Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50023475
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of GCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of MAP4K4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMisshapen-like kinase 1(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of MINK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataEC50:  6.40nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591137BDBM591137(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...)
Affinity DataEC50:  11nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataEC50:  20nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 31nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598027BDBM598027(US11612606, Compound 401 | Tetrahydro-2H-pyran-4-y...)
Affinity DataEC50:  39nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 44nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetAurora kinase B(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 46nMAssay Description:Inhibition of Aurora kinase B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataIC50: 61nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598027BDBM598027(US11612606, Compound 401 | Tetrahydro-2H-pyran-4-y...)
Affinity DataIC50: 97nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591137BDBM591137(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...)
Affinity DataIC50: 110nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50664063BDBM50664063(CHEMBL6172131)
Affinity DataEC50:  186nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591148BDBM591148(tetrahydro-2H-pyran-4-yl (8-amino- 6-(5-amino-4-me...)
Affinity DataEC50:  190nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50664063BDBM50664063(CHEMBL6172131)
Affinity DataIC50: 280nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591102BDBM591102((2R)-2-(4-(8-amino-7-fluoro-6-(4-methylpyridin-3-y...)
Affinity DataEC50:  419nMAssay Description:Inhibition of HPK1 in primary human Pan T cells assessed as increase in IL-2 secretion pretreated for 30 mins followed by incubation with anti-CD3/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591102BDBM591102((2R)-2-(4-(8-amino-7-fluoro-6-(4-methylpyridin-3-y...)
Affinity DataIC50: 570nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 591148BDBM591148(tetrahydro-2H-pyran-4-yl (8-amino- 6-(5-amino-4-me...)
Affinity DataIC50: 620nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of anti-CD3/anti-CD28-induced SLP76 phosporylation at Ser376 residue incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Genentech Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 598085BDBM598085(US11612606, Compound 441c | (cis)-4-Methyltetrahyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed