19(16)27/h5-10,12-13H,11H2,1-4H3,(H,24,27)(H,22,23,25)	IPVIBCMFVJXIEG-UHFFFAOYSA-N	383732	US10280150, Cmpd No I-15::US10550099, Compound I-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383732&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995708	404853020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766511	C[C@H](Nc1nccc(n1)N(CCC1CCOCC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H28ClN5O4S/c1-15(19-14-17-13-18(24)3-4-20(17)27-22(19)30)26-23-25-9-5-21(28-23)29(34(2,31)32)10-6-16-7-11-33-12-8-16/h3-5,9,13-16H,6-8,10-12H2,1-2H3,(H,27,30)(H,25,26,28)	INONUJKTCMKETC-UHFFFAOYSA-N	383733	US10280150, Cmpd No I-16::US10550099, Compound I-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995709	404853021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766516	CC(C)N(c1ccnc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O	InChI=1S/C19H22ClN5O3S/c1-11(2)25(29(4,27)28)17-7-8-21-19(24-17)22-12(3)15-10-13-9-14(20)5-6-16(13)23-18(15)26/h5-12H,1-4H3,(H,23,26)(H,21,22,24)	FJGJXQOALOTHEU-UHFFFAOYSA-N	383737	US10280150, Cmpd No I-20::US10550099, Compound I-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383737&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995713	404853025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766518	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)c1ccc2n(C)c(=O)oc2c1 |r|	InChI=1S/C26H25ClN6O5S/c1-14(2)33(39(36,37)18-6-8-21-22(13-18)38-26(35)32(21)4)23-9-10-28-25(31-23)29-15(3)19-12-16-11-17(27)5-7-20(16)30-24(19)34/h5-15H,1-4H3,(H,30,34)(H,28,29,31)	SENWNZCXZNKJRA-UHFFFAOYSA-N	383738	US10280150, Cmpd No I-21::US10550099, Compound I-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383738&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995714	404853026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766520	COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C17H16ClN5O3/c1-9(20-16-19-6-5-14(22-16)23-17(25)26-2)12-8-10-7-11(18)3-4-13(10)21-15(12)24/h3-9H,1-2H3,(H,21,24)(H2,19,20,22,23,25)	WFKGXYJYRVHFRO-UHFFFAOYSA-N	383739	US10280150, Cmpd No I-22::US10550099, Compound I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383739&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995715	404853027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766524	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H16ClN5O2/c1-9(20-17-19-6-5-15(23-17)21-10(2)24)13-8-11-7-12(18)3-4-14(11)22-16(13)25/h3-9H,1-2H3,(H,22,25)(H2,19,20,21,23,24)	OGHZJOVLWKGTPM-UHFFFAOYSA-N	383742	US10280150, Cmpd No I-25::US10550099, Compound I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383742&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995718	404853030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766529	C[C@H](Nc1nccc(NC(=O)C2CC2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H18ClN5O2/c1-10(14-9-12-8-13(20)4-5-15(12)23-18(14)27)22-19-21-7-6-16(25-19)24-17(26)11-2-3-11/h4-11H,2-3H2,1H3,(H,23,27)(H2,21,22,24,25,26)	AQMZRUZRHGBAJE-UHFFFAOYSA-N	383746	US10280150, Cmpd No I-29::US10550099, Compound I-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383746&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995722	404853034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766534	CCC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C18H18ClN5O2/c1-3-16(25)23-15-6-7-20-18(24-15)21-10(2)13-9-11-8-12(19)4-5-14(11)22-17(13)26/h4-10H,3H2,1-2H3,(H,22,26)(H2,20,21,23,24,25)	YEDPTPNOJUHFGL-UHFFFAOYSA-N	383750	US10280150, Cmpd No I-33::US10550099, Compound I-33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383750&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995726	404853038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766537	CC(C)CN(C(=O)C1CC1)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C23H26ClN5O2/c1-13(2)12-29(22(31)15-4-5-15)20-8-9-25-23(28-20)26-14(3)18-11-16-10-17(24)6-7-19(16)27-21(18)30/h6-11,13-15H,4-5,12H2,1-3H3,(H,27,30)(H,25,26,28)	XACNPBWTCUHCQL-UHFFFAOYSA-N	383752	US10280150, Cmpd No I-35::US10550099, Compound I-35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383752&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995728	404853040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766539	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H14ClN5O2/c1-9(21-17-20-8-11(7-19)16(23-17)25-2)13-6-10-5-12(18)3-4-14(10)22-15(13)24/h3-6,8-9H,1-2H3,(H,22,24)(H,20,21,23)	QAFWVLDKBWIXLX-UHFFFAOYSA-N	383753	US10280150, Cmpd No I-36::US10550099, Compound I-156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383753&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995729	404853041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766542	CNc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H15ClN6O/c1-9(22-17-21-8-11(7-19)15(20-2)24-17)13-6-10-5-12(18)3-4-14(10)23-16(13)25/h3-6,8-9H,1-2H3,(H,23,25)(H2,20,21,22,24)	JZPKYJWBXABXSU-UHFFFAOYSA-N	383755	US10280150, Cmpd No I-38::US10550099, Compound I-38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383755&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995731	404853043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766544	C[C@H](Nc1ncc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H14ClN5O/c1-9-12(7-19)8-20-17(21-9)22-10(2)14-6-11-5-13(18)3-4-15(11)23-16(14)24/h3-6,8,10H,1-2H3,(H,23,24)(H,20,21,22)	DXHZNUXMBDALDX-UHFFFAOYSA-N	383756	US10280150, Cmpd No I-39::US10550099, Compound I-39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383756&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995732	404853044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766547	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)ncc1C#N |r|	InChI=1S/C18H16ClN5O2/c1-10(22-18-21-9-12(8-20)16(23-18)26-3)14-7-11-6-13(19)4-5-15(11)24(2)17(14)25/h4-7,9-10H,1-3H3,(H,21,22,23)	RDWBYCLMYSKOTA-UHFFFAOYSA-N	383758	US10280150, Cmpd No I-41::US10550099, Compound I-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383758&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			118953994	404853046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766549	CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H22ClN5O3/c1-11(2)17-10-30-21(29)27(17)18-6-7-23-20(26-18)24-12(3)15-9-13-8-14(22)4-5-16(13)25-19(15)28/h4-9,11-12,17H,10H2,1-3H3,(H,25,28)(H,23,24,26)	BQXMMSHPKZRVGT-UHFFFAOYSA-N	383759	US10280150, Cmpd No I-42::US10550099, Compound I-42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383759&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995734	404853047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766552	C[C@H](Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O3/c1-10(13-9-11-8-12(19)2-3-14(11)22-16(13)25)21-17-20-5-4-15(23-17)24-6-7-27-18(24)26/h2-5,8-10H,6-7H2,1H3,(H,22,25)(H,20,21,23)	BTUGZKWGQKVBMC-UHFFFAOYSA-N	383761	US10280150, Cmpd No I-44::US10550099, Compound I-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383761&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995736	404853049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766554	C[C@@H](Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O3/c1-10(13-9-11-8-12(19)2-3-14(11)22-16(13)25)21-17-20-5-4-15(23-17)24-6-7-27-18(24)26/h2-5,8-10H,6-7H2,1H3,(H,22,25)(H,20,21,23)	BTUGZKWGQKVBMC-UHFFFAOYSA-N	383762	US10280150, Cmpd No I-45::US10550099, Compound I-45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383762&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995737	404853050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766556	CC(C)[C@H]1COC(=O)N1c1ccnc(NCc2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H20ClN5O3/c1-11(2)16-10-29-20(28)26(16)17-5-6-22-19(25-17)23-9-13-7-12-8-14(21)3-4-15(12)24-18(13)27/h3-8,11,16H,9-10H2,1-2H3,(H,24,27)(H,22,23,25)	SZSVFGOEMYLUNB-UHFFFAOYSA-N	383763	US10280150, Cmpd No I-46::US10550099, Compound I-46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383763&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995738	404853051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766558	Clc1ccc2[nH]c(=O)c(CNc3nccc(n3)N3CCOC3=O)cc2c1	InChI=1S/C17H14ClN5O3/c18-12-1-2-13-10(8-12)7-11(15(24)21-13)9-20-16-19-4-3-14(22-16)23-5-6-26-17(23)25/h1-4,7-8H,5-6,9H2,(H,21,24)(H,19,20,22)	OIYBWFJBTGLWGE-UHFFFAOYSA-N	383764	US10280150, Cmpd No I-47::US10550099, Compound I-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383764&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995739	404853052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766560	CC(Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H16ClN5O3/c1-10(13-9-11-8-12(19)2-3-14(11)22-16(13)25)21-17-20-5-4-15(23-17)24-6-7-27-18(24)26/h2-5,8-10H,6-7H2,1H3,(H,22,25)(H,20,21,23)	BTUGZKWGQKVBMC-UHFFFAOYSA-N	383765	US10280150, Cmpd No I-48::US10550099, Compound I-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383765&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995740	404853053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766564	C[C@H](Nc1nccc(n1)-n1cccc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5O/c1-12-4-3-9-26(12)18-7-8-22-20(25-18)23-13(2)16-11-14-10-15(21)5-6-17(14)24-19(16)27/h3-11,13H,1-2H3,(H,24,27)(H,22,23,25)	PGMTZTOWMIVRIA-UHFFFAOYSA-N	383768	US10280150, Cmpd No I-51::US10550099, Compound I-51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383768&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995743	404853056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766568	C[C@H](Nc1nccc(n1)-n1ccnc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN6O/c1-11(14-9-12-8-13(19)2-3-15(12)23-17(14)26)22-18-21-5-4-16(24-18)25-7-6-20-10-25/h2-11H,1H3,(H,23,26)(H,21,22,24)	GJIKDXWHVDVKFX-UHFFFAOYSA-N	383771	US10280150, Cmpd No I-54::US10550099, Compound I-54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383771&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995746	404853059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766570	C[C@H](Nc1nccc(n1)-n1cnc2CCCc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H19ClN6O/c1-12(15-10-13-9-14(22)5-6-16(13)26-20(15)29)25-21-23-8-7-19(27-21)28-11-24-17-3-2-4-18(17)28/h5-12H,2-4H2,1H3,(H,26,29)(H,23,25,27)	RYTFFDAXPNHRFO-UHFFFAOYSA-N	383772	US10280150, Cmpd No I-55::US10550099, Compound I-55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383772&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995747	404853060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766574	C[C@H](Nc1nccc(n1)-c1cnoc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClN5O2/c1-10(14-8-12-7-13(20)3-4-16(12)24-18(14)26)23-19-21-6-5-17(25-19)15-9-22-27-11(15)2/h3-10H,1-2H3,(H,24,26)(H,21,23,25)	DSURWNHICLZAIP-UHFFFAOYSA-N	383775	US10280150, Cmpd No I-58::US10550099, Compound I-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383775&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995750	404853063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766576	C[C@H](Nc1nccc(n1)-n1nnnc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H15ClN8O/c1-9(13-8-11-7-12(18)3-4-14(11)21-16(13)27)20-17-19-6-5-15(22-17)26-10(2)23-24-25-26/h3-9H,1-2H3,(H,21,27)(H,19,20,22)	UQLHGCXSQUULQE-UHFFFAOYSA-N	383776	US10280150, Cmpd No I-59::US10550099, Compound I-59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383776&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995751	404853064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766578	C[C@H](Nc1nccc(n1)-c1cncn1CC(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H16ClF3N6O/c1-11(14-7-12-6-13(21)2-3-15(12)28-18(14)31)27-19-26-5-4-16(29-19)17-8-25-10-30(17)9-20(22,23)24/h2-8,10-11H,9H2,1H3,(H,28,31)(H,26,27,29)	RITFQEXZBNEGCD-UHFFFAOYSA-N	383777	US10280150, Cmpd No I-60::US10550099, Compound I-60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995752	404853065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766580	C[C@H](Nc1nccc(n1)-c1cncn1CC1CC1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H21ClN6O/c1-13(17-9-15-8-16(23)4-5-18(15)27-21(17)30)26-22-25-7-6-19(28-22)20-10-24-12-29(20)11-14-2-3-14/h4-10,12-14H,2-3,11H2,1H3,(H,27,30)(H,25,26,28)	IOTAWKJXNJPMAB-UHFFFAOYSA-N	383778	US10280150, Cmpd No I-61::US10550099, Compound I-61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383778&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995753	404853066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766583	C[C@H](Nc1nccc(n1)-c1cnc2ccccn12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H17ClN6O/c1-13(16-11-14-10-15(23)5-6-17(14)27-21(16)30)26-22-24-8-7-18(28-22)19-12-25-20-4-2-3-9-29(19)20/h2-13H,1H3,(H,27,30)(H,24,26,28)	JUNGABYWISKKML-UHFFFAOYSA-N	383780	US10280150, Cmpd No I-63::US10550099, Compound I-63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383780&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995755	404853068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766585	CC(C)n1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H21ClN6O/c1-12(2)28-11-23-10-19(28)18-6-7-24-21(27-18)25-13(3)16-9-14-8-15(22)4-5-17(14)26-20(16)29/h4-13H,1-3H3,(H,26,29)(H,24,25,27)	HWGQNIBDVMLHMH-UHFFFAOYSA-N	383781	US10280150, Cmpd No I-64::US10550099, Compound I-64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383781&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995756	404853069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766587	C[C@H](Nc1nccc(n1)-n1cccc1C(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H15ClF3N5O/c1-11(14-10-12-9-13(21)4-5-15(12)27-18(14)30)26-19-25-7-6-17(28-19)29-8-2-3-16(29)20(22,23)24/h2-11H,1H3,(H,27,30)(H,25,26,28)	IZNMTAUTDFMJRY-UHFFFAOYSA-N	383782	US10280150, Cmpd No I-65::US10550099, Compound I-65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995757	404853070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766589	C[C@H](Nc1nccc(n1)-c1cnnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN7O/c1-10(13-8-11-7-12(19)3-4-14(11)23-17(13)27)22-18-20-6-5-15(24-18)16-9-21-25-26(16)2/h3-10H,1-2H3,(H,23,27)(H,20,22,24)	QEYLVOXRLADSDJ-UHFFFAOYSA-N	383783	US10280150, Cmpd No I-66::US10550099, Compound I-66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383783&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995758	404853071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766592	C[C@H](Nc1nccc(n1)-c1cncn1Cc1ccccc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C25H21ClN6O/c1-16(20-12-18-11-19(26)7-8-21(18)30-24(20)33)29-25-28-10-9-22(31-25)23-13-27-15-32(23)14-17-5-3-2-4-6-17/h2-13,15-16H,14H2,1H3,(H,30,33)(H,28,29,31)	YTLMNLSWKINCGV-UHFFFAOYSA-N	383785	US10280150, Cmpd No I-68::US10550099, Compound I-68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995760	404853073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766596	C[C@H](Nc1nccc(n1)-c1cncn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11(14-8-12-7-13(20)3-4-15(12)24-18(14)27)23-19-22-6-5-16(25-19)17-9-21-10-26(17)2/h3-11H,1-2H3,(H,24,27)(H,22,23,25)	WPESHFWYUVZQEM-UHFFFAOYSA-N	383788	US10280150, Cmpd No I-71::US10550099, Compound I-71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995763	404853076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766601	CC(C)n1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H21ClN6O/c1-12(2)28-19(7-9-24-28)18-6-8-23-21(27-18)25-13(3)16-11-14-10-15(22)4-5-17(14)26-20(16)29/h4-13H,1-3H3,(H,26,29)(H,23,25,27)	KHPDQJGUDAOSNG-UHFFFAOYSA-N	383792	US10280150, Cmpd No I-75::US10550099, Compound I-75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383792&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995767	404853080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766610	C[C@H](Nc1nccc(n1)-c1c(C)n[nH]c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-10(15-9-13-8-14(21)4-5-16(13)24-19(15)28)23-20-22-7-6-17(25-20)18-11(2)26-27-12(18)3/h4-10H,1-3H3,(H,24,28)(H,26,27)(H,22,23,25)	XXHBAQZGFDZZAX-UHFFFAOYSA-N	383799	US10280150, Cmpd No I-83::US10280150, Cmpd No I-82::US10550099, Compound I-82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995774	404853087							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766612	C[C@H](Nc1nccc(n1)-c1c(C)nn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H21ClN6O/c1-11(16-10-14-9-15(22)5-6-17(14)25-20(16)29)24-21-23-8-7-18(26-21)19-12(2)27-28(4)13(19)3/h5-11H,1-4H3,(H,25,29)(H,23,24,26)	UPUDSDPBPRCMSD-UHFFFAOYSA-N	383801	US10280150, Cmpd No I-84::US10550099, Compound I-84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383801&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995775	404853088							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766614	CC(C)Cn1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN6O/c1-13(2)11-29-12-24-10-20(29)19-6-7-25-22(28-19)26-14(3)17-9-15-8-16(23)4-5-18(15)27-21(17)30/h4-10,12-14H,11H2,1-3H3,(H,27,30)(H,25,26,28)	BFPIOQFECNSTLW-UHFFFAOYSA-N	383802	US10280150, Cmpd No I-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383802&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995776	404853089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766616	C[C@H](Nc1nccc(n1)-c1c[nH]nc1C(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H14ClF3N6O/c1-9(12-7-10-6-11(20)2-3-14(10)27-17(12)30)26-18-24-5-4-15(28-18)13-8-25-29-16(13)19(21,22)23/h2-9H,1H3,(H,25,29)(H,27,30)(H,24,26,28)	SEFIIHBUPFEWHO-UHFFFAOYSA-N	383803	US10280150, Cmpd No I-86::US10550099, Compound I-86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383803&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995777	404853090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766618	C[C@H](Nc1nccc(n1)-c1ccn[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN6O/c1-10(13-9-11-8-12(19)2-3-14(11)23-17(13)26)22-18-20-6-4-15(24-18)16-5-7-21-25-16/h2-10H,1H3,(H,21,25)(H,23,26)(H,20,22,24)	ICCUSBSYAZIVDA-UHFFFAOYSA-N	383804	US10280150, Cmpd No I-87::US10550099, Compound I-87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383804&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995778	404853091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766620	C[C@H](Nc1nccc(n1)-c1cnsc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H14ClN5OS/c1-10(14-7-11-6-13(19)2-3-15(11)23-17(14)25)22-18-20-5-4-16(24-18)12-8-21-26-9-12/h2-10H,1H3,(H,23,25)(H,20,22,24)	ALRYUKWZACFZIB-UHFFFAOYSA-N	383805	US10280150, Cmpd No I-88::US10550099, Compound I-88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383805&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995779	404853092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766622	C[C@H](Nc1nccc(n1)-c1coc2ccccc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H17ClN4O2/c1-13(17-11-14-10-15(24)6-7-19(14)27-22(17)29)26-23-25-9-8-20(28-23)18-12-30-21-5-3-2-4-16(18)21/h2-13H,1H3,(H,27,29)(H,25,26,28)	SLOUHCLWWONKML-UHFFFAOYSA-N	383806	US10280150, Cmpd No I-89::US10550099, Compound I-89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995780	404853093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766624	C[C@H](Nc1nccc(n1)-c1cccnc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClN5O/c1-12-16(4-3-8-23-12)19-7-9-24-21(27-19)25-13(2)17-11-14-10-15(22)5-6-18(14)26-20(17)28/h3-11,13H,1-2H3,(H,26,28)(H,24,25,27)	CPRSIVWOBJQJED-UHFFFAOYSA-N	383807	US10280150, Cmpd No I-90::US10550099, Compound I-90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995781	404853094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766626	C[C@H](Nc1nccc(n1)-c1cnn(C)c1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11(15-8-12-7-14(20)3-4-16(12)24-18(15)27)23-19-21-6-5-17(25-19)13-9-22-26(2)10-13/h3-11H,1-2H3,(H,24,27)(H,21,23,25)	WCAKGWWDSJGJHN-UHFFFAOYSA-N	383808	US10280150, Cmpd No I-91::US10550099, Compound I-91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995782	404853095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766628	C[C@H](Nc1nccc(n1)-c1cncc2ccccc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C24H18ClN5O/c1-14(19-11-16-10-17(25)6-7-21(16)29-23(19)31)28-24-27-9-8-22(30-24)20-13-26-12-15-4-2-3-5-18(15)20/h2-14H,1H3,(H,29,31)(H,27,28,30)	KOIYDCSLTBXMQB-UHFFFAOYSA-N	383809	US10280150, Cmpd No I-92::US10550099, Compound I-92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995783	404853096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766630	COc1ncccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H18ClN5O2/c1-12(16-11-13-10-14(22)5-6-17(13)26-19(16)28)25-21-24-9-7-18(27-21)15-4-3-8-23-20(15)29-2/h3-12H,1-2H3,(H,26,28)(H,24,25,27)	LHOKHOKFHMHHHC-UHFFFAOYSA-N	383810	US10280150, Cmpd No I-93::US10550099, Compound I-93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995784	404853097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766632	C[C@H](Nc1nccc(n1)-c1cccnc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H16ClN5O/c1-12(16-10-14-9-15(21)4-5-17(14)25-19(16)27)24-20-23-8-6-18(26-20)13-3-2-7-22-11-13/h2-12H,1H3,(H,25,27)(H,23,24,26)	DINSQHUXUISIEQ-UHFFFAOYSA-N	383811	US10280150, Cmpd No I-94::US10550099, Compound I-94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995785	404853098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766634	C[C@H](Nc1nccc(n1)-c1ccncc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H16ClN5O/c1-12(16-11-14-10-15(21)2-3-17(14)25-19(16)27)24-20-23-9-6-18(26-20)13-4-7-22-8-5-13/h2-12H,1H3,(H,25,27)(H,23,24,26)	ZLBMDLHBQDZAOY-UHFFFAOYSA-N	383812	US10280150, Cmpd No I-95::US10550099, Compound I-95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995786	404853099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766636	C[C@H](Nc1nccc(n1)-c1ccncc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClN5O/c1-12-11-23-7-5-16(12)19-6-8-24-21(27-19)25-13(2)17-10-14-9-15(22)3-4-18(14)26-20(17)28/h3-11,13H,1-2H3,(H,26,28)(H,24,25,27)	ZYFNXYYHWAJCDL-UHFFFAOYSA-N	383813	US10280150, Cmpd No I-96::US10550099, Compound I-96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995787	404853100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766638	COc1cnccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H18ClN5O2/c1-12(16-10-13-9-14(22)3-4-17(13)26-20(16)28)25-21-24-8-6-18(27-21)15-5-7-23-11-19(15)29-2/h3-12H,1-2H3,(H,26,28)(H,24,25,27)	CHXKOUFZWGFLLU-UHFFFAOYSA-N	383814	US10280150, Cmpd No I-97::US10550099, Compound I-97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995788	404853101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766640	C[C@H](Nc1nccc(n1)-c1cccc2CCOc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H19ClN4O2/c1-13(18-12-15-11-16(24)5-6-19(15)27-22(18)29)26-23-25-9-7-20(28-23)17-4-2-3-14-8-10-30-21(14)17/h2-7,9,11-13H,8,10H2,1H3,(H,27,29)(H,25,26,28)	GHXJNHBCMPUUDN-UHFFFAOYSA-N	383815	US10280150, Cmpd No I-98::US10550099, Compound I-98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383815&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995789	404853102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766642	COc1ccncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H18ClN5O2/c1-12(15-10-13-9-14(22)3-4-17(13)26-20(15)28)25-21-24-8-5-18(27-21)16-11-23-7-6-19(16)29-2/h3-12H,1-2H3,(H,26,28)(H,24,25,27)	GEQSTKKQQZWLIO-UHFFFAOYSA-N	383816	US10280150, Cmpd No I-99::US10550099, Compound I-99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995790	404853103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766644	COCc1ccccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C23H21ClN4O2/c1-14(19-12-16-11-17(24)7-8-20(16)27-22(19)29)26-23-25-10-9-21(28-23)18-6-4-3-5-15(18)13-30-2/h3-12,14H,13H2,1-2H3,(H,27,29)(H,25,26,28)	TVYGOHOYOGUOMC-UHFFFAOYSA-N	383817	US10280150, Cmpd No I-100::US10550099, Compound I-100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995791	404853104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766646	C[C@H](Nc1nccc(n1)-c1ccccc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H17ClN4O/c1-13(17-12-15-11-16(22)7-8-18(15)25-20(17)27)24-21-23-10-9-19(26-21)14-5-3-2-4-6-14/h2-13H,1H3,(H,25,27)(H,23,24,26)	NZOMXICZNNFASS-UHFFFAOYSA-N	383818	US10280150, Cmpd No I-101::US10550099, Compound I-101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995792	404853105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766648	COc1ccccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H19ClN4O2/c1-13(17-12-14-11-15(23)7-8-18(14)26-21(17)28)25-22-24-10-9-19(27-22)16-5-3-4-6-20(16)29-2/h3-13H,1-2H3,(H,26,28)(H,24,25,27)	IQFCCNAYJBBZJK-UHFFFAOYSA-N	383819	US10280150, Cmpd No I-102::US10550099, Compound I-102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383819&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995793	404853106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766651	CC(C)[C@H]1COCCN1c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H26ClN5O2/c1-13(2)19-12-30-9-8-28(19)20-6-7-24-22(27-20)25-14(3)17-11-15-10-16(23)4-5-18(15)26-21(17)29/h4-7,10-11,13-14,19H,8-9,12H2,1-3H3,(H,26,29)(H,24,25,27)	XWMSCEUHLMXSMF-UHFFFAOYSA-N	383821	US10280150, Cmpd No I-104::US10550099, Compound I-104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383821&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995795	404853108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766659	C[C@H](Nc1nccc(n1)S(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O2S/c1-9(19-16-18-6-5-14(21-16)24(2)23)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	AXXSHNHVVCXWHF-UHFFFAOYSA-N	383828	US10280150, Cmpd No I-111::US10550099, Compound I-111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383828&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995802	404853115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766661	C[C@H](Nc1nccc(n1)[S@@](C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O2S/c1-9(19-16-18-6-5-14(21-16)24(2)23)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	AXXSHNHVVCXWHF-UHFFFAOYSA-N	383829	US10280150, Cmpd No I-112::US10550099, Compound I-112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383829&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995803	404853116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766663	C[C@H](Nc1nccc(n1)[S@](C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O2S/c1-9(19-16-18-6-5-14(21-16)24(2)23)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	AXXSHNHVVCXWHF-UHFFFAOYSA-N	383830	US10280150, Cmpd No I-113::US10550099, Compound I-113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383830&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995804	404853117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766665	C[C@H](Nc1nccc(n1)C(N)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H14ClN5O2/c1-8(20-16-19-5-4-13(22-16)14(18)23)11-7-9-6-10(17)2-3-12(9)21-15(11)24/h2-8H,1H3,(H2,18,23)(H,21,24)(H,19,20,22)	MWOAARCSKQYXGZ-UHFFFAOYSA-N	383831	US10280150, Cmpd No I-114::US10550099, Compound I-114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383831&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995805	404853118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766667	CNC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C17H16ClN5O2/c1-9(21-17-20-6-5-14(23-17)16(25)19-2)12-8-10-7-11(18)3-4-13(10)22-15(12)24/h3-9H,1-2H3,(H,19,25)(H,22,24)(H,20,21,23)	XROXWMTXPYXKKQ-UHFFFAOYSA-N	383832	US10280150, Cmpd No I-115::US10550099, Compound I-115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383832&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995806	404853119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766669	CC(C)CNC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H22ClN5O2/c1-11(2)10-23-19(28)17-6-7-22-20(26-17)24-12(3)15-9-13-8-14(21)4-5-16(13)25-18(15)27/h4-9,11-12H,10H2,1-3H3,(H,23,28)(H,25,27)(H,22,24,26)	GQWWANCCZKWTPD-UHFFFAOYSA-N	383833	US10280150, Cmpd No I-116::US10550099, Compound I-116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383833&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995807	404853120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766671	CC(C)NC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H20ClN5O2/c1-10(2)22-18(27)16-6-7-21-19(25-16)23-11(3)14-9-12-8-13(20)4-5-15(12)24-17(14)26/h4-11H,1-3H3,(H,22,27)(H,24,26)(H,21,23,25)	LOPBJHFLEQDMOX-UHFFFAOYSA-N	383834	US10280150, Cmpd No I-117::US10550099, Compound I-117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383834&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995808	404853121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766676	CC(C)CS(=O)(=O)Cc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H23ClN4O3S/c1-12(2)10-29(27,28)11-16-6-7-22-20(24-16)23-13(3)17-9-14-8-15(21)4-5-18(14)25-19(17)26/h4-9,12-13H,10-11H2,1-3H3,(H,25,26)(H,22,23,24)	YLLMKQNZHYPHDJ-UHFFFAOYSA-N	383838	US10280150, Cmpd No I-121::US10550099, Compound I-121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383838&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995812	404853125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766679	C[C@H](Nc1nccc(n1)N1CCNC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H17ClN6O2/c1-10(13-9-11-8-12(19)2-3-14(11)23-16(13)26)22-17-20-5-4-15(24-17)25-7-6-21-18(25)27/h2-5,8-10H,6-7H2,1H3,(H,21,27)(H,23,26)(H,20,22,24)	PXBXSCWOPPEUND-UHFFFAOYSA-N	383840	US10280150, Cmpd No I-123::US10550099, Compound I-123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383840&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995814	404853127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766686	COC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C17H15ClN4O3/c1-9(20-17-19-6-5-14(22-17)16(24)25-2)12-8-10-7-11(18)3-4-13(10)21-15(12)23/h3-9H,1-2H3,(H,21,23)(H,19,20,22)	HWKOMDVYLWZOHF-UHFFFAOYSA-N	383846	US10280150, Cmpd No I-129::US10550099, Compound I-129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383846&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995820	404853133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766691	C[C@H](Nc1nccc(CS(C)(=O)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H17ClN4O3S/c1-10(20-17-19-6-5-13(21-17)9-26(2,24)25)14-8-11-7-12(18)3-4-15(11)22-16(14)23/h3-8,10H,9H2,1-2H3,(H,22,23)(H,19,20,21)	IHNPKRIHCDREAU-UHFFFAOYSA-N	383850	US10280150, Cmpd No I-133::US10550099, Compound I-133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383850&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995824	404853137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766693	COC(=O)C(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C19H19ClN4O5S/c1-10(13-9-11-8-12(20)4-5-14(11)23-17(13)25)22-19-21-7-6-15(24-19)16(18(26)29-2)30(3,27)28/h4-10,16H,1-3H3,(H,23,25)(H,21,22,24)	IPUFMQPBVAODSS-UHFFFAOYSA-N	383851	US10280150, Cmpd No I-134::US10550099, Compound I-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383851&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995825	404853138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766695	C[C@H](Nc1nccc(n1)C(C)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H19ClN4O3S/c1-10(14-9-12-8-13(19)4-5-16(12)22-17(14)24)21-18-20-7-6-15(23-18)11(2)27(3,25)26/h4-11H,1-3H3,(H,22,24)(H,20,21,23)	KXBLRXRFMXLHJH-UHFFFAOYSA-N	383852	US10280150, Cmpd No I-135::US10550099, Compound I-135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383852&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995826	404853139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766699	C[C@H](Nc1nccc(n1)N1CCCC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H18ClN5O2/c1-11(14-10-12-9-13(20)4-5-15(12)23-18(14)27)22-19-21-7-6-16(24-19)25-8-2-3-17(25)26/h4-7,9-11H,2-3,8H2,1H3,(H,23,27)(H,21,22,24)	CZWJVTIINQSCPD-UHFFFAOYSA-N	383855	US10280150, Cmpd No I-138::US10550099, Compound I-138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995829	404853142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766703	COc1nc(N[C@H](C)c2cc3cc(Cl)c(F)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-12(18)13(19)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	UCQMQHNCVXBAFQ-UHFFFAOYSA-N	383858	US10280150, Cmpd No I-141::US10550099, Compound I-141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995832	404853145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766705	COc1nc(NC(C)c2cc3cc(Cl)c(F)cc3[nH]c2=O)ncc1C#N	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-12(18)13(19)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	UCQMQHNCVXBAFQ-UHFFFAOYSA-N	383859	US10280150, Cmpd No I-142::US10550099, Compound I-142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995833	404853146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766707	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ncc(C#N)c(OC)n1 |r|	InChI=1S/C18H16ClN5O3/c1-9(22-18-21-8-11(7-20)17(24-18)27-3)12-4-10-5-13(19)15(26-2)6-14(10)23-16(12)25/h4-6,8-9H,1-3H3,(H,23,25)(H,21,22,24)	DIDCUOGCZYTDKE-UHFFFAOYSA-N	383860	US10280150, Cmpd No I-143::US10550099, Compound I-143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995834	404853147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766709	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@@H](C)Nc1ncc(C#N)c(OC)n1 |r|	InChI=1S/C18H16ClN5O3/c1-9(22-18-21-8-11(7-20)17(24-18)27-3)12-4-10-5-13(19)15(26-2)6-14(10)23-16(12)25/h4-6,8-9H,1-3H3,(H,23,25)(H,21,22,24)	DIDCUOGCZYTDKE-UHFFFAOYSA-N	383861	US10280150, Cmpd No I-144::US10550099, Compound I-144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995835	404853148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766711	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ncc(C#N)c(OC)n1	InChI=1S/C18H16ClN5O3/c1-9(22-18-21-8-11(7-20)17(24-18)27-3)12-4-10-5-13(19)15(26-2)6-14(10)23-16(12)25/h4-6,8-9H,1-3H3,(H,23,25)(H,21,22,24)	DIDCUOGCZYTDKE-UHFFFAOYSA-N	383862	US10280150, Cmpd No I-145::US10550099, Compound I-145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995836	404853149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766713	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1nccc(n1)N1CCOC1=O	InChI=1S/C19H18ClN5O4/c1-10(22-18-21-4-3-16(24-18)25-5-6-29-19(25)27)12-7-11-8-13(20)15(28-2)9-14(11)23-17(12)26/h3-4,7-10H,5-6H2,1-2H3,(H,23,26)(H,21,22,24)	CWHCWFAEESICOW-UHFFFAOYSA-N	383863	US10280150, Cmpd No I-146::US10550099, Compound I-146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995837	404853150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766717	CC(Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O	InChI=1S/C23H21ClN6O3/c1-13(27-23-26-8-6-21(30-23)28-14(2)31)17-9-15-10-18(24)20(11-19(15)29-22(17)32)33-12-16-5-3-4-7-25-16/h3-11,13H,12H2,1-2H3,(H,29,32)(H2,26,27,28,30,31)	ZLSBJNJDAPTCAQ-UHFFFAOYSA-N	383866	US10280150, Cmpd No I-149::US10550099, Compound I-149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995840	404853153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766719	COc1nc(NC(C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ncc1C#N	InChI=1S/C23H19ClN6O3/c1-13(28-23-27-11-15(10-25)22(30-23)32-2)17-7-14-8-18(24)20(9-19(14)29-21(17)31)33-12-16-5-3-4-6-26-16/h3-9,11,13H,12H2,1-2H3,(H,29,31)(H,27,28,30)	FDOFXICXZHTQAU-UHFFFAOYSA-N	383867	US10280150, Cmpd No I-150::US10550099, Compound I-150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995841	404853154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766721	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C23H19ClN6O3/c1-13(28-23-27-11-15(10-25)22(30-23)32-2)17-7-14-8-18(24)20(9-19(14)29-21(17)31)33-12-16-5-3-4-6-26-16/h3-9,11,13H,12H2,1-2H3,(H,29,31)(H,27,28,30)	FDOFXICXZHTQAU-UHFFFAOYSA-N	383868	US10280150, Cmpd No I-151::US10550099, Compound I-151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995842	404853155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766723	C[C@H](Nc1ncc(C#N)c(O)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C22H17ClN6O3/c1-12(27-22-26-10-14(9-24)20(30)29-22)16-6-13-7-17(23)19(8-18(13)28-21(16)31)32-11-15-4-2-3-5-25-15/h2-8,10,12H,11H2,1H3,(H,28,31)(H2,26,27,29,30)	PTFHNRSWZULIAX-UHFFFAOYSA-N	383869	US10280150, Cmpd No I-152::US10550099, Compound I-152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995843	404853156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766725	C[C@H](Nc1ncc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C23H19ClN6O2/c1-13-16(10-25)11-27-23(28-13)29-14(2)18-7-15-8-19(24)21(9-20(15)30-22(18)31)32-12-17-5-3-4-6-26-17/h3-9,11,14H,12H2,1-2H3,(H,30,31)(H,27,28,29)	ZZHWAZPQCJQQTG-UHFFFAOYSA-N	383870	US10280150, Cmpd No I-153::US10550099, Compound I-153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995844	404853157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766727	COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)n1 |r|	InChI=1S/C23H21ClN6O4/c1-13(27-22-26-8-6-20(29-22)30-23(32)33-2)16-9-14-10-17(24)19(11-18(14)28-21(16)31)34-12-15-5-3-4-7-25-15/h3-11,13H,12H2,1-2H3,(H,28,31)(H2,26,27,29,30,32)	LUSHQOUYLVLMAK-UHFFFAOYSA-N	383871	US10280150, Cmpd No I-154::US10550099, Compound I-154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995845	404853158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766729	COc1nc(N[C@@H](C)c2cc3cc(Cl)cnc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H13ClN6O2/c1-8(21-16-20-6-10(5-18)15(23-16)25-2)12-4-9-3-11(17)7-19-13(9)22-14(12)24/h3-4,6-8H,1-2H3,(H,19,22,24)(H,20,21,23)	NIJGOGFMWXNCAT-UHFFFAOYSA-N	383872	US10280150, Cmpd No I-155::US10550099, Compound I-155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995846	404853159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766731	COc1nc(N[C@@H](C)c2nc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H13ClN6O2/c1-8(20-16-19-7-9(6-18)15(23-16)25-2)13-14(24)22-11-4-3-10(17)5-12(11)21-13/h3-5,7-8H,1-2H3,(H,22,24)(H,19,20,23)	ITXHROZCEFEDIA-UHFFFAOYSA-N	383873	US10280150, Cmpd No I-156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995847	404853160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766733	COc1nc(N[C@H](C)c2nc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H13ClN6O2/c1-8(20-16-19-7-9(6-18)15(23-16)25-2)13-14(24)22-11-4-3-10(17)5-12(11)21-13/h3-5,7-8H,1-2H3,(H,22,24)(H,19,20,23)	ITXHROZCEFEDIA-UHFFFAOYSA-N	383874	US10280150, Cmpd No I-157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995848	404853161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766735	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(O[C@H](C)c4ccccn4)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C24H21ClN6O3/c1-13(29-24-28-12-16(11-26)23(31-24)33-3)17-8-15-9-18(25)21(10-20(15)30-22(17)32)34-14(2)19-6-4-5-7-27-19/h4-10,12-14H,1-3H3,(H,30,32)(H,28,29,31)	IHHNLVLFXFFARZ-UHFFFAOYSA-N	383875	US10280150, Cmpd No I-158::US10550099, Compound I-158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995849	404853162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766737	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OCC4CC4)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C21H20ClN5O3/c1-11(25-21-24-9-14(8-23)20(27-21)29-2)15-5-13-6-16(22)18(30-10-12-3-4-12)7-17(13)26-19(15)28/h5-7,9,11-12H,3-4,10H2,1-2H3,(H,26,28)(H,24,25,27)	IIDYGTPVIWYOGU-UHFFFAOYSA-N	383876	US10280150, Cmpd No I-159::US10550099, Compound I-159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995850	404853163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766739	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cc(F)c2[nH]c1=O |r|	InChI=1S/C17H15ClFN5O2/c1-8(21-17-20-4-3-14(23-17)22-9(2)25)12-6-10-5-11(18)7-13(19)15(10)24-16(12)26/h3-8H,1-2H3,(H,24,26)(H2,20,21,22,23,25)	ZFWGVHGZYGSYEF-UHFFFAOYSA-N	383877	US10280150, Cmpd No I-160::US10550099, Compound I-160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995851	404853164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766741	COc1nc(N[C@@H](C)c2cc3cc(Cl)cc(F)c3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)12-4-9-3-11(18)5-13(19)14(9)23-15(12)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	SNCJSEKZDINTPO-UHFFFAOYSA-N	383878	US10280150, Cmpd No I-161::US10550099, Compound I-161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995852	404853165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766743	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(Br)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13BrClN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-13(19)12(18)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	WVWHWIPYHVESPA-UHFFFAOYSA-N	383879	US10280150, Cmpd No I-162::US10550099, Compound I-162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995853	404853166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766750	Clc1ccc2[nH]c(=O)c(cc2c1)C1(CC1)Nc1nccc(n1)N1CCOC1=O	InChI=1S/C19H16ClN5O3/c20-12-1-2-14-11(9-12)10-13(16(26)22-14)19(4-5-19)24-17-21-6-3-15(23-17)25-7-8-28-18(25)27/h1-3,6,9-10H,4-5,7-8H2,(H,22,26)(H,21,23,24)	DHOJVHPWGDRGJX-UHFFFAOYSA-N	383885	US10280150, Cmpd No I-168::US10550099, Compound I-168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995859	404853172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766752	COc1nc(NC2(CC2)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N	InChI=1S/C18H14ClN5O2/c1-26-16-11(8-20)9-21-17(23-16)24-18(4-5-18)13-7-10-6-12(19)2-3-14(10)22-15(13)25/h2-3,6-7,9H,4-5H2,1H3,(H,22,25)(H,21,23,24)	SQKZXBLFCIZHCQ-UHFFFAOYSA-N	383886	US10280150, Cmpd No I-169::US10550099, Compound I-169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995860	404853173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766756	COc1nc(NC(C)c2cc3cc(Cl)c(OCC4CC(F)(F)C4)cc3[nH]c2=O)ncc1C#N	InChI=1S/C22H20ClF2N5O3/c1-11(28-21-27-9-14(8-26)20(30-21)32-2)15-3-13-4-16(23)18(5-17(13)29-19(15)31)33-10-12-6-22(24,25)7-12/h3-5,9,11-12H,6-7,10H2,1-2H3,(H,29,31)(H,27,28,30)	IUPXBQBQSGKYHG-UHFFFAOYSA-N	383889	US10280150, Cmpd No I-172::US10550099, Compound I-172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995863	404853176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766758	CC(C)n1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)n1 |r|	InChI=1S/C22H23ClN6O/c1-13(2)29-12-24-11-20(29)18-7-8-25-22(27-18)26-14(3)17-10-15-9-16(23)5-6-19(15)28(4)21(17)30/h5-14H,1-4H3,(H,25,26,27)	GFUUTRABMIWYGA-UHFFFAOYSA-N	383890	US10280150, Cmpd No I-173::US10550099, Compound I-173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			118953995	404853177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766760	COc1nc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H14ClN5O2/c1-9(21-17-20-8-11(7-19)16(23-17)25-2)13-6-10-5-12(18)3-4-14(10)22-15(13)24/h3-6,8-9H,1-2H3,(H,22,24)(H,20,21,23)	QAFWVLDKBWIXLX-UHFFFAOYSA-N	383891	US10280150, Cmpd No I-174::US10550099, Compound I-174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995864	404853178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766762	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OC(C)C)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C20H20ClN5O3/c1-10(2)29-17-7-16-12(6-15(17)21)5-14(18(27)25-16)11(3)24-20-23-9-13(8-22)19(26-20)28-4/h5-7,9-11H,1-4H3,(H,25,27)(H,23,24,26)	PVBTVTWQUGLJJL-UHFFFAOYSA-N	383892	US10280150, Cmpd No I-175::US10550099, Compound I-175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995865	404853179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766764	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(cc3[nH]c2=O)C2CC2)ncc1C#N |r|	InChI=1S/C20H18ClN5O2/c1-10(24-20-23-9-13(8-22)19(26-20)28-2)14-5-12-6-16(21)15(11-3-4-11)7-17(12)25-18(14)27/h5-7,9-11H,3-4H2,1-2H3,(H,25,27)(H,23,24,26)	IQGRWPVZOSEPGO-UHFFFAOYSA-N	383893	US10280150, Cmpd No I-176::US10550099, Compound I-176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995866	404853180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766766	COc1nc(N[C@@H](C)c2cc3ncccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H14N6O2/c1-9(20-16-19-8-10(7-17)15(22-16)24-2)11-6-13-12(21-14(11)23)4-3-5-18-13/h3-6,8-9H,1-2H3,(H,21,23)(H,19,20,22)	SRXVJORPRMEGHD-UHFFFAOYSA-N	383894	US10280150, Cmpd No I-177::US10550099, Compound I-177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995867	404853181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766768	C[C@H](Nc1ncc(C#N)c(=O)[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H12ClN5O2/c1-8(20-16-19-7-10(6-18)14(23)22-16)12-5-9-4-11(17)2-3-13(9)21-15(12)24/h2-5,7-8H,1H3,(H,21,24)(H2,19,20,22,23)	HGDXPXJSJCBWKT-UHFFFAOYSA-N	383895	US10280150, Cmpd No I-178::US10550099, Compound I-178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995868	404853182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766770	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C17H15ClFN5O2/c1-8(21-17-20-4-3-15(24-17)22-9(2)25)11-5-10-6-12(18)13(19)7-14(10)23-16(11)26/h3-8H,1-2H3,(H,23,26)(H2,20,21,22,24,25)	HEULCGXPIFZLCP-UHFFFAOYSA-N	383896	US10280150, Cmpd No I-179::US10550099, Compound I-179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995869	404853183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766772	C[C@H](Nc1nccc(NC(=O)C2CC2)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C19H17ClFN5O2/c1-9(12-6-11-7-13(20)14(21)8-15(11)24-18(12)28)23-19-22-5-4-16(26-19)25-17(27)10-2-3-10/h4-10H,2-3H2,1H3,(H,24,28)(H2,22,23,25,26,27)	PFVGLDJJFIUPMI-UHFFFAOYSA-N	383897	US10280150, Cmpd No I-180::US10550099, Compound I-180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995870	404853184							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766774	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(F)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-12(18)13(19)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	UCQMQHNCVXBAFQ-UHFFFAOYSA-N	383898	US10280150, Cmpd No I-181::US10550099, Compound I-181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995871	404853185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766776	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cnc2[nH]c1=O |r|	InChI=1S/C16H15ClN6O2/c1-8(20-16-18-4-3-13(22-16)21-9(2)24)12-6-10-5-11(17)7-19-14(10)23-15(12)25/h3-8H,1-2H3,(H,19,23,25)(H2,18,20,21,22,24)	PWDCFGXTJJQFIN-UHFFFAOYSA-N	383899	US10280150, Cmpd No I-182::US10550099, Compound I-182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995872	404853186							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766778	C[C@H](Nc1nccc(n1)-n1nnnc1C1CC1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN8O/c1-10(14-9-12-8-13(20)4-5-15(12)23-18(14)29)22-19-21-7-6-16(24-19)28-17(11-2-3-11)25-26-27-28/h4-11H,2-3H2,1H3,(H,23,29)(H,21,22,24)	VAVXHHABBZSMPQ-UHFFFAOYSA-N	383900	US10280150, Cmpd No I-183::US10550099, Compound I-183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383900&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995873	404853187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766780	C[C@H](Nc1nccc(n1)-n1nnnc1C1CC1)c1cc2cc(Cl)cnc2[nH]c1=O |r|	InChI=1S/C18H16ClN9O/c1-9(13-7-11-6-12(19)8-21-15(11)24-17(13)29)22-18-20-5-4-14(23-18)28-16(10-2-3-10)25-26-27-28/h4-10H,2-3H2,1H3,(H,20,22,23)(H,21,24,29)	TVYSRTVGQLLENL-UHFFFAOYSA-N	383901	US10280150, Cmpd No I-184::US10550099, Compound I-184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=446&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383901&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132C%5D&column=ki&startPg=0&Increment=50&submit=Search			145995874	404853188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	6IO0,5K11,5K10	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8