Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50023258
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391802BDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MEK1 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391802BDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 29nMAssay Description:Inhibition of MEK1 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetInsulin-like growth factor 1 receptor(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50315887BDBM50315887((1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidaz...)
Affinity DataIC50: 35nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391809BDBM50391809(CHEMBL2146887)
Affinity DataIC50: 44nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391807BDBM50391807(CHEMBL2146889)
Affinity DataIC50: 51nMAssay Description:Inhibition of MEK1 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50339059BDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50: 64nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391807BDBM50391807(CHEMBL2146889)
Affinity DataIC50: 82nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391813BDBM50391813(CHEMBL2146886)
Affinity DataIC50: 111nMAssay Description:Inhibition of MEK1 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50391813BDBM50391813(CHEMBL2146886)
Affinity DataIC50: 535nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed