Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50023112
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14774BDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50463838BDBM50463838(CHEMBL4238926)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14774BDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50507816BDBM50507816(Bms-986165 | Deucravacitinib | US12351572, Example...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246868BDBM246868({1-{1-[3-Fluoro-2- (trifluoromethyl) isonicotinoyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK1 (unknown origin) using Biotin-Lyn-Substrate-2 as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355501BDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 150200BDBM150200(US8980905, 108 | US9637499, Compound 108)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE4D (unknown origin) extracted from baculovirus infected Insect cells incubated for 20 mins by topcount scintillation counter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 150200BDBM150200(US8980905, 108 | US9637499, Compound 108)
Affinity DataIC50: 3nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355501BDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50463838BDBM50463838(CHEMBL4238926)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human full length JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50463838BDBM50463838(CHEMBL4238926)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50463838BDBM50463838(CHEMBL4238926)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659305BDBM50659305(CHEMBL6143080)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659305BDBM50659305(CHEMBL6143080)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetAryl hydrocarbon receptor(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50603566BDBM50603566(TAPINAROF | Tapinarof | Benvitimod | Vtama | Wbi-1...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human AhR by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 1(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 322155BDBM322155(US11311541, Example SLx-2119 | US10696660, SLx-211...)
Affinity DataIC50: 24nMAssay Description:Inhibition of ROCK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659303BDBM50659303(CHEMBL6160881)
Affinity DataIC50: 74nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659303BDBM50659303(CHEMBL6160881)
Affinity DataIC50: 74nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50439622BDBM50439622(CHEMBL2419346 | US10035797, Compound 111 | US96309...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HSP90alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50439622BDBM50439622(CHEMBL2419346 | US10035797, Compound 111 | US96309...)
Affinity DataIC50: 103nMAssay Description:Inhibition of HSP90beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 322155BDBM322155(US11311541, Example SLx-2119 | US10696660, SLx-211...)
Affinity DataIC50: 105nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Southern Medical University (The First People's Hospital of Shunde)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659304BDBM50659304(Mufemilast | HEMAY-005 | HEMAY005)
Affinity DataIC50: 114nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed