Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50022921
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataKd:  1nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as dissociation rate constant (Kd) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656203BDBM50656203(CHEMBL6159998)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656198BDBM50656198(CHEMBL6091977)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656197BDBM50656197(CHEMBL6169584)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656199BDBM50656199(CHEMBL6165125)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656201BDBM50656201(CHEMBL6152194)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656204BDBM50656204(CHEMBL6147385)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656200BDBM50656200(CHEMBL6168939)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 665697BDBM665697(US20240116918, Example 2)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 177922BDBM177922(US9675614, 166 | US10307413, Compound 337 | US1039...)
Affinity DataIC50: 22nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using SAM as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656195BDBM50656195(CHEMBL6101954)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656194BDBM50656194(CHEMBL6148092)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 665696BDBM665696(US20240116918, Example 1)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 595609BDBM595609(US11591326, Compound 24a)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 42nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656205BDBM50656205(CHEMBL6148585)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656206BDBM50656206(CHEMBL6103063)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656196BDBM50656196(CHEMBL6160403)
Affinity DataIC50: 116nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656202BDBM50656202(CHEMBL6168561)
Affinity DataIC50: 249nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 468nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 491nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 759nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 793nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656192BDBM50656192(CHEMBL6102865)
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28422BDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataIC50: 5.18E+3nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656193BDBM50656193(CHEMBL6161525)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656191BDBM50656191(CHEMBL6160922)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656190BDBM50656190(CHEMBL6159905)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged human full-length PRMT5/full length human MEP50 extracted from baculovirus expression system using [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 178166BDBM178166(US9675614, 208 | US10307413, Compound 208 | US1039...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623918BDBM50623918(CHEMBL5398215)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed