Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50023621
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 67nMAssay Description:Inhibition of human TREK-1 channel by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688393BDBM688393(US20240190824, Compound 1 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688429BDBM688429(US20240190824, Compound 28 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688410BDBM688410(US20240190824, Compound 9 | 2-chloro-5- (cycloprop...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688397BDBM688397(US20240190824, Compound 5 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665982BDBM50665982(CHEMBL6163118)
Affinity DataIC50: 290nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688438BDBM688438(US20240190824, Compound 37 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688426BDBM688426(US20240190824, Compound 25 | tert-butyl (3-((4-(be...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetAdenosine receptor A3(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataKi:  480nMAssay Description:Inhibition of human adenosine A3 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688443BDBM688443(US20240190824, Compound 42 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688488BDBM688488(US20240190824, Compound 87 | tert-butyl N-[3-[(5-b...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688487BDBM688487(US20240190824, Compound 86 | tert-butyl N-[3-[(5-b...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688446BDBM688446(US20240190824, Compound 45 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Rat)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataKi:  650nMAssay Description:Inhibition of rat Nav1.5 channel assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688491BDBM688491(US20240190824, Compound 90 | tert-butyl (3-((6-(be...)
Affinity DataIC50: 850nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688448BDBM688448(US20240190824, Compound 47 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 910nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688452BDBM688452(US20240190824, Compound 51 | tert-butyl N-[4-chlor...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688490BDBM688490(US20240190824, Compound 89 | 4-amino-N-(4-(benzylo...)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed